LOCUS       NM_002805               1331 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens proteasome 26S subunit, ATPase 5 (PSMC5), transcript
            variant 1, mRNA.
ACCESSION   NM_002805
VERSION     NM_002805.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1331)
  AUTHORS   Lee,C.Y., Hubrich,D., Varga,J.K., Schafer,C., Welzel,M.,
            Schumbera,E., Djokic,M., Strom,J.M., Schonfeld,J., Geist,J.L.,
            Polat,F., Gibson,T.J., Keller Valsecchi,C.I., Kumar,M.,
            Schueler-Furman,O. and Luck,K.
  TITLE     Systematic discovery of protein interaction interfaces using
            AlphaFold and experimental validation
  JOURNAL   Mol Syst Biol 20 (2), 75-97 (2024)
   PUBMED   38225382
REFERENCE   2  (bases 1 to 1331)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1331)
  AUTHORS   Zavodszky,E., Peak-Chew,S.Y., Juszkiewicz,S., Narvaez,A.J. and
            Hegde,R.S.
  TITLE     Identification of a quality-control factor that monitors failures
            during proteasome assembly
  JOURNAL   Science 373 (6558), 998-1004 (2021)
   PUBMED   34446601
  REMARK    GeneRIF: Identification of a quality-control factor that monitors
            failures during proteasome assembly.
REFERENCE   4  (bases 1 to 1331)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1331)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1331)
  AUTHORS   Akiyama,K., Yokota,K., Kagawa,S., Shimbara,N., DeMartino,G.N.,
            Slaughter,C.A., Noda,C. and Tanaka,K.
  TITLE     cDNA cloning of a new putative ATPase subunit p45 of the human 26S
            proteasome, a homolog of yeast transcriptional factor Sug1p
  JOURNAL   FEBS Lett 363 (1-2), 151-156 (1995)
   PUBMED   7729537
REFERENCE   7  (bases 1 to 1331)
  AUTHORS   Lee,J.W., Ryan,F., Swaffield,J.C., Johnston,S.A. and Moore,D.D.
  TITLE     Interaction of thyroid-hormone receptor with a conserved
            transcriptional mediator
  JOURNAL   Nature 374 (6517), 91-94 (1995)
   PUBMED   7870181
REFERENCE   8  (bases 1 to 1331)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
REFERENCE   9  (bases 1 to 1331)
  AUTHORS   Dubiel,W., Ferrell,K., Pratt,G. and Rechsteiner,M.
  TITLE     Subunit 4 of the 26 S protease is a member of a novel eukaryotic
            ATPase family
  JOURNAL   J Biol Chem 267 (32), 22699-22702 (1992)
   PUBMED   1429620
REFERENCE   10 (bases 1 to 1331)
  AUTHORS   Nelbock,P., Dillon,P.J., Perkins,A. and Rosen,C.A.
  TITLE     A cDNA for a protein that interacts with the human immunodeficiency
            virus Tat transactivator
  JOURNAL   Science 248 (4963), 1650-1653 (1990)
   PUBMED   2194290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP209525.1 and BC001932.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002805.5.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes one of
            the ATPase subunits, a member of the triple-A family of ATPases
            which have a chaperone-like activity. In addition to participation
            in proteasome functions, this subunit may participate in
            transcriptional regulation since it has been shown to interact with
            the thyroid hormone receptor and retinoid X receptor-alpha. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.64386.1,
                                           SRR3476690.144098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310144.11/ ENSP00000310572.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BP209525.1         22-49
            29-1331             BC001932.1         1-1303
FEATURES             Location/Qualifiers
     source          1..1331
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..1331
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /note="proteasome 26S subunit, ATPase 5"
                     /db_xref="GeneID:5705"
                     /db_xref="HGNC:HGNC:9552"
                     /db_xref="MIM:601681"
     exon            1..84
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1281
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thyroid receptor interactor 1; proteasome subunit p45;
                     MSUG1 protein; Tat-binding protein homolog 10; proteasome
                     26S ATPase subunit 5; 26S protease regulatory subunit 8;
                     thyroid hormone receptor-interacting protein 1; 26S
                     proteasome AAA-ATPase subunit RPT6; proteasome (prosome,
                     macropain) 26S subunit, ATPase, 5; testicular tissue
                     protein Li 149; 26S proteasome regulatory subunit 8"
                     /codon_start=1
                     /product="26S proteasome regulatory subunit 8 isoform 1"
                     /protein_id="NP_002796.4"
                     /db_xref="CCDS:CCDS11645.1"
                     /db_xref="GeneID:5705"
                     /db_xref="HGNC:HGNC:9552"
                     /db_xref="MIM:601681"
                     /translation="MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRR
                     LQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKN
                     IDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKE
                     IKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSE
                     LVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLEL
                     LNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSR
                     KMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQ
                     KDSEKNMSIKKLWK"
     exon            85..156
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            157..226
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..324
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..381
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..612
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..739
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            740..930
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1029
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1140
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1227
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1331
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1309..1314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /note="hexamer: AATAAA"
     polyA_site      1331
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; RPT6; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /note="major polyA site"
ORIGIN      
        1 gcttccgcgc ttgcgcgcca agacggctcg gatgccggcg gtctctgctg aagagagaag
       61 atggcgcttg acggaccaga gcagatggag ctggaggagg ggaaggcagg cagcggactc
      121 cgccaatatt atctgtccaa gattgaagaa ctccagctga ttgtgaatga taagagccaa
      181 aacctccgga ggctgcaggc acagaggaac gaactaaatg ctaaagttcg cctattgcgg
      241 gaggagctac agctgctgca ggagcagggc tcctatgtgg gggaagtagt ccgggccatg
      301 gataagaaga aagtgttggt caaggtacat cctgaaggta aatttgttgt agacgtggac
      361 aaaaacattg acatcaatga tgtgacaccc aattgccggg tggctctaag gaatgacagc
      421 tacactctgc acaagatcct gcccaacaag gtagacccat tagtgtcact gatgatggtg
      481 gagaaagtac cagattcaac ttatgagatg attggtggac tggacaaaca gatcaaggag
      541 atcaaagaag tgatcgagct gcctgttaag catcctgagc tcttcgaagc actgggcatt
      601 gctcagccca agggagtgct gctgtatgga cctccaggca ctgggaagac actgttggcc
      661 cgggctgtgg ctcatcatac ggactgtacc tttattcgtg tctctggctc tgaactggta
      721 cagaaattca taggggaagg ggcaagaatg gtgagggagc tgtttgtcat ggcacgggaa
      781 catgctccat ctatcatctt catggacgaa atcgactcca tcggctcctc gcggctggag
      841 gggggttctg gaggggacag tgaagtgcag cgcacgatgc tggagttgct caaccagctc
      901 gacggctttg aggccaccaa gaacatcaag gttatcatgg ctactaatag gattgatatc
      961 ctggactcgg cactgcttcg cccagggcgc attgacagaa aaattgaatt cccacccccc
     1021 aatgaggagg cccggctgga cattttgaag attcattctc ggaagatgaa cctgacccgg
     1081 gggatcaacc tgagaaaaat tgctgagctc atgccaggag catcaggggc tgaagtgaag
     1141 ggcgtgtgca cagaagctgg catgtatgcc ctgcgagaac ggcgagtcca tgtcactcag
     1201 gaggactttg agatggcagt agccaaggtc atgcagaagg acagtgagaa aaacatgtcc
     1261 atcaagaaat tatggaagtg agtggacagc ctttgtgtgt atctctccaa taaagctctg
     1321 tgggccaagt c
//
