LOCUS       NM_024430               3000 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens proline-serine-threonine phosphatase interacting
            protein 2 (PSTPIP2), mRNA.
ACCESSION   NM_024430
VERSION     NM_024430.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3000)
  AUTHORS   Wang,X., Wang,Y., Luo,J., Wang,L., Guo,L. and Zhu,X.
  TITLE     PSTPIP2 is associated with disease severity in patients with
            pressure ulcer sepsis and has anti-inflammatory effects
  JOURNAL   Allergol Immunopathol (Madr) 51 (5), 23-28 (2023)
   PUBMED   37695226
  REMARK    GeneRIF: PSTPIP2 is associated with disease severity in patients
            with pressure ulcer sepsis and has anti-inflammatory effects.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3000)
  AUTHORS   Zhu,H., Jiang,W., Zhao,H., He,C., Tang,X., Xu,S., Xu,C., Feng,R.,
            Li,J., Ma,T. and Huang,C.
  TITLE     PSTPIP2 inhibits cisplatin-induced acute kidney injury by
            suppressing apoptosis of renal tubular epithelial cells
  JOURNAL   Cell Death Dis 11 (12), 1057 (2020)
   PUBMED   33311489
  REMARK    GeneRIF: PSTPIP2 inhibits cisplatin-induced acute kidney injury by
            suppressing apoptosis of renal tubular epithelial cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3000)
  AUTHORS   Huai,C., Wei,Y., Li,M., Zhang,X., Wu,H., Qiu,X., Shen,L., Chen,L.,
            Zhou,W., Zhang,N., Zhu,G., Zhang,Y., Zhang,Z., He,L. and Qin,S.
  TITLE     Genome-Wide Analysis of DNA Methylation and Antituberculosis
            Drug-Induced Liver Injury in the Han Chinese Population
  JOURNAL   Clin Pharmacol Ther 106 (6), 1389-1397 (2019)
   PUBMED   31247120
  REMARK    GeneRIF: Methylation on PSTPIP2 is associated with the development
            of anti-tuberculosis drug-induced liver injury.
REFERENCE   4  (bases 1 to 3000)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 3000)
  AUTHORS   Liu,L., Wen,Q., Gong,R., Gilles,L., Stankiewicz,M.J., Li,W.,
            Guo,M., Li,L., Sun,X., Li,W., Crispino,J.D. and Huang,Z.
  TITLE     PSTPIP2 dysregulation contributes to aberrant terminal
            differentiation in GATA-1-deficient megakaryocytes by activating
            LYN
  JOURNAL   Cell Death Dis 5 (1), e988 (2014)
   PUBMED   24407241
  REMARK    GeneRIF: PSTPIP2 dysregulation contributes to aberrant terminal
            differentiation in GATA-1-deficient megakaryocytes by activating
            LYN.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3000)
  AUTHORS   Hurtado-Nedelec,M., Chollet-Martin,S., Chapeton,D., Hugot,J.P.,
            Hayem,G. and Gerard,B.
  TITLE     Genetic susceptibility factors in a cohort of 38 patients with
            SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes
  JOURNAL   J Rheumatol 37 (2), 401-409 (2010)
   PUBMED   20032092
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3000)
  AUTHORS   Pope,S.N. and Lee,I.R.
  TITLE     Yeast two-hybrid identification of prostatic proteins interacting
            with human sex hormone-binding globulin
  JOURNAL   J Steroid Biochem Mol Biol 94 (1-3), 203-208 (2005)
   PUBMED   15862967
REFERENCE   8  (bases 1 to 3000)
  AUTHORS   Yeung,Y.G., Soldera,S. and Stanley,E.R.
  TITLE     A novel macrophage actin-associated protein (MAYP) is
            tyrosine-phosphorylated following colony stimulating factor-1
            stimulation
  JOURNAL   J Biol Chem 273 (46), 30638-30642 (1998)
   PUBMED   9804836
REFERENCE   9  (bases 1 to 3000)
  AUTHORS   Wu,Y., Dowbenko,D. and Lasky,L.A.
