LOCUS       NM_002807               3323 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens proteasome 26S subunit, non-ATPase 1 (PSMD1),
            transcript variant 1, mRNA.
ACCESSION   NM_002807
VERSION     NM_002807.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3323)
  AUTHORS   Tang,D., Zhao,L., Huang,S., Li,W., He,Q. and Wang,A.
  TITLE     Mitochondrial outer membrane protein MTUS1/ATIP1 exerts antitumor
            effects through ROS-induced mitochondrial pyroptosis in head and
            neck squamous cell carcinoma
  JOURNAL   Int J Biol Sci 20 (7), 2576-2591 (2024)
   PUBMED   38725862
  REMARK    GeneRIF: Mitochondrial outer membrane protein MTUS1/ATIP1 exerts
            antitumor effects through ROS-induced mitochondrial pyroptosis in
            head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3323)
  AUTHORS   Kim,M.Y., Park,E.R., Cho,E.H., Park,S.H., Han,C.J., Kim,S.B.,
            Gu,M.B., Shin,H.J. and Lee,K.H.
  TITLE     Depletion of proteasome subunit PSMD1 induces cancer cell death via
            protein ubiquitination and DNA damage, irrespective of p53 status
  JOURNAL   Sci Rep 14 (1), 7997 (2024)
   PUBMED   38580756
  REMARK    GeneRIF: Depletion of proteasome subunit PSMD1 induces cancer cell
            death via protein ubiquitination and DNA damage, irrespective of
            p53 status.
            Erratum:[Sci Rep. 2024 May 3;14(1):10202. doi:
            10.1038/s41598-024-60634-1.. PMID: 38702504]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3323)
  AUTHORS   Park,H.C., Kim,H., Kim,J.Y., Lee,H.Y., Lee,J., Cha,W., Ahn,S.H. and
            Jeong,W.J.
  TITLE     PSMD1 as a prognostic marker and potential target in oropharyngeal
            cancer
  JOURNAL   BMC Cancer 23 (1), 1242 (2023)
   PUBMED   38104103
  REMARK    GeneRIF: PSMD1 as a prognostic marker and potential target in
            oropharyngeal cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3323)
  AUTHORS   Liu,L., Liu,A., Dong,J., Zuo,Z. and Liu,X.
  TITLE     Proteasome 26S subunit, non-ATPase 1 (PSMD1) facilitated the
            progression of lung adenocarcinoma by the de-ubiquitination and
            stability of PTEN-induced kinase 1 (PINK1)
  JOURNAL   Exp Cell Res 413 (2), 113075 (2022)
   PUBMED   35192838
  REMARK    GeneRIF: Proteasome 26S subunit, non-ATPase 1 (PSMD1) facilitated
            the progression of lung adenocarcinoma by the de-ubiquitination and
            stability of PTEN-induced kinase 1 (PINK1).
REFERENCE   5  (bases 1 to 3323)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 3323)
  AUTHORS   Simon,J.H., Gaddis,N.C., Fouchier,R.A. and Malim,M.H.
  TITLE     Evidence for a newly discovered cellular anti-HIV-1 phenotype
  JOURNAL   Nat Med 4 (12), 1397-1400 (1998)
   PUBMED   9846577
REFERENCE   7  (bases 1 to 3323)
  AUTHORS   Madani,N. and Kabat,D.
  TITLE     An endogenous inhibitor of human immunodeficiency virus in human
            lymphocytes is overcome by the viral Vif protein
  JOURNAL   J Virol 72 (12), 10251-10255 (1998)
   PUBMED   9811770
REFERENCE   8  (bases 1 to 3323)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   9  (bases 1 to 3323)
  AUTHORS   Yokota,K., Kagawa,S., Shimizu,Y., Akioka,H., Tsurumi,C., Noda,C.,
            Fujimuro,M., Yokosawa,H., Fujiwara,T., Takahashi,E., Ohba,M.,
            Yamasaki,M., DeMartino,G.N., Slaughter,C.A., Toh-e,A. and Tanaka,K.
  TITLE     CDNA cloning of p112, the largest regulatory subunit of the human
            26s proteasome, and functional analysis of its yeast homologue,
            sen3p
  JOURNAL   Mol Biol Cell 7 (6), 853-870 (1996)
   PUBMED   8816993
REFERENCE   10 (bases 1 to 3323)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA385817.1, BC094720.1,
            AC009407.8 and AA169719.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002807.3.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes the
            largest non-ATPase subunit of the 19S regulator lid, which is
            responsible for substrate recognition and binding. There is
            evidence that this proteasome and its subunits interact with viral
            proteins, including those of coronaviruses. Alternatively spliced
            transcript variants have been found for this gene.[provided by
            RefSeq, Aug 2020].
