LOCUS       NM_005047               3381 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens proteasome 26S subunit, non-ATPase 5 (PSMD5),
            transcript variant 1, mRNA.
ACCESSION   NM_005047
VERSION     NM_005047.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3381)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3381)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3381)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3381)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3381)
  AUTHORS   Levin,A., Minis,A., Lalazar,G., Rodriguez,J. and Steller,H.
  TITLE     PSMD5 Inactivation Promotes 26S Proteasome Assembly during
            Colorectal Tumor Progression
  JOURNAL   Cancer Res 78 (13), 3458-3468 (2018)
   PUBMED   29716915
  REMARK    GeneRIF: Study in HT-29 cells and mouse colorectal tumor models
            revealed that levels of the proteasome assembly inhibitor PSMD5/S5B
            are significantly decreased in tumors, and re-expression of PSMD5
            blocks 26S proteasome assembly. These results suggest that
            intestinal cancer cells escape proteotoxic stress by reducing PSMD5
            to stimulate 26S proteasome assembly.
REFERENCE   6  (bases 1 to 3381)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   7  (bases 1 to 3381)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   8  (bases 1 to 3381)
  AUTHORS   Deveraux,Q., Jensen,C. and Rechsteiner,M.
  TITLE     Molecular cloning and expression of a 26 S protease subunit
            enriched in dileucine repeats
  JOURNAL   J Biol Chem 270 (40), 23726-23729 (1995)
   PUBMED   7559544
REFERENCE   9  (bases 1 to 3381)
  AUTHORS   Deveraux,Q., Ustrell,V., Pickart,C. and Rechsteiner,M.
  TITLE     A 26 S protease subunit that binds ubiquitin conjugates
  JOURNAL   J Biol Chem 269 (10), 7059-7061 (1994)
   PUBMED   8125911
REFERENCE   10 (bases 1 to 3381)
  AUTHORS   Kanayama,H.O., Tamura,T., Ugai,S., Kagawa,S., Tanahashi,N.,
            Yoshimura,T., Tanaka,K. and Ichihara,A.
  TITLE     Demonstration that a human 26S proteolytic complex consists of a
            proteasome and multiple associated protein components and
            hydrolyzes ATP and ubiquitin-ligated proteins by closely linked
            mechanisms
  JOURNAL   Eur J Biochem 206 (2), 567-578 (1992)
   PUBMED   1317798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY023459.1, D31889.1 and
            BC014478.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005047.3.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. This
            gene encodes a non-ATPase subunit of the 19S regulator base that
            functions as a chaperone protein during 26S proteasome assembly.
            [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014478.1, SRR1660809.258522.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000210313.8/ ENSP00000210313.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                HY023459.1         101-114
            15-3334             D31889.1           1-3320
            3335-3381           BC014478.1         3325-3371
FEATURES             Location/Qualifiers
     source          1..3381
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..3381
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /note="proteasome 26S subunit, non-ATPase 5"
                     /db_xref="GeneID:5711"
                     /db_xref="HGNC:HGNC:9563"
                     /db_xref="MIM:604452"
