LOCUS       NM_014614               7250 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens proteasome activator subunit 4 (PSME4), mRNA.
ACCESSION   NM_014614 XM_040158
VERSION     NM_014614.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7250)
  AUTHORS   Javitt,A., Shmueli,M.D., Kramer,M.P., Kolodziejczyk,A.A.,
            Cohen,I.J., Radomir,L., Sheban,D., Kamer,I., Litchfield,K.,
            Bab-Dinitz,E., Zadok,O., Neiens,V., Ulman,A., Wolf-Levy,H.,
            Eisenberg-Lerner,A., Kacen,A., Alon,M., Rego,A.T.,
            Stacher-Priehse,E., Lindner,M., Koch,I., Bar,J., Swanton,C.,
            Samuels,Y., Levin,Y., da Fonseca,P.C.A., Elinav,E., Friedman,N.,
            Meiners,S. and Merbl,Y.
  TITLE     The proteasome regulator PSME4 modulates proteasome activity and
            antigen diversity to abrogate antitumor immunity in NSCLC
  JOURNAL   Nat Cancer 4 (5), 629-647 (2023)
   PUBMED   37217651
  REMARK    GeneRIF: The proteasome regulator PSME4 modulates proteasome
            activity and antigen diversity to abrogate antitumor immunity in
            NSCLC.
REFERENCE   2  (bases 1 to 7250)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 7250)
  AUTHORS   Douida,A., Batista,F., Boto,P., Regdon,Z., Robaszkiewicz,A. and
            Tar,K.
  TITLE     Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing
            Glycolysis via Distinct Opa1 Processing
  JOURNAL   Int J Mol Sci 22 (4), 1629 (2021)
   PUBMED   33562813
  REMARK    GeneRIF: Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by
            Enhancing Glycolysis via Distinct Opa1 Processing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7250)
  AUTHORS   Aladdin,A., Yao,Y., Yang,C., Kahlert,G., Ghani,M., Kiraly,N.,
            Boratko,A., Uray,K., Dittmar,G. and Tar,K.
  TITLE     The Proteasome Activators Blm10/PA200 Enhance the Proteasomal
            Degradation of N-Terminal Huntingtin
  JOURNAL   Biomolecules 10 (11), 1581 (2020)
   PUBMED   33233776
  REMARK    GeneRIF: The Proteasome Activators Blm10/PA200 Enhance the
            Proteasomal Degradation of N-Terminal Huntingtin.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7250)
  AUTHORS   Douida,A., Batista,F., Robaszkiewicz,A., Boto,P., Aladdin,A.,
            Szenykiv,M., Czinege,R., Virag,L. and Tar,K.
  TITLE     The proteasome activator PA200 regulates expression of genes
            involved in cell survival upon selective mitochondrial inhibition
            in neuroblastoma cells
  JOURNAL   J Cell Mol Med 24 (12), 6716-6730 (2020)
   PUBMED   32368861
  REMARK    GeneRIF: The proteasome activator PA200 regulates expression of
            genes involved in cell survival upon selective mitochondrial
            inhibition in neuroblastoma cells.
REFERENCE   6  (bases 1 to 7250)
  AUTHORS   Blickwedehl,J., Agarwal,M., Seong,C., Pandita,R.K., Melendy,T.,
            Sung,P., Pandita,T.K. and Bangia,N.
  TITLE     Role for proteasome activator PA200 and postglutamyl proteasome
            activity in genomic stability
  JOURNAL   Proc Natl Acad Sci U S A 105 (42), 16165-16170 (2008)
   PUBMED   18845680
REFERENCE   7  (bases 1 to 7250)
  AUTHORS   Blickwedehl,J., McEvoy,S., Wong,I., Kousis,P., Clements,J.,
            Elliott,R., Cresswell,P., Liang,P. and Bangia,N.
  TITLE     Proteasomes and proteasome activator 200 kDa (PA200) accumulate on
            chromatin in response to ionizing radiation
  JOURNAL   Radiat Res 167 (6), 663-674 (2007)
   PUBMED   17523843
REFERENCE   8  (bases 1 to 7250)
  AUTHORS   Margottin-Goguet,F., Hsu,J.Y., Loktev,A., Hsieh,H.M., Reimann,J.D.
            and Jackson,P.K.
