LOCUS       NM_002806               2163 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens proteasome 26S subunit, ATPase 6 (PSMC6), transcript
            variant 1, mRNA.
ACCESSION   NM_002806
VERSION     NM_002806.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2163)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2163)
  AUTHORS   Zhang,J.Y., Shi,K.Z., Liao,X.Y., Li,S.J., Bao,D., Qian,Y. and
            Li,D.J.
  TITLE     The Silence of PSMC6 Inhibits Cell Growth and Metastasis in Lung
            Adenocarcinoma
  JOURNAL   Biomed Res Int 2021, 9922185 (2021)
   PUBMED   34239933
  REMARK    GeneRIF: The Silence of PSMC6 Inhibits Cell Growth and Metastasis
            in Lung Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2163)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2163)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2163)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2163)
  AUTHORS   Wang,X., Chen,C.F., Baker,P.R., Chen,P.L., Kaiser,P. and Huang,L.
  TITLE     Mass spectrometric characterization of the affinity-purified human
            26S proteasome complex
  JOURNAL   Biochemistry 46 (11), 3553-3565 (2007)
   PUBMED   17323924
REFERENCE   7  (bases 1 to 2163)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   8  (bases 1 to 2163)
  AUTHORS   Fujiwara,T., Watanabe,T.K., Tanaka,K., Slaughter,C.A. and
            DeMartino,G.N.
  TITLE     cDNA cloning of p42, a shared subunit of two proteasome regulatory
            proteins, reveals a novel member of the AAA protein family
  JOURNAL   FEBS Lett 387 (2-3), 184-188 (1996)
   PUBMED   8674546
REFERENCE   9  (bases 1 to 2163)
  AUTHORS   DeMartino,G.N., Proske,R.J., Moomaw,C.R., Strong,A.A., Song,X.,
            Hisamatsu,H., Tanaka,K. and Slaughter,C.A.
  TITLE     Identification, purification, and characterization of a
            PA700-dependent activator of the proteasome
  JOURNAL   J Biol Chem 271 (6), 3112-3118 (1996)
   PUBMED   8621709
REFERENCE   10 (bases 1 to 2163)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005390.1, BP384173.1 and
            AL133453.3.
            
            On Nov 22, 2018 this sequence version replaced NM_002806.4.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway.  An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes one of
            the ATPase subunits, a member of the triple-A family of ATPases
            which have a chaperone-like activity. Pseudogenes have been
            identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005390.1, SRR1660809.118772.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000445930.7/ ENSP00000401802.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1273              BC005390.1         1-1273
            1274-1571           BP384173.1         198-495
            1572-2163           AL133453.3         191151-191742
FEATURES             Location/Qualifiers
     source          1..2163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..2163
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /note="proteasome 26S subunit, ATPase 6"
                     /db_xref="GeneID:5706"
                     /db_xref="HGNC:HGNC:9553"
                     /db_xref="MIM:602708"
     exon            1..105
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1190
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proteasome subunit p42; 26S proteasome regulatory subunit
                     10B; 26S proteasome AAA-ATPase subunit RPT4; proteasome
                     (prosome, macropain) 26S subunit, ATPase, 6"
                     /codon_start=1
                     /product="26S proteasome regulatory subunit 10B isoform 1"
                     /protein_id="NP_002797.4"
                     /db_xref="CCDS:CCDS9710.3"
                     /db_xref="GeneID:5706"
                     /db_xref="HGNC:HGNC:9553"
                     /db_xref="MIM:602708"
                     /translation="MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSE
                     NDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDM
                     TTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQ
                     RVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREM
                     FNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMI
