LOCUS       NM_005789               3182 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens proteasome activator subunit 3 (PSME3), transcript
            variant 1, mRNA.
ACCESSION   NM_005789
VERSION     NM_005789.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3182)
  AUTHORS   Yoshioka,Y., Huang,Y., Jin,X., Ngo,K.X., Kumaki,T., Jin,M.,
            Toyoda,S., Takayama,S., Inotsume,M., Fujita,K., Homma,H., Ando,T.,
            Tanaka,H. and Okazawa,H.
  TITLE     PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal
            Lamin B1 degradation
  JOURNAL   EMBO J 43 (18), 3968-3999 (2024)
   PUBMED   39103492
  REMARK    GeneRIF: PQBP3 prevents senescence by suppressing PSME3-mediated
            proteasomal Lamin B1 degradation.
REFERENCE   2  (bases 1 to 3182)
  AUTHORS   Zhu,X., Li,Y., Tian,X., Jing,Y., Wang,Z., Yue,L., Li,J., Wu,L.,
            Zhou,X., Yu,Z., Zhang,Y., Guan,F., Yang,M. and Zhang,B.
  TITLE     REGgamma Mitigates Radiation-Induced Enteritis by Preserving Mucin
            Secretion and Sustaining Microbiome Homeostasis
  JOURNAL   Am J Pathol 194 (6), 975-988 (2024)
   PUBMED   38423356
  REMARK    GeneRIF: REGgamma Mitigates Radiation-Induced Enteritis by
            Preserving Mucin Secretion and Sustaining Microbiome Homeostasis.
REFERENCE   3  (bases 1 to 3182)
  AUTHORS   Dong,C., Guo,Y., Yang,Y. and Ge,X.
  TITLE     Comprehensive analysis of PSME3: from pan-cancer analysis to
            experimental validation
  JOURNAL   Front Immunol 15, 1295693 (2024)
   PUBMED   38312840
  REMARK    GeneRIF: Comprehensive analysis of PSME3: from pan-cancer analysis
            to experimental validation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3182)
  AUTHORS   Kohda,K., Ishibashi,T., Shimbara,N., Tanaka,K., Matsuda,Y. and
            Kasahara,M.
  TITLE     Characterization of the mouse PA28 activator complex gene family:
            complete organizations of the three member genes and a physical map
            of the approximately 150-kb region containing the alpha- and
            beta-subunit genes
  JOURNAL   J Immunol 160 (10), 4923-4935 (1998)
   PUBMED   9590240
REFERENCE   5  (bases 1 to 3182)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   6  (bases 1 to 3182)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   7  (bases 1 to 3182)
  AUTHORS   Jacob,A., Kandpal,G., Patanjali,S.R. and Kandpal,R.P.
  TITLE     Molecular cloning and expression pattern of genes from a 470 Kb
            region near BRCA1 locus on chromosome 17q21
  JOURNAL   Oncogene 11 (5), 981-986 (1995)
   PUBMED   7675458
REFERENCE   8  (bases 1 to 3182)
  AUTHORS   Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K.,
            Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W. et al.
  TITLE     A strong candidate for the breast and ovarian cancer susceptibility
            gene BRCA1
  JOURNAL   Science 266 (5182), 66-71 (1994)
   PUBMED   7545954
REFERENCE   9  (bases 1 to 3182)
  AUTHORS   Albertsen,H.M., Smith,S.A., Mazoyer,S., Fujimoto,E., Stevens,J.,
            Williams,B., Rodriguez,P., Cropp,C.S., Slijepcevic,P., Carlson,M.
            et al.
  TITLE     A physical map and candidate genes in the BRCA1 region on
            chromosome 17q12-21
  JOURNAL   Nat Genet 7 (4), 472-479 (1994)
   PUBMED   7951316
REFERENCE   10 (bases 1 to 3182)
  AUTHORS   Nikaido,T., Shimada,K., Shibata,M., Hata,M., Sakamoto,M.,
            Takasaki,Y., Sato,C., Takahashi,T. and Nishida,Y.
  TITLE     Cloning and nucleotide sequence of cDNA for Ki antigen, a highly
            conserved nuclear protein detected with sera from patients with
            systemic lupus erythematosus
  JOURNAL   Clin Exp Immunol 79 (2), 209-214 (1990)
   PUBMED   1968796
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI464061.1, BC001423.2,
            AC016889.28 and AI304773.1.