  TITLE     Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin
            ligase activates the anaphase promoting complex to allow
            progression beyond prometaphase
  JOURNAL   Dev Cell 4 (6), 813-826 (2003)
   PUBMED   12791267
REFERENCE   9  (bases 1 to 7250)
  AUTHORS   Ustrell,V., Hoffman,L., Pratt,G. and Rechsteiner,M.
  TITLE     PA200, a nuclear proteasome activator involved in DNA repair
  JOURNAL   EMBO J 21 (13), 3516-3525 (2002)
   PUBMED   12093752
  REMARK    GeneRIF: identified a novel 200 kDa nuclear protein that activates
            the proteasome; findings implicate PA200 in DNA repair, possibly by
            recruiting proteasomes to double strand breaks
REFERENCE   10 (bases 1 to 7250)
  AUTHORS   Geley,S., Kramer,E., Gieffers,C., Gannon,J., Peters,J.M. and
            Hunt,T.
  TITLE     Anaphase-promoting complex/cyclosome-dependent proteolysis of human
            cyclin A starts at the beginning of mitosis and is not subject to
            the spindle assembly checkpoint
  JOURNAL   J Cell Biol 153 (1), 137-148 (2001)
   PUBMED   11285280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008068.4, AY894754.1, BC113668.1, AA884260.1 and AL045471.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014614.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38521.1, SRR1803616.98764.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404125.6/ ENSP00000384211.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC008068.4         144737-144889       c
            154-1867            AY894754.1         1-1714
            1868-5821           BC113668.1         1351-5304
            5822-6885           AY894754.1         5518-6581
            6886-7248           AA884260.1         1-363               c
            7249-7250           AL045471.1         247-248
FEATURES             Location/Qualifiers
     source          1..7250
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.2"
     gene            1..7250
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /note="proteasome activator subunit 4"
                     /db_xref="GeneID:23198"
                     /db_xref="HGNC:HGNC:20635"
                     /db_xref="MIM:607705"
     exon            1..451
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            452..592
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            593..709
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            710..754
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            755..904
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            905..968
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1043
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1166
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1259
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1525
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1712
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1802
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1867
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2018
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2117
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2187
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2255
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2471
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2629
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2725
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2781
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2838
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..2894
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..2993
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3056
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3152
