LOCUS       NM_001370511            2081 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens phosphoserine phosphatase (PSPH), transcript variant
            11, mRNA.
ACCESSION   NM_001370511
VERSION     NM_001370511.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2081)
  AUTHORS   Rawat,V., Malvi,P., Della Manna,D., Yang,E.S., Bugide,S., Zhang,X.,
            Gupta,R. and Wajapeyee,N.
  TITLE     PSPH promotes melanoma growth and metastasis by metabolic
            deregulation-mediated transcriptional activation of NR4A1
  JOURNAL   Oncogene 40 (13), 2448-2462 (2021)
   PUBMED   33674745
  REMARK    GeneRIF: PSPH promotes melanoma growth and metastasis by metabolic
            deregulation-mediated transcriptional activation of NR4A1.
REFERENCE   2  (bases 1 to 2081)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2081)
  AUTHORS   Park,S.M., Seo,E.H., Bae,D.H., Kim,S.S., Kim,J., Lin,W., Kim,K.H.,
            Park,J.B., Kim,Y.S., Yin,J. and Kim,S.Y.
  TITLE     Phosphoserine Phosphatase Promotes Lung Cancer Progression through
            the Dephosphorylation of IRS-1 and a Noncanonical
            L-Serine-Independent Pathway
  JOURNAL   Mol Cells 42 (8), 604-616 (2019)
   PUBMED   31446747
  REMARK    GeneRIF: a specific interaction between PSPH and IRS1 and the
            dephosphorylation of phospho-IRS-1 by PSPH in lung cancer cells,
            was identified.
REFERENCE   4  (bases 1 to 2081)
  AUTHORS   Haufroid,M., Mirgaux,M., Leherte,L. and Wouters,J.
  TITLE     Crystal structures and snapshots along the reaction pathway of
            human phosphoserine phosphatase
  JOURNAL   Acta Crystallogr D Struct Biol 75 (Pt 6), 592-604 (2019)
   PUBMED   31205021
  REMARK    GeneRIF: three new high-resolution crystal structures of hPSP
            (1.5-2.0 A) in complexes with phosphoserine and with serine, which
            are the substrate and the product of the reaction, respectively,
            and in complex with a noncleavable substrate analogue (homocysteic
            acid) are presented.
REFERENCE   5  (bases 1 to 2081)
  AUTHORS   Liao,L., Ge,M., Zhan,Q., Huang,R., Ji,X., Liang,X. and Zhou,X.
  TITLE     PSPH Mediates the Metastasis and Proliferation of Non-small Cell
            Lung Cancer through MAPK Signaling Pathways
  JOURNAL   Int J Biol Sci 15 (1), 183-194 (2019)
   PUBMED   30662358
  REMARK    GeneRIF: The results suggest that PSPH may act as a putative
            oncogene and a potential therapeutic target in NSCLC.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2081)
  AUTHORS   van der Crabben,S.N. and de Koning,T.J.
  TITLE     Serine Deficiency Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37347880
REFERENCE   7  (bases 1 to 2081)
  AUTHORS   Veeranna and Shetty,K.T.
  TITLE     Phosphoserine phosphatase of human brain: partial purification,
            characterization, regional distribution, and effect of certain
            modulators including psychoactive drugs
  JOURNAL   Neurochem Res 15 (12), 1203-1210 (1990)
   PUBMED   1965857
REFERENCE   8  (bases 1 to 2081)
  AUTHORS   Minelli,A., Piantanida,M., Maserati,E., Campagnoli,E., Pasquali,F.
            and Danesino,C.
  TITLE     Gene dosage effect in acquired monosomy 7: distinct behaviour of
            beta-glucuronidase and phosphoserine phosphatase
  JOURNAL   Genes Chromosomes Cancer 1 (3), 216-220 (1990)
   PUBMED   1964582
REFERENCE   9  (bases 1 to 2081)
  AUTHORS   Novelli,G. and Dallapiccola,B.
  TITLE     Gene dosage studies regionally assign the phosphoserine phosphatase
            gene to 7p15.1 or 2
  JOURNAL   Ann Genet 31 (3), 195-196 (1988)
   PUBMED   2851960
REFERENCE   10 (bases 1 to 2081)
  AUTHORS   Moro-Furlani,A.M., Turner,V.S. and Hopkinson,D.A.
  TITLE     Genetical and biochemical studies on human phosphoserine
            phosphatase
  JOURNAL   Ann Hum Genet 43 (4), 323-333 (1980)
   PUBMED   6249179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092579.3.
