LOCUS       NM_002816               4356 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens proteasome 26S subunit, non-ATPase 12 (PSMD12),
            transcript variant 1, mRNA.
ACCESSION   NM_002816 XM_942494 XM_946044 XM_946047 XM_946049 XM_946052
            XM_946055 XM_946058
VERSION     NM_002816.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4356)
  AUTHORS   Lv,J., Ma,S., Wang,X., Dang,J. and Ma,F.
  TITLE     PSMD12 promotes non-small cell lung cancer progression through
            activating the Nrf2/TrxR1 pathway
  JOURNAL   Genes Genomics 46 (3), 263-277 (2024)
   PUBMED   38243044
  REMARK    GeneRIF: PSMD12 promotes non-small cell lung cancer progression
            through activating the Nrf2/TrxR1 pathway.
REFERENCE   2  (bases 1 to 4356)
  AUTHORS   Ma,J., Zhou,W., Yuan,Y., Wang,B. and Meng,X.
  TITLE     PSMD12 interacts with CDKN3 and facilitates pancreatic cancer
            progression
  JOURNAL   Cancer Gene Ther 30 (8), 1072-1083 (2023)
   PUBMED   37037907
  REMARK    GeneRIF: PSMD12 interacts with CDKN3 and facilitates pancreatic
            cancer progression.
REFERENCE   3  (bases 1 to 4356)
  AUTHORS   Zhang,H., Li,C., Liao,S., Tu,Y., Sun,S., Yao,F., Li,Z. and Wang,Z.
  TITLE     PSMD12 promotes the activation of the MEK-ERK pathway by
            upregulating KIF15 to promote the malignant progression of liver
            cancer
  JOURNAL   Cancer Biol Ther 23 (1), 1-11 (2022)
   PUBMED   36137220
  REMARK    GeneRIF: PSMD12 promotes the activation of the MEK-ERK pathway by
            upregulating KIF15 to promote the malignant progression of liver
            cancer.
REFERENCE   4  (bases 1 to 4356)
  AUTHORS   Yan,K., Zhang,J., Lee,P.Y., Tao,P., Wang,J., Wang,S., Zhou,Q. and
            Dong,M.
  TITLE     Haploinsufficiency of PSMD12 Causes Proteasome Dysfunction and
            Subclinical Autoinflammation
  JOURNAL   Arthritis Rheumatol 74 (6), 1083-1090 (2022)
   PUBMED   35080150
  REMARK    GeneRIF: Haploinsufficiency of PSMD12 Causes Proteasome Dysfunction
            and Subclinical Autoinflammation.
            Erratum:[Arthritis Rheumatol. 2023 Jul;75(7):1138. doi:
            10.1002/art.42563.. PMID: 37377006]
REFERENCE   5  (bases 1 to 4356)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 4356)
  AUTHORS   Madani,N. and Kabat,D.
  TITLE     An endogenous inhibitor of human immunodeficiency virus in human
            lymphocytes is overcome by the viral Vif protein
  JOURNAL   J Virol 72 (12), 10251-10255 (1998)
   PUBMED   9811770
REFERENCE   7  (bases 1 to 4356)
  AUTHORS   Saito,A., Watanabe,T.K., Shimada,Y., Fujiwara,T., Slaughter,C.A.,
            DeMartino,G.N., Tanahashi,N. and Tanaka,K.
  TITLE     cDNA cloning and functional analysis of p44.5 and p55, two
            regulatory subunits of the 26S proteasome
  JOURNAL   Gene 203 (2), 241-250 (1997)
   PUBMED   9426256
REFERENCE   8  (bases 1 to 4356)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   9  (bases 1 to 4356)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   10 (bases 1 to 4356)
  AUTHORS   Kanayama,H.O., Tamura,T., Ugai,S., Kagawa,S., Tanahashi,N.,
            Yoshimura,T., Tanaka,K. and Ichihara,A.
