LOCUS       NM_001370520            2389 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens phosphoserine phosphatase (PSPH), transcript variant
            19, mRNA.
ACCESSION   NM_001370520
VERSION     NM_001370520.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2389)
  AUTHORS   Rawat,V., Malvi,P., Della Manna,D., Yang,E.S., Bugide,S., Zhang,X.,
            Gupta,R. and Wajapeyee,N.
  TITLE     PSPH promotes melanoma growth and metastasis by metabolic
            deregulation-mediated transcriptional activation of NR4A1
  JOURNAL   Oncogene 40 (13), 2448-2462 (2021)
   PUBMED   33674745
  REMARK    GeneRIF: PSPH promotes melanoma growth and metastasis by metabolic
            deregulation-mediated transcriptional activation of NR4A1.
REFERENCE   2  (bases 1 to 2389)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2389)
  AUTHORS   Park,S.M., Seo,E.H., Bae,D.H., Kim,S.S., Kim,J., Lin,W., Kim,K.H.,
            Park,J.B., Kim,Y.S., Yin,J. and Kim,S.Y.
  TITLE     Phosphoserine Phosphatase Promotes Lung Cancer Progression through
            the Dephosphorylation of IRS-1 and a Noncanonical
            L-Serine-Independent Pathway
  JOURNAL   Mol Cells 42 (8), 604-616 (2019)
   PUBMED   31446747
  REMARK    GeneRIF: a specific interaction between PSPH and IRS1 and the
            dephosphorylation of phospho-IRS-1 by PSPH in lung cancer cells,
            was identified.
REFERENCE   4  (bases 1 to 2389)
  AUTHORS   Haufroid,M., Mirgaux,M., Leherte,L. and Wouters,J.
  TITLE     Crystal structures and snapshots along the reaction pathway of
            human phosphoserine phosphatase
  JOURNAL   Acta Crystallogr D Struct Biol 75 (Pt 6), 592-604 (2019)
   PUBMED   31205021
  REMARK    GeneRIF: three new high-resolution crystal structures of hPSP
            (1.5-2.0 A) in complexes with phosphoserine and with serine, which
            are the substrate and the product of the reaction, respectively,
            and in complex with a noncleavable substrate analogue (homocysteic
            acid) are presented.
REFERENCE   5  (bases 1 to 2389)
  AUTHORS   Liao,L., Ge,M., Zhan,Q., Huang,R., Ji,X., Liang,X. and Zhou,X.
  TITLE     PSPH Mediates the Metastasis and Proliferation of Non-small Cell
            Lung Cancer through MAPK Signaling Pathways
  JOURNAL   Int J Biol Sci 15 (1), 183-194 (2019)
   PUBMED   30662358
  REMARK    GeneRIF: The results suggest that PSPH may act as a putative
            oncogene and a potential therapeutic target in NSCLC.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2389)
  AUTHORS   van der Crabben,S.N. and de Koning,T.J.
  TITLE     Serine Deficiency Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37347880
REFERENCE   7  (bases 1 to 2389)
  AUTHORS   Veeranna and Shetty,K.T.
  TITLE     Phosphoserine phosphatase of human brain: partial purification,
            characterization, regional distribution, and effect of certain
            modulators including psychoactive drugs
  JOURNAL   Neurochem Res 15 (12), 1203-1210 (1990)
   PUBMED   1965857
REFERENCE   8  (bases 1 to 2389)
  AUTHORS   Minelli,A., Piantanida,M., Maserati,E., Campagnoli,E., Pasquali,F.
            and Danesino,C.
  TITLE     Gene dosage effect in acquired monosomy 7: distinct behaviour of
            beta-glucuronidase and phosphoserine phosphatase
  JOURNAL   Genes Chromosomes Cancer 1 (3), 216-220 (1990)
   PUBMED   1964582
REFERENCE   9  (bases 1 to 2389)
  AUTHORS   Novelli,G. and Dallapiccola,B.
  TITLE     Gene dosage studies regionally assign the phosphoserine phosphatase
            gene to 7p15.1 or 2
  JOURNAL   Ann Genet 31 (3), 195-196 (1988)
   PUBMED   2851960
REFERENCE   10 (bases 1 to 2389)
  AUTHORS   Moro-Furlani,A.M., Turner,V.S. and Hopkinson,D.A.
  TITLE     Genetical and biochemical studies on human phosphoserine
            phosphatase
  JOURNAL   Ann Hum Genet 43 (4), 323-333 (1980)
   PUBMED   6249179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092579.3.
