LOCUS       NM_001370515            2275 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens phosphoserine phosphatase (PSPH), transcript variant
            15, mRNA.
ACCESSION   NM_001370515
VERSION     NM_001370515.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2275)
  AUTHORS   Rawat,V., Malvi,P., Della Manna,D., Yang,E.S., Bugide,S., Zhang,X.,
            Gupta,R. and Wajapeyee,N.
  TITLE     PSPH promotes melanoma growth and metastasis by metabolic
            deregulation-mediated transcriptional activation of NR4A1
  JOURNAL   Oncogene 40 (13), 2448-2462 (2021)
   PUBMED   33674745
  REMARK    GeneRIF: PSPH promotes melanoma growth and metastasis by metabolic
            deregulation-mediated transcriptional activation of NR4A1.
REFERENCE   2  (bases 1 to 2275)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2275)
  AUTHORS   Park,S.M., Seo,E.H., Bae,D.H., Kim,S.S., Kim,J., Lin,W., Kim,K.H.,
            Park,J.B., Kim,Y.S., Yin,J. and Kim,S.Y.
  TITLE     Phosphoserine Phosphatase Promotes Lung Cancer Progression through
            the Dephosphorylation of IRS-1 and a Noncanonical
            L-Serine-Independent Pathway
  JOURNAL   Mol Cells 42 (8), 604-616 (2019)
   PUBMED   31446747
  REMARK    GeneRIF: a specific interaction between PSPH and IRS1 and the
            dephosphorylation of phospho-IRS-1 by PSPH in lung cancer cells,
            was identified.
REFERENCE   4  (bases 1 to 2275)
  AUTHORS   Haufroid,M., Mirgaux,M., Leherte,L. and Wouters,J.
  TITLE     Crystal structures and snapshots along the reaction pathway of
            human phosphoserine phosphatase
  JOURNAL   Acta Crystallogr D Struct Biol 75 (Pt 6), 592-604 (2019)
   PUBMED   31205021
  REMARK    GeneRIF: three new high-resolution crystal structures of hPSP
            (1.5-2.0 A) in complexes with phosphoserine and with serine, which
            are the substrate and the product of the reaction, respectively,
            and in complex with a noncleavable substrate analogue (homocysteic
            acid) are presented.
REFERENCE   5  (bases 1 to 2275)
  AUTHORS   Liao,L., Ge,M., Zhan,Q., Huang,R., Ji,X., Liang,X. and Zhou,X.
  TITLE     PSPH Mediates the Metastasis and Proliferation of Non-small Cell
            Lung Cancer through MAPK Signaling Pathways
  JOURNAL   Int J Biol Sci 15 (1), 183-194 (2019)
   PUBMED   30662358
  REMARK    GeneRIF: The results suggest that PSPH may act as a putative
            oncogene and a potential therapeutic target in NSCLC.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2275)
  AUTHORS   van der Crabben,S.N. and de Koning,T.J.
  TITLE     Serine Deficiency Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37347880
REFERENCE   7  (bases 1 to 2275)
  AUTHORS   Veeranna and Shetty,K.T.
  TITLE     Phosphoserine phosphatase of human brain: partial purification,
            characterization, regional distribution, and effect of certain
            modulators including psychoactive drugs
  JOURNAL   Neurochem Res 15 (12), 1203-1210 (1990)
   PUBMED   1965857
REFERENCE   8  (bases 1 to 2275)
  AUTHORS   Minelli,A., Piantanida,M., Maserati,E., Campagnoli,E., Pasquali,F.
            and Danesino,C.
  TITLE     Gene dosage effect in acquired monosomy 7: distinct behaviour of
            beta-glucuronidase and phosphoserine phosphatase
  JOURNAL   Genes Chromosomes Cancer 1 (3), 216-220 (1990)
   PUBMED   1964582
REFERENCE   9  (bases 1 to 2275)
  AUTHORS   Novelli,G. and Dallapiccola,B.
  TITLE     Gene dosage studies regionally assign the phosphoserine phosphatase
            gene to 7p15.1 or 2
  JOURNAL   Ann Genet 31 (3), 195-196 (1988)
   PUBMED   2851960
REFERENCE   10 (bases 1 to 2275)
  AUTHORS   Moro-Furlani,A.M., Turner,V.S. and Hopkinson,D.A.
  TITLE     Genetical and biochemical studies on human phosphoserine
            phosphatase
  JOURNAL   Ann Hum Genet 43 (4), 323-333 (1980)
   PUBMED   6249179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092579.3.
