LOCUS       NM_001323410            6972 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens proteasome inhibitor subunit 1 (PSMF1), transcript
            variant 6, mRNA.
ACCESSION   NM_001323410
VERSION     NM_001323410.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6972)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6972)
  AUTHORS   Yang,S., Tang,D., Zhao,Y.C., Liu,H., Luo,S., Stinchcombe,T.E.,
            Glass,C., Su,L., Shen,S., Christiani,D.C., Wang,Q. and Wei,Q.
  TITLE     Potentially functional variants of ERAP1, PSMF1 and NCF2 in the
            MHC-I-related pathway predict non-small cell lung cancer survival
  JOURNAL   Cancer Immunol Immunother 70 (10), 2819-2833 (2021)
   PUBMED   33651148
  REMARK    GeneRIF: Potentially functional variants of ERAP1, PSMF1 and NCF2
            in the MHC-I-related pathway predict non-small cell lung cancer
            survival.
REFERENCE   3  (bases 1 to 6972)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6972)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 6972)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6972)
  AUTHORS   McCutchen-Maloney,S.L., Matsuda,K., Shimbara,N., Binns,D.D.,
            Tanaka,K., Slaughter,C.A. and DeMartino,G.N.
  TITLE     cDNA cloning, expression, and functional characterization of PI31,
            a proline-rich inhibitor of the proteasome
  JOURNAL   J Biol Chem 275 (24), 18557-18565 (2000)
   PUBMED   10764772
REFERENCE   7  (bases 1 to 6972)
  AUTHORS   Tanahashi,N., Kawahara,H., Murakami,Y. and Tanaka,K.
  TITLE     The proteasome-dependent proteolytic system
  JOURNAL   Mol Biol Rep 26 (1-2), 3-9 (1999)
   PUBMED   10363639
  REMARK    Review article
REFERENCE   8  (bases 1 to 6972)
  AUTHORS   Simon,J.H., Gaddis,N.C., Fouchier,R.A. and Malim,M.H.
  TITLE     Evidence for a newly discovered cellular anti-HIV-1 phenotype
  JOURNAL   Nat Med 4 (12), 1397-1400 (1998)
   PUBMED   9846577
REFERENCE   9  (bases 1 to 6972)
  AUTHORS   Madani,N. and Kabat,D.
  TITLE     An endogenous inhibitor of human immunodeficiency virus in human
            lymphocytes is overcome by the viral Vif protein
  JOURNAL   J Virol 72 (12), 10251-10255 (1998)
   PUBMED   9811770
REFERENCE   10 (bases 1 to 6972)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC398668.1, AL031665.19 and
            AA699495.1.
            
            On May 31, 2019 this sequence version replaced NM_001323410.1.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            protein that inhibits the activation of the proteasome by the 11S
            and 19S regulators. Alternative transcript variants have been
            identified for this gene. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.128928.1,
                                           SRR1803615.258009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                DC398668.1         10-93
            85-301              AL031665.19        5995-6211
            302-454             AL031665.19        12807-12959
            455-537             AL031665.19        14735-14817
            538-723             AL031665.19        22430-22615
            724-777             AL031665.19        50440-50493
            778-952             AL031665.19        51628-51802
            953-6816            AL031665.19        53537-59400
            6817-6972           AA699495.1         12-167              c
FEATURES             Location/Qualifiers
     source          1..6972
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..6972
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="proteasome inhibitor subunit 1"
                     /db_xref="GeneID:9491"
                     /db_xref="HGNC:HGNC:9571"
                     /db_xref="MIM:617858"
