LOCUS       NP_002807                456 aa            linear   PRI 28-APR-2025
DEFINITION  26S proteasome non-ATPase regulatory subunit 12 isoform 1 [Homo
            sapiens].
ACCESSION   NP_002807 XP_947587 XP_951137 XP_951140 XP_951142 XP_951145
            XP_951148 XP_951151
VERSION     NP_002807.1
DBSOURCE    REFSEQ: accession NM_002816.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 456)
  AUTHORS   Lv,J., Ma,S., Wang,X., Dang,J. and Ma,F.
  TITLE     PSMD12 promotes non-small cell lung cancer progression through
            activating the Nrf2/TrxR1 pathway
  JOURNAL   Genes Genomics 46 (3), 263-277 (2024)
   PUBMED   38243044
  REMARK    GeneRIF: PSMD12 promotes non-small cell lung cancer progression
            through activating the Nrf2/TrxR1 pathway.
REFERENCE   2  (residues 1 to 456)
  AUTHORS   Ma,J., Zhou,W., Yuan,Y., Wang,B. and Meng,X.
  TITLE     PSMD12 interacts with CDKN3 and facilitates pancreatic cancer
            progression
  JOURNAL   Cancer Gene Ther 30 (8), 1072-1083 (2023)
   PUBMED   37037907
  REMARK    GeneRIF: PSMD12 interacts with CDKN3 and facilitates pancreatic
            cancer progression.
REFERENCE   3  (residues 1 to 456)
  AUTHORS   Zhang,H., Li,C., Liao,S., Tu,Y., Sun,S., Yao,F., Li,Z. and Wang,Z.
  TITLE     PSMD12 promotes the activation of the MEK-ERK pathway by
            upregulating KIF15 to promote the malignant progression of liver
            cancer
  JOURNAL   Cancer Biol Ther 23 (1), 1-11 (2022)
   PUBMED   36137220
  REMARK    GeneRIF: PSMD12 promotes the activation of the MEK-ERK pathway by
            upregulating KIF15 to promote the malignant progression of liver
            cancer.
REFERENCE   4  (residues 1 to 456)
  AUTHORS   Yan,K., Zhang,J., Lee,P.Y., Tao,P., Wang,J., Wang,S., Zhou,Q. and
            Dong,M.
  TITLE     Haploinsufficiency of PSMD12 Causes Proteasome Dysfunction and
            Subclinical Autoinflammation
  JOURNAL   Arthritis Rheumatol 74 (6), 1083-1090 (2022)
   PUBMED   35080150
  REMARK    GeneRIF: Haploinsufficiency of PSMD12 Causes Proteasome Dysfunction
            and Subclinical Autoinflammation.
            Erratum:[Arthritis Rheumatol. 2023 Jul;75(7):1138. doi:
            10.1002/art.42563. PMID: 37377006]
REFERENCE   5  (residues 1 to 456)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (residues 1 to 456)
  AUTHORS   Madani,N. and Kabat,D.
  TITLE     An endogenous inhibitor of human immunodeficiency virus in human
            lymphocytes is overcome by the viral Vif protein
  JOURNAL   J Virol 72 (12), 10251-10255 (1998)
   PUBMED   9811770
REFERENCE   7  (residues 1 to 456)
  AUTHORS   Saito,A., Watanabe,T.K., Shimada,Y., Fujiwara,T., Slaughter,C.A.,
            DeMartino,G.N., Tanahashi,N. and Tanaka,K.
  TITLE     cDNA cloning and functional analysis of p44.5 and p55, two
            regulatory subunits of the 26S proteasome
  JOURNAL   Gene 203 (2), 241-250 (1997)
   PUBMED   9426256
REFERENCE   8  (residues 1 to 456)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   9  (residues 1 to 456)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   10 (residues 1 to 456)
  AUTHORS   Kanayama,H.O., Tamura,T., Ugai,S., Kagawa,S., Tanahashi,N.,
            Yoshimura,T., Tanaka,K. and Ichihara,A.
  TITLE     Demonstration that a human 26S proteolytic complex consists of a
            proteasome and multiple associated protein components and
            hydrolyzes ATP and ubiquitin-ligated proteins by closely linked
            mechanisms
  JOURNAL   Eur J Biochem 206 (2), 567-578 (1992)
   PUBMED   1317798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC366628.1, BC019062.2,
            AC110921.9 and BU616916.1.
            
            On or before Mar 4, 2006 this sequence version replaced
            XP_951137.1, XP_947587.1, XP_951140.1, XP_951142.1, XP_951145.1,
            XP_951148.1, XP_951151.1.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            non-ATPase subunit of the 19S regulator. A pseudogene has been
            identified on chromosome 3. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.13508.1, AK307821.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356126.8/ ENSP00000348442.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.2"
     Protein         1..456
                     /product="26S proteasome non-ATPase regulatory subunit 12
                     isoform 1"
                     /note="26S proteasome regulatory subunit p55; 26S
                     proteasome regulatory subunit RPN5; proteasome (prosome,
                     macropain) 26S subunit, non-ATPase, 12"
                     /calculated_mol_wt=52774
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000269|PubMed:12665801,
                     ECO:0007744|PubMed:19413330; propagated from
                     UniProtKB/Swiss-Prot (O00232.3)"
     Region          14..456
                     /region_name="RPN5"
                     /note="26S proteasome regulatory complex component
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5071"
                     /db_xref="CDD:227403"
     Site            221
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (O00232.3)"
     Site            368
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (O00232.3)"
     CDS             1..456
                     /gene="PSMD12"
                     /gene_synonym="p55; Rpn5; STISS"
                     /coded_by="NM_002816.5:59..1429"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS11669.1"
                     /db_xref="GeneID:5718"
                     /db_xref="HGNC:HGNC:9557"
                     /db_xref="MIM:604450"
ORIGIN      
        1 madggserad grivkmevdy satvdqrlpe caklakegrl qevietllsl ekqtrtasdm
       61 vstsrilvav vkmcyeakew dllnenimll skrrsqlkqa vakmvqqcct yveeitdlpi
      121 klrlidtlrm vtegkiyvei erarltktla tikeqngdvk eaasilqelq vetygsmekk
      181 ervefileqm rlclavkdyi rtqiiskkin tkffqeente klklkyynlm iqldqhegsy
      241 lsickhyrai ydtpciqaes ekwqqalksv vlyvilapfd neqsdlvhri sgdkkleeip
      301 kykdllklft tmelmrwstl vedygmelrk gslespatdv fgsteegekr wkdlknrvve
      361 hnirimakyy tritmkrmaq lldlsvdese aflsnlvvnk tifakvdrla giinfqrpkd
      421 pnnllndwsq klnslmslvn ktthliakee mihnlq
//
