LOCUS       NM_006503               1754 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens proteasome 26S subunit, ATPase 4 (PSMC4), transcript
            variant 1, mRNA.
ACCESSION   NM_006503
VERSION     NM_006503.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1754)
  AUTHORS   Liu,K., Zhang,S., Gong,Y., Zhu,P., Shen,W. and Zhang,Q.
  TITLE     PSMC4 promotes prostate carcinoma progression by regulating the
            CBX3-EGFR-PI3K-AKT-mTOR pathway
  JOURNAL   J Cell Mol Med 27 (16), 2437-2447 (2023)
   PUBMED   37436074
  REMARK    GeneRIF: PSMC4 promotes prostate carcinoma progression by
            regulating the CBX3-EGFR-PI3K-AKT-mTOR pathway.
REFERENCE   2  (bases 1 to 1754)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1754)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1754)
  AUTHORS   Marx,F.P., Soehn,A.S., Berg,D., Melle,C., Schiesling,C., Lang,M.,
            Kautzmann,S., Strauss,K.M., Franck,T., Engelender,S., Pahnke,J.,
            Dawson,S., von Eggeling,F., Schulz,J.B., Riess,O. and Kruger,R.
  TITLE     The proteasomal subunit S6 ATPase is a novel synphilin-1
            interacting protein--implications for Parkinson's disease
  JOURNAL   FASEB J 21 (8), 1759-1767 (2007)
   PUBMED   17327361
  REMARK    GeneRIF: a novel specific interaction of synphilin-1 with the
            regulatory proteasomal protein S6 ATPase (tbp7) in aggresome-like
            intracytoplasmic inclusions
REFERENCE   5  (bases 1 to 1754)
  AUTHORS   Tanahashi,N., Suzuki,M., Fujiwara,T., Takahashi,E., Shimbara,N.,
            Chung,C.H. and Tanaka,K.
  TITLE     Chromosomal localization and immunological analysis of a family of
            human 26S proteasomal ATPases
  JOURNAL   Biochem Biophys Res Commun 243 (1), 229-232 (1998)
   PUBMED   9473509
REFERENCE   6  (bases 1 to 1754)
  AUTHORS   Matoba,R., Okubo,K., Hori,N., Fukushima,A. and Matsubara,K.
  TITLE     The addition of 5'-coding information to a 3'-directed cDNA library
            improves analysis of gene expression
  JOURNAL   Gene 146 (2), 199-207 (1994)
   PUBMED   8076819
REFERENCE   7  (bases 1 to 1754)
  AUTHORS   Dubiel,W., Ferrell,K. and Rechsteiner,M.
  TITLE     Tat-binding protein 7 is a subunit of the 26S protease
  JOURNAL   Biol Chem Hoppe Seyler 375 (4), 237-240 (1994)
   PUBMED   8060531
REFERENCE   8  (bases 1 to 1754)
  AUTHORS   Shaw,D.R. and Ennis,H.L.
  TITLE     Molecular cloning and developmental regulation of Dictyostelium
            discoideum homologues of the human and yeast HIV1 Tat-binding
            protein
  JOURNAL   Biochem Biophys Res Commun 193 (3), 1291-1296 (1993)
   PUBMED   8323548
REFERENCE   9  (bases 1 to 1754)
  AUTHORS   Ohana,B., Moore,P.A., Ruben,S.M., Southgate,C.D., Green,M.R. and
            Rosen,C.A.
  TITLE     The type 1 human immunodeficiency virus Tat binding protein is a
            transcriptional activator belonging to an additional family of
            evolutionarily conserved genes
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 138-142 (1993)
   PUBMED   8419915
REFERENCE   10 (bases 1 to 1754)
  AUTHORS   Nelbock,P., Dillon,P.J., Perkins,A. and Rosen,C.A.
  TITLE     A cDNA for a protein that interacts with the human immunodeficiency
            virus Tat transactivator
  JOURNAL   Science 248 (4963), 1650-1653 (1990)
   PUBMED   2194290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313183.1 and AC007842.1.
