LOCUS       NM_002803               2712 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens proteasome 26S subunit, ATPase 2 (PSMC2), transcript
            variant 1, mRNA.
ACCESSION   NM_002803
VERSION     NM_002803.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2712)
  AUTHORS   Wang,Y., Zhang,S., Zhao,Z., Jin,Q., Wang,Z., Song,Z., Liu,L. and
            Zhao,Z.
  TITLE     PSMC2 promotes glioma progression by regulating immune
            microenvironment and PI3K/AKT/mTOR pathway
  JOURNAL   Immunobiology 229 (3), 152802 (2024)
   PUBMED   38569452
  REMARK    GeneRIF: PSMC2 promotes glioma progression by regulating immune
            microenvironment and PI3K/AKT/mTOR pathway.
REFERENCE   2  (bases 1 to 2712)
  AUTHORS   Su,J., Hu,S., Ding,S. and Feng,K.
  TITLE     PSMC2 knockdown exerts an anti-tumor role in nasopharyngeal
            carcinoma through regulating AKT signaling pathway
  JOURNAL   Cell Cycle 22 (21-22), 2381-2391 (2023)
   PUBMED   38123344
  REMARK    GeneRIF: PSMC2 knockdown exerts an anti-tumor role in
            nasopharyngeal carcinoma through regulating AKT signaling pathway.
REFERENCE   3  (bases 1 to 2712)
  AUTHORS   Zheng,X., Wang,Y., Wang,D., Wan,J., Qin,X., Mu,Z. and Hu,N.
  TITLE     PSMC2 is overexpressed in glioma and promotes proliferation and
            anti-apoptosis of glioma cells
  JOURNAL   World J Surg Oncol 20 (1), 84 (2022)
   PUBMED   35287689
  REMARK    GeneRIF: PSMC2 is overexpressed in glioma and promotes
            proliferation and anti-apoptosis of glioma cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2712)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2712)
  AUTHORS   Wang,Z., Xiong,H., Zuo,Y., Hu,S., Zhu,C. and Min,A.
  TITLE     PSMC2 knockdown inhibits the progression of oral squamous cell
            carcinoma by promoting apoptosis via PI3K/Akt pathway
  JOURNAL   Cell Cycle 21 (5), 477-488 (2022)
   PUBMED   34979867
  REMARK    GeneRIF: PSMC2 knockdown inhibits the progression of oral squamous
            cell carcinoma by promoting apoptosis via PI3K/Akt pathway.
REFERENCE   6  (bases 1 to 2712)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   7  (bases 1 to 2712)
  AUTHORS   Nacken,W., Kingsman,A.J., Kingsman,S.M., Sablitzky,F. and Sorg,C.
  TITLE     A homologue of the human MSS1 gene, a positive modulator of HIV-1
            gene expression, is massively expressed in Xenopus oocytes
  JOURNAL   Biochim Biophys Acta 1261 (2), 293-295 (1995)
   PUBMED   7711076
REFERENCE   8  (bases 1 to 2712)
  AUTHORS   Dubiel,W., Ferrell,K. and Rechsteiner,M.
  TITLE     Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated
            transactivation, as subunit 7 of the 26 S protease
  JOURNAL   FEBS Lett 323 (3), 276-278 (1993)
   PUBMED   8500623
REFERENCE   9  (bases 1 to 2712)
  AUTHORS   Shibuya,H., Irie,K., Ninomiya-Tsuji,J., Goebl,M., Taniguchi,T. and
            Matsumoto,K.
  TITLE     New human gene encoding a positive modulator of HIV Tat-mediated
            transactivation
  JOURNAL   Nature 357 (6380), 700-702 (1992)
   PUBMED   1377363
REFERENCE   10 (bases 1 to 2712)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004668.1 and AC093701.4.
