LOCUS       NM_002811               1631 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens proteasome 26S subunit, non-ATPase 7 (PSMD7), mRNA.
ACCESSION   NM_002811
VERSION     NM_002811.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1631)
  AUTHORS   Wang,J., Wang,T., Feng,Y.K., Liu,Y., Fu,B., Liu,X.T. and Wu,Q.Z.
  TITLE     Deubiquitinating enzyme PSMD7 promotes bladder cancer development:
            Involvement of RAB1A stabilization
  JOURNAL   Cell Signal 114, 110996 (2024)
   PUBMED   38040402
  REMARK    GeneRIF: Deubiquitinating enzyme PSMD7 promotes bladder cancer
            development: Involvement of RAB1A stabilization.
REFERENCE   2  (bases 1 to 1631)
  AUTHORS   Xu,Y., Wang,D. and Zhao,G.
  TITLE     Transcriptional activation of Proteasome 26S non-ATPase subunit 7
            by forkhead box P3 participates in gastric cancer cell
            proliferation and apoptosis
  JOURNAL   Bioengineered 13 (2), 2525-2536 (2022)
   PUBMED   35037550
  REMARK    GeneRIF: Transcriptional activation of Proteasome 26S non-ATPase
            subunit 7 by forkhead box P3 participates in gastric cancer cell
            proliferation and apoptosis.
REFERENCE   3  (bases 1 to 1631)
  AUTHORS   Wang,J., Liu,R., Mo,H., Xiao,X., Xu,Q. and Zhao,W.
  TITLE     Deubiquitinase PSMD7 promotes the proliferation, invasion, and
            cisplatin resistance of gastric cancer cells by stabilizing RAD23B
  JOURNAL   Int J Biol Sci 17 (13), 3331-3342 (2021)
   PUBMED   34512150
  REMARK    GeneRIF: Deubiquitinase PSMD7 promotes the proliferation, invasion,
            and cisplatin resistance of gastric cancer cells by stabilizing
            RAD23B.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1631)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1631)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1631)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   7  (bases 1 to 1631)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   8  (bases 1 to 1631)
  AUTHORS   Tsurumi,C., DeMartino,G.N., Slaughter,C.A., Shimbara,N. and
            Tanaka,K.
  TITLE     cDNA cloning of p40, a regulatory subunit of the human 26S
            proteasome, and a homolog of the Mov-34 gene product
  JOURNAL   Biochem Biophys Res Commun 210 (2), 600-608 (1995)
   PUBMED   7755639
REFERENCE   9  (bases 1 to 1631)
  AUTHORS   Gridley,T., Gray,D.A., Orr-Weaver,T., Soriano,P., Barton,D.E.,
            Francke,U. and Jaenisch,R.
  TITLE     Molecular analysis of the Mov 34 mutation: transcript disrupted by
            proviral integration in mice is conserved in Drosophila
  JOURNAL   Development 109 (1), 235-242 (1990)
   PUBMED   2209467
REFERENCE   10 (bases 1 to 1631)
  AUTHORS   Winkelmann,D.A. and Kahan,L.
  TITLE     Immunochemical accessibility of ribosomal protein S4 in the 30 S
            ribosome. The interaction of S4 with S5 and S12
  JOURNAL   J Mol Biol 165 (2), 357-374 (1983)
   PUBMED   6188845
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000338.2, BC012606.1 and
            CA429667.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002811.4.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            non-ATPase subunit of the 19S regulator. A pseudogene has been
            identified on chromosome 17. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1146516.1,
                                           SRR3476690.1155915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219313.9/ ENSP00000219313.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1048              BC000338.2         27-1074
            1049-1125           BC012606.1         1069-1145
            1126-1631           CA429667.1         17-522              c
FEATURES             Location/Qualifiers
     source          1..1631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..1631
                     /gene="PSMD7"
                     /gene_synonym="MOV34; P40; Rpn8; S12"
                     /note="proteasome 26S subunit, non-ATPase 7"
                     /db_xref="GeneID:5713"
                     /db_xref="HGNC:HGNC:9565"
                     /db_xref="MIM:157970"
     exon            1..175
                     /gene="PSMD7"
                     /gene_synonym="MOV34; P40; Rpn8; S12"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1076
                     /gene="PSMD7"
                     /gene_synonym="MOV34; P40; Rpn8; S12"
                     /note="Mov34 homolog; proteasome (prosome, macropain) 26S
                     subunit, non-ATPase, 7 (Mov34 homolog); proteasome subunit
                     p40; 26S proteasome regulatory subunit S12; Moloney
                     leukemia virus-34 proviral integration; 26S proteasome
