LOCUS       NM_005805               1567 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens proteasome 26S subunit, non-ATPase 14 (PSMD14), mRNA.
ACCESSION   NM_005805
VERSION     NM_005805.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1567)
  AUTHORS   Yuan,Y., Li,Y., Wu,X., Bo,J., Zhang,L., Zhang,J., Hu,Y., Chen,Y.,
            Zeng,Y., Wei,X. and Zhang,H.
  TITLE     POH1 induces Smad3 deubiquitination and promotes lung cancer
            metastasis
  JOURNAL   Cancer Lett 582, 216526 (2024)
   PUBMED   38061486
  REMARK    GeneRIF: POH1 induces Smad3 deubiquitination and promotes lung
            cancer metastasis.
REFERENCE   2  (bases 1 to 1567)
  AUTHORS   Yang,P., Yang,X., Wang,D., Yang,H., Li,Z., Zhang,C., Zhang,S.,
            Zhu,J., Li,X., Su,P. and Zhuang,T.
  TITLE     PSMD14 stabilizes estrogen signaling and facilitates breast cancer
            progression via deubiquitinating ERalpha
  JOURNAL   Oncogene 43 (4), 248-264 (2024)
   PUBMED   38017133
  REMARK    GeneRIF: PSMD14 stabilizes estrogen signaling and facilitates
            breast cancer progression via deubiquitinating ERalpha.
REFERENCE   3  (bases 1 to 1567)
  AUTHORS   Song,W., Li,Z., Xia,M. and Xiao,W.
  TITLE     Regulation of Drp1 and enhancement of mitochondrial fission by the
            deubiquitinating enzyme PSMD14 facilitates the proliferation of
            bladder cancer cells
  JOURNAL   Oncol Rep 51 (1) (2024)
   PUBMED   37975230
  REMARK    GeneRIF: Regulation of Drp1 and enhancement of mitochondrial
            fission by the deubiquitinating enzyme PSMD14 facilitates the
            proliferation of bladder cancer cells.
REFERENCE   4  (bases 1 to 1567)
  AUTHORS   Jing,T., Xu,X., Wu,C., Wei,D., Yuan,L., Huang,Y., Liu,Y. and
            Wang,B.
  TITLE     POH1 facilitates pancreatic carcinogenesis through MYC-driven
            acinar-to-ductal metaplasia and is a potential therapeutic target
  JOURNAL   Cancer Lett 577, 216444 (2023)
   PUBMED   37844756
  REMARK    GeneRIF: POH1 facilitates pancreatic carcinogenesis through
            MYC-driven acinar-to-ductal metaplasia and is a potential
            therapeutic target.
REFERENCE   5  (bases 1 to 1567)
  AUTHORS   Jia,C., Zhang,X., Qu,T., Wu,X., Li,Y., Zhao,Y., Sun,L. and Wang,Q.
  TITLE     Depletion of PSMD14 suppresses bladder cancer proliferation by
            regulating GPX4
  JOURNAL   PeerJ 11, e14654 (2023)
   PUBMED   36632137
  REMARK    GeneRIF: Depletion of PSMD14 suppresses bladder cancer
            proliferation by regulating GPX4.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1567)
  AUTHORS   Listovsky,T., Oren,Y.S., Yudkovsky,Y., Mahbubani,H.M., Weiss,A.M.,
            Lebendiker,M. and Brandeis,M.
  TITLE     Mammalian Cdh1/Fzr mediates its own degradation
  JOURNAL   EMBO J 23 (7), 1619-1626 (2004)
   PUBMED   15029244
REFERENCE   7  (bases 1 to 1567)
  AUTHORS   Ambroggio,X.I., Rees,D.C. and Deshaies,R.J.
  TITLE     JAMM: a metalloprotease-like zinc site in the proteasome and
            signalosome
  JOURNAL   PLoS Biol 2 (1), E2 (2004)
   PUBMED   14737182
REFERENCE   8  (bases 1 to 1567)
  AUTHORS   Margottin-Goguet,F., Hsu,J.Y., Loktev,A., Hsieh,H.M., Reimann,J.D.
            and Jackson,P.K.
  TITLE     Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin
            ligase activates the anaphase promoting complex to allow
            progression beyond prometaphase
  JOURNAL   Dev Cell 4 (6), 813-826 (2003)
   PUBMED   12791267
REFERENCE   9  (bases 1 to 1567)
  AUTHORS   Geley,S., Kramer,E., Gieffers,C., Gannon,J., Peters,J.M. and
            Hunt,T.
  TITLE     Anaphase-promoting complex/cyclosome-dependent proteolysis of human
            cyclin A starts at the beginning of mitosis and is not subject to
            the spindle assembly checkpoint
  JOURNAL   J Cell Biol 153 (1), 137-148 (2001)
   PUBMED   11285280
REFERENCE   10 (bases 1 to 1567)
  AUTHORS   Spataro,V., Toda,T., Craig,R., Seeger,M., Dubiel,W., Harris,A.L.
            and Norbury,C.
  TITLE     Resistance to diverse drugs and ultraviolet light conferred by
            overexpression of a novel human 26 S proteasome subunit
  JOURNAL   J Biol Chem 272 (48), 30470-30475 (1997)
   PUBMED   9374539
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA133201.1, BC066336.1,
            U86782.1 and BM978668.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005805.5.
