LOCUS       NM_002809               2147 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens proteasome 26S subunit, non-ATPase 3 (PSMD3), mRNA.
ACCESSION   NM_002809
VERSION     NM_002809.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2147)
  AUTHORS   Chen,J., Lian,P., Zhao,X., Li,J., Yu,X., Huang,X., Chen,S. and
            Lu,L.
  TITLE     PSMD3 gene mutations cause pathological myopia
  JOURNAL   J Med Genet 60 (9), 918-924 (2023)
   PUBMED   36948574
  REMARK    GeneRIF: PSMD3 gene mutations cause pathological myopia.
REFERENCE   2  (bases 1 to 2147)
  AUTHORS   Zhang,J., Ma,Q., Yu,Q., Xiao,F., Zhang,Z., Feng,H. and Liang,C.
  TITLE     PSMD3-ILF3 signaling cascade drives lung cancer cell proliferation
            and migration
  JOURNAL   Biol Direct 18 (1), 33 (2023)
   PUBMED   37337223
  REMARK    GeneRIF: PSMD3-ILF3 signaling cascade drives lung cancer cell
            proliferation and migration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2147)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2147)
  AUTHORS   Rubio,A.J., Bencomo-Alvarez,A.E., Young,J.E., Velazquez,V.V.,
            Lara,J.J., Gonzalez,M.A. and Eiring,A.M.
  TITLE     26S Proteasome Non-ATPase Regulatory Subunits 1 (PSMD1) and 3
            (PSMD3) as Putative Targets for Cancer Prognosis and Therapy
  JOURNAL   Cells 10 (9), 2390 (2021)
   PUBMED   34572038
  REMARK    GeneRIF: 26S Proteasome Non-ATPase Regulatory Subunits 1 (PSMD1)
            and 3 (PSMD3) as Putative Targets for Cancer Prognosis and Therapy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2147)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2147)
  AUTHORS   Simon,J.H., Gaddis,N.C., Fouchier,R.A. and Malim,M.H.
  TITLE     Evidence for a newly discovered cellular anti-HIV-1 phenotype
  JOURNAL   Nat Med 4 (12), 1397-1400 (1998)
   PUBMED   9846577
REFERENCE   7  (bases 1 to 2147)
  AUTHORS   Madani,N. and Kabat,D.
  TITLE     An endogenous inhibitor of human immunodeficiency virus in human
            lymphocytes is overcome by the viral Vif protein
  JOURNAL   J Virol 72 (12), 10251-10255 (1998)
   PUBMED   9811770
REFERENCE   8  (bases 1 to 2147)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   9  (bases 1 to 2147)
  AUTHORS   Kominami,K., Okura,N., Kawamura,M., DeMartino,G.N., Slaughter,C.A.,
            Shimbara,N., Chung,C.H., Fujimuro,M., Yokosawa,H., Shimizu,Y.,
            Tanahashi,N., Tanaka,K. and Toh-e,A.
  TITLE     Yeast counterparts of subunits S5a and p58 (S3) of the human 26S
            proteasome are encoded by two multicopy suppressors of nin1-1
  JOURNAL   Mol Biol Cell 8 (1), 171-187 (1997)
   PUBMED   9017604
REFERENCE   10 (bases 1 to 2147)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY034626.1, D67025.1 and
            AA143716.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002809.3.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. This
            gene encodes a member of the proteasome subunit S3 family that
            functions as one of the non-ATPase subunits of the 19S regulator
            lid. Single nucleotide polymorphisms in this gene are associated
            with neutrophil count. [provided by RefSeq, Jul 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054611.1, SRR3476690.333839.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264639.9/ ENSP00000264639.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               HY034626.1         41-383
            344-2141            D67025.1           337-2134
            2142-2147           AA143716.1         5-10                c
FEATURES             Location/Qualifiers
     source          1..2147
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.1"
     gene            1..2147
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /note="proteasome 26S subunit, non-ATPase 3"
                     /db_xref="GeneID:5709"
                     /db_xref="HGNC:HGNC:9560"
                     /db_xref="MIM:617676"
     exon            1..384
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1769
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /note="tissue specific transplantation antigen 2; 26S
                     proteasome regulatory subunit S3; proteasome subunit p58;
                     26S proteasome regulatory subunit RPN3; proteasome
                     (prosome, macropain) 26S subunit, non-ATPase, 3"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 3"
                     /protein_id="NP_002800.2"
                     /db_xref="CCDS:CCDS11356.1"
                     /db_xref="GeneID:5709"