     exon            1..301
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..964
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="isoform 6 is encoded by transcript variant 6;
                     proteasome inhibitor PI31 subunit; proteasome (prosome,
                     macropain) inhibitor subunit 1 (PI31)"
                     /codon_start=1
                     /product="proteasome inhibitor PI31 subunit isoform 6"
                     /protein_id="NP_001310339.1"
                     /db_xref="GeneID:9491"
                     /db_xref="HGNC:HGNC:9571"
                     /db_xref="MIM:617858"
                     /translation="MAGLEVLFASAAPAITCRQDALVCFLHWEVVTHGYFGLGVGDQP
                     GPNDKKSELLPAGWNNNKDLYVLRYEYKDGSRKLLVKAITVESSMILNVLEYGSQQVA
                     DLTLNLDDYIDAEHLGDFHRTYKNSEELRSRIVSGIITPIHEQWEKANVSSPHREFPP
                     ATAREVDPLRIPPHHPHTSRQPPWCDPLGPFVVGGEDLDPFGPRRGGMIVDPLRSGFP
                     RALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPPGYVVTQPEA"
     exon            302..454
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     exon            455..537
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     exon            538..723
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     exon            724..777
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     exon            778..952
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     exon            953..6972
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2026..2031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="hexamer: AATAAA"
     polyA_site      2047
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="major polyA site"
     regulatory      3080..3085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="hexamer: AATAAA"
     polyA_site      3104
                     /gene="PSMF1"
                     /gene_synonym="PI31"
     regulatory      3625..3630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="hexamer: CATAAA"
     polyA_site      3647
                     /gene="PSMF1"
                     /gene_synonym="PI31"
     polyA_site      5000
                     /gene="PSMF1"
                     /gene_synonym="PI31"
     regulatory      6945..6950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="hexamer: ATTAAA"
     polyA_site      6972
                     /gene="PSMF1"
                     /gene_synonym="PI31"
ORIGIN      
        1 ggcttccccg ccccgccccg tccccgggcg tctccatttt ggtctcaggt gtggactcgg
       61 caagaaccag cgcaagaggg aagcagagtt atagctaccc cggccgcgga gccggctcac
      121 tgcactaccc ccgccccctt ctttcctcca gacgccgaag tcgcgggcgc tcatggcggg
      181 cctggaggta ctgttcgcat cggcagcgcc ggccatcacc tgcaggcagg acgcgctcgt
      241 ctgcttcttg cattgggaag tggtgacaca cggttacttc ggcttgggtg tcggtgacca
      301 gccgggtccc aatgataaga agtcagaact gctgccagct gggtggaaca acaataaaga
      361 cctgtatgtc ctccggtatg agtataagga tgggtccaga aagctccttg tgaaagccat
      421 caccgtggag agcagcatga tcctcaatgt gctggaatat ggctcacagc aagtggcaga
      481 cttgaccctg aacttggatg attatatcga tgcagaacac ctgggtgact tccacaggac
      541 ctacaagaac agtgaggagc ttcggtctcg tattgtgtct ggaatcatca cacctatcca
      601 tgagcagtgg gaaaaggcta atgtaagcag tccccaccgg gagttccccc ctgctaccgc
      661 cagagaggtg gacccactcc ggattcctcc acaccaccca cacaccagtc ggcagcctcc
      721 ctggtgtgat cccctgggcc cgtttgttgt cgggggagaa gacttagacc cttttgggcc
      781 tcggagaggt ggcatgattg tggatcccct gagatctggc ttcccaagag cacttattga
      841 cccttcctca ggcctcccga accgacttcc tccaggcgct gtgcccccag gagctcgctt
      901 tgaccccttt ggacccattg ggaccagccc acccgggtac gtagtcactc agcccgaggc
      961 ctgacagacg cgggcagtga tgagccctgt tctggagtgg aaagagcacg atagagcacc
