LOCUS       NM_001370522            2088 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens phosphoserine phosphatase (PSPH), transcript variant
            21, mRNA.
ACCESSION   NM_001370522
VERSION     NM_001370522.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2088)
  AUTHORS   Rawat,V., Malvi,P., Della Manna,D., Yang,E.S., Bugide,S., Zhang,X.,
            Gupta,R. and Wajapeyee,N.
  TITLE     PSPH promotes melanoma growth and metastasis by metabolic
            deregulation-mediated transcriptional activation of NR4A1
  JOURNAL   Oncogene 40 (13), 2448-2462 (2021)
   PUBMED   33674745
  REMARK    GeneRIF: PSPH promotes melanoma growth and metastasis by metabolic
            deregulation-mediated transcriptional activation of NR4A1.
REFERENCE   2  (bases 1 to 2088)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2088)
  AUTHORS   Park,S.M., Seo,E.H., Bae,D.H., Kim,S.S., Kim,J., Lin,W., Kim,K.H.,
            Park,J.B., Kim,Y.S., Yin,J. and Kim,S.Y.
  TITLE     Phosphoserine Phosphatase Promotes Lung Cancer Progression through
            the Dephosphorylation of IRS-1 and a Noncanonical
            L-Serine-Independent Pathway
  JOURNAL   Mol Cells 42 (8), 604-616 (2019)
   PUBMED   31446747
  REMARK    GeneRIF: a specific interaction between PSPH and IRS1 and the
            dephosphorylation of phospho-IRS-1 by PSPH in lung cancer cells,
            was identified.
REFERENCE   4  (bases 1 to 2088)
  AUTHORS   Haufroid,M., Mirgaux,M., Leherte,L. and Wouters,J.
  TITLE     Crystal structures and snapshots along the reaction pathway of
            human phosphoserine phosphatase
  JOURNAL   Acta Crystallogr D Struct Biol 75 (Pt 6), 592-604 (2019)
   PUBMED   31205021
  REMARK    GeneRIF: three new high-resolution crystal structures of hPSP
            (1.5-2.0 A) in complexes with phosphoserine and with serine, which
            are the substrate and the product of the reaction, respectively,
            and in complex with a noncleavable substrate analogue (homocysteic
            acid) are presented.
REFERENCE   5  (bases 1 to 2088)
  AUTHORS   Liao,L., Ge,M., Zhan,Q., Huang,R., Ji,X., Liang,X. and Zhou,X.
  TITLE     PSPH Mediates the Metastasis and Proliferation of Non-small Cell
            Lung Cancer through MAPK Signaling Pathways
  JOURNAL   Int J Biol Sci 15 (1), 183-194 (2019)
   PUBMED   30662358
  REMARK    GeneRIF: The results suggest that PSPH may act as a putative
            oncogene and a potential therapeutic target in NSCLC.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2088)
  AUTHORS   van der Crabben,S.N. and de Koning,T.J.
  TITLE     Serine Deficiency Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37347880
REFERENCE   7  (bases 1 to 2088)
  AUTHORS   Veeranna and Shetty,K.T.
  TITLE     Phosphoserine phosphatase of human brain: partial purification,
            characterization, regional distribution, and effect of certain
            modulators including psychoactive drugs
  JOURNAL   Neurochem Res 15 (12), 1203-1210 (1990)
   PUBMED   1965857
REFERENCE   8  (bases 1 to 2088)
  AUTHORS   Minelli,A., Piantanida,M., Maserati,E., Campagnoli,E., Pasquali,F.
            and Danesino,C.
  TITLE     Gene dosage effect in acquired monosomy 7: distinct behaviour of
            beta-glucuronidase and phosphoserine phosphatase
  JOURNAL   Genes Chromosomes Cancer 1 (3), 216-220 (1990)
   PUBMED   1964582
REFERENCE   9  (bases 1 to 2088)
  AUTHORS   Novelli,G. and Dallapiccola,B.
  TITLE     Gene dosage studies regionally assign the phosphoserine phosphatase
            gene to 7p15.1 or 2
  JOURNAL   Ann Genet 31 (3), 195-196 (1988)
   PUBMED   2851960
REFERENCE   10 (bases 1 to 2088)
  AUTHORS   Moro-Furlani,A.M., Turner,V.S. and Hopkinson,D.A.
  TITLE     Genetical and biochemical studies on human phosphoserine
            phosphatase
  JOURNAL   Ann Hum Genet 43 (4), 323-333 (1980)
   PUBMED   6249179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092579.3.
