LOCUS       NM_001032291            1720 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens proline and serine rich coiled-coil 1 (PSRC1),
            transcript variant 3, mRNA.
ACCESSION   NM_001032291
VERSION     NM_001032291.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1720)
  AUTHORS   Nehlig,A., Seiler,C., Steblyanko,Y., Dingli,F., Arras,G., Loew,D.,
            Welburn,J., Prigent,C., Barisic,M. and Nahmias,C.
  TITLE     Reciprocal regulation of Aurora kinase A and ATIP3 in the control
            of metaphase spindle length
  JOURNAL   Cell Mol Life Sci 78 (4), 1765-1779 (2021)
   PUBMED   32789689
  REMARK    GeneRIF: Reciprocal regulation of Aurora kinase A and ATIP3 in the
            control of metaphase spindle length.
REFERENCE   2  (bases 1 to 1720)
  AUTHORS   Rodriguez-Arellano,M.E., Solares-Tlapechco,J., Costa-Urrutia,P.,
            Cardenas-Hernandez,H., Vallejo-Gomez,M., Granados,J. and
            Salas-Padilla,S.
  TITLE     Association of the PSRC1 rs599839 Variant with Coronary Artery
            Disease in a Mexican Population
  JOURNAL   Medicina (Kaunas) 56 (9), 427 (2020)
   PUBMED   32858814
  REMARK    GeneRIF: Association of the PSRC1 rs599839 Variant with Coronary
            Artery Disease in a Mexican Population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1720)
  AUTHORS   Keller,M., Gebhardt,C., Huth,S., Schleinitz,D., Heyne,H.,
            Scholz,M., Stumvoll,M., Bottcher,Y., Tonjes,A. and Kovacs,P.
  TITLE     Genetically programmed changes in transcription of the novel
            progranulin regulator
  JOURNAL   J Mol Med (Berl) 98 (8), 1139-1148 (2020)
   PUBMED   32620998
  REMARK    GeneRIF: Genetically programmed changes in transcription of the
            novel progranulin regulator.
REFERENCE   4  (bases 1 to 1720)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1720)
  AUTHORS   Sanchez Munoz-Torrero,J.F., Rivas,M.D., Zamorano,J.,
            Joya-Vazquez,P.P., de Isla,L.P., Padro,T., Mata,P. and The
            Safeheart,Investigators.
  TITLE     Multivariate analysis for coronary heart disease in heterozygote
            familial hypercholesterolemia patients
  JOURNAL   Per Med 15 (2), 87-92 (2018)
   PUBMED   29714125
  REMARK    GeneRIF: the frequency of SNP rs599839 located in the 3' UTR of the
            PSRC1 gene in patients with genetically confirmed diagnosis of
            heterozygous familial hypercholesterolemia was analyzed. It was
            found that there was no association between rs599839 alleles and
            coronary heart disease in the multivariate analysis.
REFERENCE   6  (bases 1 to 1720)
  AUTHORS   Hsieh,W.J., Hsieh,S.C., Chen,C.C. and Wang,F.F.
  TITLE     Human DDA3 is an oncoprotein down-regulated by p53 and DNA damage
  JOURNAL   Biochem Biophys Res Commun 369 (2), 567-572 (2008)
   PUBMED   18291097
  REMARK    GeneRIF: Together our results show that hDDA3 is a p53- and
            DNA-damage down-regulated target that exhibits oncogenic
            characteristics.
REFERENCE   7  (bases 1 to 1720)
  AUTHORS   Jang,C.Y., Wong,J., Coppinger,J.A., Seki,A., Yates,J.R. 3rd and
            Fang,G.
  TITLE     DDA3 recruits microtubule depolymerase Kif2a to spindle poles and
            controls spindle dynamics and mitotic chromosome movement
  JOURNAL   J Cell Biol 181 (2), 255-267 (2008)
   PUBMED   18411309
  REMARK    GeneRIF: DDA3 represents a new class of microtubule-destabilizing
            protein that controls spindle dynamics and mitotic progression by
            regulating microtubule depolymerases.
