LOCUS       NM_002818                793 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens proteasome activator subunit 2 (PSME2), mRNA.
ACCESSION   NM_002818
VERSION     NM_002818.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 793)
  AUTHORS   Li,R., Yan,L., Jiu,J., Liu,H., Li,D., Li,X., Zhang,J., Li,S.,
            Fan,Z., Lv,Z., Zhu,Y. and Wang,B.
  TITLE     PSME2 offers value as a biomarker of M1 macrophage infiltration in
            pan-cancer and inhibits osteosarcoma malignant phenotypes
  JOURNAL   Int J Biol Sci 20 (4), 1452-1470 (2024)
   PUBMED   38385075
  REMARK    GeneRIF: PSME2 offers value as a biomarker of M1 macrophage
            infiltration in pan-cancer and inhibits osteosarcoma malignant
            phenotypes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 793)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 793)
  AUTHORS   Wang,X., Wu,F., Deng,Y., Chai,J., Zhang,Y., He,G. and Li,X.
  TITLE     Increased expression of PSME2 is associated with clear cell renal
            cell carcinoma invasion by regulating BNIP3-mediated autophagy
  JOURNAL   Int J Oncol 59 (6) (2021)
   PUBMED   34779489
  REMARK    GeneRIF: Increased expression of PSME2 is associated with clear
            cell renal cell carcinoma invasion by regulating BNIP3mediated
            autophagy.
REFERENCE   4  (bases 1 to 793)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 793)
  AUTHORS   Qi,A., Ju,M., Liu,Y., Bi,J., Wei,Q., He,M., Wei,M. and Zhao,L.
  TITLE     Development of a Novel Prognostic Signature Based on Antigen
            Processing and Presentation in Patients with Breast Cancer
  JOURNAL   Pathol Oncol Res 27, 600727 (2021)
   PUBMED   34257557
  REMARK    GeneRIF: Development of a Novel Prognostic Signature Based on
            Antigen Processing and Presentation in Patients with Breast Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 793)
  AUTHORS   Ahn,K., Erlander,M., Leturcq,D., Peterson,P.A., Fruh,K. and Yang,Y.
  TITLE     In vivo characterization of the proteasome regulator PA28
  JOURNAL   J Biol Chem 271 (30), 18237-18242 (1996)
   PUBMED   8663520
REFERENCE   7  (bases 1 to 793)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   8  (bases 1 to 793)
  AUTHORS   Ahn,J.Y., Tanahashi,N., Akiyama,K., Hisamatsu,H., Noda,C.,
            Tanaka,K., Chung,C.H., Shibmara,N., Willy,P.J., Mott,J.D. et al.
  TITLE     Primary structures of two homologous subunits of PA28, a
            gamma-interferon-inducible protein activator of the 20S proteasome
  JOURNAL   FEBS Lett 366 (1), 37-42 (1995)
   PUBMED   7789512
REFERENCE   9  (bases 1 to 793)
  AUTHORS   Mott,J.D., Pramanik,B.C., Moomaw,C.R., Afendis,S.J., DeMartino,G.N.
            and Slaughter,C.A.
  TITLE     PA28, an activator of the 20 S proteasome, is composed of two
            nonidentical but homologous subunits
  JOURNAL   J Biol Chem 269 (50), 31466-31471 (1994)
   PUBMED   7989312
REFERENCE   10 (bases 1 to 793)
  AUTHORS   Dubiel,W., Pratt,G., Ferrell,K. and Rechsteiner,M.
  TITLE     Purification of an 11 S regulator of the multicatalytic protease
  JOURNAL   J Biol Chem 267 (31), 22369-22377 (1992)
   PUBMED   1429590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136295.3.