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3284
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3494
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            3495..3631
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3685
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..3815
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            3816..3897
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            3898..4051
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            4052..4121
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            4122..4247
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            4248..4400
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4505
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            4506..4597
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            4598..4729
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            4730..4938
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            4939..5024
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            5025..5153
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            5154..5309
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            5310..5472
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            5473..5606
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            5607..5745
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     exon            5746..7250
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6447..6452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /note="hexamer: AATAAA"
     polyA_site      6454
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /note="major polyA site"
     regulatory      7231..7236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
                     /note="hexamer: AATAAA"
     polyA_site      7250
                     /gene="PSME4"
                     /gene_synonym="Blm10; hBlm10; PA200"
ORIGIN      
        1 agagcggccg ctgccgccgc caacgaactg agagccgcgt ggggcccagc agcacgccgg
       61 ccagggaagg gggcctagcg atcggtccga gggcgacggg ccgccagcgg ccgcagggcg
      121 acgaagacgc ggaggaggcg gagcccggag aggggtgggg gccggggagg gttcgggtgg
      181 gagggggtgg ggggggtgtc cctgggctca tggagccggc cgagcgggcg ggagtcggag
      241 agcccccgga gccgggcggg cgtcccgagc cgggcccgcg gggcttcgtc ccgcagaagg
      301 agatcgtcta caacaagctg ctgccctacg cggagcggct agacgccgag tccgacttgc
      361 agctggccca gatcaaatgc aacctgggcc gggccgtgca gctccaagag ctgtggcccg
      421 ggggcctctt ctggaccagg aaactctcca catatattcg actttatggg agaaaattta
      481 gcaaagaaga tcatgttctt tttattaagt tattgtatga gctggtatca attccaaaac
      541 tggaaatcag catgatgcag ggatttgccc gccttttgat caacttgtta aagaaaaagg
      601 aacttctttc aagagctgat ttggagttac cctggagacc actttatgac atggtagaaa
      661 gaatattata ttccaagaca gagcacctag gattaaattg gtttcctaat tctgtagaaa
      721 atattctcaa aacactcgtg aaaagctgcc gaccatattt tccagcagat gccaccgctg
      781 agatgctaga agaatggcga cctttaatgt gcccttttga tgtaaccatg caaaaggcca
      841 tcacttattt tgaaatattt cttcctacct cccttcctcc agaacttcat cataaaggtt
      901 ttaaactttg gtttgatgaa ttaattggcc tttgggtttc agtgcaaaat ctcccacaat
      961 gggaggggca actagtaaat ctctttgctc gattggctac agataatata gggtacatag
     1021 attgggatcc atatgtacca aagatattta caagaattct gagaagcttg aacctcccag
     1081 tgggaagcag tcaagtgtta gtcccaagat ttttaacaaa tgcttatgat ataggacatg
     1141 ctgtaatatg gatcaccgcc atgatgggtg gaccaagtaa gctagtgcaa aaacacttag
     1201 ctggtttgtt taacagcatc acatcttttt accatccttc aaataatggg cgctggctga
     1261 acaagttaat gaaactactt cagcggttgc caaacagtgt tgttagaaga ttgcatcgtg
