LOCUS       NM_002814               1470 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens proteasome 26S subunit, non-ATPase 10 (PSMD10),
            transcript variant 1, mRNA.
ACCESSION   NM_002814
VERSION     NM_002814.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1470)
  AUTHORS   Peng,G., Wang,C., Wang,H., Qu,M., Dong,K., Yu,Y., Jiang,Y., Gan,S.
            and Gao,X.
  TITLE     Gankyrin-mediated interaction between cancer cells and
            tumor-associated macrophages facilitates prostate cancer
            progression and androgen deprivation therapy resistance
  JOURNAL   Oncoimmunology 12 (1), 2173422 (2023)
   PUBMED   36776524
  REMARK    GeneRIF: Gankyrin-mediated interaction between cancer cells and
            tumor-associated macrophages facilitates prostate cancer
            progression and androgen deprivation therapy resistance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1470)
  AUTHORS   Yin,Z., Wang,J., Li,T., Ma,L., Kang,J. and Liu,G.
  TITLE     miR-188-5p and Host MALAT1 Regulate RBE Cell Migration, Invasion,
            and Apoptosis via Up-regulating PSMD10 in Cholangiocarcinoma
  JOURNAL   Appl Biochem Biotechnol 195 (1), 655-671 (2023)
   PUBMED   36121635
  REMARK    GeneRIF: miR-188-5p and Host MALAT1 Regulate RBE Cell Migration,
            Invasion, and Apoptosis via Up-regulating PSMD10 in
            Cholangiocarcinoma.
REFERENCE   3  (bases 1 to 1470)
  AUTHORS   Wang,C., Wang,B., Liang,W., Zhou,C., Lin,W., Meng,Z., Wu,W., Wu,M.,
            Liao,Y., Li,X., Zhao,J. and He,Y.
  TITLE     Hsa-miR-1248 suppressed the proliferation, invasion and migration
            of colorectal cancer cells via inhibiting PSMD10
  JOURNAL   BMC Cancer 22 (1), 922 (2022)
   PUBMED   36028821
  REMARK    GeneRIF: Hsa-miR-1248 suppressed the proliferation, invasion and
            migration of colorectal cancer cells via inhibiting PSMD10.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1470)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1470)
  AUTHORS   Krzywda,S., Brzozowski,A.M., Higashitsuji,H., Fujita,J.,
            Welchman,R., Dawson,S., Mayer,R.J. and Wilkinson,A.J.
  TITLE     The crystal structure of gankyrin, an oncoprotein found in
            complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase
            regulator, and the tumor suppressors Rb and p53
  JOURNAL   J Biol Chem 279 (2), 1541-1545 (2004)
   PUBMED   14573599
  REMARK    GeneRIF: gankyrin interactions with partner proteins are mediated
            by residues situated on its concave surface
REFERENCE   6  (bases 1 to 1470)
  AUTHORS   Madani,N. and Kabat,D.
  TITLE     An endogenous inhibitor of human immunodeficiency virus in human
            lymphocytes is overcome by the viral Vif protein
  JOURNAL   J Virol 72 (12), 10251-10255 (1998)
   PUBMED   9811770
REFERENCE   7  (bases 1 to 1470)
  AUTHORS   Hori,T., Kato,S., Saeki,M., DeMartino,G.N., Slaughter,C.A.,
            Takeuchi,J., Toh-e,A. and Tanaka,K.
  TITLE     cDNA cloning and functional analysis of p28 (Nas6p) and p40.5
            (Nas7p), two novel regulatory subunits of the 26S proteasome
  JOURNAL   Gene 216 (1), 113-122 (1998)
   PUBMED   9714768
REFERENCE   8  (bases 1 to 1470)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   9  (bases 1 to 1470)
  AUTHORS   Sastry,L., Cao,T. and King,C.R.
  TITLE     Multiple Grb2-protein complexes in human cancer cells
  JOURNAL   Int J Cancer 70 (2), 208-213 (1997)
   PUBMED   9009162
REFERENCE   10 (bases 1 to 1470)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D83197.1 and R15438.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002814.3.