            
            Summary: This gene encodes a component of the 26S proteasome. The
            26S proteasome is a large multiprotein complex that catalyzes the
            degradation of ubiquitinated intracellular proteins. The encoded
            protein is a component of the 19S regulatory cap complex of the 26S
            proteasome and mediates substrate deubiquitination. A pseudogene of
            this gene is also located on the long arm of chromosome 2.
            [provided by RefSeq, Feb 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.719900.1,
                                           SRR1660807.135555.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409682.8/ ENSP00000386541.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DA133201.1         151-154
            5-1054              BC066336.1         1-1050
            1055-1250           U86782.1           937-1132
            1251-1567           BM978668.1         18-334              c
FEATURES             Location/Qualifiers
     source          1..1567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.2"
     gene            1..1567
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /note="proteasome 26S subunit, non-ATPase 14"
                     /db_xref="GeneID:10213"
                     /db_xref="HGNC:HGNC:16889"
                     /db_xref="MIM:607173"
     exon            1..180
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /inference="alignment:Splign:2.1.0"
     exon            181..313
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /inference="alignment:Splign:2.1.0"
     exon            314..365
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1250
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /EC_number="3.4.19.-"
                     /note="26S proteasome regulatory subunit rpn11; 26S
                     proteasome-associated PAD1 homolog 1; proteasome (prosome,
                     macropain) 26S subunit, non-ATPase, 14; testis tissue
                     sperm-binding protein Li 69n"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 14"
                     /protein_id="NP_005796.1"
                     /db_xref="CCDS:CCDS46437.1"
                     /db_xref="GeneID:10213"
                     /db_xref="HGNC:HGNC:16889"
                     /db_xref="MIM:607173"
                     /translation="MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKH
                     GRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQT
                     GRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAF
                     RLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLL
                     NLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVG
                     KQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK"
     exon            366..437
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /inference="alignment:Splign:2.1.0"
     exon            438..557
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /inference="alignment:Splign:2.1.0"
     exon            558..628
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /inference="alignment:Splign:2.1.0"
     exon            629..779
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /inference="alignment:Splign:2.1.0"
     exon            780..887
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /inference="alignment:Splign:2.1.0"
     exon            888..962
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1088
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1151
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1567
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1546..1551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /note="hexamer: AATAAA"
     polyA_site      1567
                     /gene="PSMD14"
                     /gene_synonym="PAD1; POH1; RPN11"
                     /note="major polyA site"
ORIGIN      
        1 aagtgcttcg cggcggaggc ccgggcaact cttttgaatg gaatcgggct gattcatcgc
       61 cggtttgcag acagagccgc gtcgggtgtg cgccgctgct gctgttgcct ctgtcttcgc
      121 gtcaccacag aggcaagaca agggtccata tcgcggcatc cggctcccgc ccgtcttcag
      181 gagagaaaga aaaaataaaa tatacttggg gaagttgtac ctgccagaat tagcaagagc
      241 tttctttaag aagacatttg tcaaactcaa caaattgaag gttaacacct taagagttgt
      301 agttactgac cagaaatatg gacagacttc ttagacttgg aggaggtatg cctggactgg
      361 gccaggggcc acctacagat gctcctgcag tggacacagc agaacaagtc tatatctctt
      421 ccctggcact gttaaaaatg ttaaaacatg gccgtgctgg agttccaatg gaagttatgg
      481 gtttgatgct tggagaattt gttgatgatt ataccgtcag agtgattgat gtgtttgcta
      541 tgccacagtc aggaacaggt gtcagtgtgg aggcagttga tccagtgttc caagctaaaa
      601 tgttggatat gttgaagcag acaggaaggc cggagatggt tgttggttgg tatcacagtc
      661 accctggctt tggttgttgg ctttctggtg tggatatcaa cactcagcag agctttgaag
      721 ccttgtcgga gagagctgtg gcagtggttg tggatcccat tcagagtgta aaaggaaagg
      781 ttgttattga tgccttcaga ttgatcaatg ctaatatgat ggtcttagga catgaaccaa
      841 gacaaacaac ttcgaatctg ggtcacttaa acaagccatc tatccaggca ttaattcatg
      901 gactaaacag acattattac tccattacta ttaactatcg gaaaaatgaa ctggaacaga
      961 agatgttgct aaatttgcat aagaagagtt ggatggaagg tttgacactt caggactaca
     1021 gtgaacattg taaacacaat gaatcagtgg taaaagagat gttggaatta gccaagaatt
     1081 acaataaggc tgtagaagaa gaagataaga tgacacctga acagctggca ataaagaatg
     1141 ttggcaagca ggaccccaaa cgtcatttgg aggaacatgt ggatgtactt atgacctcaa
     1201 atattgtcca gtgtttagca gctatgttgg atactgtcgt atttaaataa agcaacgaaa
     1261 aacgctatta atgatgcctt cagtgtatat tcctctgttg ttcctaatgc tcaaaatcaa
     1321 gggacctctg aaggtgtact tggctaaatg taagacatct ggcatcattt gcagcactgt
     1381 aacaccttca gtctcagttg tgcaattact tctgtttctt tagtcagggt ctttgcagat
     1441 tctaaagtta tacatgaata catcaaagtg gacaaatttt gttaagatcc catttaatat
     1501 ttgaaaaaat cagtagcaca aatatatttt gattgtcact tacaaaataa aatacattta
     1561 cagtcta
//