     1321 aaagatacaa gaagccctct tggttaactc ctgtgcctga tagccacaag cttactgatc
     1381 aagatgttac agactttgta caatgcatta ttcagcctgt cctcttggct atgtttagca
     1441 aaaccggtag tctagaagca gcccaggctt tgcagaatct tgcactcatg agacctgaat
     1501 tggtaatacc ccctgtactt gaaagaacat atcctgcatt agagacatta acagaacctc
     1561 accagctcac agctacttta agttgtgtaa ttggagtagc ccgcagtttg gtatcaggag
     1621 gcagatggtt tcctgaaggt cctacacata tgctacctct gttgatgaga gcattgcctg
     1681 gggtggatcc aaatgacttt agtaaatgca tgatcacatt ccagttcata gcaacatttt
     1741 ctactctggt gcctttagta gattgttcat ctgtactaca agaaagaaat gacctcacag
     1801 aagtggaacg agaactttgt tcagccacag ctgaatttga ggatttcgtc ttacagttta
     1861 tggacagatg ttttggactt atagaaagta gcacattgga gcaaacaaga gaagagacag
     1921 aaactgagaa aatgacacac ttggagagtt tggtcgaatt aggtctgtct tctacgttta
     1981 gtacaatcct cacccaatgt tccaaagaaa tatttatggt ggcccttcag aaggttttta
     2041 atttttctac ttcacatata tttgaaacaa gagtagcagg tcgcatggtg gcagacatgt
     2101 gccgcgctgc tgtaaagtgc tgcccagaag aatctttgaa gctctttgtt ccccactgct
     2161 gcagtgttat aactcagctt acaatgaatg atgatgtatt aaatgatgaa gagctagaca
     2221 aggaattact atggaatctt caacttttgt ctgagattac tcgagtggat ggaaggaagt
     2281 tgcttcttta tagggagcag cttgtaaaga ttctccaaag aaccctacat ttaacctgta
     2341 agcagggtta cactctgtct tgtaaccttt tgcatcatct tctccgttct accacactta
     2401 tctaccctac agaatactgc agtgtgccag gtggctttga caagcctcct tctgaatact
     2461 ttcctatcaa ggactggggc aaacccgggg acttgtggaa tctgggaatc cagtggcatg
     2521 ttccttcttc agaagaagtg tcttttgcct tttatctttt ggactccttt cttcagcctg
     2581 agctcgtcaa actccagcat tgtggggatg gaaaacttga aatgtctaga gatgatattc
     2641 tacagagtct gactatagtg cacaactgtt taattggctc tggaaacctc ctacctccgt
     2701 tgaaaggaga gccagttact aacttagtac caagtatggt gtccttggaa gagacaaagt
     2761 tgtatactgg acttgaatat gatctgtctc gagagaacca ccgagaagta attgctacag
     2821 ttataaggaa acttcttaac cacatacttg ataattcaga agatgatact aagtcattgt
     2881 ttcttattat aaagattatt ggagaccttt tacaattcca aggatctcac aagcatgaat
     2941 ttgactcccg atggaaaagc ttcaacttag taaagaaatc aatggaaaat cggctccatg
     3001 ggaaaaaaca acatatcaga gcactgttga ttgatagagt aatgttacag catgagctac
     3061 ggacactaac tgttgagggt tgtgaataca aaaagataca tcaagatatg atcagagatc
     3121 ttcttcgttt atctacaagt tcatacagtc aggtgagaaa taaggctcag caaacatttt
     3181 ttgctgcctt gggagcatat aacttctgtt gcagagatat cattcccttg gttttggagt
     3241 tcttaaggcc tgatagacaa ggtgttacac agcaacaatt caagggtgcc ttgtactgtc
     3301 tccttggaaa tcacagtggt gtgtgcttgg caaaccttca tgattgggac tgtattgtac
     3361 agacgtggcc agcgattgtt tcttcagggc ttagccaagc aatgtccctg gaaaagccat
     3421 caatagtgag attgtttgat gatcttgcag aaaagattca taggcagtat gaaacaattg
     3481 gcttggactt cacaattcca aagtcatgtg ttgaaatagc ggaattactt caacagtcaa
     3541 aaaacccctc tatcaaccag atattgctta gcccagaaaa aattaaggaa ggaattaaac
     3601 gccaacagga aaagaatgcc gatgccctaa ggaactatga aaatttggta gacaccttgc
     3661 tagatggtgt ggagcaaaga aacctgccct ggaaatttga acatataggc attgggcttc
     3721 tgtctctact gctgagagat gaccgagtgt tgcctcttcg tgccatacgg ttttttgttg
     3781 agaatctcaa ccatgatgca attgtagttc gaaagatggc tatctcagct gttgctggta
     3841 tccttaaaca gctaaaaaga acccacaaaa agctgaccat taacccctgt gaaatcagtg
     3901 gatgccctaa acccacccaa attattgctg gtgataggcc tgataatcat tggttgcatt
     3961 atgacagcaa aactatacca agaactaaaa aagaatggga gtcaagttgc tttgtggaaa
     4021 aaactcactg gggatactac acctggccaa agaatatggt tgtttatgct ggtgtggaag
     4081 agcagcctaa gcttggcaga agcagggagg atatgacaga ggcagaacag attatatttg
     4141 atcatttttc tgatcctaaa tttgttgagc agttaattac ttttctatca ttagaagaca
     4201 gaaaaggaaa agataagttt aatccacgac gtttttgcct ctttaagggt atattcagga
     4261 attttgatga tgccttcctg ccagttctga agccccattt agaacatttg gttgcagatt
