LOCUS       NM_001323408            6956 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens proteasome inhibitor subunit 1 (PSMF1), transcript
            variant 4, mRNA.
ACCESSION   NM_001323408
VERSION     NM_001323408.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6956)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6956)
  AUTHORS   Yang,S., Tang,D., Zhao,Y.C., Liu,H., Luo,S., Stinchcombe,T.E.,
            Glass,C., Su,L., Shen,S., Christiani,D.C., Wang,Q. and Wei,Q.
  TITLE     Potentially functional variants of ERAP1, PSMF1 and NCF2 in the
            MHC-I-related pathway predict non-small cell lung cancer survival
  JOURNAL   Cancer Immunol Immunother 70 (10), 2819-2833 (2021)
   PUBMED   33651148
  REMARK    GeneRIF: Potentially functional variants of ERAP1, PSMF1 and NCF2
            in the MHC-I-related pathway predict non-small cell lung cancer
            survival.
REFERENCE   3  (bases 1 to 6956)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6956)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 6956)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6956)
  AUTHORS   McCutchen-Maloney,S.L., Matsuda,K., Shimbara,N., Binns,D.D.,
            Tanaka,K., Slaughter,C.A. and DeMartino,G.N.
  TITLE     cDNA cloning, expression, and functional characterization of PI31,
            a proline-rich inhibitor of the proteasome
  JOURNAL   J Biol Chem 275 (24), 18557-18565 (2000)
   PUBMED   10764772
REFERENCE   7  (bases 1 to 6956)
  AUTHORS   Tanahashi,N., Kawahara,H., Murakami,Y. and Tanaka,K.
  TITLE     The proteasome-dependent proteolytic system
  JOURNAL   Mol Biol Rep 26 (1-2), 3-9 (1999)
   PUBMED   10363639
  REMARK    Review article
REFERENCE   8  (bases 1 to 6956)
  AUTHORS   Simon,J.H., Gaddis,N.C., Fouchier,R.A. and Malim,M.H.
  TITLE     Evidence for a newly discovered cellular anti-HIV-1 phenotype
  JOURNAL   Nat Med 4 (12), 1397-1400 (1998)
   PUBMED   9846577
REFERENCE   9  (bases 1 to 6956)
  AUTHORS   Madani,N. and Kabat,D.
  TITLE     An endogenous inhibitor of human immunodeficiency virus in human
            lymphocytes is overcome by the viral Vif protein
  JOURNAL   J Virol 72 (12), 10251-10255 (1998)
   PUBMED   9811770
REFERENCE   10 (bases 1 to 6956)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC398668.1, AL031665.19 and
            AA699495.1.
            
            On May 31, 2019 this sequence version replaced NM_001323408.1.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            protein that inhibits the activation of the proteasome by the 11S
            and 19S regulators. Alternative transcript variants have been
            identified for this gene. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.238746.1,
                                           SRR1803617.90327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                DC398668.1         10-93
            85-301              AL031665.19        5995-6211
            302-454             AL031665.19        12807-12959
            455-537             AL031665.19        14735-14817
            538-723             AL031665.19        22430-22615
            724-777             AL031665.19        50440-50493
            778-936             AL031665.19        51628-51786
            937-6800            AL031665.19        53537-59400
            6801-6956           AA699495.1         12-167              c
FEATURES             Location/Qualifiers
     source          1..6956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..6956
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="proteasome inhibitor subunit 1"
                     /db_xref="GeneID:9491"
                     /db_xref="HGNC:HGNC:9571"
                     /db_xref="MIM:617858"
     exon            1..301
