LOCUS       NM_001363531            1173 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens phosphoseryl-tRNA kinase (PSTK), transcript variant 1,
            mRNA.
ACCESSION   NM_001363531 XM_017015640
VERSION     NM_001363531.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1173)
  AUTHORS   Smejda,M., Kadziolka,D., Radczuk,N., Krutyholowa,R.,
            Chramiec-Glabik,A., Kedracka-Krok,S., Jankowska,U., Biela,A. and
            Glatt,S.
  TITLE     Same but different - Molecular comparison of human KTI12 and PSTK
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (4), 118945 (2021)
   PUBMED   33417976
  REMARK    GeneRIF: Same but different - Molecular comparison of human KTI12
            and PSTK.
REFERENCE   2  (bases 1 to 1173)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1173)
  AUTHORS   Carlson,B.A., Xu,X.M., Kryukov,G.V., Rao,M., Berry,M.J.,
            Gladyshev,V.N. and Hatfield,D.L.
  TITLE     Identification and characterization of phosphoseryl-tRNA[Ser]Sec
            kinase
  JOURNAL   Proc Natl Acad Sci U S A 101 (35), 12848-12853 (2004)
   PUBMED   15317934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073585.8.
            
            On Jun 2, 2019 this sequence version replaced NM_001363531.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.36030.1,
                                           SRR1163658.310752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406217.8/ ENSP00000384653.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               AC073585.8         57691-57985         c
            296-587             AC073585.8         55362-55653         c
            588-786             AC073585.8         54916-55114         c
            787-862             AC073585.8         52011-52086         c
            863-956             AC073585.8         51424-51517         c
            957-1173            AC073585.8         47996-48212         c
FEATURES             Location/Qualifiers
     source          1..1173
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..1173
                     /gene="PSTK"
                     /gene_synonym="C10orf89"
                     /note="phosphoseryl-tRNA kinase"
                     /db_xref="GeneID:118672"
                     /db_xref="HGNC:HGNC:28578"
                     /db_xref="MIM:611310"
     exon            1..295
                     /gene="PSTK"
                     /gene_synonym="C10orf89"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1156
                     /gene="PSTK"
                     /gene_synonym="C10orf89"
                     /EC_number="2.7.1.164"
                     /note="isoform 1 is encoded by transcript variant 1;
                     L-seryl-tRNA(Sec) kinase; O-phosphoseryl-tRNA(Sec) kinase"
                     /codon_start=1
                     /product="L-seryl-tRNA(Sec) kinase isoform 1"
                     /protein_id="NP_001350460.1"
                     /db_xref="CCDS:CCDS86153.1"
                     /db_xref="GeneID:118672"
                     /db_xref="HGNC:HGNC:28578"
                     /db_xref="MIM:611310"
                     /translation="MKTAENIRGTGSDGPRKRGLCVLCGLPAAGKSTFARALAHRLQQ
                     EQGWAIGVVAYDDVMPDAFLAGARARPAPSQWKLLRQELLKYLEYFLMAVINGCQMSV
                     PPNRTEAMWEDFITCLKDQDLIFSAAFEAQSCYLLTKTAVSRPLFLVLDDNFYYQSMR
                     YEVYQLARKYSLGFCQLFLDCPLETCLQRNGQRPQALPPETIHLMGRKLEKPNPEKNA
                     WEHNSLTIPSPACASEASLEVTDLLLTALENPVKYAEDNMEQKDTDRIICSTNILHKT
                     DQTLRRIVSQTMKEAKDEQVLPHNLKLLAEELNKLKAEFLEDLKQGNKKYLCFQQTID
                     IPDVISFFHYEKDNIVQKYFSKQH"
     exon            296..587
                     /gene="PSTK"
                     /gene_synonym="C10orf89"
                     /inference="alignment:Splign:2.1.0"
     exon            588..786
                     /gene="PSTK"
                     /gene_synonym="C10orf89"
                     /inference="alignment:Splign:2.1.0"
     exon            787..862
                     /gene="PSTK"
                     /gene_synonym="C10orf89"
                     /inference="alignment:Splign:2.1.0"
     exon            863..956
                     /gene="PSTK"
                     /gene_synonym="C10orf89"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1173
                     /gene="PSTK"
                     /gene_synonym="C10orf89"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1152..1157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSTK"
                     /gene_synonym="C10orf89"
                     /note="hexamer: ATTAAA"
     polyA_site      1173
                     /gene="PSTK"
                     /gene_synonym="C10orf89"
                     /note="major polyA site"
ORIGIN      
        1 ggagacgctg cgcgtgcgcg cagggcagac ggtagagcgg agacgacgct cccagactcc
       61 tccggtctcc ccgggcagca tgaagaccgc cgagaacatc agaggaaccg gcagcgacgg
      121 gccgcggaaa cgaggcctct gcgtcctctg tggcctcccc gcggcaggaa aatcgacttt
      181 cgcgcgcgcc ctcgcccacc ggctgcagca ggagcagggt tgggccatcg gtgttgtcgc
      241 gtatgatgac gtcatgcccg acgcgtttct cgccggggca agagcgcgac cggcgccatc
      301 ccaatggaaa ttgcttcgac aggaactgtt gaagtacctg gaatacttct tgatggctgt
      361 cattaatggg tgtcagatgt ctgtcccacc caacaggact gaagccatgt gggaagattt
      421 tataacctgc ttaaaggatc aagatctgat attttctgca gcatttgagg cccagtcttg
      481 ctacctctta acaaaaactg ctgtttctag acctttgttt ttggttttgg atgacaattt
      541 ttattatcag agtatgagat atgaagtcta ccagctggct cggaaatatt cgttgggctt
      601 ttgccagctc tttttagatt gtcctcttga gacctgttta cagaggaatg gccagaggcc
      661 acaggcactg cctcctgaga ccatccacct gatgggaaga aagctagaaa agcccaaccc
      721 tgagaaaaat gcttgggaac acaacagcct cacaattccg agtccagcat gtgcttcgga
      781 ggccagcctg gaagtgactg atttattgct cactgctttg gaaaatccag taaaatatgc
      841 tgaggacaat atggaacaaa aggacacaga cagaattatt tgttcaacta acattcttca
      901 taaaactgat cagacactcc gaaggattgt atctcagaca atgaaggaag caaaagatga
      961 acaagtgctt cctcacaact tgaagcttct agcagaagaa cttaacaagc tcaaagcaga
     1021 gtttttggaa gacctaaaac aaggaaacaa aaaatatctg tgctttcagc aaaccattga
     1081 cataccagat gtcatttctt tttttcatta tgagaaagat aatattgtac agaagtattt
     1141 ttcaaagcag cattaaaatt tctgaactgc caa
//