  TITLE     PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated
            protein that binds a PEST-type protein-tyrosine phosphatase
  JOURNAL   J Biol Chem 273 (46), 30487-30496 (1998)
   PUBMED   9804817
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP352927.1, BC035395.1, DA943980.1 and AC090355.9.
            
            On Nov 23, 2018 this sequence version replaced NM_024430.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.13567.1,
                                           SRR11853564.13282.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409746.5/ ENSP00000387261.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BP352927.1         25-27
            4-813               BC035395.1         1-810
            814-1284            DA943980.1         96-566
            1285-2555           BC035395.1         1185-2455
            2556-2571           AC090355.9         153146-153161       c
            2572-3000           BC035395.1         2472-2900
FEATURES             Location/Qualifiers
     source          1..3000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..3000
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /note="proline-serine-threonine phosphatase interacting
                     protein 2"
                     /db_xref="GeneID:9050"
                     /db_xref="HGNC:HGNC:9581"
                     /db_xref="MIM:616046"
     exon            1..105
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1077
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /note="PEST phosphatase-interacting protein 2"
                     /codon_start=1
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 2"
                     /protein_id="NP_077748.3"
                     /db_xref="CCDS:CCDS32820.2"
                     /db_xref="GeneID:9050"
                     /db_xref="HGNC:HGNC:9581"
                     /db_xref="MIM:616046"
                     /translation="MTRSLFKGNFWSADILSTIGYDNIIQHLNNGRKNCKEFEDFLKE
                     RAAIEERYGKDLLNLSRKKPCGQSEINTLKRALEVFKQQVDNVAQCHIQLAQSLREEA
                     RKMEEFREKQKLQRKKTELIMDAIHKQKSLQFKKTMDAKKNYEQKCRDKDEAEQAVSR
                     SANLVNPKQQEKLFVKLATSKTAVEDSDKAYMLHIGTLDKVREEWQSEHIKACEAFEA
                     QECERINFFRNALWLHVNQLSQQCVTSDEMYEQVRKSLEMCSIQRDIEYFVNQRKTGQ
                     IPPAPIMYENFYSSQKNAVPAGKATGPNLARRGPLPIPKSSPDDPNYSLVDDYSLLYQ
                     "
     exon            106..206
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            207..284
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            285..319
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            320..426
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            427..489
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            490..588
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            589..634
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            635..714
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            715..813
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            814..910
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            911..992
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1027
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1085
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..3000
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2976..2981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /note="hexamer: AATAAA"
     polyA_site      3000
                     /gene="PSTPIP2"
                     /gene_synonym="MAYP"
                     /note="major polyA site"
ORIGIN      
        1 agtggcagtc aggcctcccc gctctgtgct acctgcggcc cggctctcct ccgcgccccc