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..964
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="isoform 4 is encoded by transcript variant 4;
                     proteasome inhibitor PI31 subunit; proteasome (prosome,
                     macropain) inhibitor subunit 1 (PI31)"
                     /codon_start=1
                     /product="proteasome inhibitor PI31 subunit isoform 4"
                     /protein_id="NP_001310337.1"
                     /db_xref="CCDS:CCDS82589.1"
                     /db_xref="GeneID:9491"
                     /db_xref="HGNC:HGNC:9571"
                     /db_xref="MIM:617858"
                     /translation="MAGLEVLFASAAPAITCRQDALVCFLHWEVVTHGYFGLGVGDQP
                     GPNDKKSELLPAGWNNNKDLYVLRYEYKDGSRKLLVKAITVESSMILNVLEYGSQQVA
                     DLTLNLDDYIDAEHLGDFHRTYKNSEELRSRIVSGIITPIHEQWEKANVSSPHREFPP
                     ATAREVDPLRIPPHHPHTSRQPPWCDPLGPFVVGGEDLDPFGPRRGGMIVDPLRSGFP
                     RALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPPGPRPDRRGQ"
     exon            302..454
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     exon            455..537
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     exon            538..723
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     exon            724..777
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     exon            778..936
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     exon            937..6956
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2010..2015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="hexamer: AATAAA"
     polyA_site      2031
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="major polyA site"
     regulatory      3064..3069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="hexamer: AATAAA"
     polyA_site      3088
                     /gene="PSMF1"
                     /gene_synonym="PI31"
     regulatory      3609..3614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="hexamer: CATAAA"
     polyA_site      3631
                     /gene="PSMF1"
                     /gene_synonym="PI31"
     polyA_site      4984
                     /gene="PSMF1"
                     /gene_synonym="PI31"
     regulatory      6929..6934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMF1"
                     /gene_synonym="PI31"
                     /note="hexamer: ATTAAA"
     polyA_site      6956
                     /gene="PSMF1"
                     /gene_synonym="PI31"
ORIGIN      
        1 ggcttccccg ccccgccccg tccccgggcg tctccatttt ggtctcaggt gtggactcgg
       61 caagaaccag cgcaagaggg aagcagagtt atagctaccc cggccgcgga gccggctcac
      121 tgcactaccc ccgccccctt ctttcctcca gacgccgaag tcgcgggcgc tcatggcggg
      181 cctggaggta ctgttcgcat cggcagcgcc ggccatcacc tgcaggcagg acgcgctcgt
      241 ctgcttcttg cattgggaag tggtgacaca cggttacttc ggcttgggtg tcggtgacca
      301 gccgggtccc aatgataaga agtcagaact gctgccagct gggtggaaca acaataaaga
      361 cctgtatgtc ctccggtatg agtataagga tgggtccaga aagctccttg tgaaagccat
      421 caccgtggag agcagcatga tcctcaatgt gctggaatat ggctcacagc aagtggcaga
      481 cttgaccctg aacttggatg attatatcga tgcagaacac ctgggtgact tccacaggac
      541 ctacaagaac agtgaggagc ttcggtctcg tattgtgtct ggaatcatca cacctatcca
      601 tgagcagtgg gaaaaggcta atgtaagcag tccccaccgg gagttccccc ctgctaccgc
      661 cagagaggtg gacccactcc ggattcctcc acaccaccca cacaccagtc ggcagcctcc
      721 ctggtgtgat cccctgggcc cgtttgttgt cgggggagaa gacttagacc cttttgggcc
      781 tcggagaggt ggcatgattg tggatcccct gagatctggc ttcccaagag cacttattga
      841 cccttcctca ggcctcccga accgacttcc tccaggcgct gtgcccccag gagctcgctt
      901 tgaccccttt ggacccattg ggaccagccc acccggcccg aggcctgaca gacgcgggca