                     regulatory subunit rpn8"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 7"
                     /protein_id="NP_002802.2"
                     /db_xref="CCDS:CCDS10910.1"
                     /db_xref="GeneID:5713"
                     /db_xref="HGNC:HGNC:9565"
                     /db_xref="MIM:157970"
                     /translation="MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQ
                     KKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLH
                     KNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTS
                     EIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVATG
                     KLPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLI
                     NNKIANRDAEKKEGQEKEESKKDRKEDKEKDKDKEKSDVKKEEKKEKK"
     exon            176..267
                     /gene="PSMD7"
                     /gene_synonym="MOV34; P40; Rpn8; S12"
                     /inference="alignment:Splign:2.1.0"
     exon            268..360
                     /gene="PSMD7"
                     /gene_synonym="MOV34; P40; Rpn8; S12"
                     /inference="alignment:Splign:2.1.0"
     exon            361..458
                     /gene="PSMD7"
                     /gene_synonym="MOV34; P40; Rpn8; S12"
                     /inference="alignment:Splign:2.1.0"
     exon            459..539
                     /gene="PSMD7"
                     /gene_synonym="MOV34; P40; Rpn8; S12"
                     /inference="alignment:Splign:2.1.0"
     exon            540..631
                     /gene="PSMD7"
                     /gene_synonym="MOV34; P40; Rpn8; S12"
                     /inference="alignment:Splign:2.1.0"
     exon            632..1631
                     /gene="PSMD7"
                     /gene_synonym="MOV34; P40; Rpn8; S12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1109..1114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD7"
                     /gene_synonym="MOV34; P40; Rpn8; S12"
                     /note="hexamer: ATTAAA"
     polyA_site      1129
                     /gene="PSMD7"
                     /gene_synonym="MOV34; P40; Rpn8; S12"
                     /note="major polyA site"
     regulatory      1611..1616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD7"
                     /gene_synonym="MOV34; P40; Rpn8; S12"
                     /note="hexamer: ATTAAA"
     polyA_site      1631
                     /gene="PSMD7"
                     /gene_synonym="MOV34; P40; Rpn8; S12"
                     /note="major polyA site"
ORIGIN      
        1 ggaagaagag gaactgggcc tgaaagggta ccggtgaccg ctactgctgc cggtgtttgc
       61 gtgtggcagg gagccaggcc tggcgagcgg ggtgtgtcgc gatgccggag ctggcagtgc
      121 agaaggtggt ggtccacccc ctggtgctgc tcagtgtggt ggatcatttc aaccgaatcg
      181 gcaaggttgg aaaccagaag cgtgttgttg gtgtgctttt ggggtcatgg caaaagaaag
      241 tacttgatgt atcgaacagt tttgcagttc cttttgatga agatgacaaa gacgattctg
      301 tatggttttt agaccatgat tatttggaaa acatgtatgg aatgtttaag aaagtcaatg
      361 ccagggaaag aatagttggc tggtaccaca caggccctaa actacacaag aatgacattg
      421 ccatcaacga actcatgaaa agatactgtc ctaattccgt attggtcatc attgatgtga
      481 agccgaagga cctagggctg cctacagaag cgtacatttc agtggaagaa gtccatgatg
      541 atggaactcc aacctcgaaa acatttgaac acgtgaccag tgaaattgga gcagaggaag
      601 ctgaggaagt tggagttgaa cacttgttac gagatatcaa agacacgacg gtgggcactc
      661 tgtcccagcg gatcacaaac caggtccatg gtttgaaggg actgaactcc aagcttctgg
      721 atatcaggag ctacctggaa aaagtcgcca caggcaagct gcccatcaac caccagatca
      781 tctaccagct gcaggacgtc ttcaacctgc tgccagatgt cagcctgcag gagttcgtca
      841 aggcctttta cctgaagacc aatgaccaga tggtggtagt gtacttggcc tcgctgatcc
      901 gttccgtggt cgccctgcac aacctcatca acaacaagat tgccaaccgg gatgcagaga
      961 agaaagaagg gcaggagaaa gaagagagca aaaaggatag gaaagaggac aaggagaaag
     1021 ataaagataa ggaaaagagt gatgtaaaga aagaggagaa aaaggagaaa aagtaaaaca
     1081 tgtattaaat agctttttta atttgtaaat taaaatctta caaactaaat cagtgtgctg
     1141 ctagagggtt ctttttcact tgacatgctt attagaaagc tgacccaaca agagctctct
     1201 gcctccggtc actcttgctg tggtgctacg tggaagtgaa tggagactga tctcaaatct
     1261 gaactgcagc tttcgctgct gtgagttggg gatatgatag tcagctcagg cttcagattg
     1321 tatgagaaaa atgaagagaa gtcaacaaat attttggtac tcttcattca tttatctcta
     1381 aaaccaggag ttgaattttc ctcatcttga aagactcttg gggtctgttt ctggtatttt
     1441 acaaaattgc taagtggaat gcatgaattg cattatgttc tctggtaaca cgtagagttc
     1501 agacccttct gaactctgtt gataatacca caccatgttc tggacccata gctctggcat
     1561 cctcaggggt tgtgatccag ctccatatat tgtttacctt caaagataca attaaatggc
     1621 ttgattttta a
//