     1021 aggctaagag gcacgagatc aaggcggtag tcacttccgc tctgcagcta gcatttcaac
     1081 catatgtgga tcctttcatt tctcagctcc ctggattcct tcccctaaat taggacctat
     1141 tatttacctg taggtaagca agctactgta gctcttctga ggtatctgcc aggctgtttt
     1201 ctgtagcctc agattgccta tctgcttagc ctgagaacag gtagatgaaa actaaactga
     1261 tgcctaggcc cagggtcagt ctcagatgga agctgggcct gggtggggag gctagcatgc
     1321 gtggctccct gggtatttct gtcagtcccc atggcaagca gtgatttagt aaaacacccc
     1381 agagtcaggg aagccaacca ccttgaaacc tttagaacat ctctgctttg gagaaagacc
     1441 cagagatcag gcagaggtgc agattcaatc attactcata acctttgaga gatggcaaat
     1501 gggaggagtg ttagtctttg ttttggaatt ggaccattct tgcaaccaaa aggacttaga
     1561 gcagtttgct cataaagaca tcctttatta taaaaggaag tatttaaagg atgatagaga
     1621 ccatcagata gaagcaggga aggtagataa cttttaggac cttgatgtga ggaaaagata
     1681 aaatttaaac aataaatttg ccacttagat tttctagcag caaagtccga aaagatagtt
     1741 atatacaaaa ttctgttttc tgaaaacaaa attgtgattc accttcagaa ttggccattt
     1801 tttttgtgag tttccttgca tcaaggacac tgagaaacac agtcattgtc ttaggtgttc
     1861 tatgggagga agtgaataga gcctttagga acttcctggt caagcttatg gtgcttattt
     1921 tgatctgggc cacttccctc cttccagtca tgagtaatca tcaaggagca agttggagtg
     1981 tttcaggtgt atattttgta gaacccaaaa gattggagcc ttaacaataa acatcagcac
     2041 taagtgacct gttcctcctt ttttaaatag cagctttatt gagatataat ttacataccc
     2101 ataatttaca tacctgttta aagtatacaa ttcagtggat ttagtatgtt cacagtgttg
     2161 cacatccacc accatttcta attcctgaac attttcacca cctcaaaaag aaaccacaca
     2221 cccattggca tgactcccca ttcccttgct cccagcccca ggcaaccact aacatctgtc
     2281 tctaaagatt tttttttttt ttctggacag ttctcataag tggaatcact cagtattatg
     2341 gccttttgtg tctggcttct ttcatttcat gtgatgtttt caagattcat tcatgctgta
     2401 gcatgtatcc atggtatgga tatatcacat tttgcttatc cttttatcag ttgatggaca
     2461 gttgggttgt ttctacaaaa aggctattat gagtaatgca gccaagaaca tttgtgtacc
     2521 agtttttgag ttttcagttg tttgagtttc agatgttttc agttcatttg ggtatatacc
     2581 aaggagtgga attgctggtt cacatggtag ctctatattc tactttgtga ggaattgtca
     2641 gactgttttc cacggaagct gcaccatttt acatttccac tggtaattta tgagggttcc
     2701 agtttcccca catcttcacc aactcttgtt atttttcatg cttatggcca tcctagttag
     2761 cgtgaagtag catctcattg tggtcttctc ttccattttt taaaaaagaa ttttgaccta
     2821 caccaagcaa ggcagagacc agagtcagtc ccccttgggg agcaatctgt ggttttgata
     2881 atcaccacct tgggatgaac atggctggtg agctgcagag cagttgattt gacttttggg
     2941 gatggttcta ggctggatgt gatacagggc aggttttgtc tctagagaaa gttctcatga
     3001 ccttcaggtc taatgagatt cagatcatca ctttggtttg gtttgaaatt tctttgttta
     3061 tccagtgaat tacaagtaga ataaagatct ggttctaaat tgtcttttgg tggtgaagtg
     3121 ccatagacca tttcggacca tttctatgat gtaccagcag cccccacatc acacctcctc
     3181 ttccttggct tgtctcttcc ccaattctta gagttagcag tgtttcttac tgcattcatc
     3241 tcctcagtca taagtgtctg tcaacctccg ttgtgaagtc atgagtctct tgagactgaa
     3301 actccaagaa tgtattgtgc tcacagtggc gatggtgttc ctgtgctgga tggtcagtgg
     3361 ttgttgacat gtagttagaa aataggtagc aagttccacg cagcctcact ctttggaacc
     3421 tagtttctcc tatggcctcc ctttctactg ttgttaataa cattctatta atgatccatg
     3481 cctctcttca caggaggaat attagaatct atggagcagt tagtattctt tgtcacctaa
     3541 atttgtctac ttctgtacat ttccaataag gcaccaccag ggcaagggaa gattccccac
     3601 atgtatatcc ccagctgttt ctgtcataaa acttgcatgt gtataaacca ctattgactt
     3661 tttgcaccaa aggagatatt caaggacaga catccaagtc cccagccctt tattgccctt
     3721 gggataccac aaggcacaga tacaggcagc tgctgtgtgg ctctggagtt cctaatcccc
     3781 agattgtagc aatgatgatg tgatcctgct gctctctgga ccgtaacctt tttggttaca
     3841 aaaggtaaat ttctgtttac tgcatctgaa ccccaggact aatgcgtcac tgcattaacc
     3901 ccaggacaca tggaccaagt cactgcggcc gtacttggcc ctgaatctgt cctggagggt
     3961 gggtcaaaag gcaagggtgg caggtaggat ggtaggcagt gaggggtggc aaggcctagc