      961 gtgatgagcc ctgttctgga gtggaaagag cacgatagag caccaggcta agaggcacga
     1021 gatcaaggcg gtagtcactt ccgctctgca gctagcattt caaccatatg tggatccttt
     1081 catttctcag ctccctggat tccttcccct aaattaggac ctattattta cctgtaggta
     1141 agcaagctac tgtagctctt ctgaggtatc tgccaggctg ttttctgtag cctcagattg
     1201 cctatctgct tagcctgaga acaggtagat gaaaactaaa ctgatgccta ggcccagggt
     1261 cagtctcaga tggaagctgg gcctgggtgg ggaggctagc atgcgtggct ccctgggtat
     1321 ttctgtcagt ccccatggca agcagtgatt tagtaaaaca ccccagagtc agggaagcca
     1381 accaccttga aacctttaga acatctctgc tttggagaaa gacccagaga tcaggcagag
     1441 gtgcagattc aatcattact cataaccttt gagagatggc aaatgggagg agtgttagtc
     1501 tttgttttgg aattggacca ttcttgcaac caaaaggact tagagcagtt tgctcataaa
     1561 gacatccttt attataaaag gaagtattta aaggatgata gagaccatca gatagaagca
     1621 gggaaggtag ataactttta ggaccttgat gtgaggaaaa gataaaattt aaacaataaa
     1681 tttgccactt agattttcta gcagcaaagt ccgaaaagat agttatatac aaaattctgt
     1741 tttctgaaaa caaaattgtg attcaccttc agaattggcc attttttttg tgagtttcct
     1801 tgcatcaagg acactgagaa acacagtcat tgtcttaggt gttctatggg aggaagtgaa
     1861 tagagccttt aggaacttcc tggtcaagct tatggtgctt attttgatct gggccacttc
     1921 cctccttcca gtcatgagta atcatcaagg agcaagttgg agtgtttcag gtgtatattt
     1981 tgtagaaccc aaaagattgg agccttaaca ataaacatca gcactaagtg acctgttcct
     2041 ccttttttaa atagcagctt tattgagata taatttacat acccataatt tacatacctg
     2101 tttaaagtat acaattcagt ggatttagta tgttcacagt gttgcacatc caccaccatt
     2161 tctaattcct gaacattttc accacctcaa aaagaaacca cacacccatt ggcatgactc
     2221 cccattccct tgctcccagc cccaggcaac cactaacatc tgtctctaaa gatttttttt
     2281 ttttttctgg acagttctca taagtggaat cactcagtat tatggccttt tgtgtctggc
     2341 ttctttcatt tcatgtgatg ttttcaagat tcattcatgc tgtagcatgt atccatggta
     2401 tggatatatc acattttgct tatcctttta tcagttgatg gacagttggg ttgtttctac
     2461 aaaaaggcta ttatgagtaa tgcagccaag aacatttgtg taccagtttt tgagttttca
     2521 gttgtttgag tttcagatgt tttcagttca tttgggtata taccaaggag tggaattgct
     2581 ggttcacatg gtagctctat attctacttt gtgaggaatt gtcagactgt tttccacgga
     2641 agctgcacca ttttacattt ccactggtaa tttatgaggg ttccagtttc cccacatctt
     2701 caccaactct tgttattttt catgcttatg gccatcctag ttagcgtgaa gtagcatctc
     2761 attgtggtct tctcttccat tttttaaaaa agaattttga cctacaccaa gcaaggcaga
     2821 gaccagagtc agtccccctt ggggagcaat ctgtggtttt gataatcacc accttgggat
     2881 gaacatggct ggtgagctgc agagcagttg atttgacttt tggggatggt tctaggctgg
     2941 atgtgataca gggcaggttt tgtctctaga gaaagttctc atgaccttca ggtctaatga
     3001 gattcagatc atcactttgg tttggtttga aatttctttg tttatccagt gaattacaag
     3061 tagaataaag atctggttct aaattgtctt ttggtggtga agtgccatag accatttcgg
     3121 accatttcta tgatgtacca gcagccccca catcacacct cctcttcctt ggcttgtctc
     3181 ttccccaatt cttagagtta gcagtgtttc ttactgcatt catctcctca gtcataagtg
     3241 tctgtcaacc tccgttgtga agtcatgagt ctcttgagac tgaaactcca agaatgtatt
     3301 gtgctcacag tggcgatggt gttcctgtgc tggatggtca gtggttgttg acatgtagtt
     3361 agaaaatagg tagcaagttc cacgcagcct cactctttgg aacctagttt ctcctatggc
     3421 ctccctttct actgttgtta ataacattct attaatgatc catgcctctc ttcacaggag
     3481 gaatattaga atctatggag cagttagtat tctttgtcac ctaaatttgt ctacttctgt
     3541 acatttccaa taaggcacca ccagggcaag ggaagattcc ccacatgtat atccccagct
     3601 gtttctgtca taaaacttgc atgtgtataa accactattg actttttgca ccaaaggaga
     3661 tattcaagga cagacatcca agtccccagc cctttattgc ccttgggata ccacaaggca
     3721 cagatacagg cagctgctgt gtggctctgg agttcctaat ccccagattg tagcaatgat
     3781 gatgtgatcc tgctgctctc tggaccgtaa cctttttggt tacaaaaggt aaatttctgt
     3841 ttactgcatc tgaaccccag gactaatgcg tcactgcatt aaccccagga cacatggacc
     3901 aagtcactgc ggccgtactt ggccctgaat ctgtcctgga gggtgggtca aaaggcaagg