            
            On Nov 23, 2018 this sequence version replaced NM_002803.3.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes one of
            the ATPase subunits, a member of the triple-A family of ATPases
            which have a chaperone-like activity. This subunit has been shown
            to interact with several of the basal transcription factors so, in
            addition to participation in proteasome functions, this subunit may
            participate in the regulation of transcription. This subunit may
            also compete with PSMC3 for binding to the HIV tat protein to
            regulate the interaction between the viral protein and the
            transcription complex. Alternative splicing results in multiple
            transcript variants encoding distinct isoforms. [provided by
            RefSeq, Mar 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.271779.1,
                                           SRR1660805.216461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292644.5/ ENSP00000292644.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC004668.1         6978-7116           c
            140-177             AC093701.4         1163-1200
            178-259             AC093701.4         2110-2191
            260-359             AC093701.4         2936-3035
            360-491             AC093701.4         9199-9330
            492-564             AC093701.4         9928-10000
            565-660             AC093701.4         10586-10681
            661-825             AC093701.4         11385-11549
            826-913             AC093701.4         13318-13405
            914-1116            AC093701.4         14655-14857
            1117-1213           AC093701.4         14955-15051
            1214-2712           AC093701.4         15139-16637
FEATURES             Location/Qualifiers
     source          1..2712
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2712
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /note="proteasome 26S subunit, ATPase 2"
                     /db_xref="GeneID:5701"
                     /db_xref="HGNC:HGNC:9548"
                     /db_xref="MIM:154365"
     exon            1..139
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1371
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mammalian suppressor of sgv-1 of yeast; protease 26S
                     subunit 7; 26S protease regulatory subunit 7; putative
                     protein product of Nbla10058; testis secretory
                     sperm-binding protein Li 197a; 26S proteasome AAA-ATPase
                     subunit RPT1; proteasome (prosome, macropain) 26S subunit,
                     ATPase, 2; 26S proteasome regulatory subunit 7"
                     /codon_start=1
                     /product="26S proteasome regulatory subunit 7 isoform 1"
                     /protein_id="NP_002794.1"
                     /db_xref="CCDS:CCDS5731.1"
                     /db_xref="GeneID:5701"
                     /db_xref="HGNC:HGNC:9548"
                     /db_xref="MIM:154365"
                     /translation="MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQ
                     IKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKII
                     NADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPT
                     VTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPP
                     GTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDE
                     IDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRP
                     GRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEA
                     GMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN"
     exon            140..177
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            178..259
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            260..359
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            360..491
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            492..564
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            565..660
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            661..825
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            826..913