            
            Summary: The protein encoded by this gene belongs to a subfamily of
            the phosphotransferases. This encoded enzyme is responsible for the
            third and last step in L-serine formation. It catalyzes
            magnesium-dependent hydrolysis of L-phosphoserine and is also
            involved in an exchange reaction between L-serine and
            L-phosphoserine. Deficiency of this protein is thought to be linked
            to Williams syndrome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.84987.1,
                                           SRR1660809.39822.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AC092579.3         110517-110823       c
            308-421             AC092579.3         102527-102640       c
            422-567             AC092579.3         93340-93485         c
            568-693             AC092579.3         91308-91433         c
            694-852             AC092579.3         80452-80610         c
            853-987             AC092579.3         78979-79113         c
            988-1133            AC092579.3         76613-76758         c
            1134-1282           AC092579.3         74402-74550         c
            1283-2088           AC092579.3         70443-71248         c
FEATURES             Location/Qualifiers
     source          1..2088
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p11.2"
     gene            1..2088
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="phosphoserine phosphatase"
                     /db_xref="GeneID:5723"
                     /db_xref="HGNC:HGNC:9577"
                     /db_xref="MIM:172480"
     exon            1..307
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            308..421
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            422..567
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            568..693
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            694..852
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     CDS             713..1390
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /EC_number="3.1.3.3"
                     /note="L-3-phosphoserine phosphatase; O-phosphoserine
                     phosphohydrolase; PSPase"
                     /codon_start=1
                     /product="phosphoserine phosphatase"
                     /protein_id="NP_001357451.1"
                     /db_xref="CCDS:CCDS5522.1"
                     /db_xref="GeneID:5723"
                     /db_xref="HGNC:HGNC:9577"
                     /db_xref="MIM:172480"
                     /translation="MVSHSELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAV
                     SEMTRRAMGGAVPFKAALTERLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERN
                     VQVFLISGGFRSIVEHVASKLNIPATNVFANRLKFYFNGEYAGFDETQPTAESGGKGK
                     VIKLLKEKFHFKKIIMIGDGATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVE
                     LLGELEE"
     exon            853..987
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1133
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1282
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..2088
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1991..1996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="hexamer: ATTAAA"
     polyA_site      2014
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="major polyA site"
     regulatory      2063..2068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="hexamer: AATAAA"
     polyA_site      2088
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="major polyA site"
ORIGIN      
        1 attggagctt cccggaccgt gtgctcgacg gtgccctagg tgccgtgggg ccacacgcga
       61 gtctgataag caccctcccc cggaatcatg cggtgctgtg aggcctagcg aagatgaaga
      121 tagaatgcaa ggtagaaagt gctggatacc tttagaaagc tgcaggactg gtgcgatggg
      181 agttgagacg taagaacctg cccgtccgta gggctctgga tgctgctgag gcccgaggcc
      241 cctatggcag atttgaaaat tcacccttgt agagtcattc ctgcctttga gcggactccc
      301 ttttaagagt ctcactctat cgcccaggct ggagtgcaat ggtgccatct cagctcactg
      361 caacctcccc ttcccaagtt caagcaattt tcatgccgca gcctcctagc tgggattaca
      421 gcagatctca agagagcgtt cggtggaggc cctgggtctg cacagctcac ctccctggga
      481 actgctcgcc cgagcgtcgg agccggcgct ggccccctgc agccggaagg ttgcagccgc
      541 aggagccccg gaggcccagg acacagggct cttgctcttg cagaatccac aggtctttct
      601 tgaggaaatc tgtagacaga actttgtgct gcgtttttat ctagggaagg aacagaagag
      661 tgtcgtctcc tagaaatcta gcactggaga aacgaggaaa attcttccag cgatggtctc
      721 ccactcagag ctgaggaagc ttttctactc agcagatgct gtgtgttttg atgttgacag
      781 cacggtcatc agagaagaag gaatcgatga gctagccaaa atctgtggcg ttgaggacgc
      841 ggtgtcagaa atgacacggc gagccatggg cggggcagtg cctttcaaag ctgctctcac
      901 agagcgctta gccctcatcc agccctccag ggagcaggtg cagagactca tagcagagca
      961 acccccacac ctgacccccg gcataaggga gctggtaagt cgcctacagg agcgaaatgt
     1021 tcaggttttc ctaatatctg gtggctttag gagtattgta gagcatgttg cttcaaagct
     1081 caatatccca gcaaccaatg tatttgccaa taggctgaaa ttctacttta acggtgaata
     1141 tgcaggtttt gatgagacgc agccaacagc tgaatctggt ggaaaaggaa aagtgattaa
     1201 acttttaaag gaaaaatttc attttaagaa aataatcatg attggagatg gtgccacaga
     1261 tatggaagcc tgtcctcctg ctgatgcttt cattggattt ggaggaaatg tgatcaggca
     1321 acaagtcaag gataacgcca aatggtatat cactgatttt gtagagctgc tgggagaact
     1381 ggaagaataa catccattgt cgtacagctc caaacaactt cagatgaatt tttacaagtt
     1441 atacagattg atactgtttg cttacagttg cctattacaa cttgctatag aaagttggta
     1501 caaatgatct gtactttaaa ctacagttag gaatcctaga agattgcttt tttttttttt
     1561 ttaactgtag ttccagtatt atatgatgac tattgatttc ctggagaggt tttttttttt
     1621 tttgagacag aatcttgctc tgttgcccag gctggagtgc agtggcgcgg tctcggctca
     1681 ctgcaagctc tgcctcccag gttcacgcca ttctcctgcc tcagcctccc gagtagctgg
     1741 gactacaggc acccgccacc acatccggct aattttttgt atttttagta gagacggggt
     1801 ttgaccgtgt tagccaggat ggtcttgatc tcctgacctt gtgatccgcc tgcctcagcc
     1861 tcccaaagtg ctgggattac aggcttgggc caccgcgccc agccaatgtc ctagagagtt
     1921 ttgtgatctg aattctttat gtatatttgt agctatattt catacaaagt gctttaagtg
     1981 tggagagtca attaaacacc tttactctta gaaatacgga ttcggcagcc ttcagtgaat
     2041 attggtttct ctttggtatg tcaataaaag tttatccgta tgtcagaa
//
