LOCUS       NM_002813               2725 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens proteasome 26S subunit, non-ATPase 9 (PSMD9),
            transcript variant 1, mRNA.
ACCESSION   NM_002813
VERSION     NM_002813.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2725)
  AUTHORS   Su,Y., Meng,L., Ge,C., Liu,Y., Zhang,C., Yang,Y., Tian,W. and
            Tian,H.
  TITLE     PSMD9 promotes the malignant progression of hepatocellular
            carcinoma by interacting with c-Cbl to activate EGFR signaling and
            recycling
  JOURNAL   J Exp Clin Cancer Res 43 (1), 142 (2024)
   PUBMED   38745188
  REMARK    GeneRIF: PSMD9 promotes the malignant progression of hepatocellular
            carcinoma by interacting with c-Cbl to activate EGFR signaling and
            recycling.
            Erratum:[J Exp Clin Cancer Res. 2024 Oct 18;43(1):287. doi:
            10.1186/s13046-024-03209-2.. PMID: 39420369]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2725)
  AUTHORS   Li,Y., Liu,X., Zhao,F., Zhao,Z., Li,X., Wang,J., Huang,B. and
            Chen,A.
  TITLE     Comprehensive analysis of PSMD family members and validation of
            PSMD9 as a potential therapeutic target in human glioblastoma
  JOURNAL   CNS Neurosci Ther 30 (2), e14366 (2024)
   PUBMED   37485655
  REMARK    GeneRIF: Comprehensive analysis of PSMD family members and
            validation of PSMD9 as a potential therapeutic target in human
            glioblastoma.
REFERENCE   3  (bases 1 to 2725)
  AUTHORS   Christie,J., Anthony,C.M., Harish,M., Mudartha,D., Ud Din
            Farooqee,S.B. and Venkatraman,P.
  TITLE     The interaction network of the proteasome assembly chaperone PSMD9
            regulates proteostasis
  JOURNAL   FEBS J 290 (23), 5581-5604 (2023)
   PUBMED   37665644
  REMARK    GeneRIF: The interaction network of the proteasome assembly
            chaperone PSMD9 regulates proteostasis.
REFERENCE   4  (bases 1 to 2725)
  AUTHORS   Del Bosque-Plata,L., Amin,M. and Gragnoli,C.
  TITLE     PSMD9 is linked to T2D age of onset, years of isolated and combined
            insulin therapy, irregular menses, and hot flashes
  JOURNAL   Eur Rev Med Pharmacol Sci 26 (23), 8873-8878 (2022)
   PUBMED   36524506
  REMARK    GeneRIF: PSMD9 is linked to T2D age of onset, years of isolated and
            combined insulin therapy, irregular menses, and hot flashes.
REFERENCE   5  (bases 1 to 2725)
  AUTHORS   Zhang,J., Buranjiang,G., Mutalifu,Z., Jin,H. and Yao,L.
  TITLE     KIF14 affects cell cycle arrest and cell viability in cervical
            cancer by regulating the p27Kip1 pathway
  JOURNAL   World J Surg Oncol 20 (1), 125 (2022)
   PUBMED   35439960
  REMARK    GeneRIF: KIF14 affects cell cycle arrest and cell viability in
            cervical cancer by regulating the p27(Kip1) pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2725)
  AUTHORS   Simon,J.H., Gaddis,N.C., Fouchier,R.A. and Malim,M.H.
  TITLE     Evidence for a newly discovered cellular anti-HIV-1 phenotype
  JOURNAL   Nat Med 4 (12), 1397-1400 (1998)
   PUBMED   9846577
REFERENCE   7  (bases 1 to 2725)
  AUTHORS   Madani,N. and Kabat,D.
  TITLE     An endogenous inhibitor of human immunodeficiency virus in human
            lymphocytes is overcome by the viral Vif protein
  JOURNAL   J Virol 72 (12), 10251-10255 (1998)
   PUBMED   9811770
REFERENCE   8  (bases 1 to 2725)
  AUTHORS   Watanabe,T.K., Saito,A., Suzuki,M., Fujiwara,T., Takahashi,E.,
            Slaughter,C.A., DeMartino,G.N., Hendil,K.B., Chung,C.H.,
            Tanahashi,N. and Tanaka,K.
  TITLE     cDNA cloning and characterization of a human proteasomal modulator
            subunit, p27 (PSMD9)
  JOURNAL   Genomics 50 (2), 241-250 (1998)
   PUBMED   9653651
REFERENCE   9  (bases 1 to 2725)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   10 (bases 1 to 2725)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC002383.2, BU726372.1,
            KF459562.1 and AC069503.25.