            
            Summary: This gene encodes a subunit of the PA700/19S complex,
            which is the regulatory component of the 26S proteasome. The 26S
            proteosome complex is required for ubiquitin-dependent protein
            degradation. This protein is a non-ATPase subunit that may be
            involved in protein-protein interactions. Aberrant expression of
            this gene may paly a role in tumorigenesis. Two transcripts
            encoding different isoforms have been described. Pseudogenes have
            been identified on chromosomes 3 and 20.[provided by RefSeq, Mar
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011960.1, SRR3476690.211019.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161674, SAMN03267750
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217958.8/ ENSP00000217958.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1468              D83197.1           77-1544
            1469-1470           R15438.1           14-15               c
FEATURES             Location/Qualifiers
     source          1..1470
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.3"
     gene            1..1470
                     /gene="PSMD10"
                     /gene_synonym="dJ889N15.2; p28; p28(GANK)"
                     /note="proteasome 26S subunit, non-ATPase 10"
                     /db_xref="GeneID:5716"
                     /db_xref="HGNC:HGNC:9555"
                     /db_xref="MIM:300880"
     exon            1..136
                     /gene="PSMD10"
                     /gene_synonym="dJ889N15.2; p28; p28(GANK)"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..703
                     /gene="PSMD10"
                     /gene_synonym="dJ889N15.2; p28; p28(GANK)"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hepatocellular carcinoma-associated protein p28-II;
                     ankyrin repeat protein; gankyrin; 26S proteasome
                     non-ATPase regulatory subunit 10; 26S proteasome
                     regulatory subunit p28; proteasome (prosome, macropain)
                     26S subunit, non-ATPase, 10"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 10
                     isoform 1"
                     /protein_id="NP_002805.1"
                     /db_xref="CCDS:CCDS14536.1"
                     /db_xref="GeneID:5716"
                     /db_xref="HGNC:HGNC:9555"
                     /db_xref="MIM:300880"
                     /translation="MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTAL
                     HWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV
                     NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY
                     YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGL
                     ILKRMVEG"
     exon            137..235
                     /gene="PSMD10"
                     /gene_synonym="dJ889N15.2; p28; p28(GANK)"
                     /inference="alignment:Splign:2.1.0"
     exon            236..382
                     /gene="PSMD10"
                     /gene_synonym="dJ889N15.2; p28; p28(GANK)"
                     /inference="alignment:Splign:2.1.0"
     exon            383..549
                     /gene="PSMD10"
                     /gene_synonym="dJ889N15.2; p28; p28(GANK)"
                     /inference="alignment:Splign:2.1.0"
     exon            550..1470
                     /gene="PSMD10"
                     /gene_synonym="dJ889N15.2; p28; p28(GANK)"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1318..1323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD10"
                     /gene_synonym="dJ889N15.2; p28; p28(GANK)"
                     /note="hexamer: AATAAA"
     polyA_site      1342
                     /gene="PSMD10"
                     /gene_synonym="dJ889N15.2; p28; p28(GANK)"
                     /note="major polyA site"
     regulatory      1453..1458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD10"
                     /gene_synonym="dJ889N15.2; p28; p28(GANK)"
                     /note="hexamer: AATAAA"
     polyA_site      1470
                     /gene="PSMD10"
                     /gene_synonym="dJ889N15.2; p28; p28(GANK)"
                     /note="major polyA site"
ORIGIN      
        1 aagtagttgc tgggacagcg aaatggaggg gtgtgtgtct aacctaatgg tctgcaacct
       61 ggcctacagc gggaagctgg aagagttgaa ggagagtatt ctggccgata aatccctggc
      121 tactagaact gaccaggaca gcagaactgc attgcactgg gcatgctcag ctggacatac
      181 agaaattgtt gaatttttgt tgcaacttgg agtgccagtg aatgataaag acgatgcagg
      241 ttggtctcct cttcatattg cggcttctgc tggccgggat gagattgtaa aagcccttct
      301 gggaaaaggt gctcaagtga atgctgtcaa tcaaaatggc tgtactccct tacattatgc
      361 agcttcgaaa aacaggcatg agatcgctgt catgttactg gaaggcgggg ctaatccaga
      421 tgctaaggac cattatgagg ctacagcaat gcaccgggca gcagccaagg gtaacttgaa
      481 gatgattcat atccttctgt actacaaagc atccacaaac atccaagaca ctgagggtaa
      541 cactcctcta cacttagcct gtgatgagga gagagtggaa gaagcaaaac tgctggtgtc
      601 ccaaggagca agtatttaca ttgagaataa agaagaaaag acacccctgc aagtggccaa
      661 aggtggcctg ggtttaatac tcaagagaat ggtggaaggt taaacagctt ggatttattc
      721 ttactttgta tgttgtgttg ttgtccccag tgtcctacaa actaatgtat ttgtgcacaa
      781 gacatcatct atgaatgatg aagttttctc accttcaaag tcttataaac atgttgactc
      841 ttgttcctgc tgagttactt gttcgaagct tacagcttgt tttccaggca tcgaataact
      901 gttgagattg ttctactgtt gtcgtatatt cttctatatt gaattctggt taatttggag
      961 taactaattc tgtggctgtt gtgagtcttc agcaccctcc catgtacctt atatccctct
     1021 ctgaaacaga acagctccaa tagcaacaag ctagttgttc tgccagatgt ttctatgtgg
     1081 attctgtaat gttcctccat acagttaaaa catcctaact tgtttttcaa gctcactcag
     1141 gcctacgcca aacgtttctg ttttttttaa ccatgaggtt taatttattt ttgtgatagg
     1201 agggatattt acatatttta gtggaccaca ttttaagttg gatggtgtgc tctaaaatac
     1261 tgaaaaacaa tagcccatat acctatgtat ttgtttttga tgggttgttt actctgaaat
     1321 aaaatgtatg gttttcttaa aaggaagttt taaagtacct attttgtgtc atcctgtatt
     1381 gaaaagaatg tcaagcttgt taaaatgaca tgtaacaaaa atgtattttg atttgtattt
     1441 cagaaactaa aaaataaaat gttgaaagaa
//
