LOCUS       NM_002808               2913 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens proteasome 26S subunit ubiquitin receptor, non-ATPase
            2 (PSMD2), transcript variant 1, mRNA.
ACCESSION   NM_002808
VERSION     NM_002808.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2913)
  AUTHORS   Zhang,Q., Feng,P., Zhu,X.H., Zhou,S.Q., Ye,M.L., Yang,X.J.,
            Gong,S., Huang,S.Y., Tan,X.R., He,S.W. and Li,Y.Q.
  TITLE     DNAJA4 suppresses epithelial-mesenchymal transition and metastasis
            in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation
  JOURNAL   Cell Death Dis 14 (10), 697 (2023)
   PUBMED   37875476
  REMARK    GeneRIF: DNAJA4 suppresses epithelial-mesenchymal transition and
            metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9
            degradation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2913)
  AUTHORS   Dhingra,R., Rabinovich-Nikitin,I., Rothman,S., Guberman,M.,
            Gang,H., Margulets,V., Jassal,D.S., Alagarsamy,K.N., Dhingra,S.,
            Valenzuela Ripoll,C., Billia,F., Diwan,A., Javaheri,A. and
            Kirshenbaum,L.A.
  TITLE     Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction
            in Doxorubicin-Cardiomyopathy
  JOURNAL   Circulation 146 (12), 934-954 (2022)
   PUBMED   35983756
  REMARK    GeneRIF: Proteasomal Degradation of TRAF2 Mediates Mitochondrial
            Dysfunction in Doxorubicin-Cardiomyopathy.
            Erratum:[Circulation. 2022 Oct 11;146(15):e224. doi:
            10.1161/CIR.0000000000001108.. PMID: 36214137]
REFERENCE   3  (bases 1 to 2913)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2913)
  AUTHORS   Ying,K., Wang,C., Liu,S., Kuang,Y., Tao,Q. and Hu,X.
  TITLE     Diverse Ras-related GTPase DIRAS2, downregulated by PSMD2 in a
            proteasome-mediated way, inhibits colorectal cancer proliferation
            by blocking NF-kappaB signaling
  JOURNAL   Int J Biol Sci 18 (3), 1039-1050 (2022)
   PUBMED   35173535
  REMARK    GeneRIF: Diverse Ras-related GTPase DIRAS2, downregulated by PSMD2
            in a proteasome-mediated way, inhibits colorectal cancer
            proliferation by blocking NF-kappaB signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2913)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2913)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   7  (bases 1 to 2913)
  AUTHORS   Tsurumi,C., Shimizu,Y., Saeki,M., Kato,S., Demartino,G.N.,
            Slaughter,C.A., Fujimuro,M., Yokosawa,H., Yamasaki,M., Hendil,K.B.,
            Toh-e,A., Tanahashi,N. and Tanaka,K.
  TITLE     cDNA cloning and functional analysis of the p97 subunit of the 26S
            proteasome, a polypeptide identical to the type-1
            tumor-necrosis-factor-receptor-associated protein-2/55.11
  JOURNAL   Eur J Biochem 239 (3), 912-921 (1996)
   PUBMED   8774743
REFERENCE   8  (bases 1 to 2913)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   9  (bases 1 to 2913)
  AUTHORS   Song,H.Y. and Donner,D.B.
  TITLE     Association of a RING finger protein with the cytoplasmic domain of
            the human type-2 tumour necrosis factor receptor
  JOURNAL   Biochem J 309 (Pt 3) (Pt 3), 825-829 (1995)
   PUBMED   7639698
REFERENCE   10 (bases 1 to 2913)
  AUTHORS   Boldin,M.P., Mett,I.L. and Wallach,D.
