LOCUS       NM_153001               1661 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens proteasome 26S subunit, ATPase 4 (PSMC4), transcript
            variant 2, mRNA.
ACCESSION   NM_153001
VERSION     NM_153001.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1661)
  AUTHORS   Liu,K., Zhang,S., Gong,Y., Zhu,P., Shen,W. and Zhang,Q.
  TITLE     PSMC4 promotes prostate carcinoma progression by regulating the
            CBX3-EGFR-PI3K-AKT-mTOR pathway
  JOURNAL   J Cell Mol Med 27 (16), 2437-2447 (2023)
   PUBMED   37436074
  REMARK    GeneRIF: PSMC4 promotes prostate carcinoma progression by
            regulating the CBX3-EGFR-PI3K-AKT-mTOR pathway.
REFERENCE   2  (bases 1 to 1661)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1661)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1661)
  AUTHORS   Marx,F.P., Soehn,A.S., Berg,D., Melle,C., Schiesling,C., Lang,M.,
            Kautzmann,S., Strauss,K.M., Franck,T., Engelender,S., Pahnke,J.,
            Dawson,S., von Eggeling,F., Schulz,J.B., Riess,O. and Kruger,R.
  TITLE     The proteasomal subunit S6 ATPase is a novel synphilin-1
            interacting protein--implications for Parkinson's disease
  JOURNAL   FASEB J 21 (8), 1759-1767 (2007)
   PUBMED   17327361
  REMARK    GeneRIF: a novel specific interaction of synphilin-1 with the
            regulatory proteasomal protein S6 ATPase (tbp7) in aggresome-like
            intracytoplasmic inclusions
REFERENCE   5  (bases 1 to 1661)
  AUTHORS   Tanahashi,N., Suzuki,M., Fujiwara,T., Takahashi,E., Shimbara,N.,
            Chung,C.H. and Tanaka,K.
  TITLE     Chromosomal localization and immunological analysis of a family of
            human 26S proteasomal ATPases
  JOURNAL   Biochem Biophys Res Commun 243 (1), 229-232 (1998)
   PUBMED   9473509
REFERENCE   6  (bases 1 to 1661)
  AUTHORS   Matoba,R., Okubo,K., Hori,N., Fukushima,A. and Matsubara,K.
  TITLE     The addition of 5'-coding information to a 3'-directed cDNA library
            improves analysis of gene expression
  JOURNAL   Gene 146 (2), 199-207 (1994)
   PUBMED   8076819
REFERENCE   7  (bases 1 to 1661)
  AUTHORS   Dubiel,W., Ferrell,K. and Rechsteiner,M.
  TITLE     Tat-binding protein 7 is a subunit of the 26S protease
  JOURNAL   Biol Chem Hoppe Seyler 375 (4), 237-240 (1994)
   PUBMED   8060531
REFERENCE   8  (bases 1 to 1661)
  AUTHORS   Shaw,D.R. and Ennis,H.L.
  TITLE     Molecular cloning and developmental regulation of Dictyostelium
            discoideum homologues of the human and yeast HIV1 Tat-binding
            protein
  JOURNAL   Biochem Biophys Res Commun 193 (3), 1291-1296 (1993)
   PUBMED   8323548
REFERENCE   9  (bases 1 to 1661)
  AUTHORS   Ohana,B., Moore,P.A., Ruben,S.M., Southgate,C.D., Green,M.R. and
            Rosen,C.A.
  TITLE     The type 1 human immunodeficiency virus Tat binding protein is a
            transcriptional activator belonging to an additional family of
            evolutionarily conserved genes
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 138-142 (1993)
   PUBMED   8419915
REFERENCE   10 (bases 1 to 1661)
  AUTHORS   Nelbock,P., Dillon,P.J., Perkins,A. and Rosen,C.A.
  TITLE     A cDNA for a protein that interacts with the human immunodeficiency
            virus Tat transactivator
  JOURNAL   Science 248 (4963), 1650-1653 (1990)
   PUBMED   2194290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI828251.1, BC010396.1 and
            AC007842.1.