            
            Transcript Variant: This variant (1) is the longest transcript and
            encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.86949.1,
                                           SRR1660803.13938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000308696.11/ ENSP00000309474.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA385817.1         4-14
            12-3023             BC094720.1         1-3012
            3024-3030           AC009407.8         156343-156349
            3031-3295           AC009407.8         158163-158427
            3296-3323           AA169719.1         4-31                c
FEATURES             Location/Qualifiers
     source          1..3323
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..3323
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /note="proteasome 26S subunit, non-ATPase 1"
                     /db_xref="GeneID:5707"
                     /db_xref="HGNC:HGNC:9554"
                     /db_xref="MIM:617842"
     exon            1..175
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..3021
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /note="isoform 1 is encoded by transcript variant 1; 26S
                     proteasome non-ATPase regulatory subunit 1; 26S proteasome
                     subunit p112; 26S proteasome regulatory subunit S1; 26S
                     proteasome regulatory subunit RPN2; proteasome (prosome,
                     macropain) 26S subunit, non-ATPase, 1"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 1
                     isoform 1"
                     /protein_id="NP_002798.2"
                     /db_xref="CCDS:CCDS2482.1"
                     /db_xref="GeneID:5707"
                     /db_xref="HGNC:HGNC:9554"
                     /db_xref="MIM:617842"
                     /translation="MITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDK
                     IEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIA
                     KCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRL
                     DVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQ
                     CLIFLDDPQAVSDILEKLVKEDNLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIA
                     SVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMA
                     IELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEW
                     LARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQEGGGLYALGLIH
                     ANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVT
                     GEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADAL
                     IESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGF
                     ILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNY
                     VRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDKHDDVMAKFGAILAQGILDAG
                     GHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLKMP
                     KVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAKKKEKEKEKKEEEKMEV
                     DEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLTMPETCRYQPFKPLSIGGIIIL
                     KDTSEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD"
     exon            176..219
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            220..293
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..463
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..669
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..813
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1040
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1101
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1230
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1319
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1398
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1572
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1684
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1881
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1977
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2042
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2157
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2274
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2377
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2547
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2640
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2727
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2874
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3030
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3323