REFERENCE   8  (bases 1 to 1720)
  AUTHORS   Hsieh,P.C., Chang,J.C., Sun,W.T., Hsieh,S.C., Wang,M.C. and
            Wang,F.F.
  TITLE     p53 downstream target DDA3 is a novel microtubule-associated
            protein that interacts with end-binding protein EB3 and activates
            beta-catenin pathway
  JOURNAL   Oncogene 26 (34), 4928-4940 (2007)
   PUBMED   17310996
REFERENCE   9  (bases 1 to 1720)
  AUTHORS   Lo,P.K. and Wang,F.F.
  TITLE     Cloning and characterization of human and mouse DDA3 genes
  JOURNAL   Biochim Biophys Acta 1579 (2-3), 214-218 (2002)
   PUBMED   12427559
  REMARK    GeneRIF: molecular cloning, sequence analysis and gene expression
REFERENCE   10 (bases 1 to 1720)
  AUTHORS   Hsieh,S.C., Lo,P.K. and Wang,F.F.
  TITLE     Mouse DDA3 gene is a direct transcriptional target of p53 and p73
  JOURNAL   Oncogene 21 (19), 3050-3057 (2002)
   PUBMED   12082536
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BJ992594.1, AK289593.1,
            AL390252.9 and BI857497.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001032291.2.
            
            Summary: This gene encodes a proline-rich protein that is a target
            for regulation by the tumor suppressor protein p53. The encoded
            protein plays an important role in mitosis by recruiting and
            regulating microtubule depolymerases that destabalize microtubules.
            Alternatively spliced transcript variants encoding different
            isoforms have been described. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 3 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.272385.1, AK289593.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369909.7/ ENSP00000358925.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               BJ992594.1         24-230
            208-1552            AK289593.1         168-1512
            1553-1708           AL390252.9         32818-32973         c
            1709-1720           BI857497.1         357-368
FEATURES             Location/Qualifiers
     source          1..1720
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..1720
                     /gene="PSRC1"
                     /gene_synonym="DDA3; FP3214"
                     /note="proline and serine rich coiled-coil 1"
                     /db_xref="GeneID:84722"
                     /db_xref="HGNC:HGNC:24472"
                     /db_xref="MIM:613126"
     exon            1..83
                     /gene="PSRC1"
                     /gene_synonym="DDA3; FP3214"
                     /inference="alignment:Splign:2.1.0"
     exon            84..140
                     /gene="PSRC1"
                     /gene_synonym="DDA3; FP3214"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1123
                     /gene="PSRC1"
                     /gene_synonym="DDA3; FP3214"
                     /note="isoform a is encoded by transcript variant 3;
                     differential display and activated by p53; p53-regulated
                     DDA3; proline/serine-rich coiled-coil protein 1;
                     proline/serine-rich coiled-coil 1"
                     /codon_start=1
                     /product="proline/serine-rich coiled-coil protein 1
                     isoform a"
                     /protein_id="NP_001027462.1"
                     /db_xref="CCDS:CCDS797.1"
                     /db_xref="GeneID:84722"
                     /db_xref="HGNC:HGNC:24472"
                     /db_xref="MIM:613126"
                     /translation="MEDLEEDVRFIVDETLDFGGLSPSDSREEEDITVLVTPEKPLRR
                     GLSHRSDPNAVAPAPQGVRLSLGPLSPEKLEEILDEANRLAAQLEQCALQDRESAGEG
                     LGPRRVKPSPRRETFVLKDSPVRDLLPTVNSLTRSTPSPSSLTPRLRSNDRKGSVRAL