            
            On Aug 13, 2020 this sequence version replaced NM_153001.2.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. This
            gene encodes a member of the triple-A family of ATPases that is a
            component of the 19S regulatory subunit and plays a role in 26S
            proteasome assembly. The encoded protein interacts with gankyrin, a
            liver oncoprotein, and may also play a role in Parkinson's disease
            through interactions with synphilin-1. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' coding region, but maintains the reading frame, compared
            to variant 1. The encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010396.1, SRR14038191.2542673.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BI828251.1         161-165
            6-1335              BC010396.1         5-1334
            1336-1661           AC007842.1         99681-100006
FEATURES             Location/Qualifiers
     source          1..1661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1661
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /note="proteasome 26S subunit, ATPase 4"
                     /db_xref="GeneID:5704"
                     /db_xref="HGNC:HGNC:9551"
                     /db_xref="MIM:602707"
     exon            1..74
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1202
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protease 26S subunit 6; Tat-binding protein 7; 26S
                     protease regulatory subunit 6B; MB67-interacting protein;
                     26S proteasome AAA-ATPase subunit RPT3; proteasome
                     (prosome, macropain) 26S subunit, ATPase, 4; 26S
                     proteasome regulatory subunit 6B"
                     /codon_start=1
                     /product="26S proteasome regulatory subunit 6B isoform 2"
                     /protein_id="NP_694546.1"
                     /db_xref="CCDS:CCDS46076.1"
                     /db_xref="GeneID:5704"
                     /db_xref="HGNC:HGNC:9551"
                     /db_xref="MIM:602707"
                     /translation="MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRY
                     KEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALH
                     KHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELY
                     KQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRD
                     VFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKV
                     IMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVA
                     RPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK"
     exon            75..173
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            174..267
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            268..414
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            415..524
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            525..618
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            619..786
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            787..863
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1032
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1088
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1661
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /note="hexamer: AATAAA"
     regulatory      1319..1324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /note="hexamer: AATAGA"
     polyA_site      1338
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /note="major polyA site"
     polyA_site      1343
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
ORIGIN      
        1 agatcatccc aggccacaca gaggccggct tggtcactat ggaggagata ggcatcttgg
       61 tggagaaggc tcaggatgag atcccagcac tgtccgtgtc ccggccccag accggcctgt
      121 ccttcctggg ccctgagcct gaggacctgg aggacctgta cagccgctac aaggaggagg
      181 tgaagcgaat ccaaagcatc ccgctggtca tcggacaatt tctggaggct gtggatcaga
      241 atacagccat cgtgggctct accacaggct ccaactatta tgtgcgcatc ctgagcacca
      301 tcgatcggga gctgctcaag cccaacgcct cagtggccct ccacaagcac agcaatgcac
      361 tggtggacgt gctgcccccc gaagccgaca gcagcatcat gatgctcacc tcagaccaga
      421 agccagatgt gatgtacgcg gacatcggag gcatggacat ccagaagcag gaggtgcggg
      481 aggccgtgga gctcccgctc acgcatttcg agctctacaa gcagatcggc atcgatcccc
      541 cccgaggcgt cctcatgtat ggcccacctg gctgtgggaa gaccatgttg gcaaaggcgg
      601 tggcacatca cacaacagct gcattcatcc gggtcgtggg ctcggagttt gtacagaagt
      661 atctgggtga gggcccccgc atggtccggg atgtgttccg cctggccaag gagaatgcac
      721 ctgccatcat cttcatagac gagattgatg ccatcgccac caagagattc gatgctcaga
      781 caggggccga cagggaggtt cagaggatcc tgctggagct gctgaatcag atggatggat
      841 ttgatcagaa tgtcaatgtc aaggtaatca tggccacaaa cagagcagac accctggatc
      901 cggccctgct acggccagga cggctggacc gtaaaattga atttccactt cctgaccgcc
      961 gccagaagag attgattttc tccactatca ctagcaagat gaacctctct gaggaggttg
     1021 acttggaaga ctatgtggcc cggccagata agatttcagg agctgatatt aactccatct
     1081 gtcaggagag tggaatgttg gctgtccgtg aaaaccgcta cattgtcctg gccaaggact
     1141 tcgagaaagc atacaagact gtcatcaaga aggacgagca ggagcatgag ttttacaagt
     1201 gacccttccc ttccctccac cacaccactc aggggctggg gcttctctcg cacccccagc
     1261 acctctgtcc caaaacctca ttcccttttt tctttaccca ggattggttt cttcaataaa
     1321 tagataagat cgaatccatt taatttcttc ttagaagttt aactcctttg gagaatgtgg
     1381 gccttgaata ggatcctctg ggtccctctt aatctgacag atgagcagac gaggtgcatg
     1441 gcctgggttg cagcttgaga gaaccaaaat attcaaacca gatgacttcc aaaatgtggg
     1501 gaaagggatg gaaaatgaac ctgagatgga gtccttaatc acgggataaa gccctgtgca
     1561 tctccctcat ttcctacagg taaaagacag taaagaaatt caggtcacag gccttgggag
     1621 ttcataggaa ggagatgtcc agtgctgtcc agtagaactt t
//
