LOCUS       NM_014814               1362 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens proteasome 26S subunit, non-ATPase 6 (PSMD6),
            transcript variant 2, mRNA.
ACCESSION   NM_014814
VERSION     NM_014814.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1362)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1362)
  AUTHORS   Zhou,C., Li,H., Han,X., Pang,H., Wu,M., Tang,Y. and Luo,X.
  TITLE     Prognostic Value and Molecular Mechanisms of Proteasome 26S
            Subunit, Non-ATPase Family Genes for Pancreatic Ductal
            Adenocarcinoma Patients after Pancreaticoduodenectomy
  JOURNAL   J Invest Surg 35 (2), 330-346 (2022)
   PUBMED   33525943
  REMARK    GeneRIF: Prognostic Value and Molecular Mechanisms of Proteasome
            26S Subunit, Non-ATPase Family Genes for Pancreatic Ductal
            Adenocarcinoma Patients after Pancreaticoduodenectomy.
REFERENCE   3  (bases 1 to 1362)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1362)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1362)
  AUTHORS   Zhu,Y., Wang,W.L., Yu,D., Ouyang,Q., Lu,Y. and Mao,Y.
  TITLE     Structural mechanism for nucleotide-driven remodeling of the
            AAA-ATPase unfoldase in the activated human 26S proteasome
  JOURNAL   Nat Commun 9 (1), 1360 (2018)
   PUBMED   29636472
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1362)
  AUTHORS   Gudmundsdottir,K., Lord,C.J. and Ashworth,A.
  TITLE     The proteasome is involved in determining differential utilization
            of double-strand break repair pathways
  JOURNAL   Oncogene 26 (54), 7601-7606 (2007)
   PUBMED   17563742
REFERENCE   7  (bases 1 to 1362)
  AUTHORS   Wang,X., Chen,C.F., Baker,P.R., Chen,P.L., Kaiser,P. and Huang,L.
  TITLE     Mass spectrometric characterization of the affinity-purified human
            26S proteasome complex
  JOURNAL   Biochemistry 46 (11), 3553-3565 (2007)
   PUBMED   17323924
REFERENCE   8  (bases 1 to 1362)
  AUTHORS   Hamazaki,J., Iemura,S., Natsume,T., Yashiroda,H., Tanaka,K. and
            Murata,S.
  TITLE     A novel proteasome interacting protein recruits the
            deubiquitinating enzyme UCH37 to 26S proteasomes
  JOURNAL   EMBO J 25 (19), 4524-4536 (2006)
   PUBMED   16990800
REFERENCE   9  (bases 1 to 1362)
  AUTHORS   Tomarev,S.I., Wistow,G., Raymond,V., Dubois,S. and Malyukova,I.
  TITLE     Gene expression profile of the human trabecular meshwork: NEIBank
            sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 44 (6), 2588-2596 (2003)
   PUBMED   12766061
REFERENCE   10 (bases 1 to 1362)
  AUTHORS   Ren,S., Smith,M.J., Louro,I.D., McKie-Bell,P., Bani,M.R.,
            Wagner,M., Zochodne,B., Redden,D.T., Grizzle,W.E., Wang,Nd.,
            Smith,D.I., Herbst,R.A., Bardenheuer,W., Opalka,B., Schutte,J.,
            Trent,J.M., Ben-David,Y. and Ruppert,J.M.
  TITLE     The p44S10 locus, encoding a subunit of the proteasome regulatory
            particle, is amplified during progression of cutaneous malignant
            melanoma
  JOURNAL   Oncogene 19 (11), 1419-1427 (2000)
   PUBMED   10723133
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY010377.1, BC000904.2,
            BC012369.1 and CD678025.1.
            
            On Feb 27, 2020 this sequence version replaced NM_014814.2.
            
            Summary: This gene encodes a member of the protease subunit S10
            family. The encoded protein is a subunit of the 26S proteasome
            which colocalizes with DNA damage foci and is involved in the
            ATP-dependent degradation of ubiquinated proteins. Alternative
            splicing results in multiple transcript variants [provided by
            RefSeq, Nov 2012].
            