                     RATSGKRPSNMKRESPTCNLFPASKSPASSPLTRSTPPVRGRAGPSGRAAASPPTPIR
                     SVLAPQPSTSNSQRLPRPQGAAAKSSSQLPIPSAIPRPASRMPLTSRSVPPGRGALPP
                     DSLSTRKGLPRPSTAGHRVRESGHKVPVSQRLNLPVMGATRSNLQPPRKVAVPGPTR"
     exon            141..198
                     /gene="PSRC1"
                     /gene_synonym="DDA3; FP3214"
                     /inference="alignment:Splign:2.1.0"
     exon            199..640
                     /gene="PSRC1"
                     /gene_synonym="DDA3; FP3214"
                     /inference="alignment:Splign:2.1.0"
     exon            641..755
                     /gene="PSRC1"
                     /gene_synonym="DDA3; FP3214"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1025
                     /gene="PSRC1"
                     /gene_synonym="DDA3; FP3214"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1119
                     /gene="PSRC1"
                     /gene_synonym="DDA3; FP3214"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1720
                     /gene="PSRC1"
                     /gene_synonym="DDA3; FP3214"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1689..1694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSRC1"
                     /gene_synonym="DDA3; FP3214"
                     /note="hexamer: AATAAA"
     polyA_site      1720
                     /gene="PSRC1"
                     /gene_synonym="DDA3; FP3214"
                     /note="major polyA site"
ORIGIN      
        1 gattcccggg actaggttgc gggagaaagc ctgttgcgtg gaagataagg cggcgcggga
       61 agtggacaca gggtgggctg gagctcagat ctaactggac tctcgctcct gctggctgga
      121 catggaggat ttggaggaag atgtaaggtt tattgtggat gagaccttgg actttggggg
      181 gctgtcacca tctgacagcc gtgaggagga agacataaca gtgttggtga ctccagagaa
      241 accacttcga cggggcctct cccaccgaag tgacccaaat gcagtggcac ctgcccccca
      301 gggtgtgagg ctcagcctag gccccctcag tccagagaag ctggaggaga tcctcgatga
      361 ggccaaccgg ctggccgctc agctggagca gtgtgccctg caggatcggg agagcgcagg
      421 cgagggcctg gggcctcgcc gagtgaagcc cagtcctcgg cgggagacct ttgtgctgaa
      481 ggatagtcct gtccgagacc tgctgcccac tgtgaactct ttgacgcgga gcaccccctc
      541 cccaagcagc ctgacgcctc gactccggag taatgatagg aaggggtcag tcagggctct
      601 ccgggctaca tctggaaaga ggccctccaa catgaagagg gagtcaccca cttgcaatct
      661 gttccctgca tccaaaagcc cagcatcttc tcctcttacc cgatcgactc ccccagtccg
      721 ggggagagcc gggcccagtg ggagagcagc agccagccca cccaccccca tcagatccgt
      781 cctggcccca cagccttcta ccagcaactc tcaacgcctg ccccggccgc agggagcagc
      841 tgctaaatct tccagtcaac tgcccattcc ctcggccatc cccaggcctg ccagccgaat
      901 gccactcacc agccggagtg tgccacctgg cagaggtgcc ctacctccgg attctctgtc
      961 aactcgaaaa gggcttccaa gaccaagcac tgcaggacac agagtgcggg aaagtggaca
     1021 caaggttcct gtttcccagc gactaaatct tcctgtcatg ggtgccactc gcagcaatct
     1081 gcagcccccc aggaaagtgg cagtcccagg acctaccagg taaagagatc aggacagcaa
     1141 gcaagacttc agtagcaaac cactacagtc agtacctgga ctcgcctcta cccagcagac
     1201 cctgactcca gcagattctg gcccagggac aggaggaaga gatgccacca gggctggtct
     1261 cccaggagta gagaccatgg gaaatggggt ggattaggat tgagctggag aagacttaaa
     1321 ctctctgggt tgaaagaaga ttaggggaaa agaggtcacc ttccagcagt gaaatgaaca
     1381 aatagaagat gagaagtaca ggcaagtggt ttgtctttat ccacccccac tgttgtggtc
     1441 agccccagag aattttatct tcttccttgg cattggttca ctggacattt ccacgtgagc
     1501 ggcctccgta gctaacctcc ctgccctctg aggagccatc ttcctgaatc gcattctcta
     1561 ctggactctg gcctgcttgg agaggtggca gcaggcacct ggtcttcaga aattgtttcc
     1621 tgtgaattct gtgactccta ataggccagt ttgtgataag cttactctat gagtcttcat
     1681 ttttctaaaa taaagtgaat gtatttttat attctctgta
//
