LOCUS       NM_024946               2823 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens proteasome activator subunit 3 interacting protein 1
            (PSME3IP1), transcript variant 20, mRNA.
ACCESSION   NM_024946 NM_001354093
VERSION     NM_024946.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2823)
  AUTHORS   Wu,X., Fang,Y., Gu,Y., Shen,H., Xu,Y., Xu,T., Shi,R., Xu,D.,
            Zhang,J., Leng,K., Shu,Y. and Ma,P.
  TITLE     Fat mass and obesity-associated protein (FTO) mediated m6A
            modification of circFAM192A promoted gastric cancer proliferation
            by suppressing SLC7A5 decay
  JOURNAL   Mol Biomed 5 (1), 11 (2024)
   PUBMED   38556586
  REMARK    GeneRIF: Fat mass and obesity-associated protein (FTO) mediated
            m[6]A modification of circFAM192A promoted gastric cancer
            proliferation by suppressing SLC7A5 decay.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2823)
  AUTHORS   Lipinski,K.A., Senn,K.A., Zeps,N.J. and Hoskins,A.A.
  TITLE     Biochemical and genetic evidence supports Fyv6 as a second-step
            splicing factor in Saccharomyces cerevisiae
  JOURNAL   RNA 29 (11), 1792-1802 (2023)
   PUBMED   37625852
REFERENCE   3  (bases 1 to 2823)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2823)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2823)
  AUTHORS   Gao,X., Wang,Q., Wang,Y., Liu,J., Liu,S., Liu,J., Zhou,X., Zhou,L.,
            Chen,H., Pan,L., Chen,J., Wang,D., Zhang,Q., Shen,S., Xiao,Y.,
            Wu,Z., Cheng,Y., Chen,G., Kubra,S., Qin,J., Huang,L., Zhang,P.,
            Wang,C., Moses,R.E., Lonard,D.M., Malley,B.W.O., Fares,F.,
            Zhang,B., Li,X., Li,L. and Xiao,J.
  TITLE     The REGgamma inhibitor NIP30 increases sensitivity to chemotherapy
            in p53-deficient tumor cells
  JOURNAL   Nat Commun 11 (1), 3904 (2020)
   PUBMED   32764536
  REMARK    GeneRIF: The REGgamma inhibitor NIP30 increases sensitivity to
            chemotherapy in p53-deficient tumor cells.
            Erratum:[Nat Commun. 2020 Sep 23;11(1):4888. doi:
            10.1038/s41467-020-18767-0.. PMID: 32968062]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2823)
  AUTHORS   Jonik-Nowak,B., Menneteau,T., Fesquet,D., Baldin,V.,
            Bonne-Andrea,C., Mechali,F., Fabre,B., Boisguerin,P., de Rossi,S.,
            Henriquet,C., Pugniere,M., Ducoux-Petit,M., Burlet-Schiltz,O.,
            Lamond,A.I., Fort,P., Boulon,S., Bousquet,M.P. and Coux,O.
  TITLE     PIP30/FAM192A is a novel regulator of the nuclear proteasome
            activator PA28gamma
  JOURNAL   Proc Natl Acad Sci U S A 115 (28), E6477-E6486 (2018)
   PUBMED   29934401
  REMARK    GeneRIF: data show that PIP30 deeply affects PA28gamma interactions
            with cellular proteins, including the 20S proteasome, demonstrating
            that it is an important regulator of PA28gamma in cells and thus a
            new player in the control of the multiple functions of the
            proteasome within the nucleus.
REFERENCE   7  (bases 1 to 2823)
  AUTHORS   Waddell,D.S., Duffin,P.J., Haddock,A.N., Triplett,V.E.,
            Saredy,J.J., Kakareka,K.M. and Eldredge,J.T.