            
            On May 17, 2019 this sequence version replaced NM_002813.6.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            non-ATPase subunit of the 19S regulator. Three transcript variants
            encoding two different isoforms have been found for this gene.
            [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.36874.1, BC004213.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000541212.6/ ENSP00000440485.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1895              BC002383.2         20-1914
            1896-2237           BU726372.1         73-414              c
            2238-2238           KF459562.1         108-108             c
            2239-2293           BU726372.1         17-71               c
            2294-2345           KF459562.1         1-52                c
            2346-2725           AC069503.25        139438-139817       c
FEATURES             Location/Qualifiers
     source          1..2725
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..2725
                     /gene="PSMD9"
                     /gene_synonym="p27; Rpn4"
                     /note="proteasome 26S subunit, non-ATPase 9"
                     /db_xref="GeneID:5715"
                     /db_xref="HGNC:HGNC:9567"
                     /db_xref="MIM:603146"
     exon            1..205
                     /gene="PSMD9"
                     /gene_synonym="p27; Rpn4"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..739
                     /gene="PSMD9"
                     /gene_synonym="p27; Rpn4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proteasome 26S non-ATPase regulatory subunit 9; homolog of
                     rat Bridge 1; 26S proteasome regulatory subunit p27; 26S
                     proteasome non-ATPase regulatory subunit 9; proteasome
                     (prosome, macropain) 26S subunit, non-ATPase, 9"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 9
                     isoform 1"
                     /protein_id="NP_002804.2"
                     /db_xref="CCDS:CCDS9225.1"
                     /db_xref="GeneID:5715"
                     /db_xref="HGNC:HGNC:9567"
                     /db_xref="MIM:603146"
                     /translation="MSDEEARQSGGSSQAGVVTVSDVQELMRRKEEIEAQIKANYDVL
                     ESQKGIGMNEPLVDCEGYPRSDVDLYQVRTARHNIICLQNDHKAVMKQVEEALHQLHA
                     RDKEKQARDMAEAHKEAMSRKLGQSESQGPPRAFAKVNSISPGSPASIAGLQVDDEIV
                     EFGSVNTQNFQSLHNIGSVVQHSEGKPLNVTVIRRGEKHQLRLVPTRWAGKGLLGCNI
                     IPLQR"
     exon            206..308
                     /gene="PSMD9"
                     /gene_synonym="p27; Rpn4"
                     /inference="alignment:Splign:2.1.0"
     exon            309..520
                     /gene="PSMD9"
                     /gene_synonym="p27; Rpn4"
                     /inference="alignment:Splign:2.1.0"
     exon            521..622
                     /gene="PSMD9"
                     /gene_synonym="p27; Rpn4"
                     /inference="alignment:Splign:2.1.0"
     exon            623..711
                     /gene="PSMD9"
                     /gene_synonym="p27; Rpn4"
                     /inference="alignment:Splign:2.1.0"
     exon            712..2725
                     /gene="PSMD9"
                     /gene_synonym="p27; Rpn4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1045..1050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD9"
                     /gene_synonym="p27; Rpn4"
                     /note="hexamer: AATAAA"
     polyA_site      1072
                     /gene="PSMD9"
                     /gene_synonym="p27; Rpn4"
                     /note="major polyA site"