                     MATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKL
                     SDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV"
     exon            106..185
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     exon            186..225
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     exon            226..278
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     exon            279..346
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     exon            347..461
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     exon            462..549
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..611
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..735
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     exon            736..797
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     exon            798..918
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..999
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1071
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..2163
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1537..1542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /note="hexamer: AATAAA"
     polyA_site      1567
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /note="major polyA site"
     regulatory      1717..1722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /note="hexamer: AATAAA"
     polyA_site      1739
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /note="hexamer: AATAAA"
     polyA_site      2163
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
ORIGIN      
        1 atgagagacg gcttctcatc atggcggacc ctagagataa ggcgcttcag gactaccgca
       61 agaagttgct tgaacacaag gagatcgacg gccgtcttaa ggagttaagg gaacaattaa
      121 aagaacttac caagcagtat gaaaagtctg aaaatgatct gaaggcccta cagagtgttg
      181 ggcagatcgt gggtgaagtg cttaaacagt taactgaaga aaaattcatt gttaaagcta
      241 ccaatggacc aagatatgtt gtgggttgtc gtcgacagct tgacaaaagt aagctgaagc
      301 caggaacaag agttgctttg gatatgacta cactaactat catgagatat ttgccgagag
      361 aggtggatcc actggtttat aacatgtctc atgaggaccc tgggaatgtt tcttattctg
      421 agattggagg gctatcagaa cagatccggg aattaagaga ggtgatagaa ttacctctta
      481 caaacccaga gttatttcag cgtgtaggaa taatacctcc aaaaggctgt ttgttatatg
      541 gaccaccagg tacgggaaaa acactcttgg cacgagccgt tgctagccag ctggactgca
      601 atttcttaaa ggttgtatct agttctattg tagacaagta cattggtgaa agtgctcgtt
      661 tgatcagaga aatgtttaat tatgctagag atcatcaacc atgcatcatt tttatggatg
      721 aaatagatgc tattggtggt cgtcggtttt ctgagggtac ttcagctgac agagagattc
      781 agagaacgtt aatggagtta ctgaatcaaa tggatggatt tgatactctg catagagtta
      841 aaatgatcat ggctacaaac agaccagata cactggatcc tgctttgctg cgtccaggaa
      901 gattagatag aaaaatacat attgatttgc caaatgaaca agcaagatta gacatactga
      961 aaatccatgc aggtcccatt acaaagcatg gtgaaataga ttatgaagca attgtgaagc
     1021 tttcggatgg ctttaatgga gcagatctga gaaatgtttg tactgaagca ggtatgttcg
     1081 caattcgtgc tgatcatgat tttgtagtac aggaagactt catgaaagca gtcagaaaag
     1141 tggctgattc taagaagctg gagtctaaat tggactacaa acctgtgtaa tttactgtaa
     1201 gatttttgat ggctgcatga cagatgttgg cttattgtaa aaataaagtt aaagaaaata
     1261 atgtatgtat tggtaatgat gtcattaaaa gtatatgaat aaaaatatga gtaacatcat
     1321 aaaaattagt aattcaactt ttaagataca gaagaaattt gtatgtttgt taaagttgca
     1381 tttattgcag caagttacaa agggaaagtg ttgaagcttt tcatatttgc tgcgtgagca
     1441 ttttgtaaaa tattgaaagt ggtttgagat agtggtataa gaaagcattt cttatgactt
     1501 attttgtatc atttgttttc ctcatctaaa aagttgaata aaatctgttt gattcagttc
     1561 tcctacatat atattcttgt cttttctgag tatatttact gtggtccttt aggttcttta
     1621 gcaagtaaac tatttgataa cccagatgga ttgtggattt ttgaatatta ttttaaaata
     1681 gtacacatac ttaatgttca taagatcatc ttcttaaata aaacatggat gtgtgggtat
     1741 gtctgtactc ctcctttcag aaagtgttta catattcttc atctactgtg attaagctca
     1801 ttgttggtta attgaaaata tacatgcaca tccataactt tttaaagagt atgattcaac
     1861 gtaatatttg ctaatatgtg actgggtttt cttggtttat gtaagacgat aggtccctgt
     1921 tgaggatgtg gaggtctgga ccctcttcca ggaaaaattc taacatacaa ttttgcgtat
     1981 actataattt caggaaattt attgtttccc aagctcatcc aaggactctt taggtatgta
     2041 tggatacctg gctaagagtg tatgatgtag gggatgtagg agtgtcagaa atgttcaaaa
     2101 catgatttct gttacctata catgattctt atatcatctg gcaataaaag ctataacaaa
     2161 gta
//