            
            On Nov 26, 2018 this sequence version replaced NM_002818.2.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway.  An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. The immunoproteasome
            contains an alternate regulator, referred to as the 11S regulator
            or PA28, that replaces the 19S regulator. Three subunits (alpha,
            beta and gamma) of the 11S regulator have been identified. This
            gene encodes the beta subunit of the 11S regulator, one of the two
            11S subunits that is induced by gamma-interferon. Three beta and
            three alpha subunits combine to form a heterohexameric ring. Six
            pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225876.1, BC004368.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216802.10/ ENSP00000216802.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AL136295.3         63422-63498
            78-110              AL136295.3         63792-63824
            111-173             AL136295.3         64260-64322
            174-260             AL136295.3         64567-64653
            261-291             AL136295.3         64759-64789
            292-389             AL136295.3         64877-64974
            390-458             AL136295.3         65564-65632
            459-526             AL136295.3         65773-65840
            527-581             AL136295.3         66003-66057
            582-668             AL136295.3         66361-66447
            669-793             AL136295.3         66543-66667
FEATURES             Location/Qualifiers
     source          1..793
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..793
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /note="proteasome activator subunit 2"
                     /db_xref="GeneID:5721"
                     /db_xref="HGNC:HGNC:9569"
                     /db_xref="MIM:602161"
     exon            1..77
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..749
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /note="11S regulator complex beta subunit; proteasome
                     activator hPA28 subunit beta; proteasome activator
                     28-beta; MCP activator, 31-kD subunit; activator of
                     multicatalytic protease subunit 2; cell migration-inducing
                     protein 22; REG-beta; 11S regulator complex subunit beta;
                     proteasome activator 28 subunit beta; proteasome (prosome,
                     macropain) activator subunit 2 (PA28 beta)"
                     /codon_start=1
                     /product="proteasome activator complex subunit 2"
                     /protein_id="NP_002809.2"
                     /db_xref="CCDS:CCDS9614.1"
                     /db_xref="GeneID:5721"
                     /db_xref="HGNC:HGNC:9569"
                     /db_xref="MIM:602161"
                     /translation="MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLN
                     QLLQEDSLNVADLTSLRAPLDIPIPDPPPKDDEMETDKQEKKEVHKCGFLPGNEKVLS
                     LLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAF
                     QTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYH
                     IISSNLEKIVNPKGEEKPSMY"
     exon            78..110
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            111..173
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            174..260
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            261..291
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            292..389
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            390..458
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            459..526
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            527..581
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            582..668
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            669..793
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      768..773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /note="hexamer: AATAAA"
     polyA_site      793
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /note="major polyA site"
ORIGIN      
        1 gagaccagag atctagcgac tgaagcagca tggccaagcc gtgtggggtg cgcctgagcg
       61 gggaagcccg caaacaggtg gaggtcttca gacagaatct tttccaggag gctgaggaat
      121 tcctctacag attcttgcca cagaaaatca tatacctgaa tcagctcttg caagaggact
      181 ccctcaatgt ggctgacttg acttccctcc gggccccact ggacatcccc atcccagacc
      241 ctccacccaa ggatgatgag atggaaacag ataagcagga gaagaaagaa gtccataagt
      301 gtggatttct ccctgggaat gagaaagtcc tgtccctgct tgccctggtt aagccagaag
      361 tctggactct caaagagaaa tgcattctgg tgattacatg gatccaacac ctgatcccca
      421 agattgaaga tggaaatgat tttggggtag caatccagga gaaggtgctg gagagggtga
      481 atgccgtcaa gaccaaagtg gaagctttcc agacaaccat ttccaagtac ttctcagaac
      541 gtggggatgc tgtggccaag gcctccaagg agactcatgt aatggattac cgggccttgg
      601 tgcatgagcg agatgaggca gcctatgggg agctcagggc catggtgctg gacctgaggg
      661 ccttctatgc tgagctttat catatcatca gcagcaacct ggagaaaatt gtcaacccaa
      721 agggtgaaga aaagccatct atgtactgaa cccgggacta gaaggaaaat aaatgatcta
      781 tatgttgtgt gga
//