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1116
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1213
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..2712
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1451..1456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /note="hexamer: AATAAA"
     polyA_site      1472
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /note="major polyA site"
     regulatory      1503..1508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /note="hexamer: AATAAA"
     polyA_site      1538
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
     regulatory      2688..2693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
                     /note="hexamer: AATAAA"
     polyA_site      2712
                     /gene="PSMC2"
                     /gene_synonym="MSS1; Nbla10058; RPT1; S7"
ORIGIN      
        1 aagacaccac cggaagcaag gaaggtgctg tgtaatcatt aaggagcgga ggcttttgga
       61 gctgctaaaa tgccggatta cctcggtgcc gatcagcgga agaccaaaga ggatgagaag
      121 gacgacaagc ccatccgagc tctggatgag ggggatattg ccttgttgaa aacttatggt
      181 cagagcactt actctaggca gatcaagcaa gttgaagatg acattcagca acttctcaag
      241 aaaattaatg agctcactgg tattaaagaa tctgacactg gcctggcccc accagcactc
      301 tgggatttgg ctgcagataa gcagacactc cagagtgaac agcctttaca ggttgccagg
      361 tgtacaaaga taatcaatgc tgattcggag gacccaaaat acattatcaa cgtaaagcag
      421 tttgccaagt ttgtggtgga ccttagtgat caggtggcac ctactgacat tgaagaaggg
      481 atgagagtgg gcgtggatag aaataaatat caaattcaca ttccattgcc tcctaagatt
      541 gacccaacag ttaccatgat gcaggtggaa gagaaacctg atgtcacata cagtgatgtt
      601 ggtggctgta aggaacagat tgagaaactg cgagaagtag ttgaaacccc attacttcat
      661 ccagagaggt ttgtgaacct tggcattgag cctcccaagg gcgtgctgct ctttggtcca
      721 cccggtacag gcaagacact ctgtgcgcgg gcagttgcta atcggactga tgcgtgcttc
      781 attcgagtta ttggatctga gcttgtacag aaatacgtcg gtgagggggc tcgaatggtt
      841 cgtgaactct ttgaaatggc cagaacaaaa aaagcctgcc ttatcttctt tgatgaaatt
      901 gatgctattg gaggggctcg ttttgatgat ggtgctggag gtgacaatga agtgcagaga
      961 acaatgttgg aactgatcaa tcagcttgat ggttttgatc ctagaggcaa tattaaagtg
     1021 ctgatggcca ctaacagacc tgatactttg gatccagcac tgatgaggcc agggagattg
     1081 gatagaaaaa ttgaatttag cttgcccgat ctagagggtc ggacccacat atttaagatt
     1141 cacgctcgtt caatgagtgt tgaaagagat atcagatttg aactgttagc acgactgtgt
     1201 ccaaatagca ctggtgctga gattagaagc gtctgcacag aggctggtat gtttgccatc
     1261 agagcacggc gaaaaattgc taccgagaag gatttcttgg aagctgtaaa taaggtcatt
     1321 aagtcttatg ccaaattcag tgctactcct cgttacatga catacaactg aaccctgaag
     1381 gctttcaagt gaaaacttta aattggaatc ctaaccttat atagacttgt taataaccaa
     1441 ttcataaaca aataaatggc ttcaaaattg tatgcttttt tccatatctc ttcttgtaat
     1501 ataataaaag gtgatttcta atgttattag gcagaaaagc ttgttagaat atattttgac
     1561 tatttttttg acccacaccc gtttaaggat ttcacatcat acaaagcgct tgcttagatg
     1621 gcttctatcc taggcatatg ctggccgggt gctctacata taaattctca ttgtatcctc
     1681 ccatctgtcc actgaggaag attatcaaat ggatcttcat ccaatggatg cataaacttt
     1741 cctacttact tgtagtggca aagctggctt tcaagtacaa gtttgttggc tccattacct
     1801 atgctcctat tatccgcttc tgtcccgcaa caaagtagct cacttaggcg tatgaccaca
     1861 tgcattatga tagtttccca ccaccatatt gaataataaa agctttggcc aaagcttttt
     1921 taaagtagga gaaacattgg atgtatatgt tttgcattgc catttgattt caaattaatc
     1981 aggaagaatt agtgatttta atgagcagta aagtggtgca ataaagcaga aagaaaaatg
     2041 ttcagccaga agtgaaagac tagtaaaaaa agaaaaaaaa atatttgtac atatgatcta
     2101 atttagaaag tccagaattg gcttcataca gaaaagtgat tactttcatt ttacaaatta
     2161 ctttaaaatt ttggtaaagt ttctgttagg cttctggtct acagtgaggt attttaaaaa
     2221 taaaggttat attagaatcc tcaacatctc tttaaaatta cctcctgtgt aaccaccacc
     2281 aaatcctatc ttctaccaca attacccctt cccccaatgc caagaccaaa gcacaataat
     2341 gaatattttt attgaagttc gatattcata aataagttgc aaaataagag ttggatatat
     2401 ttttaattca caatagaaaa agttgacaac atagaaaatg ctgctttgca ctgaaatact
     2461 taaaattatg aaagttttca agtaaagaaa ttaaagcctt ttataaaatc caaccaacat
     2521 tcttgatttt tcatttttat gaacttgatc agaaaaattc atctttttta accctgccct
     2581 aatttttctt gaggaattaa atagagcaaa ctattttcag gttatgctta caataaaata
     2641 tacttaagaa aatgactgaa gatgtatgtt tttgaatgtt ttgattaaat aaatgtacac
     2701 atttagaaca ca
//