            
            Summary: The protein encoded by this gene belongs to a subfamily of
            the phosphotransferases. This encoded enzyme is responsible for the
            third and last step in L-serine formation. It catalyzes
            magnesium-dependent hydrolysis of L-phosphoserine and is also
            involved in an exchange reaction between L-serine and
            L-phosphoserine. Deficiency of this protein is thought to be linked
            to Williams syndrome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.279771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AC092579.3         110517-110823       c
            308-450             AC092579.3         93340-93482         c
            451-560             AC092579.3         92760-92869         c
            561-686             AC092579.3         91308-91433         c
            687-845             AC092579.3         80452-80610         c
            846-980             AC092579.3         78979-79113         c
            981-1126            AC092579.3         76613-76758         c
            1127-1275           AC092579.3         74402-74550         c
            1276-2081           AC092579.3         70443-71248         c
FEATURES             Location/Qualifiers
     source          1..2081
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p11.2"
     gene            1..2081
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="phosphoserine phosphatase"
                     /db_xref="GeneID:5723"
                     /db_xref="HGNC:HGNC:9577"
                     /db_xref="MIM:172480"
     exon            1..307
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            308..450
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            451..560
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            561..686
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            687..845
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     CDS             706..1383
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /EC_number="3.1.3.3"
                     /note="L-3-phosphoserine phosphatase; O-phosphoserine
                     phosphohydrolase; PSPase"
                     /codon_start=1
                     /product="phosphoserine phosphatase"
                     /protein_id="NP_001357440.1"
                     /db_xref="CCDS:CCDS5522.1"
                     /db_xref="GeneID:5723"
                     /db_xref="HGNC:HGNC:9577"
                     /db_xref="MIM:172480"
                     /translation="MVSHSELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAV
                     SEMTRRAMGGAVPFKAALTERLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERN
                     VQVFLISGGFRSIVEHVASKLNIPATNVFANRLKFYFNGEYAGFDETQPTAESGGKGK
                     VIKLLKEKFHFKKIIMIGDGATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVE
                     LLGELEE"
     exon            846..980
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1126
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1275
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..2081
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1984..1989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="hexamer: ATTAAA"
     polyA_site      2007
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="major polyA site"
     regulatory      2056..2061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="hexamer: AATAAA"
     polyA_site      2081
                     /gene="PSPH"
                     /gene_synonym="PSP; PSPHD"
                     /note="major polyA site"
ORIGIN      
        1 attggagctt cccggaccgt gtgctcgacg gtgccctagg tgccgtgggg ccacacgcga
       61 gtctgataag caccctcccc cggaatcatg cggtgctgtg aggcctagcg aagatgaaga
      121 tagaatgcaa ggtagaaagt gctggatacc tttagaaagc tgcaggactg gtgcgatggg
      181 agttgagacg taagaacctg cccgtccgta gggctctgga tgctgctgag gcccgaggcc
      241 cctatggcag atttgaaaat tcacccttgt agagtcattc ctgcctttga gcggactccc
      301 ttttaagatc tcaagagagc gttcggtgga ggccctgggt ctgcacagct cacctccctg
      361 ggaactgctc gcccgagcgt cggagccggc gctggccccc tgcagccgga aggttgcagc
      421 cgcaggagcc ccggaggccc aggacacagg agtctcgttc tgtcgcccag gctggagtgc
      481 agtggtgtga tctcggctca cttcaacctc cgcctacagg gttcaaggga ttctcctgcc
      541 tcagcctcct gagtatctgg gctcttgctc ttgcagaatc cacaggtctt tcttgaggaa
      601 atctgtagac agaactttgt gctgcgtttt tatctaggga aggaacagaa gagtgtcgtc
      661 tcctagaaat ctagcactgg agaaacgagg aaaattcttc cagcgatggt ctcccactca
      721 gagctgagga agcttttcta ctcagcagat gctgtgtgtt ttgatgttga cagcacggtc
      781 atcagagaag aaggaatcga tgagctagcc aaaatctgtg gcgttgagga cgcggtgtca
      841 gaaatgacac ggcgagccat gggcggggca gtgcctttca aagctgctct cacagagcgc
      901 ttagccctca tccagccctc cagggagcag gtgcagagac tcatagcaga gcaaccccca
      961 cacctgaccc ccggcataag ggagctggta agtcgcctac aggagcgaaa tgttcaggtt
     1021 ttcctaatat ctggtggctt taggagtatt gtagagcatg ttgcttcaaa gctcaatatc
     1081 ccagcaacca atgtatttgc caataggctg aaattctact ttaacggtga atatgcaggt
     1141 tttgatgaga cgcagccaac agctgaatct ggtggaaaag gaaaagtgat taaactttta
     1201 aaggaaaaat ttcattttaa gaaaataatc atgattggag atggtgccac agatatggaa
     1261 gcctgtcctc ctgctgatgc tttcattgga tttggaggaa atgtgatcag gcaacaagtc
     1321 aaggataacg ccaaatggta tatcactgat tttgtagagc tgctgggaga actggaagaa
     1381 taacatccat tgtcgtacag ctccaaacaa cttcagatga atttttacaa gttatacaga
     1441 ttgatactgt ttgcttacag ttgcctatta caacttgcta tagaaagttg gtacaaatga
     1501 tctgtacttt aaactacagt taggaatcct agaagattgc tttttttttt tttttaactg
     1561 tagttccagt attatatgat gactattgat ttcctggaga ggtttttttt ttttttgaga
     1621 cagaatcttg ctctgttgcc caggctggag tgcagtggcg cggtctcggc tcactgcaag
     1681 ctctgcctcc caggttcacg ccattctcct gcctcagcct cccgagtagc tgggactaca
     1741 ggcacccgcc accacatccg gctaattttt tgtattttta gtagagacgg ggtttgaccg
     1801 tgttagccag gatggtcttg atctcctgac cttgtgatcc gcctgcctca gcctcccaaa
     1861 gtgctgggat tacaggcttg ggccaccgcg cccagccaat gtcctagaga gttttgtgat
     1921 ctgaattctt tatgtatatt tgtagctata tttcatacaa agtgctttaa gtgtggagag
     1981 tcaattaaac acctttactc ttagaaatac ggattcggca gccttcagtg aatattggtt
     2041 tctctttggt atgtcaataa aagtttatcc gtatgtcaga a
//