     exon            1..186
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1528
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /note="isoform 1 is encoded by transcript variant 1; 26S
                     protease subunit S5 basic; 26S proteasome subunit S5B; 26S
                     proteasome non-ATPase regulatory subunit 5; proteasome
                     (prosome, macropain) 26S subunit, non-ATPase, 5"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 5
                     isoform 1"
                     /protein_id="NP_005038.1"
                     /db_xref="CCDS:CCDS6824.1"
                     /db_xref="GeneID:5711"
                     /db_xref="HGNC:HGNC:9563"
                     /db_xref="MIM:604452"
                     /translation="MAAQALALLREVARLEAPLEELRALHSVLQAVPLNELRQQAAEL
                     RLGPLFSLLNENHREKTTLCVSILERLLQAMEPVHVARNLRVDLQRGLIHPDDSVKIL
                     TLSQIGRIVENSDAVTEILNNAELLKQIVYCIGGENLSVAKAAIKSLSRISLTQAGLE
                     ALFESNLLDDLKSVMKTNDIVRYRVYELIIEISSVSPESLNYCTTSGLVTQLLRELTG
                     EDVLVRATCIEMVTSLAYTHHGRQYLAQEGVIDQISNIIVGADSDPFSSFYLPGFVKF
                     FGNLAVMDSPQQICERYPIFVEKVFEMIESQDPTMIGVAVDTVGILGSNVEGKQVLQK
                     TGTRFERLLMRIGHQSKNAPVELKIRCLDAISSLLYLPPEQQTDDLLRMTESWFSSLS
                     RDPLELFRGISSQPFPELHCAALKVFTAIANQPWAQKLMFNSPGFVEYVVDRSVEHDK
                     ASKDAKYELVKALANSKTIAEIFGNPNYLRLRTYLSEGPYYVKPVSTTAVEGAE"
     exon            187..331
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:2.1.0"
     exon            332..445
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:2.1.0"
     exon            446..574
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:2.1.0"
     exon            575..684
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:2.1.0"
     exon            685..827
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1019
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1129
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1270
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..3381
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3062..3067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /note="hexamer: AATAAA"
     polyA_site      3081
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /note="major polyA site"
     regulatory      3342..3347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD5"
                     /gene_synonym="S5B"
                     /note="hexamer: AATAAA"
     polyA_site      3381
                     /gene="PSMD5"
                     /gene_synonym="S5B"
ORIGIN      
        1 gtcggggggc aagatggcag cccaggcttt ggcgctgctg agagaggtag cgaggctgga
       61 agcgccgctg gaggagctac gcgcgcttca ctccgtgctg caggcagtgc cgctcaacga
      121 gcttcgccag caagcggcgg agctgcgcct cggcccgctc ttctccctgc ttaacgagaa
      181 ccatagggaa aagactactt tgtgtgtatc cattctggag agattgctcc aagctatgga
      241 accggttcac gtggcccgga acctcagggt tgacctgcag aggggactaa ttcaccctga
      301 tgattctgta aaaatcctca ctctttccca gattggaaga attgttgaaa attctgatgc
      361 tgttactgag attctaaata atgctgaatt actaaaacaa attgtttatt gcattggtgg
      421 agagaatcta tctgtagcaa aagcggctat caaatccctg tcaagaatat cactaaccca
      481 agctggactg gaggctttat ttgaaagcaa tctgctggat gatttgaaaa gtgtaatgaa
      541 aacaaatgac attgttcgat acagggtgta tgagctaatt atagagattt cttccgtgtc
      601 accagaatct ttaaactact gtaccacaag tggattggta acccagctcc tgagagagct