  TITLE     A protein related to a proteasomal subunit binds to the
            intracellular domain of the p55 TNF receptor upstream to its 'death
            domain'
  JOURNAL   FEBS Lett 367 (1), 39-44 (1995)
   PUBMED   7601280
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY006627.1 and BC002997.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002808.4.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes one of
            the non-ATPase subunits of the 19S regulator lid. In addition to
            participation in proteasome function, this subunit may also
            participate in the TNF signalling pathway since it interacts with
            the tumor necrosis factor type 1 receptor. A pseudogene has been
            identified on chromosome 1. Alternative splicing results in
            multiple transcript variants of this gene. [provided by RefSeq, Jul
            2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.125519.1,
                                           SRR1803611.109138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310118.9/ ENSP00000310129.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 HY006627.1         145-148
            5-2913              BC002997.1         1-2909
FEATURES             Location/Qualifiers
     source          1..2913
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..2913
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /note="proteasome 26S subunit ubiquitin receptor,
                     non-ATPase 2"
                     /db_xref="GeneID:5708"
                     /db_xref="HGNC:HGNC:9559"
                     /db_xref="MIM:606223"
     exon            1..161
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2753
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TNFR-associated protein 2; 55.11 protein; 26S proteasome
                     non-ATPase regulatory subunit 2; protein 55.11; tumor
                     necrosis factor type 1 receptor-associated protein 2;
                     proteasome (prosome, macropain) 26S subunit, non-ATPase,
                     2; proteasome 26S subunit, non-ATPase 2"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 2
                     isoform 1"
                     /protein_id="NP_002799.3"
                     /db_xref="CCDS:CCDS3258.1"
                     /db_xref="GeneID:5708"
                     /db_xref="HGNC:HGNC:9559"
                     /db_xref="MIM:606223"
                     /translation="MEEGGRDKAPVQPQQSPAAAPGGTDEKPSGKERRDAGDKDKEQE
                     LSEEDKQLQDELEMLVERLGEKDTSLYRPALEELRRQIRSSTTSMTSVPKPLKFLRPH
                     YGKLKEIYENMAPGENKRFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVR
                     HLAGEVAKEWQELDDAEKVQREPLLTLVKEIVPYNMAHNAEHEACDLLMEIEQVDMLE
                     KDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDME
                     LVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALA
                     RELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFGQDKLLT
                     DDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGI
                     VNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDS
                     KSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNH
                     LGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKE
                     KEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYG
                     EPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNAR
                     LAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLT
                     VLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQA
                     GKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL"
     exon            162..218
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            219..383
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            384..505
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..730
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..889
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1034
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1095
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1242
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1349
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1477
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1565
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1728
