LOCUS       NM_002815               3850 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens proteasome 26S subunit, non-ATPase 11 (PSMD11),
            transcript variant 2, mRNA.
ACCESSION   NM_002815
VERSION     NM_002815.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3850)
  AUTHORS   Deb,W., Rosenfelt,C., Vignard,V., Papendorf,J.J., Moller,S.,
            Wendlandt,M., Studencka-Turski,M., Cogne,B., Besnard,T.,
            Ruffier,L., Toutain,B., Poirier,L., Cuinat,S., Kritzer,A.,
            Crunk,A., diMonda,J., Vengoechea,J., Mercier,S., Kleinendorst,L.,
            van Haelst,M.M., Zuurbier,L., Sulem,T., Katrinardottir,H.,
            Friethriksdottir,R., Sulem,P., Stefansson,K., Jonsdottir,B.,
            Zeidler,S., Sinnema,M., Stegmann,A.P.A., Naveh,N., Skraban,C.M.,
            Gray,C., Murrell,J.R., Isikay,S., Pehlivan,D., Calame,D.G.,
            Posey,J.E., Nizon,M., McWalter,K., Lupski,J.R., Isidor,B.,
            Bolduc,F.V., Bezieau,S., Kruger,E., Kury,S. and Ebstein,F.
  TITLE     PSMD11 loss-of-function variants correlate with a neurobehavioral
            phenotype, obesity, and increased interferon response
  JOURNAL   Am J Hum Genet 111 (7), 1352-1369 (2024)
   PUBMED   38866022
  REMARK    GeneRIF: PSMD11 loss-of-function variants correlate with a
            neurobehavioral phenotype, obesity, and increased interferon
            response.
REFERENCE   2  (bases 1 to 3850)
  AUTHORS   Cal-Kayitmazbatir,S., Francey,L.J., Lee,Y., Liu,A.C. and
            Hogenesch,J.B.
  TITLE     PSMD11 modulates circadian clock function through PER and CRY
            nuclear translocation
  JOURNAL   PLoS One 18 (3), e0283463 (2023)
   PUBMED   36961772
  REMARK    GeneRIF: PSMD11 modulates circadian clock function through PER and
            CRY nuclear translocation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3850)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3850)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3850)
  AUTHORS   Madani,N. and Kabat,D.
  TITLE     An endogenous inhibitor of human immunodeficiency virus in human
            lymphocytes is overcome by the viral Vif protein
  JOURNAL   J Virol 72 (12), 10251-10255 (1998)
   PUBMED   9811770
REFERENCE   6  (bases 1 to 3850)
  AUTHORS   Saito,A., Watanabe,T.K., Shimada,Y., Fujiwara,T., Slaughter,C.A.,
            DeMartino,G.N., Tanahashi,N. and Tanaka,K.
  TITLE     cDNA cloning and functional analysis of p44.5 and p55, two
            regulatory subunits of the 26S proteasome
  JOURNAL   Gene 203 (2), 241-250 (1997)
   PUBMED   9426256
REFERENCE   7  (bases 1 to 3850)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   8  (bases 1 to 3850)
  AUTHORS   Hoffman,L. and Rechsteiner,M.
  TITLE     Molecular cloning and expression of subunit 9 of the 26S proteasome
  JOURNAL   FEBS Lett 404 (2-3), 179-184 (1997)
   PUBMED   9119060
REFERENCE   9  (bases 1 to 3850)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   10 (bases 1 to 3850)
  AUTHORS   Kanayama,H.O., Tamura,T., Ugai,S., Kagawa,S., Tanahashi,N.,
            Yoshimura,T., Tanaka,K. and Ichihara,A.
  TITLE     Demonstration that a human 26S proteolytic complex consists of a
            proteasome and multiple associated protein components and
            hydrolyzes ATP and ubiquitin-ligated proteins by closely linked
            mechanisms
  JOURNAL   Eur J Biochem 206 (2), 567-578 (1992)
   PUBMED   1317798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP246240.1, AB003102.1,
            AC079336.5 and BQ006240.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002815.3.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. This
            gene encodes a member of the proteasome subunit S9 family that
            functions as a non-ATPase subunit of the 19S regulator and is
            phosphorylated by AMP-activated protein kinase. Alternatively
            spliced transcript variants have been observed for this gene.