            
            On May 17, 2019 this sequence version replaced NM_005789.3.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. The immunoproteasome
            contains an alternate regulator, referred to as the 11S regulator
            or PA28, that replaces the 19S regulator. Three subunits (alpha,
            beta and gamma) of the 11S regulator have been identified. This
            gene encodes the gamma subunit of the 11S regulator. Six gamma
            subunits combine to form a homohexameric ring. Alternate splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2012].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.72502.1,
                                           SRR1803617.89827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590720.6/ ENSP00000466794.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BI464061.1         259-276
            19-2670             BC001423.2         1-2652
            2671-3174           AC016889.28        108861-109364
            3175-3182           AI304773.1         19-26               c
FEATURES             Location/Qualifiers
     source          1..3182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..3182
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /note="proteasome activator subunit 3"
                     /db_xref="GeneID:10197"
                     /db_xref="HGNC:HGNC:9570"
                     /db_xref="MIM:605129"
     exon            1..277
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1000
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /note="isoform 1 is encoded by transcript variant 1; Ki
                     nuclear autoantigen; REG gamma-3; epididymis secretory
                     protein Li 283; Ki antigen; proteasome activator 28-gamma;
                     11S regulator complex gamma subunit; activator of
                     multicatalytic protease subunit 3; proteasome activator
                     complex subunit 3; 11S regulator complex subunit gamma;
                     proteasome activator 28 subunit gamma; proteasome
                     (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)"
                     /codon_start=1
                     /product="proteasome activator complex subunit 3 isoform
                     1"
                     /protein_id="NP_005780.2"
                     /db_xref="CCDS:CCDS45689.1"
                     /db_xref="GeneID:10197"
                     /db_xref="HGNC:HGNC:9570"
                     /db_xref="MIM:605129"
                     /translation="MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSF
                     LKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVF
                     VMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEE
                     TVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLR
                     LIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY"
     exon            278..310
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            311..373
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            374..478
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            479..527
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            528..640
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            641..709
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            710..777
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            778..832
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            833..919
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            920..3182
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2637..2642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /note="hexamer: AATACA"
     polyA_site      2664
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /note="major polyA site"
     regulatory      3153..3158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
                     /note="hexamer: AATAAA"
     polyA_site      3182
                     /gene="PSME3"
                     /gene_synonym="HEL-S-283; Ki; PA28-gamma; PA28G;