            
            On May 17, 2019 this sequence version replaced NM_006503.3.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. This
            gene encodes a member of the triple-A family of ATPases that is a
            component of the 19S regulatory subunit and plays a role in 26S
            proteasome assembly. The encoded protein interacts with gankyrin, a
            liver oncoprotein, and may also play a role in Parkinson's disease
            through interactions with synphilin-1. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.134097.1,
                                           SRR1660805.207220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000157812.7/ ENSP00000157812.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1295              AK313183.1         3-1297
            1296-1754           AC007842.1         99548-100006
FEATURES             Location/Qualifiers
     source          1..1754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1754
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /note="proteasome 26S subunit, ATPase 4"
                     /db_xref="GeneID:5704"
                     /db_xref="HGNC:HGNC:9551"
                     /db_xref="MIM:602707"
     exon            1..74
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1295
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protease 26S subunit 6; Tat-binding protein 7; 26S
                     protease regulatory subunit 6B; MB67-interacting protein;
                     26S proteasome AAA-ATPase subunit RPT3; proteasome
                     (prosome, macropain) 26S subunit, ATPase, 4; 26S
                     proteasome regulatory subunit 6B"
                     /codon_start=1
                     /product="26S proteasome regulatory subunit 6B isoform 1"
                     /protein_id="NP_006494.1"
                     /db_xref="CCDS:CCDS12547.1"
                     /db_xref="GeneID:5704"
                     /db_xref="HGNC:HGNC:9551"
                     /db_xref="MIM:602707"
                     /translation="MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRY
                     KKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAI
                     VGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKP
                     DVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKA
                     VAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD
                     AQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFP
                     LPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRY
                     IVLAKDFEKAYKTVIKKDEQEHEFYK"
     exon            75..173
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            174..360
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            361..507
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            508..617
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            618..711
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            712..879
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            880..956
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1125
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1181
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1754
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1408..1413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /note="hexamer: AATAAA"
     regulatory      1412..1417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /note="hexamer: AATAGA"
     polyA_site      1431
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
                     /note="major polyA site"
     polyA_site      1436
                     /gene="PSMC4"
                     /gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
ORIGIN      
        1 agatcatccc aggccacaca gaggccggct tggtcactat ggaggagata ggcatcttgg
       61 tggagaaggc tcaggatgag atcccagcac tgtccgtgtc ccggccccag accggcctgt
      121 ccttcctggg ccctgagcct gaggacctgg aggacctgta cagccgctac aagaagctgc
      181 agcaagagct ggagttcctg gaggtgcagg aggaatacat caaagatgag caaaagaacc
      241 tgaaaaagga atttctccat gcccaggagg aggtgaagcg aatccaaagc atcccgctgg
      301 tcatcggaca atttctggag gctgtggatc agaatacagc catcgtgggc tctaccacag
      361 gctccaacta ttatgtgcgc atcctgagca ccatcgatcg ggagctgctc aagcccaacg
      421 cctcagtggc cctccacaag cacagcaatg cactggtgga cgtgctgccc cccgaagccg
      481 acagcagcat catgatgctc acctcagacc agaagccaga tgtgatgtac gcggacatcg
      541 gaggcatgga catccagaag caggaggtgc gggaggccgt ggagctcccg ctcacgcatt
      601 tcgagctcta caagcagatc ggcatcgatc ccccccgagg cgtcctcatg tatggcccac
      661 ctggctgtgg gaagaccatg ttggcaaagg cggtggcaca tcacacaaca gctgcattca
      721 tccgggtcgt gggctcggag tttgtacaga agtatctggg tgagggcccc cgcatggtcc
      781 gggatgtgtt ccgcctggcc aaggagaatg cacctgccat catcttcata gacgagattg
      841 atgccatcgc caccaagaga ttcgatgctc agacaggggc cgacagggag gttcagagga
      901 tcctgctgga gctgctgaat cagatggatg gatttgatca gaatgtcaat gtcaaggtaa
      961 tcatggccac aaacagagca gacaccctgg atccggccct gctacggcca ggacggctgg
     1021 accgtaaaat tgaatttcca cttcctgacc gccgccagaa gagattgatt ttctccacta
     1081 tcactagcaa gatgaacctc tctgaggagg ttgacttgga agactatgtg gcccggccag
     1141 ataagatttc aggagctgat attaactcca tctgtcagga gagtggaatg ttggctgtcc
     1201 gtgaaaaccg ctacattgtc ctggccaagg acttcgagaa agcatacaag actgtcatca
     1261 agaaggacga gcaggagcat gagttttaca agtgaccctt cccttccctc caccacacca
     1321 ctcaggggct ggggcttctc tcgcaccccc agcacctctg tcccaaaacc tcattccctt
     1381 ttttctttac ccaggattgg tttcttcaat aaatagataa gatcgaatcc atttaatttc
     1441 ttcttagaag tttaactcct ttggagaatg tgggccttga ataggatcct ctgggtccct
     1501 cttaatctga cagatgagca gacgaggtgc atggcctggg ttgcagcttg agagaaccaa
     1561 aatattcaaa ccagatgact tccaaaatgt ggggaaaggg atggaaaatg aacctgagat
     1621 ggagtcctta atcacgggat aaagccctgt gcatctccct catttcctac aggtaaaaga
     1681 cagtaaagaa attcaggtca caggccttgg gagttcatag gaaggagatg tccagtgctg
     1741 tccagtagaa cttt
//