     4321 cacatgaaag cacccagcga tgtgttgcag aaattatagc tggtttaatc agaggttcta
     4381 agcactggac atttgaaaag gtggagaagc tttgggagct tctgtgccct ctgcttagaa
     4441 cagcactgtc caatattacc gtagaaactt ataatgactg gggagcttgt atagcaacat
     4501 cctgtgaaag cagagatccc cggaaacttc actggctttt tgaactgctg ttggaatcac
     4561 cattgagtgg tgaaggagga tcctttgtag atgcatgtcg actttatgta ctacaaggtg
     4621 gccttgccca gcaagaatgg agagtgcctg aactattgca cagactactg aagtacttgg
     4681 aacccaaact cacccaggtt tacaaaaatg tcagagaaag aataggaagt gtgctgacct
     4741 acatattcat gatagatgta tctttgccaa ataccacacc aaccatatcg cctcatgtcc
     4801 ctgagtttac tgctcgaatt ctggagaaat tgaaacctct catggatgtg gatgaagaaa
     4861 ttcagaacca tgttatggaa gaaaatggaa ttggtgaaga agatgagcga actcagggca
     4921 ttaaactctt gaaaaccata ttgaaatggc tgatggcaag tgcaggaaga tccttttcta
     4981 cagcagttac agaacaactt cagcttctac ctttgttttt caagattgcc ccagtggaaa
     5041 atgacaatag ctacgatgaa ctgaaaagag atgcaaagtt atgtttatca ttaatgtctc
     5101 aggggttgct ttaccctcat caagtgcctt tggtacttca ggtgctaaaa caaacagcaa
     5161 gaagcagttc ttggcatgca cgatacacag tactgaccta cctccagacc atggtatttt
     5221 ataacctctt tattttccta aacaatgaag atgcagttaa agatatcagg tggctggtta
     5281 taagtctttt ggaggacgaa caactggagg ttcgagaaat ggctgctact accttaagcg
     5341 gtctgctaca gtgtaacttt cttaccatgg acagtcctat gcagattcat tttgagcaac
     5401 tttgcaaaac aaaactacct aagaaaagaa agcgagaccc tggttctgta ggagatacca
     5461 ttccttctgc agagttggtc aaacgccatg ctggggtgct aggacttggt gcatgtgttc
     5521 tttctagtcc ttacgatgtt cccacctgga tgccccagct cctcatgaat ctcagtgcac
     5581 atctaaatga tcctcagcct attgagatga ctgtaaaaaa aaccttatcc aatttccgaa
     5641 ggactcacca tgacaactgg caggaacata aacagcaatt cactgatgac caactgcttg
     5701 ttctcaccga tcttcttgtg tcaccatgct attatgcata gaaagatgac tagtcctcac
     5761 ttcaggctct tttcatcaaa aattccacac cctcaggtac catctgtggt ggctctctgc
     5821 aagttttaaa actgcctctg ctgagctctc atcattttgg tggtttctgt gttagatctc
     5881 gttagtctgc attccacagc ttctcagttg ccatttgatt tcccaacttg tccggaagtg
     5941 tttccagaat actgatcact tttttttttt gaggcatctg acaaagtcac aaagtctcag
     6001 actagaaata attacccagt atgatcatgg catccaagac cagagtctca gaactcatta
     6061 agaaacagtt tacttggaat ggagaatacc catctgtaat acaggtcctg tcatttcatt
     6121 catctcaaat tattttgaat tcttcccaaa tggctgctgg atttaggtgg taataggggc
     6181 tgtgggccat aaatctgaag ccttgagaac cttgggtctg gagagccatg aagagggaag
     6241 gaaaagaggg caagtcctga acctaaccaa tgacctgatg gattgctcga ccaagacaca
     6301 gaagtgaagt ctgtgtctgt gcacttccca cagactggag tttttggtgc tgaatagagc
     6361 cagttgctaa aaaattgggg gtttggtgaa gaaatctgat tgttgtgtgt attcaatgtg
     6421 tgattttaaa aataaacagc aacaacaata aaaaccctga ctggctgttt tttccctgta
     6481 ttctttacaa ctattttttg accctctgaa aattattata cttcacctaa atggaagact
     6541 gctgtgtttg tggaaatttt gtaatttttt aatttatttt attctctctc cctttttatt
     6601 ttgcctgcag aatcgttgag agactaataa ggcttaatat ttaattgatt tgtttaatat
     6661 gttatataaa tgtaaaagag tgtataaact gtagagatag cattggcaag acattgtaca
     6721 gatgcaacct tttacacaac atcattgtgt aatttgtaaa gattcacgtg tagttcttta
     6781 ttatagtgat tttgggcttt gtacccactg aatgccattt tttgtgtttt taaattattt
     6841 tctttatctt gttacaaaaa ctgagatgtg gggttttttt tttttcagtt cacttatcat
     6901 tagaatgtct gaacttttat gtaacatttt tgtgtgcatc tctcaatgct aacaccacat
     6961 gtttgcctat gacaagttta tagagtgaaa ggtatcttct gggttgaaat aattcacaaa
     7021 ttggtgaatg tcatcttgca acacaccctg tacagtcttc cttaaaggaa cactacagta
     7081 tatttttagt atctacatgc tgaatgactg aatacagacc taagcacagc agtggtcctg
     7141 gtacagtatt taagtgtcgg catacacagg cgtaatccct gtataaagta gtgccaaact
     7201 gatttcagtt gtgtaactag tttaaaaccc aataaatgga ttctttttaa
//