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1830
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1976
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2060
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2229
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2324
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2451
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2570
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2913
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2893..2898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /note="hexamer: AATAAA"
     polyA_site      2913
                     /gene="PSMD2"
                     /gene_synonym="P97; RPN1; S2; TRAP2"
                     /note="major polyA site"
ORIGIN      
        1 gcagcgggcc ggcagtggcg gcggagatgg aggagggagg ccgggacaag gcgccggtgc
       61 agccccagca gtctccagcg gcggcccccg gcggcacgga cgagaagccg agcggcaagg
      121 agcggcggga tgccggggac aaggacaaag aacaggagct gtctgaagag gataaacagc
      181 ttcaagatga actggagatg ctcgtggaac gactagggga gaaggataca tccctgtatc
      241 gaccagcgct ggaggaattg cgaaggcaga ttcgttcttc tacaacttcc atgacttcag
      301 tgcccaagcc tctcaaattt ctgcgtccac actatggcaa actgaaggaa atctatgaga
      361 acatggcccc tggggagaat aagcgttttg ctgctgacat catctccgtt ttggccatga
      421 ccatgagtgg ggagcgtgag tgcctcaagt atcggctagt gggctcccag gaggaattgg
      481 catcatgggg tcatgagtat gtcaggcatc tggcaggaga agtggctaag gagtggcagg
      541 agctggatga cgcagagaag gtccagcggg agcctctgct cactctggtg aaggaaatcg
      601 tcccctataa catggcccac aatgcagagc atgaggcttg cgacctgctt atggaaattg
      661 agcaggtgga catgctggag aaggacattg atgaaaatgc atatgcaaag gtctgccttt
      721 atctcaccag ttgtgtgaat tacgtgcctg agcctgagaa ctcagcccta ctgcgttgtg
      781 ccctgggtgt gttccgaaag tttagccgct tccctgaagc tctgagattg gcattgatgc
      841 tcaatgacat ggagttggta gaagacatct tcacctcctg caaggatgtg gtagtacaga
      901 aacagatggc attcatgcta ggccggcatg gggtgttcct ggagctgagt gaagatgtcg
      961 aggagtatga ggacctgaca gagatcatgt ccaatgtaca gctcaacagc aacttcttgg
     1021 ccttagctcg ggagctggac atcatggagc ccaaggtgcc tgatgacatc tacaaaaccc
     1081 acctagagaa caacaggttt gggggcagtg gctctcaggt ggactctgcc cgcatgaacc
     1141 tggcctcctc ttttgtgaat ggctttgtga atgcagcttt tggccaagac aagctgctaa
     1201 cagatgatgg caacaaatgg ctttacaaga acaaggacca cggaatgttg agtgcagctg
     1261 catctcttgg gatgattctg ctgtgggatg tggatggtgg cctcacccag attgacaagt
     1321 acctgtactc ctctgaggac tacattaagt caggagctct tcttgcctgt ggcatagtga
     1381 actctggggt ccggaatgag tgtgaccctg ctctggcact gctctcagac tatgttctcc
     1441 acaacagcaa caccatgaga cttggttcca tctttgggct aggcttggct tatgctggct
     1501 caaatcgtga agatgtccta acactgctgc tgcctgtgat gggagattca aagtccagca
     1561 tggaggtggc aggtgtcaca gctttagcct gtggaatgat agcagtaggg tcctgcaatg
     1621 gagatgtaac ttccactatc cttcagacca tcatggagaa gtcagagact gagctcaagg
     1681 atacttatgc tcgttggctt cctcttggac tgggtctcaa ccacctgggg aagggtgagg
     1741 ccatcgaggc aatcctggct gcactggagg ttgtgtcaga gccattccgc agttttgcca
     1801 acacactggt ggatgtgtgt gcatatgcag gctctgggaa tgtgctgaag gtgcagcagc
     1861 tgctccacat ttgtagcgaa cactttgact ccaaagagaa ggaggaagac aaagacaaga
     1921 aggaaaagaa agacaaggac aagaaggaag cccctgctga catgggagca catcagggag
     1981 tggctgttct ggggattgcc cttattgcta tgggggagga gattggtgca gagatggcat
     2041 tacgaacctt tggccacttg ctgagatatg gggagcctac actccggagg gctgtacctt
     2101 tagcactggc cctcatctct gtttcaaatc cacgactcaa catcctggat accctaagca
     2161 aattctctca tgatgctgat ccagaagttt cctataactc catttttgcc atgggcatgg
     2221 tgggcagtgg taccaataat gcccgtctgg ctgcaatgct gcgccagtta gctcaatatc
     2281 atgccaagga cccaaacaac ctcttcatgg tgcgcttggc acagggcctg acacatttag
     2341 ggaagggcac ccttaccctc tgcccctacc acagcgaccg gcagcttatg agccaggtgg
     2401 ccgtggctgg actgctcact gtgcttgtct ctttcctgga tgttcgaaac attattctag
     2461 gcaaatcaca ctatgtattg tatgggctgg tggctgccat gcagccccga atgctggtta
     2521 cgtttgatga ggagctgcgg ccattgccag tgtctgtccg tgtgggccag gcagtggatg
     2581 tggtgggcca ggctggcaag ccgaagacta tcacagggtt ccagacgcat acaaccccag
     2641 tgttgttggc ccacggggaa cgggcagaat tggccactga ggagtttctt cctgttaccc
     2701 ccattctgga aggttttgtt atccttcgga agaaccccaa ttatgatctc taagtgacca
     2761 ccaggggctc tgaactgcag ctgatgttat cagcaggcca tgcatcctgc tgccaagggt
     2821 ggacacggct gcagacttct gggggaattg tcgcctcctg ctcttttgtt actgagtgag
     2881 ataaggttgt tcaataaaga cttttatccc caa
//