  TITLE     Isolation, expression analysis and characterization of
            NEFA-interacting nuclear protein 30 and RING finger and SPRY domain
            containing 1 in skeletal muscle
  JOURNAL   Gene 576 (1 Pt 2), 319-332 (2016)
   PUBMED   26497270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB101263.1, BC020536.1, AC009090.12 and CA308353.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024946.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.203948.1,
                                           SRR1803615.69265.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309137.13/ ENSP00000335808.6
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-426               DB101263.1         1-426
            427-1158            BC020536.1         420-1151
            1159-2151           AC009090.12        109448-110440
            2152-2823           CA308353.1         18-689              c
FEATURES             Location/Qualifiers
     source          1..2823
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..2823
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /note="proteasome activator subunit 3 interacting protein
                     1"
                     /db_xref="GeneID:80011"
                     /db_xref="HGNC:HGNC:29856"
                     /db_xref="MIM:617766"
     exon            1..219
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /inference="alignment:Splign:2.1.0"
     exon            220..361
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..999
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /note="isoform a is encoded by transcript variant 20;
                     NEFA-interacting nuclear protein NIP30; PA28G-interacting
                     protein; protein FAM192A; PA28G interacting protein 30kDa;
                     PSME3 interacting protein 30kDa; PSME3-interacting
                     protein; family with sequence similarity 192 member A"
                     /codon_start=1
                     /product="PSME3-interacting protein isoform a"
                     /protein_id="NP_079222.1"
                     /db_xref="CCDS:CCDS42168.1"
                     /db_xref="GeneID:80011"
                     /db_xref="HGNC:HGNC:29856"
                     /db_xref="MIM:617766"
                     /translation="MDGGDDGNLIIKKRFVSEAELDERRKRRQEEWEKVRKPEDPEEC
                     PEEVYDPRSLYERLQEQKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELIEK
                     QRREEELKELKEYRNNLKKVGISQENKKEVEKKLTVKPIETKNKFSQAKLLAGAVKHK
                     SSESGNSVKRLKPDPEPDDKNQEPSSCKSLGNTSLSGPSIHCPSAAVCIGILPGLGAY
                     SGSSDSESSSDSEGTINATGKIVSSIFRTNTFLEAP"
     exon            362..460
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /inference="alignment:Splign:2.1.0"
     exon            461..582
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /inference="alignment:Splign:2.1.0"
     exon            583..716
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /inference="alignment:Splign:2.1.0"
     exon            717..781
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /inference="alignment:Splign:2.1.0"
     exon            782..2823
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1534..1539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /note="hexamer: AGTAAA"
     polyA_site      1553
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /note="major polyA site"
     regulatory      1729..1734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /note="hexamer: AATAAA"
     polyA_site      1756
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
     regulatory      2801..2806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /note="hexamer: AATAAA"
     polyA_site      2823
                     /gene="PSME3IP1"