     regulatory      2270..2275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD9"
                     /gene_synonym="p27; Rpn4"
                     /note="hexamer: AATAAA"
     polyA_site      2291
                     /gene="PSMD9"
                     /gene_synonym="p27; Rpn4"
ORIGIN      
        1 acggtcgact ggggcgtcgt ccctagcccg ggagccgggt ctctggagtc gcggcccggg
       61 gttcacgatg tccgacgagg aagcgaggca gagcggaggc tcctcgcagg ccggcgtcgt
      121 gactgtcagc gacgtccagg agctgatgcg gcgcaaggag gagatagaag cgcagatcaa
      181 ggccaactat gacgtgctgg aaagccaaaa aggcattggg atgaacgagc cgctggtgga
      241 ctgtgagggc tacccccggt cagacgtgga cctgtaccaa gtccgcaccg ccaggcacaa
      301 catcatatgc ctgcagaatg atcacaaggc agtgatgaag caggtggagg aggccctgca
      361 ccagctgcac gctcgcgaca aggagaagca ggcccgggac atggctgagg cccacaaaga
      421 ggccatgagc cgcaaactgg gtcagagtga gagccagggc cctccacggg ccttcgccaa
      481 agtgaacagc atcagccccg gctccccagc cagcatcgcg ggtctgcaag tggatgatga
      541 gattgtggag ttcggctctg tgaacaccca gaacttccag tcactgcata acattggcag
      601 tgtggtgcag cacagtgagg ggaagcccct gaatgtgaca gtgatccgca ggggggaaaa
      661 acaccagctt agacttgttc caacacgctg ggcaggaaaa ggactgctgg gctgcaacat
      721 tattcctctg caaagatgat tgtccctggg gaacagtaac aggaaagcat cttcccttgc
      781 cctggacttg ggtctaggga tttccaactt gtcttctctc cctgaagcat aaggatctgg
      841 aagaggcttg taacctgaac ttctgtgtgg tggcagtact gtggcccacc agtgtaatct
      901 ccctggatta aggcattctt aaaaacttag gcttggcctc tttcacaaat taggccacgg
      961 ccctaaatag gaattccctg gattgtgggc aagtgggcgg aagttattct ggcaggtact
     1021 ggtgtgatta ttattattat ttttaataaa gagttttaca gtgctgatat gaccctgttg
     1081 tcaccccagc tgaatttctt atgaccctcc caaaccaaag ctcagatggg gtcagaagag
     1141 cttcatagaa agttgggcaa aacaggctag caattgcaaa gtcaggcttt gaccaacata
     1201 tttctttgca ctgaggcctt gctgctgtgg atacggaaat ggttaagtac tgtgcttcct
     1261 cagcagctgg gctgtcaggg ccatagtagc tccctttgga gaacagggaa agcctggagg
     1321 cttcccaggt ggcccagcgt ggtgtcctgt cagcttcctc tttaggaacc caccagaggg
     1381 cagcaagctc ctttcacttc gctagtaaga acccctccgt ttttgtgtgt ttttgttttt
     1441 gttttctgga gacaaggtct tgctttgtca cccaggctgg agtgcagtgt cgtgatcaag
     1501 gttcactgaa gccttgacgc tgtgggcact gcctcagccg cccaagtatc tgggaccaca
     1561 ggcgtgcacc accatgcata gctaatttat tttttgtaga gacagggtct ccctgtgttg
     1621 accaggttgg tctcgaactc ctgggctcaa gcagtcctcc tgccttggcc tcctaaagtg
     1681 ctgggatcac aggcgtgagc cactgcgccc agcccactgc tagtttgact ttttataatt
     1741 gaacctcctg gctatgccct gagatcagcg ctattttgta aaccgctgag gtatggatag
     1801 gaacgagtag atcagacctc ttgaaaatgc ttattcttcc tcccttttat tttttgtctc
     1861 ttttaagatg gtaaaatggt tctcagggat tcctgccaat actttgaatt attttttcct
     1921 ctccatggta tcagtgttca tttccccagt tcttgcacac cgctttctgt tttggcagtt
     1981 ctgccaggca agccctgtgt tccttgggac tggttttgct gtggttggat acagatacca
     2041 gcttgccttg atgggattgg tattgctgtg tgcttccagc cacaggttct cacactcaat
     2101 tccaaagcct tcctattggg cgaattccct caaactctat ttgacctgac agccatacgt
     2161 attcccctct ggtagccaca gacatgctgt gtttaccaat gtttgctgtt taaattgcat
     2221 gttctaattc cacgtatttt ccagtctctt ttataaagtc tcagactata ataaacacag
     2281 cttgcccagt ttatcctttc ttttttattt taagatgtat gcatattaat caatttacca
     2341 tcactggggc atggcagtgt gggcggggag aattattcac attctcctaa aatgacagca
     2401 gcagagagcc ttctgcctca gtggctctgg ctggtttcct gcaggggtcc cagtggaaac
     2461 ccgtgtggcc acctgttgcc gtcttccatg agatgttagt ggagagccac tttgacgtgg
     2521 aatgatccta atagatatag ccagaccggt tttgcggaaa cgctttgtgc tgagaaccgc
     2581 aagctggtgc accctgtgtc atatctgccc ccagccagct ggaattgtct gcaacacgcg
     2641 gtgcccggtg aggaggcagg caggacggtt gtgtgctgca tccatgagac ctggaaattc
     2701 agtttgcttt tggaaaagag cattg
//