     4021 tgactgagga cagacccagc aacaatgaca ggaggtttga acacctcacg agtggtagtg
     4081 cccatgggag gtgcgaagtg gaaggcccag cccttgcttg gaggaacgtg aggctgatgg
     4141 tgcagtgcaa tagaggtcac tggatgccca tttgaacagc tgcgttccag atgagccacc
     4201 taaggtggat gttgtgagag tcacagtggg tttagaggga caaggtagtg agaggatgct
     4261 gctgacgcat tagtcctggg attcagctgc agtaaacaga aatttacctt ttgtaaccaa
     4321 aaaggtaatg gtccagagag cagcaggatc acatcatcat tgctacaatc tggggattag
     4381 gaactccaga gccacacagc agctgcctat atctgcacca aaaagtagat gtccttcaca
     4441 ctgccatctg gacaccactc agctagctca tccaagttca aggctcaatt gaatgcgtct
     4501 ggttgttgga acctacatgg cctctcaaat ggtactggca tggaatattg gggagatgtc
     4561 tttattccct cttcccacct ttcctggaag gtgcactggg acagaggtct agtgagccaa
     4621 tcttctgtgt tgtctacgcc atggaccatg atataaatgg gtaccacagc cttgcatgcc
     4681 tgagcctaac catctcctga gatgcttgct ctaagtacac attagtacat gctgggcccc
     4741 aatctagatc tcaagggaac ggccttcaga tccatttttg acaagttcct tttgtgagtc
     4801 ctatgatcat gcaagtttga gaactgagaa gggaggggaa gacctacctc cttgttactc
     4861 agaccaccag caacagcagc atcacctggg aacctgttac acatgcagaa tctcaagccc
     4921 caccccagac attgaatgag aatctgcatt ttaacaagtt ctccatgaga tttgtgtaaa
     4981 cttaaagtga gagaagctca catggactat gtctttttcc tttacgtgaa tatcgagtac
     5041 aaagaattga gccagtcagt cctcttggtt aatggcacat tatgattaat gcatgcatga
     5101 actctgattc gaagttttcg ttgattttac ccccagtatc cactccattc ctttgccccc
     5161 atgggtcact tagatgtgtt tcatgttatc tttaaaaatg cagcaccttt atagcataca
     5221 ttatatcttc aaaccataac cataatgagg tgttatcccc atttcctgta ccagaaaagg
     5281 aaggattggg aaggtccagt aatttgctca gggtcaagca ggagtctcag actcagtcaa
     5341 gcgtggttac tcacagccct ccctttctca gtgtgtggcc ttcctcatcc acaaaatgag
     5401 catcacccct acctgcagga ttcttgcaag atccaaccaa ataatgtgtc ttattaacag
     5461 agagttgggg ctcggtgggt gcttgctgca attgttacta aagtcatatg ggtagataag
     5521 ggtgggactc aaggacaaga gaggaacctt ggaatatccc ccagtgcagg aaacaagcat
     5581 ttatcaggtg cacacagcgt gctaggcttc tcctcatcgc atgtagtacc cctgacaacc
     5641 ccaaggtaaa cacagctagt ggcattagtt gagatgctgc acctaccccc tggggtggca
     5701 gaaccgtgat tggaacccag gtcagtgctc ttttcagtag aactgctgta cccagacctc
     5761 acatcctctc taggtgaggt gcatgggtcc ctgggcaaaa cccattccag aagctgggaa
     5821 accacgtcag gacttgtgtg agaaaggagt gatgcttcat aatccccagg atggtcttaa
     5881 ggctcctcag tcagtcctat ttgcacagcg tgcctcatgc tcctgagtac ctccacctgc
     5941 agccacagtg cccagagcac ctggttagga ggagcatctg aaaccacctg cacaacctcc
     6001 attccacaga ggaagaaaca ggctcaagaa acccatatgt gatggggagc tcctaacagg
     6061 cttccctggg ccacaggaat gggctcgggc tctctgctgg gctctgtcac ctggctccat
     6121 gtgctgctca cctcggcctt ctgagtttag taggatggca gctagtcttc cctattgaca
     6181 ggtgaaaaag caggtccaca gctgttgagt gactttccca aggccacaca gaccacaaat
     6241 cctggctcca agtccagggc gtttccagta agcactgtcc aaatcagtca tggaggtccc
     6301 tgagtgacaa aaatatgcag gaccccttct ttccccctcc cagttcccgc agctaggctg
     6361 agtgttaaga ggaaggtgcc atacaggttc agcaccctgg tcagcgccca gcctccctaa
     6421 agccgctgga ggaggccttt ggagccagct caggtcagtg tctgctgctt ccttacccag
     6481 gatggcccac tcttggggac agacaggcat cctgagagga gggggcctgg acctaggtgt
     6541 cttgccaccc aatacagagc cctgccctct ccctctcctt cagaaggaag tatgggagca
     6601 gttccatcct caaggtttct tggttcccag gacagaaatt tgagtgagaa gcatgtgaag
     6661 agagggatgg cccaggggcc cttggccatg gtggccttgg acaagtttgg ctttccccat
     6721 ctgtaaaatg tagataagga tggacccacc tccccaagat cctgcctatc tgtgagagtc
     6781 catgactaag tgggccatgg gctggactga gttcagtgct cccccaacct gccctcctcc
     6841 tctcccccac agagcttccc aatttacatg taaaccttgg gcatcaaagt gacagctgat
     6901 agcccaggtt tgcccacaaa tgtgctctga ctggcgtgca tgttattaaa tttgataaga
     6961 tgcatgatgg ca
//