       61 actcgcgctg cgatgacgcg ctcactgttc aagggaaact tttggagtgc agacatcctc
      121 agcaccatcg gctatgacaa cattatccaa catctgaaca atggccgcaa gaactgcaaa
      181 gagtttgaag actttctaaa agaaagggca gcaattgaag agaggtatgg caaagatctg
      241 ctcaacctct ctaggaagaa gccgtgtgga cagtctgaaa tcaacaccct gaagcgggcc
      301 cttgaagtct tcaagcagca agtagacaat gtggcacaat gtcacattca gcttgcacag
      361 agtttaagag aagaggccag gaagatggaa gaattcaggg aaaagcaaaa actacaacga
      421 aaaaagacag agctcataat ggatgctatc cataaacaaa agagcttaca attcaagaaa
      481 accatggatg caaagaagaa ctatgagcag aaatgccggg acaaagatga ggcagaacag
      541 gccgtcagcc ggagtgccaa cctggtgaac ccgaagcaac aagaaaagct ttttgtgaaa
      601 ctggcaactt caaagaccgc agtagaggac tcagacaaag catacatgct gcacatcggc
      661 accctggata aggtccgaga agagtggcag agtgagcaca tcaaggcctg cgaggcattt
      721 gaggctcaag aatgtgaacg aataaacttc ttccggaatg cattgtggtt acatgtgaat
      781 cagctgtcac aacaatgtgt caccagtgat gaaatgtacg aacaagtccg aaagagttta
      841 gaaatgtgca gcattcagag ggacattgaa tactttgtga atcaacgcaa aactggacag
      901 attccaccag cacccatcat gtatgagaat ttctactcct cccagaagaa tgcagtccca
      961 gcaggaaagg ctacagggcc taacttggca aggagaggac ccctcccaat tcctaaaagc
     1021 tcaccagatg atcccaatta ctctttggtt gatgactaca gtttgctcta tcagtaaaat
     1081 caatgaaacc agagcttttt ccggctagtg cttctgtgat atggaaaggg cacccagagc
     1141 agcaggacct atagccacgt tatgtcagca atgaagactt tgaagtgaac ccttgctata
     1201 attttttaga gatttaaaat ttatggtaga catttaggac aacataagca agtagagttc
     1261 tgcagttttt tgaagtttac aaattgcccc attctgaaga attattcttt cccagttact
     1321 caggttatga atgaattagg ttttcaacat gggaagcatg aaatccactt ctggatttgg
     1381 agcatccact tgaggagcag aggtggcagc agaggattct gagccaccaa ctgcagtagt
     1441 ggctcctttg gctttgggca gcctggctgt ggagtttcca cggcgacaca cagcctcagt
     1501 ggtgcaagat ttaaaattac cttccttttt ggctggaaga cttagaagcc gcctgatcat
     1561 actttctcat tttacagatg aggaaataaa gcctacaagt gtgaaattaa tttccttaca
     1621 gttttcctag ctgatgaggg acagaaccag aactagagcc tgagcccaac ccacatcact
     1681 attcttctaa cccttcctga agttgtgatg ctcatgctga aatttaagat gccaaatatt
     1741 tttgccagca ctttttcagt tgggagaatc accagggttt aaatgtcaga tttattttta
     1801 tgtggatccc tgtgtatgct gaactacaga gcatgatgtt taatctaatt taaggagcca
     1861 ctgattgtaa aacatgccat tattttatgt tgcactaaga aggtggggtc gaggagttgc
     1921 caataaactt gggacagact attgatggcc aagcccatct gaatttaaga tgctaaagta
     1981 tgaaaaaaat acatcttaga atcaatgaaa taccatattt tgattccatt cctcaagata
     2041 attttagagt tataaaacca gtcctcaatt ttgggtcttc acagagaatc tttcccttgc
     2101 tagaccccag aattttaaat gcatccgtct tacactttca caaatatttg ggttttcctt
     2161 tttcactcac aaacagcagg gaggtcatgt actttttgta caacacctgt gcactatgag
     2221 aaaatggtac cttttagtta ttgacaagtt aaaatagcac tctcagtttt tcagtattac
     2281 agagagcaaa tagtttcctc tcctgctctg tgcagtagct tttccagaac tatggacaaa
     2341 ttgatcagaa gaagattgat tatttcctca tctttttttc ttttttttga gacagagtct
     2401 ctctctgtcc cccaggctga agtgcagcgg catgatctca gctcactgca acctctgcct
     2461 cccgggttca agtgattctc ctgcctcagc ctcctgagta gctgggatta caggcaccca
     2521 ccaccacacc tggctaattt tttgtatttt tagtaaagac agggttttac catgttggtc
     2581 aggctggtct caaactcctg acctcaggtg atccacctgc ctcggcctcc caaagtgctg
     2641 ggattacagg cgtgagccac tgcgcccggc ctatttcccc acctttcgtg taaggtgcta
     2701 ctgaacatga cagcttcttg tcatgacagg aaacttgcat cagttggata tccttttgag
     2761 aaactgaatt ttgcaaaggg ccaaatttcc ccaaactgaa cgggctcagg aaatgttcct
     2821 ttacactcag aacattctat tttaagtata ttatttattg ttggcagttc ctcagggatt
     2881 tcccttttct ctgtattggt cagtgtagtt gatgtaaaac cgttttgtgg atggaaaata
     2941 tttttatttt attgctcttt tagtttggta ggttaaataa aggttcttgg taatttggga
//