            [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (2) differs in the 3' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.368227.1,
                                           SRR1660807.171823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261712.8/ ENSP00000261712.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BP246240.1         51-53
            4-1554              AB003102.1         1-1551
            1555-3196           AC079336.5         59049-60690
            3197-3850           BQ006240.1         18-671              c
FEATURES             Location/Qualifiers
     source          1..3850
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..3850
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /note="proteasome 26S subunit, non-ATPase 11"
                     /db_xref="GeneID:5717"
                     /db_xref="HGNC:HGNC:9556"
                     /db_xref="MIM:604449"
     exon            1..105
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1283
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /note="26S proteasome regulatory subunit 9; 26S proteasome
                     regulatory subunit S9; 26S proteasome regulatory subunit
                     p44.5; 26S proteasome regulatory subunit RPN6; proteasome
                     (prosome, macropain) 26S subunit, non-ATPase, 11"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 11"
                     /protein_id="NP_002806.2"
                     /db_xref="CCDS:CCDS11272.1"
                     /db_xref="GeneID:5717"
                     /db_xref="HGNC:HGNC:9556"
                     /db_xref="MIM:604449"
                     /translation="MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQ
                     VKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAA
                     TGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKM
                     DDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIH
                     AAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLA
                     LRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQN
                     LIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIFDEPP
                     VDKTYEAALETIQNMSKVVDSLYNKAKKLT"
     exon            106..207
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     exon            208..332
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     exon            333..404
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     exon            405..462
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     exon            463..657
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     exon            658..802
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     exon            803..863
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     exon            864..926
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1052
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1088
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1140
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1283
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..3850
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1531..1536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /note="hexamer: AATAAA"
     polyA_site      1555
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
     regulatory      2889..2894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /note="hexamer: AATAAT"
     polyA_site      2911
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /note="major polyA site"
     regulatory      3827..3832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
                     /note="hexamer: AATAAA"
     polyA_site      3850
                     /gene="PSMD11"
                     /gene_synonym="p44.5; Rpn6; S9"
ORIGIN      
        1 gtgagagcgg taagatggcg gcggcggcgg tggtggagtt ccagagagcc cagtctctac
       61 tcagcaccga ccgggaggcc tccatcgaca tcctccactc catcgtgaag cgtgacattc
      121 aggaaaacga tgaagaggca gtgcaagtca aagagcagag catcctggaa ctgggatctc
      181 tcctggcaaa gactggacaa gctgcagagc ttggaggact cctgaagtat gtacgaccct
      241 tcttgaattc catcagcaag gctaaagcag ctcgcctggt ccgatctctt cttgatctgt
      301 ttcttgatat ggaagcagct acagggcagg aggtcgagct gtgtttagag tgcatcgaat
      361 gggccaagtc agagaaaaga actttcttac gccaagcttt ggaggcaaga ctggtgtctt