                     PA28gamma; REG-GAMMA"
ORIGIN      
        1 gcagtttccg gcgtgagcgg cgaaagccgg gagggcgagc gagagagcaa gcaggcagca
       61 ggctgccggc gggcgggcgg acggcacaga gggagggagc gagcgagcag tgagtaagcc
      121 agcaagggcg gtcgggtccc gaggtcagcc gagatttctc aggtccctcc ggccccctcc
      181 ctggagtcca cagcgcctcc ggtgtccaga ggatcggaca cggcccggcc cggccatggc
      241 ctcgttgctg aaggtggatc aggaagtgaa gctcaaggtt gattctttca gggagcggat
      301 cacaagtgag gcagaagact tggtggcaaa ttttttccca aagaagttat tagaacttga
      361 tagttttctg aaggaaccaa tcttaaacat ccatgaccta actcagatcc actctgacat
      421 gaatctccca gtccctgacc ccattcttct caccaatagc catgatggac tggatggtcc
      481 cacttataag aagcgaaggt tggatgagtg tgaagaagcc ttccaaggaa ccaaggtgtt
      541 tgtgatgccc aatgggatgc tgaaaagcaa ccagcagctg gtggacatta ttgagaaagt
      601 gaaacctgag atccggctgt tgattgagaa atgtaacacg gtcaaaatgt gggtacagct
      661 cctgattccc aggatagaag atggaaacaa ctttggggtg tccattcagg aggaaacagt
      721 tgcagagcta agaactgttg agagtgaagc tgcatcttat ctggaccaga tttctagata
      781 ttatattaca agagccaaat tggtttctaa aatagctaaa tatccccatg tggaggacta
      841 tcgccgcacc gtgacagaga ttgatgagaa agaatatatc agccttcggc tcatcatatc
      901 agagctgagg aatcaatatg tcactctaca tgacatgatc ctgaaaaata tcgagaagat
      961 caaacggccc cggagcagca atgcagagac tctgtactga ggccagggcc agggccaggg
     1021 gactctgtga gtctggctca agaccgacat tgccttggtt tgttacatga ctatcgtgat
     1081 ggggaaactg gctggaaata gtaatcacac ctctctgttt ttagttagag tctaatgaaa
     1141 ctctcatcta gttctgtgat gtgtttacct cttttttcag gcctcaggaa ctcttctatt
     1201 tccttcccta ataccccaca cccaacctgt cgtaatttct ggagaactcc aggtttgtgt
     1261 gtgcaggatg ttggcacaaa aatacctgtg ttttcattct ccccctctct ccctcctgtg
     1321 tcttgcgctt tatgttttct tccgtttgat aattagttgg ttaaaagctg agggaaccgg
     1381 aaggaaagtg ctaggtgttt tttaggaact agggtggcgg ggggacgaac ttctcttcct
     1441 cacatgaggt tactgtttct ttcctctgtg gggcattgga tcctcccaca gttgccctgg
     1501 tgatgactta gggcttccca tctgtgtaca tcccactttg aatcttgatc gtgacaagaa
     1561 ataccttagg ccttcagtca attccgaagc tccttcagtt gtttttataa tgggcgtttt
     1621 cacatgcaca tatgtgtatg catgtatacg cccatacaga catgcacaca cagactccta
     1681 ctccattagc taacataccc tccctctcca caacccctgt cacatacctt tcaggaggtg
     1741 acagttgtct tagttgtcat ctacccagac aaacgtcctg ggcccgtcct ccctcctgat
     1801 actgtagcct cttggtaccc agggtgagtt ggtggagaac agagagatga gaagcagagg
     1861 gcttggggaa agcctgttcc tctctgactc agcccttttt ggcattattg caagagcttg
     1921 actcctggtt gccttttccc agccagtttt cagttggggt gaaggtttct gcaagtgtga
     1981 ggtccagatg ctgctgctca tgttgggctt tccttttggg aactatttct ctttatttat
     2041 agtgtcgggc ttccggggaa agcaatcatt ggtgtgtatg tgtatgtgca tgcacacacg
     2101 tgcatataca catttgtgta tgtggaaatg tgctgggcaa gtcaaaacta tagaagagtt
     2161 gcctcctgtc tctcgaatct tccagagata tcacttaatt gttaacagct tttgtgttaa
     2221 tccccttcag cccctagctc ttttattcta ccacggctgg agagttgata cctgcagtca
     2281 gcctgccagt gactcttagt gtctgtttct gacttatttt tcctgtctct gtcttccaac
     2341 ccccaataat atttccaccg gggatgcatc atttttactc ccaatattct gtagagaggg
     2401 agtcaggatg ctgtcttccc acgaatagta ctcagtaaca aaccaattgc attttagttg
     2461 ggcagtgctc ccacccaccc tccagatccc ttccagctaa aacccttccc ccttccctcc
     2521 atgtgtttct cagtttcccg tttcgtttgt tggactgttc cactgcccct cctcctcacc
     2581 ctatcaccca tggatcgtaa tgtaaaattc ttttaccatg tcaagaaatt attaaaaata
     2641 caggtacttt gacctctttc taaagccgca gaccctggtg caatgctctg gtggctaggg
     2701 atgtactcat gctcatatgt gtgcacgctt ggacacccac ctccatggac acctagccac
     2761 cctgttgtgt gtccttatgc cagttgagct gaatcttttc cccagtatag tggaaagact
     2821 gaggcttctg cctactgagc aaggttgggt gcttcatttg tgttcagtct gaattatggg
     2881 aaagttagct cttcccagac ctaagctgcc ttctctccct actttcagaa gatcctagtt
     2941 ccttccttcc cgagtgatac ccatgaactg ccagtagagg ctgctatcgt tccatgtgta
     3001 aggaatgaac tggttcaagg cgcgtcctac ccagtcattt tctttacctt atactaattc
     3061 ttcctgaata atgtcttcag tttcttgagg agactcctag ttttggtttt caaattactt
     3121 ggagggctgc ctaggaatct atctccctct gaaataaagt ttcctcatct tccaccttgc
     3181 aa
//