                     /gene_synonym="C16orf94; CDA018; CDA10; FAM192A; NIP30;
                     PIP30"
                     /note="major polyA site"
ORIGIN      
        1 attgtggcgg tgaggaacag gaagccctga agggtcaaaa gaaatacaaa agcaaaggct
       61 attttctttt tttttttctt tctttcattc attccttcct ctgtttcttt ctttcttcct
      121 ttcatttttt tttctttttt aagagcgagc ggctctgcgg tggcggtttg gggtgggcgc
      181 cgccgaggtg aggtcgtctc gcctcccgcg cgccggtaga ttggttgttt cattatggat
      241 ggaggggatg atggtaacct tattatcaaa aagaggtttg tgtctgaggc agaactagat
      301 gaacggcgca aaaggaggca agaagaatgg gagaaagttc gaaaacctga agatccagaa
      361 gaatgtccag aggaggttta tgaccctcga tctctatatg aaaggctaca ggaacagaag
      421 gacaggaagc agcaggagta cgaggaacag ttcaaattca aaaacatggt aagaggctta
      481 gatgaagatg agaccaactt ccttgatgag gtttctcgac agcaggaact aatagaaaag
      541 caacgaagag aagaagaact gaaagaactg aaggaataca gaaataacct caagaaggtt
      601 ggaatttctc aagagaacaa gaaggaagtg gaaaagaaac tgactgtgaa gcctatagaa
      661 accaagaaca agttctccca ggcgaagctg ttggcaggag ctgtgaagca taagagctca
      721 gagagtggca acagtgtgaa aagactgaaa ccggaccctg agccagatga caagaatcaa
      781 gagccctcat cctgcaagtc tctcggaaac acctccctga gtggcccctc catccactgc
      841 ccctctgctg cagtatgtat cggcatcctc ccaggcctgg gtgcctactc tgggagcagc
      901 gactccgagt ccagctcaga cagcgaaggc accatcaatg ccaccggaaa gattgtctcc
      961 tccatcttcc gaaccaacac cttcctcgag gccccctagt ttctccgtcc ctacacaggg
     1021 agctcctccc caagggtaga tcggaccgtt catgctgcct ataggcatta tgtccctcaa
     1081 aaaaaaactc ctttgcctgc atcctgtgta caacatgaca tttttaacca atccaatcta
     1141 aaaatgtgcc agaatccacc tgtggcccga atcgtgtttg gttcctcttt ctactccact
     1201 gcagatgacc aaacctgtcc cgctgccact ttcctcactg atattgggag gagggcaagg
     1261 cccagccgaa gttccactaa aaatgcccca ggagaatagg caccggctgg cttgccaaag
     1321 ggtttgggtt ttattgcttt ctgttttttc ttttcccgac agcacaaaga agtaagggca
     1381 gttattggac aggtgttatt taaacattct attgtaaatg aatgtgttgt ttggttctac
     1441 tgcattgtgg agcatgcggg ggaagagaac tgacccaggt agtgaaatgg agcccttccc
     1501 tggaactaac cagtccttga tgttgtgtga ctaagtaaag atgataaacc ccatctgctg
     1561 ggggtgtcac ttcacactcg gcatgcattg tgaaagcttt ccataccctt ggccattccc
     1621 tctctcctct ctctccaacc ccatttatgc aggaagggac tgctaacaag aacgcttcca
     1681 tctcaaacct tttctctgcc tgggaaatta ttttatgttt gtttttgaaa taaaggattt
     1741 agtttaagat tctaaatttt agagaaacaa acgtaggcct tgtttactaa tagccagaca
     1801 tcagaactgc aggtaggtat gttaatgaga tgacttattt ctggcagctc ctggaatcct
     1861 aatattgtaa atgagtggga cacacttgca tattgtgacc attctattga ggcccttctc
     1921 tgtttaatgc atattatact tgtgctttta actgtggaat ctatttctaa cctaaaggtg
     1981 ctgccctagt acttttcttt gctgcctctg ctgctctttt tcctttccaa acagcaactc
     2041 tgaggccatg agcagccaaa aactagaggt actgctccac ctcgtctcat aaagggaaac
     2101 gggctcatcc cttggattct ggaggaggga gagggagatg gtgtggaggc ctcgaggaca
     2161 gagatagaca tgagctttga caacaatctg taggctctcc tgctttagaa taagcatgta
     2221 ccattcttta tccattcccc ttattcctac atcaattgtt tttactttct tgggtgtgag
     2281 actgagtgag acacacacaa aatgtgttga cactgtgatg ccggcaggca gagcagctac
     2341 tgactttgaa catgggcaga gaggcccctg gatctcatcc agcccactcc ttttcccctt
     2401 ccagtacagt gacactctgg tgcccattgg cagatggcga cttccctgca cccataactg
     2461 atgctttgtg aattcttcct ccttttcaga actactctgt gctaattgtt ctgccagtat
     2521 gggcgcatca gctccatcct gacaaacaag acatttaggt aaaactttgt aggcaccttc
     2581 tgcttctctg cttcattgtt cctgtgatag tcctgttgtt attacagcat gtacccaaaa
     2641 cagcctcaca ttgttacagg aggcaggcca ggacatcaaa gtcatcatct ttatgtggca
     2701 tgactcttaa gaggccatta ctgtatctca tggcctcttg atgtggaaag aagttgacag
     2761 agggttgcag ggtttaaaaa catccattaa catgaaagct aataaacctg tcagagaaca
     2821 aga
//
