LOCUS       NM_001354909            2435 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens paraspeckle component 1 (PSPC1), transcript variant 4,
            mRNA.
ACCESSION   NM_001354909 XM_006719844
VERSION     NM_001354909.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2435)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2435)
  AUTHORS   Tripathi,S.K., Aneja,A., Borgaonkar,T. and Das,S.
  TITLE     PSPC1 Binds to HCV IRES and Prevents Ribosomal Protein S5 Binding,
            Inhibiting Viral RNA Translation
  JOURNAL   Viruses 16 (5), 738 (2024)
   PUBMED   38793620
  REMARK    GeneRIF: PSPC1 Binds to HCV IRES and Prevents Ribosomal Protein S5
            Binding, Inhibiting Viral RNA Translation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2435)
  AUTHORS   Lemster,A.L., Weingart,A., Bottner,J., Perner,S., Sailer,V.,
            Offermann,A. and Kirfel,J.
  TITLE     Elevated PSPC1 and KDM5C expression indicates poor prognosis in
            prostate cancer
  JOURNAL   Hum Pathol 138, 1-11 (2023)
   PUBMED   37209920
  REMARK    GeneRIF: Elevated PSPC1 and KDM5C expression indicates poor
            prognosis in prostate cancer.
REFERENCE   4  (bases 1 to 2435)
  AUTHORS   Cubillos-Zapata,C., Martinez-Garcia,M.A., Diaz-Garcia,E.,
            Garcia-Tovar,S., Campos-Rodriguez,F., Sanchez-de-la-Torre,M.,
            Nagore,E., Martorell-Calatayud,A., Blasco,L.H., Pastor,E.,
            Abad-Capa,J., Montserrat,J.M., Cabriada-Nuno,V., Cano-Pumarega,I.,
            Corral-Penafiel,J., Arias,E., Mediano,O., Somoza-Gonzalez,M.,
            Dalmau-Arias,J., Almendros,I., Farre,R., Gozal,D. and Garcia-Rio,F.
  CONSRTM   Spanish Sleep Network
  TITLE     Obstructive sleep apnoea is related to melanoma aggressiveness
            through paraspeckle protein-1 upregulation
  JOURNAL   Eur Respir J 61 (2), 2200707 (2023)
   PUBMED   36265878
  REMARK    GeneRIF: Obstructive sleep apnoea is related to melanoma
            aggressiveness through paraspeckle protein-1 upregulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2435)
  AUTHORS   Knott,G.J., Bond,C.S. and Fox,A.H.
  TITLE     The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular
            scaffold
  JOURNAL   Nucleic Acids Res 44 (9), 3989-4004 (2016)
   PUBMED   27084935
REFERENCE   6  (bases 1 to 2435)
  AUTHORS   Fox,A.H. and Lamond,A.I.
  TITLE     Paraspeckles
  JOURNAL   Cold Spring Harb Perspect Biol 2 (7), a000687 (2010)
   PUBMED   20573717
  REMARK    Review article
REFERENCE   7  (bases 1 to 2435)
  AUTHORS   Clemson,C.M., Hutchinson,J.N., Sara,S.A., Ensminger,A.W., Fox,A.H.,
            Chess,A. and Lawrence,J.B.
  TITLE     An architectural role for a nuclear noncoding RNA: NEAT1 RNA is
            essential for the structure of paraspeckles
  JOURNAL   Mol Cell 33 (6), 717-726 (2009)
   PUBMED   19217333
REFERENCE   8  (bases 1 to 2435)
  AUTHORS   Sasaki,Y.T., Ideue,T., Sano,M., Mituyama,T. and Hirose,T.
  TITLE     MENepsilon/beta noncoding RNAs are essential for structural
            integrity of nuclear paraspeckles
  JOURNAL   Proc Natl Acad Sci U S A 106 (8), 2525-2530 (2009)
   PUBMED   19188602
REFERENCE   9  (bases 1 to 2435)
  AUTHORS   Fox,A.H., Bond,C.S. and Lamond,A.I.