            
            Summary: The protein encoded by this gene belongs to a subfamily of
            the phosphotransferases. This encoded enzyme is responsible for the
            third and last step in L-serine formation. It catalyzes
            magnesium-dependent hydrolysis of L-phosphoserine and is also
            involved in an exchange reaction between L-serine and
            L-phosphoserine. Deficiency of this protein is thought to be linked
            to Williams syndrome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.192192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2159912
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AC092579.3         110517-110823       c
            308-560             AC092579.3         101770-102022       c
            561-754             AC092579.3         93340-93533         c
            755-880             AC092579.3         91308-91433         c
            881-1039            AC092579.3         80452-80610         c
            1040-1174           AC092579.3         78979-79113         c
            1175-1320           AC092579.3         76613-76758         c
            1321-1469           AC092579.3         74402-74550         c
            1470-2275           AC092579.3         70443-71248         c
FEATURES             Location/Qualifiers
     source          1..2275
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p11.2"
     gene            1..2275
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="phosphoserine phosphatase"
                     /db_xref="GeneID:5723"
                     /db_xref="HGNC:HGNC:9577"
                     /db_xref="MIM:172480"
     exon            1..307
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            308..560
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            561..754
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            755..880
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1039
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     CDS             900..1577
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /EC_number="3.1.3.3"
                     /note="L-3-phosphoserine phosphatase; O-phosphoserine
                     phosphohydrolase; PSPase"
                     /codon_start=1
                     /product="phosphoserine phosphatase"
                     /protein_id="NP_001357444.1"
                     /db_xref="CCDS:CCDS5522.1"
                     /db_xref="GeneID:5723"
                     /db_xref="HGNC:HGNC:9577"
                     /db_xref="MIM:172480"
                     /translation="MVSHSELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAV
                     SEMTRRAMGGAVPFKAALTERLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERN
                     VQVFLISGGFRSIVEHVASKLNIPATNVFANRLKFYFNGEYAGFDETQPTAESGGKGK
                     VIKLLKEKFHFKKIIMIGDGATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVE
                     LLGELEE"
     exon            1040..1174
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1320
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1469
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..2275
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2178..2183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="hexamer: ATTAAA"
     polyA_site      2201
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="major polyA site"
     regulatory      2250..2255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="hexamer: AATAAA"
     polyA_site      2275
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="major polyA site"
ORIGIN      
        1 attggagctt cccggaccgt gtgctcgacg gtgccctagg tgccgtgggg ccacacgcga
       61 gtctgataag caccctcccc cggaatcatg cggtgctgtg aggcctagcg aagatgaaga
      121 tagaatgcaa ggtagaaagt gctggatacc tttagaaagc tgcaggactg gtgcgatggg
      181 agttgagacg taagaacctg cccgtccgta gggctctgga tgctgctgag gcccgaggcc
      241 cctatggcag atttgaaaat tcacccttgt agagtcattc ctgcctttga gcggactccc
      301 ttttaagggt cccactctgt tgccgaagct ggagtgcagt ggcacgaaca tgtctcactg
      361 cagcctcaac ctcctgggct caagctttcc tcctgcctca gcctcctgtg tagctgggac
      421 cacaagcact cgtcaccaca cctggataat tttttgatgt tttgtagaga cagtgcttca
      481 gtttgttgcc tgtgctggtc ttgaactcct ggcctcaagc aatccttctg ctttggcctc
      541 ccagattgct gagattacag tttacagaag cacttgcaga actcatcaga agccaccccg
      601 cttatcagca gatctcaaga gagcgttcgg tggaggccct gggtctgcac agctcacctc
      661 cctgggaact gctcgcccga gcgtcggagc cggcgctggc cccctgcagc cggaaggttg
      721 cagccgcagg agccccggag gcccaggaca cagggctctt gctcttgcag aatccacagg
      781 tctttcttga ggaaatctgt agacagaact ttgtgctgcg tttttatcta gggaaggaac
      841 agaagagtgt cgtctcctag aaatctagca ctggagaaac gaggaaaatt cttccagcga
      901 tggtctccca ctcagagctg aggaagcttt tctactcagc agatgctgtg tgttttgatg
      961 ttgacagcac ggtcatcaga gaagaaggaa tcgatgagct agccaaaatc tgtggcgttg
     1021 aggacgcggt gtcagaaatg acacggcgag ccatgggcgg ggcagtgcct ttcaaagctg
     1081 ctctcacaga gcgcttagcc ctcatccagc cctccaggga gcaggtgcag agactcatag
     1141 cagagcaacc cccacacctg acccccggca taagggagct ggtaagtcgc ctacaggagc
     1201 gaaatgttca ggttttccta atatctggtg gctttaggag tattgtagag catgttgctt
     1261 caaagctcaa tatcccagca accaatgtat ttgccaatag gctgaaattc tactttaacg
     1321 gtgaatatgc aggttttgat gagacgcagc caacagctga atctggtgga aaaggaaaag
     1381 tgattaaact tttaaaggaa aaatttcatt ttaagaaaat aatcatgatt ggagatggtg
     1441 ccacagatat ggaagcctgt cctcctgctg atgctttcat tggatttgga ggaaatgtga
     1501 tcaggcaaca agtcaaggat aacgccaaat ggtatatcac tgattttgta gagctgctgg
     1561 gagaactgga agaataacat ccattgtcgt acagctccaa acaacttcag atgaattttt
     1621 acaagttata cagattgata ctgtttgctt acagttgcct attacaactt gctatagaaa
     1681 gttggtacaa atgatctgta ctttaaacta cagttaggaa tcctagaaga ttgctttttt
     1741 ttttttttta actgtagttc cagtattata tgatgactat tgatttcctg gagaggtttt
     1801 tttttttttt gagacagaat cttgctctgt tgcccaggct ggagtgcagt ggcgcggtct
     1861 cggctcactg caagctctgc ctcccaggtt cacgccattc tcctgcctca gcctcccgag
     1921 tagctgggac tacaggcacc cgccaccaca tccggctaat tttttgtatt tttagtagag
     1981 acggggtttg accgtgttag ccaggatggt cttgatctcc tgaccttgtg atccgcctgc
     2041 ctcagcctcc caaagtgctg ggattacagg cttgggccac cgcgcccagc caatgtccta
     2101 gagagttttg tgatctgaat tctttatgta tatttgtagc tatatttcat acaaagtgct
     2161 ttaagtgtgg agagtcaatt aaacaccttt actcttagaa atacggattc ggcagccttc
     2221 agtgaatatt ggtttctctt tggtatgtca ataaaagttt atccgtatgt cagaa
//