      421 tgtactttga taccaagagg taccaggaag cattgcattt gggttctcag ctgctgcggg
      481 agttgaaaaa gatggacgac aaagctcttt tggtggaagt acagctttta gaaagcaaaa
      541 cataccatgc cctgagcaac ctgccgaaag cccgagctgc cttaacttct gctcgaacca
      601 cagcaaatgc catctactgc ccccctaaat tgcaggccac cttggacatg cagtcgggta
      661 ttatccatgc agcagaagag aaggactgga aaactgcgta ctcatacttc tatgaggcat
      721 ttgagggtta tgactccatc gacagcccca aggccatcac atctctgaag tacatgttgc
      781 tgtgcaaaat catgctcaac accccagaag atgtccaggc tttggtgagc gggaagcttg
      841 cacttcggta tgcagggagg cagacagaag cattaaaatg cgtggctcag gctagcaaga
      901 acagatcact ggcagatttt gaaaaggctc tgacagatta ccgggcagag ctccgggatg
      961 acccaatcat cagcacacac ttggccaagt tgtatgataa cttactagaa cagaatctga
     1021 tccgagtcat tgagcctttt tccagagtac agattgaaca catatctagt ctcatcaaac
     1081 tctccaaggc cgacgtggaa aggaaattat cacagatgat tcttgacaag aaatttcatg
     1141 ggattttgga ccagggggag ggtgtcctga ttattttcga tgaaccccca gtagataaaa
     1201 cttacgaagc tgctctggaa acaattcaga acatgagcaa agtagtggat tccctctaca
     1261 acaaagccaa gaaactgaca tagagttgga tctgtagcgg tcctttggag agtgtgtgtg
     1321 gcgggagagt gaaaccttgg gggaaaatgc taggagattc ttttttcttt ttgttctact
     1381 tttcgctcgg aaagttttta aatcctcatt tggtgcatct gtattccagc caataggtgt
     1441 gccagttttc atgtaatctt tactggccca acttgggagt ggggaaattg cttaaaaaaa
     1501 aagaaaaaga aaaaaaaaaa gattattcta aataaaagga aaaaggctta cactacctaa
     1561 agctgtgctc tctgcctcct gggagagggc cgcaaagcca ggcaccccgc caaccactgg
     1621 gggtcctaat ccacctgctg ggcatcacct ctcctcctcc tcagaattgg gtgtttgctg
     1681 accatcaaaa gcaatgactt tttattctgt ttgtactgaa ccaaaacaaa caactgtgta
     1741 tagactgctg ttttcttttt tatttgaaat gaggcatttt ggtgttcttt cccctaccat
     1801 acggcctgtc tgcccttccc tccccacatt ggctccagca gagtagccga aggtcctgcc
     1861 gccgccgcca ccaccaccac cactgcagca acaacagcag cagcagcagc agcgcctgca
     1921 tagctccact ctgacctgtg aaggaatggg gatgaggcca ggagctagtg tctaccacgg
     1981 ccacacaggg agcagtgtgg gcccttagcc cccaaggggc ctgctatgca tgtggctttt
     2041 tttttttttt taaacacagt aaactagatt agtcgtcagt gttttaattg cccctcttct
     2101 cctctcctgc attcctctcc tctcttcttt cctctctgtc ccttctcttt cccctctcaa
     2161 ccaggagacc atcatgtctc tctgccttcc tcctctcccc tccaggggag tcaggctgtc
     2221 tgtgaaagcc atgagcttct ctccctctcc cactcctcct ctcctacttt cagatggatt
     2281 tattcctttt ttaaacaatg aacatcggaa atgagactgt ggggtgtggt ttctctctct
     2341 cttttttttt taattttctt tgttgggttt ttgagcaacc tcatgtcccc ttcccaggga
     2401 gctttttaat ttacctctta gaactcaagt ggatgggaag tagagcacta tgtgtcagta
     2461 tgctttgttt tctgacacga ttacacagcg aggctttaat gccatttggg taggtgagct
     2521 tctgcacttc tgttgtgctg aactgtattt tcttctctca tctcctcttt gtctttttct
     2581 cttttcctct ccttcctgcc ttcttctgct ggcctccttt tctctttctt taccttcctt
     2641 ggattatcct tccaggtttt cataataaat ttatattttg taaaaggatt ttgttgtacc
     2701 aggttttgca tcctcactga atctgactgg cttttatttt cctctccaaa atcaggtttt
     2761 tgttctcaac atctttcccc atcatgtcta gtcactgttt tggttttggc accatcagta
     2821 tcaaatgtac aaacggttct tgctaaccaa caccaggtat atctgatgtt cagatgagtt
     2881 ccaataaaaa taattttttt ttttttcaaa aggtgtcttt ttcttgagtg ctggagggct
     2941 tccaagcaag tccagacagc tctgtgtggc cccacactag tctagctctc atctggccaa
     3001 agctgttatc tcatttgtgt aatgggagtc cttaaggtaa atttggggtc caaacttgga
     3061 gggctttggg ggcaagaaag ttggtgtgtg agttctgagg ttggaaatga gttcaggtgt
     3121 cttcttccag ggcagcatgg tccagtgagc acatgtaagt ttgggcagta gatcctctga
     3181 gcctactttc tcttctactc agtgaggatg ctgcttcctt ggcaggtgat tgtgatgtga
     3241 agcttagtaa gtcatagacg tgcaggtgtc tggagagtcc tgacatgcag ttgtggtttc
     3301 gtttcctttt ggaatcttca aaggcagcga ttttcatatt gcctcacacc ctggcggggg
     3361 cggggggctc tgggaccact gggggacctg ctaaatcctc ttcagtctga gcagttcagc
     3421 cattgtcagt tttagtattg tgtctctgta tttcacttgc agaaagagct ttgcttctat
     3481 aaaggacttt aaaaagtact ccaaagagat ctagttttgg agtagagggg agatgttttc
     3541 tcaaacttag ggcagtcctg agatgctcag gcagtagccc ttttctcagt tccctttgcg
     3601 ggtcttggtc agatgatgcc ctctagaccc gtgctgtcca atatgtagcc gctagccatg
     3661 tgcagctgtc aggcccttgc aacgtggctg gttcgagctg tgatacactg caagtgtaaa
     3721 cacaaaccag acttcgaagg cttagtatga taacaaaaga aaaggagtgt aaaatatgtc
     3781 aataactttt ttatatatgt gttgaaatat tttgggtatt gggttaaata aaatatatta
     3841 ttaaaattca
//