  TITLE     P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles
            in an RNA-dependent manner
  JOURNAL   Mol Biol Cell 16 (11), 5304-5315 (2005)
   PUBMED   16148043
  REMARK    GeneRIF: We map the domain within PSP1 that is mediating this
            interaction and show it is required for the correct localization of
            PSP1 to paraspeckles. This interaction is necessary but not
            sufficient for paraspeckle targeting by PSP1
REFERENCE   10 (bases 1 to 2435)
  AUTHORS   Fox,A.H., Lam,Y.W., Leung,A.K., Lyon,C.E., Andersen,J., Mann,M. and
            Lamond,A.I.
  TITLE     Paraspeckles: a novel nuclear domain
  JOURNAL   Curr Biol 12 (1), 13-25 (2002)
   PUBMED   11790299
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354808.24.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001354909.1.
            
            Summary: This gene encodes a nucleolar protein that localizes to
            punctate subnuclear structures that occur close to splicing
            speckles, known as paraspeckles. These paraspeckles are composed of
            RNA-protein structures that include a non-coding RNA, NEAT1/Men
            epsilon/beta, and the Drosophila Behavior Human Splicing family of
            proteins, which include the product of this gene and the
            P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the
            control of gene expression via an RNA nuclear retention mechanism.
            The protein encoded by this gene is found in paraspeckles in
            transcriptionally active cells, but it localizes to unique cap
            structures at the nucleolar periphery when RNA polymerase II
            transcription is inhibited, or during telophase. Alternative
            splicing of this gene results in multiple transcript variants. A
            related pseudogene, which is also located on chromosome 13, has
            been identified. [provided by RefSeq, Aug 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.129354.1,
                                           SRR1660805.72108.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338910.9/ ENSP00000343966.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               AL354808.24        117289-117848       c
            561-862             AL354808.24        107145-107446       c
            863-958             AL354808.24        94226-94321         c
            959-1155            AL354808.24        86174-86370         c
            1156-1240           AL354808.24        76468-76552         c
            1241-1346           AL354808.24        65142-65247         c
            1347-1404           AL354808.24        44445-44502         c
            1405-1574           AL354808.24        40565-40734         c
            1575-2435           AL354808.24        37403-38263         c
FEATURES             Location/Qualifiers
     source          1..2435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.11"
     gene            1..2435
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /note="paraspeckle component 1"
                     /db_xref="GeneID:55269"
                     /db_xref="HGNC:HGNC:20320"
                     /db_xref="MIM:612408"
     exon            1..560
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1760
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /note="isoform 1 is encoded by transcript variant 4;
                     paraspeckle protein 1"
                     /codon_start=1
                     /product="paraspeckle component 1 isoform 1"
                     /protein_id="NP_001341838.1"
                     /db_xref="CCDS:CCDS41870.1"
                     /db_xref="GeneID:55269"
                     /db_xref="HGNC:HGNC:20320"
                     /db_xref="MIM:612408"
                     /translation="MMLRGNLKQVRIEKNPARLRALESAVGESEPAAAAAMALALAGE
                     PAPPAPAPPEDHPDEEMGFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLF
                     ERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTV
                     KNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGD
                     GAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYA
                     SRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRL
                     EELRNQELQKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGFKPNYMENREQEMR
                     MGDMGPRGAINMGDAFSPAPAGNQGPPPMMGMNMNNRATIPGPPMGPGPAMGPEGAAN
                     MGTPMMPDNGAVHNDRFPQGPPSQMGSPMGSRTGSETPQAPMSGVGPVSGGPGGFGRG
                     SQGGNFEGPNKRRRY"
     exon            561..862
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..958
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1155
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1240
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1346
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1404
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1574
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..2435
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2043..2048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /note="hexamer: AAGAAA"
     polyA_site      2068
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /note="major polyA site"
ORIGIN      
        1 gccattttga atgtgcagct gcagcgggcg tgagttgggg gaggacgggt tgccgactcg
       61 cctacctagc ggtctcttga ttgtcgatat tttgttggca taggtttatg tagagacgta
      121 tacatatata tagacacact gtctataaat ctaggcctgt atccggtgtc cgaggcgaac
      181 tcagtaagat gatgttaaga ggaaacctga agcaagtgcg cattgagaaa aacccggccc
      241 gccttcgcgc cctggagtcc gcggtgggcg agagcgagcc ggcggccgcg gcagccatgg
      301 cgctcgctct tgccggggag ccggcaccgc ccgcgcccgc gcctccagag gaccacccgg
      361 acgaggagat ggggttcact atcgacatca agagtttcct caagccgggc gagaagacgt
      421 acacgcagcg ctgccgcctc ttcgtgggaa atctgcccac cgacatcacg gaggaggact
      481 tcaagaggct cttcgaacgc tatggcgagc ccagcgaagt cttcatcaac cgggaccgtg
      541 gcttcggctt catccgcttg gaatccagaa ccctggctga aattgcaaaa gcagagctgg
      601 acggcaccat tctcaagagc agacctctac ggattcgctt cgctacacat ggagcagcct
      661 tgactgtcaa gaacctttct ccagttgttt ccaatgagct gctagagcaa gcattttctc
      721 agtttggtcc agtagagaaa gctgttgtgg ttgtggatga tcgcggtaga gctacaggaa
      781 aaggttttgt agagtttgca gcaaaacctc ctgcacgaaa ggctctggaa agatgtggtg
      841 atggggcatt cttgctaaca acgacccctc gtccagtcat tgtggaaccc atggagcagt
      901 ttgatgatga agatggcttg ccagagaagc tgatgcagaa aactcaacaa tatcataagg
      961 aaagagaaca accaccacgt tttgctcaac ctgggacatt tgaatttgag tatgcatctc
     1021 gatggaaggc tcttgatgaa atggaaaagc agcagcgtga gcaggttgat agaaacatca
     1081 gagaagccaa agagaaactg gaggcagaaa tggaagcagc taggcatgaa caccaattaa
     1141 tgctaatgag gcaagatcta atgaggcgtc aagaagaact cagacgcttg gaagaactca
     1201 gaaaccaaga gttgcaaaaa cggaagcaaa tacaactaag acatgaagag gagcatcggc
     1261 ggcgtgagga agaaatgatc cgacacagag aacaggagga actgaggcga cagcaagagg
     1321 gctttaagcc aaactacatg gaaaatagag aacaggaaat gagaatgggt gatatgggtc
     1381 cccgtggagc aataaacatg ggagatgcgt ttagcccagc ccctgctggt aaccaaggtc
     1441 ctcctccaat gatgggtatg aatatgaaca acagagcaac tatacctggc ccaccaatgg
     1501 gtcctggtcc tgccatggga ccagaaggag ccgcaaatat gggaactcca atgatgccag
     1561 ataatggagc agtgcacaat gacagatttc ctcaaggacc accatctcag atgggttcac
     1621 ctatggggag tagaacaggt tctgaaaccc ctcaagcacc aatgagtggt gtaggtcctg
     1681 tgagtggtgg tcctggtggc tttggtagag gaagtcaagg gggcaacttt gaaggcccta
     1741 ataagcgtcg tagatattaa acattcgttc attcctggct atctagaaaa aaaaaagtca
     1801 gtggtatgcc tttatacttt tacctgttat ctggaagaaa tggttttatt gttaatgtat
     1861 gtagacttaa aagttttttt ttttttgtaa aacttgaggt ttttgtattt ttctttattc
     1921 atgagctttg tagattagaa tggtaatgat gctcatcatt ttgaatgttg aaatgtgttt
     1981 gtgactttag ctaaatataa gtattccata gtactgtgaa atctatgtag ttaatctcaa
     2041 taaagaaatc attttggata atttaaaact gttattagtg gtattctctt acggtcttac
     2101 taaactttgc tgtaacagta atgctttggt tgctttaact aatcctatca ttaaaaatga
     2161 aaatgatttt gctttttaat ttgcgcaagt agcactaaag atagaagctt aattaatgaa
     2221 agctaatgtc aataaggggt agatagagta gtatatgtgg gggtgggagg gtatgggagt
     2281 ttaatttgta taaaccactg atgttctgtg aaatcggaat ttccagctac atttcatata
     2341 gcttctgaat attcaggtat tctgagacag attattaagg atatctttgt cctgtgctga
     2401 tttttccaaa taaatctttt tcatcttgaa aaaaa
//