  TITLE     Demonstration that a human 26S proteolytic complex consists of a
            proteasome and multiple associated protein components and
            hydrolyzes ATP and ubiquitin-ligated proteins by closely linked
            mechanisms
  JOURNAL   Eur J Biochem 206 (2), 567-578 (1992)
   PUBMED   1317798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC366628.1, BC019062.2,
            AC110921.9 and BU616916.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002816.4.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            non-ATPase subunit of the 19S regulator. A pseudogene has been
            identified on chromosome 3. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.13508.1, AK307821.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356126.8/ ENSP00000348442.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DC366628.1         61-79
            20-1769             BC019062.2         1-1750
            1770-3706           AC110921.9         41274-43210         c
            3707-4356           BU616916.1         18-667              c
FEATURES             Location/Qualifiers
     source          1..4356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.2"
     gene            1..4356
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /note="proteasome 26S subunit, non-ATPase 12"
                     /db_xref="GeneID:5718"
                     /db_xref="HGNC:HGNC:9557"
                     /db_xref="MIM:604450"
     exon            1..166
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1429
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /note="isoform 1 is encoded by transcript variant 1; 26S
                     proteasome regulatory subunit p55; 26S proteasome
                     regulatory subunit RPN5; proteasome (prosome, macropain)
                     26S subunit, non-ATPase, 12"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 12
                     isoform 1"
                     /protein_id="NP_002807.1"
                     /db_xref="CCDS:CCDS11669.1"
                     /db_xref="GeneID:5718"
                     /db_xref="HGNC:HGNC:9557"
                     /db_xref="MIM:604450"
                     /translation="MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVI
                     ETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVA
                     KMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVK
                     EAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEEN
                     TEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVIL
                     APFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLE
                     SPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAF
                     LSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEE
                     MIHNLQ"
     exon            167..226
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /inference="alignment:Splign:2.1.0"
     exon            227..355
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /inference="alignment:Splign:2.1.0"
     exon            356..463
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /inference="alignment:Splign:2.1.0"
     exon            464..568
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /inference="alignment:Splign:2.1.0"
     exon            569..718
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /inference="alignment:Splign:2.1.0"
     exon            719..853
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /inference="alignment:Splign:2.1.0"
     exon            854..966
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1141
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1219
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..4356
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1749..1754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /note="hexamer: AATAAA"
     polyA_site      1769
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /note="major polyA site"
     regulatory      4332..4337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /note="hexamer: AATAAA"
     polyA_site      4356
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /note="major polyA site"
ORIGIN      
        1 gtgggtgacg agtggtggcc gaagcagggg gacagcaagg gacgctcagg cggggaccat
       61 ggcggacggc ggctcggagc gggctgacgg gcgcatcgtc aagatggagg tggactacag
      121 cgccacggtg gatcagcgcc tacccgagtg tgcgaagcta gccaaggaag gaagacttca
      181 agaagtcatt gaaacccttc tctctctgga aaagcagact cgtactgctt ccgatatggt
      241 atcgacatcc cgtatcttag ttgcagtagt gaagatgtgc tatgaggcta aagaatggga
      301 tttacttaat gaaaatatta tgcttttgtc caaaaggcgg agtcagttaa aacaagctgt
      361 tgccaaaatg gttcaacagt gctgtactta tgttgaggaa atcacagacc ttcctatcaa
      421 acttcgatta attgatactc tacgaatggt taccgaaggc aagatttatg ttgaaattga