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3231..3236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /note="hexamer: AATATA"
     polyA_site      3256
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /note="major polyA site"
     regulatory      3282..3287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
                     /note="hexamer: AATAAA"
     polyA_site      3323
                     /gene="PSMD1"
                     /gene_synonym="P112; Rpn2; S1"
ORIGIN      
        1 gtcctggcga gaagcgagcc ggcggcctga ggaggcgact gactgagcag cgcacccggg
       61 gagcaaggag gcgcggtgaa ctgagcggcc cctgagctga cagatacact gcgcagctgg
      121 aacggcgagc gagccgacgg gcgagtgagg ggcgcagcca tgatcacctc ggccgctgga
      181 attatttctc ttctggatga agatgaacca cagcttaagg aatttgcact acacaaattg
      241 aatgcagttg ttaatgactt ctgggcagaa atttccgagt ccgtagacaa aatagaggtt
      301 ttatacgaag atgaaggttt ccggagtcgg cagtttgcag ccttagtggc atctaaagta
      361 ttttatcacc tgggggcttt tgaggagtct ctgaattatg ctcttggagc aggggacctc
      421 ttcaatgtca atgataactc tgaatatgtg gaaactatta tagcaaaatg cattgatcac
      481 tacaccaaac aatgtgtgga aaatgcagat ttgcctgaag gagaaaaaaa accaattgac
      541 cagagattgg aaggcatcgt aaataaaatg ttccagcgat gtctagatga tcacaagtat
      601 aaacaggcta ttggcattgc tctggagaca cgaagactgg acgtctttga aaagaccata
      661 ctggagtcga atgatgtccc aggaatgtta gcttatagcc ttaagctctg catgtcttta
      721 atgcagaata aacagtttcg gaataaagta ctaagagttc tagttaaaat ctacatgaac
      781 ttggagaaac ctgatttcat caatgtttgt cagtgcttaa ttttcttaga tgatcctcag
      841 gctgtgagtg atatcttaga gaaactggta aaggaagaca acctcctgat ggcatatcag
      901 atttgttttg atttgtatga aagtgctagc cagcagtttt tgtcatctgt aatccagaat
      961 cttcgaactg ttggcacccc tattgcttct gtgcctggat ccactaatac gggtactgtt
     1021 ccgggatcag agaaagacag tgactcgatg gaaacagaag aaaagacaag cagtgcattt
     1081 gtaggaaaga caccagaagc cagtccagag cctaaggacc agactttgaa aatgattaaa
     1141 attttaagtg gtgaaatggc tattgagtta catctgcagt tcttaatacg aaacaataat
     1201 acagacctca tgattctaaa aaacacaaag gatgcagtac ggaattctgt atgtcatact
     1261 gcaaccgtta tagcaaactc ttttatgcac tgtgggacaa ccagtgacca gtttcttaga
     1321 gataatttgg aatggttagc cagagccact aactgggcaa aatttactgc tacagccagt
     1381 ttgggtgtaa ttcataaggg tcatgaaaaa gaagcattac agttaatggc aacatacctt
     1441 cccaaggata cttctccagg atcagcctat caggaaggtg gaggtctcta tgcactaggt
     1501 cttattcatg ccaatcatgg tggtgatata attgactatc tgcttaatca gcttaagaac
     1561 gccagcaatg atatcgttag acacggtggc agtctgggcc ttggtttggc agccatggga
     1621 actgcacgtc aagatgttta tgatttgcta aaaacaaacc tttatcagga tgatgcagta
     1681 acaggggaag cagctggcct ggccctaggt ttggttatgt tgggctctaa aaatgctcag
     1741 gctattgagg acatggttgg ttatgcacaa gaaactcaac atgagaagat tctgcgtggt
     1801 cttgcagttg gcatagcttt agtaatgtat gggaggatgg aagaggctga tgctctcatt
     1861 gaatctctct gtcgtgacaa ggacccaatt cttcgaaggt ctggaatgta tactgtagcc
     1921 atggcttatt gtggctctgg taacaacaaa gcaattcgac gcctgctaca tgttgctgta
     1981 agtgatgtta atgatgatgt caggagggca gcagtagaat cacttgggtt cattctattc
     2041 agaacccctg aacagtgccc aagtgttgtc tctttgttgt cagagagtta caaccctcat
     2101 gtgcgctacg gagctgcaat ggccttgggg atatgctgtg ctggtacagg aaacaaggaa
     2161 gccattaatt tgctagaacc aatgacaaac gaccccgtga actacgtgag gcaaggggca
     2221 ctcatagctt cagctctcat catgatccag cagactgaaa tcacttgtcc aaaggtgaat
     2281 cagttcagac agctgtattc caaagtcatc aatgataagc atgatgatgt catggccaag
     2341 tttggcgcta ttctggccca gggcatactg gatgcaggtg gtcataatgt cacaatctcc
     2401 ttgcagtcca ggactgggca tactcatatg ccttctgtgg ttggcgtcct tgtatttacc
     2461 cagttttggt tctggtttcc tctttcacac ttcctgtcat tggcttatac ccctacctgt
     2521 gtcattggcc ttaacaagga cttaaagatg ccgaaagttc agtataaatc gaactgtaaa
     2581 ccatccacat ttgcatatcc tgcccctctg gaagtaccaa aagaaaaaga aaaggaaaag
     2641 gtttctactg ctgtattatc tataactgcc aaggctaaaa agaaggaaaa agaaaaggaa
     2701 aaaaaggagg aggagaaaat ggaagtggat gaggcagaga aaaaggagga aaaagagaag
     2761 aaaaaagaac ctgagccaaa cttccagtta ttggataacc cagcccgagt tatgcctgcc
     2821 cagcttaagg tcctaaccat gccggagacc tgtagatacc agcctttcaa accactctct
     2881 attggaggca tcatcattct gaaggatacc agtgaagaca ttgaggagct ggtggaacct
     2941 gtggcagcac atggcccaaa aatcgaggag gaggaacaag agccagaacc cccagaacca
     3001 tttgagtata ttgatgatta agggccagag gatctcactt gcttatctga agaagattgt
     3061 ccaggctcat attgggaatg cttatgagga aattcatgcc gagacctgct attcaatgca
     3121 tgtatcgttg cctctgcact gacctgaaga accctgtctc caagtctttg gttgaagaga
     3181 agatatatga ctgttgagtg tgctctttca cagaacttgg ttttcaaata aatataagat
     3241 ctccagatgg acaagacatt tgtttttcag cctgggtttt taataaatgt atctaatcct
     3301 ccccacacca tgaaatgcct aaa
//