      661 gactggtgag gatgtgttgg tcagagccac ctgtatagaa atggtgacat cactggcata
      721 tactcatcat gggcgacaat atcttgctca agaaggagta attgaccaaa tttctaatat
      781 aattgttggg gcagattcag accctttctc tagcttctat ctgccaggat tcgtgaagtt
      841 ttttggaaac ctggctgtca tggatagtcc tcaacagatc tgtgagcgtt atcctatctt
      901 tgtggaaaaa gtctttgaaa tgatagaaag tcaggacccc actatgattg gtgtagctgt
      961 agacacagtt ggaatcttgg gatccaatgt tgaaggaaaa caggttttac agaaaacagg
     1021 aactcgcttt gaacgcttgc ttatgagaat aggacatcaa tcaaagaatg ccccagtgga
     1081 gctaaaaatt agatgtttgg atgcaatttc atctcttctg tacttaccac ctgagcagca
     1141 gactgatgac cttctgagga tgacagaatc ctggttttct tctttatctc gggatccact
     1201 ggagctcttc cgtggcatta gtagtcagcc cttccctgaa ctacactgtg ctgccttaaa
     1261 agtgtttacg gccattgcaa accaaccctg ggctcagaaa cttatgttta acagtccagg
     1321 ttttgtagaa tatgtggtgg accggtctgt ggagcatgac aaagcttcaa aggatgccaa
     1381 atatgaacta gtgaaagcac ttgccaattc caagacaatt gcagaaatct ttgggaaccc
     1441 aaattatttg aggctcagaa cttacctgag tgaagggcca tactatgtga aacctgtttc
     1501 cacgacagca gtagaaggag ccgaatgatt tcttctagag ctcatgtaga ggaccacgtt
     1561 ttgaccaaaa cttctcctaa ggcatttgac tccatctata tttcacaaaa gagacttcct
     1621 ttccccaaga attatcatgg aatgtcagat gttactttgt taccaacact gttatatttc
     1681 tacattgaaa tgcaaagtgg aactaggagt ttggaatgca ttaagagcag acaagcttgg
     1741 tcataataga tccagtgttt ttcagattcc tttcactgcc ttaatctttg caacagggtg
     1801 gaagtttttt tcttccctca aaattttcat ggacatgcaa tcttatctaa aagcctgctt
     1861 cagggctggg cgcggtggct aacacctata attcccagca ctttgggagg ccaagatggg
     1921 caaatcactt gagtctagga gttcaagacc agcctggcca atatggcaaa accctgtctc
     1981 tactaaaaat ataaaatcag ccaggcatgg tggcgcacac ctataatctc agctactcag
     2041 gaggctgagg cacgagaatc gcttgagcct gggaggcaga ggttgcagtg agctgagatc
     2101 ttgccactgc acaccagcct gggcaacaca gcaagactct gtctcaaaaa taaatgaata
     2161 aaataaaaac ctgccaccaa attatttctg gattctcttc actatctttt tttttctttt
     2221 tggtcctttt tccatttctg attccacttt caaagtcttg gatatattct ttgaaaaatg
     2281 agtagtatgg aatattaaga ttatgttcct tatactcaga atacttttta tgagctctct
     2341 tgtttttttg ttactattat tcctttgaaa aaaagacaaa atatctaaaa aatgtttata
     2401 gtgttcatgt aatttttttt gctgtttacc aatgaacttt gccctgttgt ggttttgggg
     2461 gatcagaagg attcctaaac tgtcatttca tttattggta ggtcatgatt gctgagggtt
     2521 ttgctttgga tttttcatac ctataaagtc aatcttgagt tgatcagaga aagggaaact
     2581 tactcctaat aaacagactc agaacagaag ggacatatgc ataaatcagg ataccatctc
     2641 attaatttac aaaggataat ctttcttttc attgacaaca cctacaccca cctgttttcc
     2701 agtgttcttc tctctaaaca gcaaagccaa agcactctgc acaccaaatc acctgttcag
     2761 aggtttatgc atgagcatat ttcttttagg ccgtggtgaa gttgataaac cacccctgct
     2821 ttgtaacaaa attattttaa agtgactgga attatctagt ccccagattg atcatctccc
     2881 ctggcaacgt gactctgttt tttgtgtgtg tttccatgct gactagtccc ctactgttaa
     2941 tatcactact aattaggcta taaccaggtc tttcctggcc tgagaaatat tctcttaaaa
     3001 tgacctttgt tttaatctca ttcatgatgt tgattttttt tcaatgtggt gcaatatata
     3061 caataaaatt tgtcataact attttaagtg tacagttcag tatattacat atgttcataa
     3121 gttgtacaac catcaccacc atccatcttc agaattattt tcatcttata caattgaaac
     3181 tgtattcatt aaacaataac tgtctattcc ctcttttccc cagcctctgg caaccaccat
     3241 tctgcttcat gacattgatt ttattcactt aacatcagat tttgggggga tgccctctct
     3301 cctatgtatg gtctacacat tctgattttt tttttagatt gaataaaatt tgtaaatcat
     3361 tattttcatt tcataagtaa a
//