     3961 gtggcaggta ggatggtagg cagtgagggg tggcaaggcc tagctgactg aggacagacc
     4021 cagcaacaat gacaggaggt ttgaacacct cacgagtggt agtgcccatg ggaggtgcga
     4081 agtggaaggc ccagcccttg cttggaggaa cgtgaggctg atggtgcagt gcaatagagg
     4141 tcactggatg cccatttgaa cagctgcgtt ccagatgagc cacctaaggt ggatgttgtg
     4201 agagtcacag tgggtttaga gggacaaggt agtgagagga tgctgctgac gcattagtcc
     4261 tgggattcag ctgcagtaaa cagaaattta ccttttgtaa ccaaaaaggt aatggtccag
     4321 agagcagcag gatcacatca tcattgctac aatctgggga ttaggaactc cagagccaca
     4381 cagcagctgc ctatatctgc accaaaaagt agatgtcctt cacactgcca tctggacacc
     4441 actcagctag ctcatccaag ttcaaggctc aattgaatgc gtctggttgt tggaacctac
     4501 atggcctctc aaatggtact ggcatggaat attggggaga tgtctttatt ccctcttccc
     4561 acctttcctg gaaggtgcac tgggacagag gtctagtgag ccaatcttct gtgttgtcta
     4621 cgccatggac catgatataa atgggtacca cagccttgca tgcctgagcc taaccatctc
     4681 ctgagatgct tgctctaagt acacattagt acatgctggg ccccaatcta gatctcaagg
     4741 gaacggcctt cagatccatt tttgacaagt tccttttgtg agtcctatga tcatgcaagt
     4801 ttgagaactg agaagggagg ggaagaccta cctccttgtt actcagacca ccagcaacag
     4861 cagcatcacc tgggaacctg ttacacatgc agaatctcaa gccccacccc agacattgaa
     4921 tgagaatctg cattttaaca agttctccat gagatttgtg taaacttaaa gtgagagaag
     4981 ctcacatgga ctatgtcttt ttcctttacg tgaatatcga gtacaaagaa ttgagccagt
     5041 cagtcctctt ggttaatggc acattatgat taatgcatgc atgaactctg attcgaagtt
     5101 ttcgttgatt ttacccccag tatccactcc attcctttgc ccccatgggt cacttagatg
     5161 tgtttcatgt tatctttaaa aatgcagcac ctttatagca tacattatat cttcaaacca
     5221 taaccataat gaggtgttat ccccatttcc tgtaccagaa aaggaaggat tgggaaggtc
     5281 cagtaatttg ctcagggtca agcaggagtc tcagactcag tcaagcgtgg ttactcacag
     5341 ccctcccttt ctcagtgtgt ggccttcctc atccacaaaa tgagcatcac ccctacctgc
     5401 aggattcttg caagatccaa ccaaataatg tgtcttatta acagagagtt ggggctcggt
     5461 gggtgcttgc tgcaattgtt actaaagtca tatgggtaga taagggtggg actcaaggac
     5521 aagagaggaa ccttggaata tcccccagtg caggaaacaa gcatttatca ggtgcacaca
     5581 gcgtgctagg cttctcctca tcgcatgtag tacccctgac aaccccaagg taaacacagc
     5641 tagtggcatt agttgagatg ctgcacctac cccctggggt ggcagaaccg tgattggaac
     5701 ccaggtcagt gctcttttca gtagaactgc tgtacccaga cctcacatcc tctctaggtg
     5761 aggtgcatgg gtccctgggc aaaacccatt ccagaagctg ggaaaccacg tcaggacttg
     5821 tgtgagaaag gagtgatgct tcataatccc caggatggtc ttaaggctcc tcagtcagtc
     5881 ctatttgcac agcgtgcctc atgctcctga gtacctccac ctgcagccac agtgcccaga
     5941 gcacctggtt aggaggagca tctgaaacca cctgcacaac ctccattcca cagaggaaga
     6001 aacaggctca agaaacccat atgtgatggg gagctcctaa caggcttccc tgggccacag
     6061 gaatgggctc gggctctctg ctgggctctg tcacctggct ccatgtgctg ctcacctcgg
     6121 ccttctgagt ttagtaggat ggcagctagt cttccctatt gacaggtgaa aaagcaggtc
     6181 cacagctgtt gagtgacttt cccaaggcca cacagaccac aaatcctggc tccaagtcca
     6241 gggcgtttcc agtaagcact gtccaaatca gtcatggagg tccctgagtg acaaaaatat
     6301 gcaggacccc ttctttcccc ctcccagttc ccgcagctag gctgagtgtt aagaggaagg
     6361 tgccatacag gttcagcacc ctggtcagcg cccagcctcc ctaaagccgc tggaggaggc
     6421 ctttggagcc agctcaggtc agtgtctgct gcttccttac ccaggatggc ccactcttgg
     6481 ggacagacag gcatcctgag aggagggggc ctggacctag gtgtcttgcc acccaataca
     6541 gagccctgcc ctctccctct ccttcagaag gaagtatggg agcagttcca tcctcaaggt
     6601 ttcttggttc ccaggacaga aatttgagtg agaagcatgt gaagagaggg atggcccagg
     6661 ggcccttggc catggtggcc ttggacaagt ttggctttcc ccatctgtaa aatgtagata
     6721 aggatggacc cacctcccca agatcctgcc tatctgtgag agtccatgac taagtgggcc
     6781 atgggctgga ctgagttcag tgctccccca acctgccctc ctcctctccc ccacagagct
     6841 tcccaattta catgtaaacc ttgggcatca aagtgacagc tgatagccca ggtttgccca
     6901 caaatgtgct ctgactggcg tgcatgttat taaatttgat aagatgcatg atggca
//
