LOCUS       NM_032302               1428 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens proteasome assembly chaperone 3 (PSMG3), transcript
            variant 1, mRNA.
ACCESSION   NM_032302
VERSION     NM_032302.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1428)
  AUTHORS   Ma,Z., Li,R., Hu,R., Zheng,W., Yu,S., Cheng,K., Zhang,H., Xiao,Y.,
            Yi,J., Wang,Z., Wang,Y. and Chen,C.
  TITLE     Anaplasma phagocytophilum AptA enhances the UPS, autophagy, and
            anti-apoptosis of host cells by PSMG3
  JOURNAL   Int J Biol Macromol 184, 497-508 (2021)
   PUBMED   34126152
  REMARK    GeneRIF: Anaplasma phagocytophilum AptA enhances the UPS,
            autophagy, and anti-apoptosis of host cells by PSMG3.
REFERENCE   2  (bases 1 to 1428)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1428)
  AUTHORS   Wu,W., Sahara,K., Hirayama,S., Zhao,X., Watanabe,A., Hamazaki,J.,
            Yashiroda,H. and Murata,S.
  TITLE     PAC1-PAC2 proteasome assembly chaperone retains the core
            alpha4-alpha7 assembly intermediates in the cytoplasm
  JOURNAL   Genes Cells 23 (10), 839-848 (2018)
   PUBMED   30133132
REFERENCE   4  (bases 1 to 1428)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1428)
  AUTHORS   Le Tallec,B., Barrault,M.B., Courbeyrette,R., Guerois,R.,
            Marsolier-Kergoat,M.C. and Peyroche,A.
  TITLE     20S proteasome assembly is orchestrated by two distinct pairs of
            chaperones in yeast and in mammals
  JOURNAL   Mol Cell 27 (4), 660-674 (2007)
   PUBMED   17707236
REFERENCE   6  (bases 1 to 1428)
  AUTHORS   Hirano,Y., Hayashi,H., Iemura,S., Hendil,K.B., Niwa,S.,
            Kishimoto,T., Kasahara,M., Natsume,T., Tanaka,K. and Murata,S.
  TITLE     Cooperation of multiple chaperones required for the assembly of
            mammalian 20S proteasomes
  JOURNAL   Mol Cell 24 (6), 977-984 (2006)
   PUBMED   17189198
  REMARK    GeneRIF: we report the identification of a chaperone, designated
            PAC3, as a component of alpha rings. PAC3 dissociates before the
            formation of half-proteasomes, a process coupled with the
            recruitment of beta subunits and hUmp1.[PAC3]
REFERENCE   7  (bases 1 to 1428)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093734.3, BC027171.1 and CN261807.1.
            
            On May 17, 2019 this sequence version replaced NM_032302.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027171.1, SRR1163655.531796.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288607.3/ ENSP00000288607.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC093734.3         76414-76452         c
            40-409              BC027171.1         1-370
            410-1088            BC027171.1         372-1050
            1089-1428           CN261807.1         435-774
FEATURES             Location/Qualifiers
     source          1..1428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..1428
                     /gene="PSMG3"
                     /gene_synonym="C7orf48; PAC3; Pba3"
                     /note="proteasome assembly chaperone 3"
                     /db_xref="GeneID:84262"
                     /db_xref="HGNC:HGNC:22420"
                     /db_xref="MIM:617528"
     exon            1..909
                     /gene="PSMG3"
                     /gene_synonym="C7orf48; PAC3; Pba3"
                     /inference="alignment:Splign:2.1.0"
     CDS             694..1062
                     /gene="PSMG3"
                     /gene_synonym="C7orf48; PAC3; Pba3"
                     /note="proteasome assembling chaperone 3; PAC-3; hPAC3;
                     proteasome (prosome, macropain) assembly chaperone 3;
                     proteasome chaperone homolog 3"
                     /codon_start=1
                     /product="proteasome assembly chaperone 3"
                     /protein_id="NP_115678.1"
                     /db_xref="CCDS:CCDS5327.1"
                     /db_xref="GeneID:84262"
                     /db_xref="HGNC:HGNC:22420"
                     /db_xref="MIM:617528"
                     /translation="MEDTPLVISKQKTEVVCGVPTQVVCTAFSSHILVVVTQFGKMGT
                     LVSLEPSSVASDVSKPVLTTKVLLGQDEPLIHVFAKNLVAFVSQEAGNRAVLLAVAVK
                     DKSMEGLKALREVIRVCQVW"
     exon            910..1428
                     /gene="PSMG3"
                     /gene_synonym="C7orf48; PAC3; Pba3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1403..1408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMG3"
                     /gene_synonym="C7orf48; PAC3; Pba3"
                     /note="hexamer: ATTAAA"
     polyA_site      1428
                     /gene="PSMG3"
                     /gene_synonym="C7orf48; PAC3; Pba3"
                     /note="major polyA site"
ORIGIN      
        1 acttccgggc gcggcgccgg cttggtgagc gcgggtaccc gcgggcttcc ccgggcggct
       61 gcgtccccag tagcccggcc ggcctcggca ccgcgtgtcg tgggggtccc gggccgcggc
      121 tgcagggccg gggcggcggc gaggccgagg ggcgggaagc cactgcccgg cctggcagtg
      181 tgaacgtgca agtcgatccc ctaacccaga aagccccagg cgcggtctct atgggcggcc
      241 ccgctcctgc ttctgtttta tttttttacg gacagggtct cgctctaccg cccgggttgt
      301 aatgcaatgg tgtgatcacg gctcaccgca gcctcgacct cccgggctga agcgatcttc
      361 ccgcctcagc ctcctgagta actgggacca caggcgcgcc ctgctggttt tttttttttt
      421 tttttttggt agagatgggg gtctcgctat gttggccagg ctggtctcga attcctggcc
      481 tcaacgatcg tcctgtctcg gcctcccaaa gtgccgggat gacaggcatg agccaccgcg
      541 cctggcccct tcttttgaat gggcctcctt gcgtttccgt ttcaatgccc cgtgctactt
      601 ttttgggagc cccaaggctg tactgtttga ttgactcctt tttttcccct ttctttttaa
      661 cctaaattaa agctgccact gcagagcccc gccatggaag acacgccgtt ggtgatatcg
      721 aagcagaaga cggaggtggt gtgcggggtc cccacccagg tggtgtgtac ggccttcagc
      781 agtcacatcc tggtggtggt gacccagttt gggaagatgg gcaccctggt ctccctggag
      841 cccagcagcg tggccagtga cgtcagcaag cctgtgctca ccacaaaagt ccttctgggg
      901 caggatgagc ctctcatcca tgtctttgca aagaacctgg tagcgtttgt gtctcaagaa
      961 gctggaaaca gagcagtcct cctcgccgtg gccgtgaagg acaaaagcat ggaggggctg
     1021 aaggcgctga gggaggtgat ccgggtgtgc caggtgtggt gacctggagg cagccgcccc
     1081 gcgctgctca gcaggacacg tgaacaccca gacacccact cagggactca agtctcacct
     1141 ccctccccgg tggagggagg aactttggca ctagcccttg gagccaggaa aaaagactcg
     1201 tgtctcaggc agactcttac tctggttact aagatcatct gtgcatgacg gggagggtgg
     1261 aacaggtccc ggaggagtcg tgaatggttc tcaccaggac ctgaatcgtt gcttgtgttt
     1321 gagaattgga ggaatgagtc agcaggcgtg gctcatggcc cccccgtgtg caggatcaat
     1381 tgtaggagga aatttctttt ttattaaaag cgaatgtgta tcccaaaa
//