            
            Summary: The protein encoded by this gene belongs to a subfamily of
            the phosphotransferases. This encoded enzyme is responsible for the
            third and last step in L-serine formation. It catalyzes
            magnesium-dependent hydrolysis of L-phosphoserine and is also
            involved in an exchange reaction between L-serine and
            L-phosphoserine. Deficiency of this protein is thought to be linked
            to Williams syndrome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.155723.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2161674
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AC092579.3         110517-110823       c
            308-560             AC092579.3         101770-102022       c
            561-754             AC092579.3         93340-93533         c
            755-868             AC092579.3         92760-92873         c
            869-994             AC092579.3         91308-91433         c
            995-1153            AC092579.3         80452-80610         c
            1154-1288           AC092579.3         78979-79113         c
            1289-1434           AC092579.3         76613-76758         c
            1435-1583           AC092579.3         74402-74550         c
            1584-2389           AC092579.3         70443-71248         c
FEATURES             Location/Qualifiers
     source          1..2389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p11.2"
     gene            1..2389
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="phosphoserine phosphatase"
                     /db_xref="GeneID:5723"
                     /db_xref="HGNC:HGNC:9577"
                     /db_xref="MIM:172480"
     exon            1..307
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            308..560
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            561..754
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            755..868
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            869..994
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1153
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     CDS             1014..1691
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /EC_number="3.1.3.3"
                     /note="L-3-phosphoserine phosphatase; O-phosphoserine
                     phosphohydrolase; PSPase"
                     /codon_start=1
                     /product="phosphoserine phosphatase"
                     /protein_id="NP_001357449.1"
                     /db_xref="CCDS:CCDS5522.1"
                     /db_xref="GeneID:5723"
                     /db_xref="HGNC:HGNC:9577"
                     /db_xref="MIM:172480"
                     /translation="MVSHSELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAV
                     SEMTRRAMGGAVPFKAALTERLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERN
                     VQVFLISGGFRSIVEHVASKLNIPATNVFANRLKFYFNGEYAGFDETQPTAESGGKGK
                     VIKLLKEKFHFKKIIMIGDGATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVE
                     LLGELEE"
     exon            1154..1288
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1434
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1583
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..2389
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="hexamer: ATTAAA"
     polyA_site      2315
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="major polyA site"
     regulatory      2364..2369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="hexamer: AATAAA"
     polyA_site      2389
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="major polyA site"
ORIGIN      
        1 attggagctt cccggaccgt gtgctcgacg gtgccctagg tgccgtgggg ccacacgcga
       61 gtctgataag caccctcccc cggaatcatg cggtgctgtg aggcctagcg aagatgaaga
      121 tagaatgcaa ggtagaaagt gctggatacc tttagaaagc tgcaggactg gtgcgatggg
      181 agttgagacg taagaacctg cccgtccgta gggctctgga tgctgctgag gcccgaggcc
      241 cctatggcag atttgaaaat tcacccttgt agagtcattc ctgcctttga gcggactccc
      301 ttttaagggt cccactctgt tgccgaagct ggagtgcagt ggcacgaaca tgtctcactg
      361 cagcctcaac ctcctgggct caagctttcc tcctgcctca gcctcctgtg tagctgggac
      421 cacaagcact cgtcaccaca cctggataat tttttgatgt tttgtagaga cagtgcttca
      481 gtttgttgcc tgtgctggtc ttgaactcct ggcctcaagc aatccttctg ctttggcctc
      541 ccagattgct gagattacag tttacagaag cacttgcaga actcatcaga agccaccccg
      601 cttatcagca gatctcaaga gagcgttcgg tggaggccct gggtctgcac agctcacctc
      661 cctgggaact gctcgcccga gcgtcggagc cggcgctggc cccctgcagc cggaaggttg
      721 cagccgcagg agccccggag gcccaggaca caggacagag tctcgttctg tcgcccaggc
      781 tggagtgcag tggtgtgatc tcggctcact tcaacctccg cctacagggt tcaagggatt
      841 ctcctgcctc agcctcctga gtatctgggc tcttgctctt gcagaatcca caggtctttc
      901 ttgaggaaat ctgtagacag aactttgtgc tgcgttttta tctagggaag gaacagaaga
      961 gtgtcgtctc ctagaaatct agcactggag aaacgaggaa aattcttcca gcgatggtct
     1021 cccactcaga gctgaggaag cttttctact cagcagatgc tgtgtgtttt gatgttgaca
     1081 gcacggtcat cagagaagaa ggaatcgatg agctagccaa aatctgtggc gttgaggacg
     1141 cggtgtcaga aatgacacgg cgagccatgg gcggggcagt gcctttcaaa gctgctctca
     1201 cagagcgctt agccctcatc cagccctcca gggagcaggt gcagagactc atagcagagc
     1261 aacccccaca cctgaccccc ggcataaggg agctggtaag tcgcctacag gagcgaaatg
     1321 ttcaggtttt cctaatatct ggtggcttta ggagtattgt agagcatgtt gcttcaaagc
     1381 tcaatatccc agcaaccaat gtatttgcca ataggctgaa attctacttt aacggtgaat
     1441 atgcaggttt tgatgagacg cagccaacag ctgaatctgg tggaaaagga aaagtgatta
     1501 aacttttaaa ggaaaaattt cattttaaga aaataatcat gattggagat ggtgccacag
     1561 atatggaagc ctgtcctcct gctgatgctt tcattggatt tggaggaaat gtgatcaggc
     1621 aacaagtcaa ggataacgcc aaatggtata tcactgattt tgtagagctg ctgggagaac
     1681 tggaagaata acatccattg tcgtacagct ccaaacaact tcagatgaat ttttacaagt
     1741 tatacagatt gatactgttt gcttacagtt gcctattaca acttgctata gaaagttggt
     1801 acaaatgatc tgtactttaa actacagtta ggaatcctag aagattgctt tttttttttt
     1861 tttaactgta gttccagtat tatatgatga ctattgattt cctggagagg tttttttttt
     1921 ttttgagaca gaatcttgct ctgttgccca ggctggagtg cagtggcgcg gtctcggctc
     1981 actgcaagct ctgcctccca ggttcacgcc attctcctgc ctcagcctcc cgagtagctg
     2041 ggactacagg cacccgccac cacatccggc taattttttg tatttttagt agagacgggg
     2101 tttgaccgtg ttagccagga tggtcttgat ctcctgacct tgtgatccgc ctgcctcagc
     2161 ctcccaaagt gctgggatta caggcttggg ccaccgcgcc cagccaatgt cctagagagt
     2221 tttgtgatct gaattcttta tgtatatttg tagctatatt tcatacaaag tgctttaagt
     2281 gtggagagtc aattaaacac ctttactctt agaaatacgg attcggcagc cttcagtgaa
     2341 tattggtttc tctttggtat gtcaataaaa gtttatccgt atgtcagaa
//