      481 gcgtgcgcga ctgactaaaa cattagcaac tataaaagaa caaaatggtg atgtgaaaga
      541 ggcagcctcc attttacagg agttacaggt ggaaacctac gggtcaatgg aaaagaaaga
      601 gcgagtggaa tttattttgg agcaaatgag gctctgccta gctgtgaagg attacattcg
      661 aacacaaatc atcagcaaga aaattaacac caaatttttc caggaagaaa atacagagaa
      721 attaaagttg aagtactata atttaatgat tcagctggat caacatgagg gatcctattt
      781 gtctatttgt aagcactaca gagcaatata tgatactccc tgtatacagg cagaaagtga
      841 aaaatggcag caggctctga agagtgttgt actctatgtt atcctggctc cttttgacaa
      901 tgaacagtca gatttggttc accgaataag tggtgacaag aagttagaag aaattcccaa
      961 atacaaggat cttttaaagc tttttaccac aatggagttg atgcgttggt ccacacttgt
     1021 tgaggactat ggaatggaat taagaaaagg ttcccttgag agtcctgcaa cggatgtttt
     1081 tggttctaca gaggaaggtg aaaaaaggtg gaaagacttg aagaacagag ttgttgaaca
     1141 taatattaga ataatggcca agtattatac tcggataaca atgaaaagga tggcacagct
     1201 tctggatcta tctgttgatg agtccgaagc ctttctctca aatctagtag ttaacaagac
     1261 catctttgct aaagtagaca gattagcagg aattatcaac ttccagagac ccaaggatcc
     1321 aaataattta ttaaatgact ggtctcagaa actgaactca ttaatgtctc tggttaacaa
     1381 aactacgcat ctcatagcca aagaggagat gatacataat ctacaataag ggtcttagtg
     1441 ctttagaaaa aagttaaaat tggaagtcat taaaaaaaga ctgttataat ggtgtatatg
     1501 ttggggtttt ttttctaagc ttctttgtct taaattttaa aatagtgaat atgtttgaga
     1561 ctccctttga cctttcagtt ccccaagttc attgttaact ttgcatttgc aattggtgca
     1621 aaaatacaga tttctgtcgt ctgaatacac aaaaagttgt gtcataactt acccagatat
     1681 gtttttctat catttgaaac ctttttagct actgtttgtt ttcattcaac taacaaacat
     1741 attccaataa taaaagcagt atatacatat ttcctttcta cagttacctc tgattctcaa
     1801 cattttgtgg ggtagtgatt tggcaagtgt tttttaaata aaacaaatct cattgtaaag
     1861 ctatcagtca tttagtagaa tagaaaagca acatagagca tacaagaaca tttgggatag
     1921 agttgtgatt tgtgaagaat ttgtactttg atattgtggc ggaaagtcta gactgagtgt
     1981 gtatgctggt aaactgtaga cttttttttt tttttttttg agtccggctg gttccaatca
     2041 cagtagcttg attgctttca gccctcatcc tctcacttga tcagttgttc aacagaatca
     2101 gctgacataa ttgacacagt ttattgggtg ttaagtccgc tctataggga tagtgactac
     2161 tttttttttt tttttttttt tgctcttctt cctctcccct ttctttatat gggtttaaat
     2221 ttaacataaa gttgttttta taaggcttat ttgtggcttt aacttgtaag tctgattaca
     2281 tcattattgt tccaaattca ttatctctgt aggaactttt agttccatta tatgaacact
     2341 ggataaccta atttttttta atgctttaaa aaaatggcaa aaagacgtca ggccaccctc
     2401 atagtaagtg gtgtagtatt aaaatatttt cacggaatta aaagtagctt gctgtcaaag
     2461 aaacacctga gatgaattgg tgtgaacgaa ttttgcaagt ttaatttgat ttatttcaga
     2521 gaaaatagaa aaaacaatgt tagaaggtta tttaaaatga tacttaaata aagaaagtgt
     2581 gaggtctact ttaaaaaaat tcaaatgaag agaaaaagaa aaacagcatt ctagaaatgg
     2641 catttctcct aattaatttt ccacttaatg gaagattatc aattgtccta ttttatgatc
     2701 ccaggactga agacagttgt gggatatctg tcatatttat cctgtgagtc attgtgaata
     2761 atgacataca gtactgaagt aatctgattt tattctttgg aaattcaatg cattggtcac
     2821 actaataaca tcaacatctg ctatcactta tctttttaaa actaaccaaa aaaggccggg
     2881 tgcagtggat cccagcactt tgggaggcca aggcgggtgg atcatctaag gtcaggattt
     2941 cgagactagc ctggccaaca tggcaaaacc ctgtctctac taaaaaaaat acaaaaattt
     3001 gccgggcgtg gtggcgtgtg cctgtagtcc cagttacttg ggaggctgag gtgggagaat
     3061 tccttgaagc caggaggcgg aggttgcagt gagccaagat cacaccattg cactccagcc
     3121 tgggtgacag agtgagactc cgtctcaaaa aaaaaaaaac aaaactggaa agttcagaaa
     3181 cagaagttca cactaacaga gtatggtttt aattttcctt tgaatgaaaa ggatagaaga
     3241 taaaattgtg tattgttaac atgtaaataa aattggagct aatttgaaac tagcttctca
     3301 ataacttcat ctttctagag actcattacc tgtgggcttg tcaaacctgg actatttggc
     3361 caaataggtt gctatagaga ttgcaagtgt tcctcctctt tatttttttc atattttttg
     3421 agacggagtt tcactcttgt tgcccaggct ggattgcagt gtcacgatct cggctcactg
     3481 caacctttgc ctcccatatt caagcagttc tcctgcctca acctcccaag tagctgggat
     3541 tataggcgcc tgccaccaca cctagctaat ttttgtgttt ttagtagaga tggtttcatc
     3601 atgttggccg ggctggtctc aaactcctga cctcaggtga tccacccgcc ttggctgccc
     3661 aaagtgctgg gattacaggc atgagccact gcacccaact cctctttcgt ctttctttaa
     3721 cacacactag gctctttgtg tattatgatt cagtgctatt tgtaactgtg tcccagtgac
     3781 caaattgcac tcgactcgat cagctgttca tccatttcgt gttttttcct gtcaaacatt
     3841 aatccagcaa atatatgagg tatttaccaa tttattttct tagtattaca aaataattca
     3901 ttagcataaa gtacaatagt gaaatatttg agttgttcgg aacctcaatt aatcctgttt
     3961 tacatttcag acctaaagct ggcaatcagg agaagaagca ctttgtttta aatgtggaga
     4021 agataacact tgattccatt tcattgtcat tagtgtatta accagcagga gaggtgatga
     4081 gccatttttc aaatgaaata ccttttattt ccatataatt tttttatttt agagttcaat
     4141 agctgtttct atgattatcc tcaatttcca tatgttactg aatctgaaaa acatctttaa
     4201 aattcaaaca gttccatttt ctctcttgta agtgttaaat gtgataaaag tacatatttt
     4261 aaattgtttt cagctcttgg atatagcagc aataaaaaca ctaatttgtg ggtatttaag
     4321 aaaacctgga gaataaactc atactttaaa agatca
//