            Transcript Variant: This variant (2) lacks an exon in the coding
            region, compared to variant 1. The encoded isoform (2) is shorter
            than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.20598.1, BC012369.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295901.9/ ENSP00000295901.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                HY010377.1         114-150
            38-1309             BC000904.2         1-1272
            1310-1358           BC012369.1         1270-1318
            1359-1362           CD678025.1         536-539
FEATURES             Location/Qualifiers
     source          1..1362
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.1"
     gene            1..1362
                     /gene="PSMD6"
                     /gene_synonym="p42A; p44S10; Rpn7; S10; SGA-113M"
                     /note="proteasome 26S subunit, non-ATPase 6"
                     /db_xref="GeneID:9861"
                     /db_xref="HGNC:HGNC:9564"
                     /db_xref="MIM:617857"
     exon            1..220
                     /gene="PSMD6"
                     /gene_synonym="p42A; p44S10; Rpn7; S10; SGA-113M"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1245
                     /gene="PSMD6"
                     /gene_synonym="p42A; p44S10; Rpn7; S10; SGA-113M"
                     /note="isoform 2 is encoded by transcript variant 2; 26S
                     proteasome non-ATPase regulatory subunit 6; proteasome
                     regulatory particle subunit p44S10; breast
                     cancer-associated protein SGA-113M; phosphonoformate
                     immuno-associated protein 4; proteasome (prosome,
                     macropain) 26S subunit, non-ATPase, 6"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 6
                     isoform 2"
                     /protein_id="NP_055629.1"
                     /db_xref="CCDS:CCDS2901.1"
                     /db_xref="GeneID:9861"
                     /db_xref="HGNC:HGNC:9564"
                     /db_xref="MIM:617857"
                     /translation="MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAA
                     VRDNNMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRD
                     AMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRN
                     TEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKT
                     FVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLA
                     VVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQEL
                     SRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIKKGDLLLNRVQKLSRVINM"
     exon            221..426
                     /gene="PSMD6"
                     /gene_synonym="p42A; p44S10; Rpn7; S10; SGA-113M"
                     /inference="alignment:Splign:2.1.0"
     exon            427..572
                     /gene="PSMD6"
                     /gene_synonym="p42A; p44S10; Rpn7; S10; SGA-113M"
                     /inference="alignment:Splign:2.1.0"
     exon            573..792
                     /gene="PSMD6"
                     /gene_synonym="p42A; p44S10; Rpn7; S10; SGA-113M"
                     /inference="alignment:Splign:2.1.0"
     exon            793..901
                     /gene="PSMD6"
                     /gene_synonym="p42A; p44S10; Rpn7; S10; SGA-113M"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1070
                     /gene="PSMD6"
                     /gene_synonym="p42A; p44S10; Rpn7; S10; SGA-113M"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1148
                     /gene="PSMD6"
                     /gene_synonym="p42A; p44S10; Rpn7; S10; SGA-113M"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1362
                     /gene="PSMD6"
                     /gene_synonym="p42A; p44S10; Rpn7; S10; SGA-113M"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD6"
                     /gene_synonym="p42A; p44S10; Rpn7; S10; SGA-113M"
                     /note="hexamer: AATAAA"
     polyA_site      1362
                     /gene="PSMD6"
                     /gene_synonym="p42A; p44S10; Rpn7; S10; SGA-113M"
                     /note="major polyA site"
ORIGIN      
        1 gactcctccc gcttccgctg ccgcagccgg tcgtaaccaa gttgtgtcct gtcagccgct
       61 gtccccttcg ccgcgatgcc gctggagaac ctggaggagg agggtctgcc caagaacccc
      121 gacttgcgta tcgcgcagct gcgcttcctg ctcagcctgc ccgagcaccg cggagacgct
      181 gccgtgcgcg acgagctgat ggcggccgtc cgcgataaca acatggctcc ttactatgaa
      241 gccttgtgca aatccctcga ctggcagata gacgtggacc tactcaataa aatgaagaag
      301 gcaaatgaag atgagttgaa gcgtttggat gaggagctgg aagatgcaga gaagaatcta
      361 ggagagagcg aaattcgcga tgcaatgatg gcaaaggccg agtacctctg ccggataggt
      421 gacaaagagg gagctctgac agcctttcgc aagacatatg acaaaactgt ggccctgggt
      481 caccgattgg atattgtatt ctatctcctt aggattggct tattttatat ggataatgat
      541 ctcatcacac gaaacacaga aaaggccaaa agcttaatag aagaaggagg agactgggac
      601 aggagaaacc gcctaaaagt gtatcagggt ctttattgtg tggctattcg tgatttcaaa
      661 caggcagctg aactcttcct tgacactgtt tcaacattta catcctatga actcatggat
      721 tataaaacat ttgtgactta tactgtctat gtcagtatga ttgccttaga aagaccagat
      781 ctcagggaaa aggtcattaa aggagcagag attcttgaag tgttgcacag tcttccagca
      841 gttcggcagt atctgttttc actctatgaa tgccgttact ctgttttctt ccaatcatta
      901 gcggttgtgg aacaggaaat gaaaaaggac tggctttttg cccctcatta tcgatactat
      961 gtaagagaaa tgagaattca tgcatacagt cagctgctgg aatcatatag gtcattaacc
     1021 cttggctata tggcagaagc gtttggtgtt ggtgtggaat tcattgatca ggaactgtcc
     1081 aggtttattg ctgccgggag actacactgc aaaatagata aagtgaatga aatagtagaa
     1141 accaacagac ctgatagcaa gaactggcag taccaagaaa ctatcaagaa aggagatctg
     1201 ctactaaaca gagttcaaaa actttccaga gtaattaata tgtaaagcca tgtaactaac
     1261 aaaggatttg ctttagagat aattatttgg aatttttata gcttacttca caatgtgccc
     1321 aggtcagctg tataaaataa atactgcatt gttgtttctt tc
//