                     /db_xref="HGNC:HGNC:9560"
                     /db_xref="MIM:617676"
                     /translation="MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATG
                     GGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLP
                     STSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLL
                     PEVEAYLQLLVVIFMMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVY
                     EFLDKLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVF
                     PEQANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIV
                     VELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTY
                     TLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEAS
                     INHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESA
                     EERREREQQDLEFAKEMAEDDDDSFP"
     exon            385..575
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..713
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            714..850
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1041
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1145
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1260
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1380
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1484
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1640
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1691
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..2147
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2127..2132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /note="hexamer: AATAAA"
     polyA_site      2147
                     /gene="PSMD3"
                     /gene_synonym="P58; RPN3; S3; TSTA2"
                     /note="major polyA site"
ORIGIN      
        1 agaaggccca gcgccgggaa ggggtttgca gctgctccgt catcgtgcgg cccgacgcta
       61 tctcgcgctc gtgtgcaggc ccggctcggc tcctggtccc cggtgcgagg gttaacgcga
      121 ggccccggcc tcggtccccg gactaggccg tgaccccggg tgccatgaag caggagggct
      181 cggcgcggcg ccgcggcgcg gacaaggcga aaccgccgcc cggcggagga gaacaagaac
      241 ccccaccgcc gccggccccc caggatgtgg agatgaaaga ggaggcagcg acgggtggcg
      301 ggtcgacggg ggaggcagac ggcaagacgg cggcggcagc ggctgagcac tcccagcgag
      361 agctggacac agtcaccttg gaggacatca aggagcacgt gaaacagcta gagaaagcgg
      421 tttcaggcaa ggagccgaga ttcgtgctgc gggccctgcg gatgctgcct tccacatcac
      481 gccgcctcaa ccactatgtt ctgtataagg ctgtgcaggg cttcttcact tcaaataatg
      541 ccactcgaga ctttttgctc cccttcctgg aagagcccat ggacacagag gctgatttac
      601 agttccgtcc ccgcacggga aaagctgcgt cgacacccct cctgcctgaa gtggaagcct
      661 atctccaact cctcgtggtc atcttcatga tgaacagcaa gcgctacaaa gaggcacaga
      721 agatctctga tgatctgatg cagaagatca gtactcagaa ccgccgggcc ctagaccttg
      781 tagccgcaaa gtgttactat tatcacgccc gggtctatga gttcctggac aagctggatg
      841 tggtgcgcag cttcttgcat gctcggctcc ggacagctac gcttcggcat gacgcagacg
      901 ggcaggccac cctgttgaac ctcctgctgc ggaattacct acactacagc ttgtacgacc
      961 aggctgagaa gctggtgtcc aagtctgtgt tcccagagca ggccaacaac aatgagtggg
     1021 ccaggtacct ctactacaca gggcgaatca aagccatcca gctggagtac tcagaggccc
     1081 ggagaacgat gaccaacgcc cttcgcaagg cccctcagca cacagctgtc ggcttcaaac
     1141 agacggtgca caagcttctc atcgtggtgg agctgttgct gggggagatc cctgaccggc
     1201 tgcagttccg ccagccctcc ctcaagcgct cactcatgcc ctatttcctt ctgactcaag
     1261 ctgtcaggac aggaaaccta gccaagttca accaggtcct ggatcagttt ggggagaagt
     1321 ttcaagcaga tgggacctac accctaatta tccggctgcg gcacaacgtg attaagacag
     1381 gtgtacgcat gatcagcctc tcctattccc gaatctcctt ggctgacatc gcccagaagc
     1441 tgcagttgga tagccccgaa gatgcagagt tcattgttgc caaggccatc cgggatggtg
     1501 tcattgaggc cagcatcaac cacgagaagg gctatgtcca atccaaggag atgattgaca
     1561 tctattccac ccgagagccc cagctagcct tccaccagcg catctccttc tgcctagata
     1621 tccacaacat gtctgtcaag gccatgaggt ttcctcccaa atcgtacaac aaggacttgg
     1681 agtctgcaga ggaacggcgt gagcgagaac agcaggactt ggagtttgcc aaggagatgg
     1741 cagaagatga tgatgacagc ttcccttgag ctggggggct ggggaggggt agggggaatg
     1801 gggacaggct ctttccccct tgggggtccc ctgcccaggg cactgtcccc attttcccac
     1861 acacagctca tatgctgcat tcgtgcaggg ggtgggggtg ctgggagcca gccaccctga
     1921 cctcccccag ggctcctccc cagccggtga cttactgtac agcaggcagg agggtgggca
     1981 ggcaacctcc ccgggcaggg tcctggccag cagtgtggga gcaggagggg aaggatagtt
     2041 ctgtgtactc ctttagggag tgggggacta gaactgggat gtcttggctt gtatgttttt
     2101 tgaagcttcg attatgattt ttaaacaata aaaagttctc cacagtg
//
