LOCUS       NM_002800               1017 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens proteasome 20S subunit beta 9 (PSMB9), mRNA.
ACCESSION   NM_002800
VERSION     NM_002800.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1017)
  AUTHORS   Hu,X., Hu,Z., Zhang,H., Zhang,N., Feng,H., Jia,X., Zhang,C. and
            Cheng,Q.
  TITLE     Deciphering the tumor-suppressive role of PSMB9 in melanoma through
            multi-omics and single-cell transcriptome analyses
  JOURNAL   Cancer Lett 581, 216466 (2024)
   PUBMED   37944578
  REMARK    GeneRIF: Deciphering the tumor-suppressive role of PSMB9 in
            melanoma through multi-omics and single-cell transcriptome
            analyses.
REFERENCE   2  (bases 1 to 1017)
  AUTHORS   Rutkowska,J., Kasacka,I., Rogowski,M. and Olszewska,E.
  TITLE     Immunohistochemical Identification and Assessment of the Location
            of Immunoproteasome Subunits LMP2 and LMP7 in Acquired
            Cholesteatoma
  JOURNAL   Int J Mol Sci 24 (18), 14137 (2023)
   PUBMED   37762439
  REMARK    GeneRIF: Immunohistochemical Identification and Assessment of the
            Location of Immunoproteasome Subunits LMP2 and LMP7 in Acquired
            Cholesteatoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1017)
  AUTHORS   Kim,M., Serwa,R.A., Samluk,L., Suppanz,I., Kodron,A.,
            Stepkowski,T.M., Elancheliyan,P., Tsegaye,B., Oeljeklaus,S.,
            Wasilewski,M., Warscheid,B. and Chacinska,A.
  TITLE     Immunoproteasome-specific subunit PSMB9 induction is required to
            regulate cellular proteostasis upon mitochondrial dysfunction
  JOURNAL   Nat Commun 14 (1), 4092 (2023)
   PUBMED   37433777
  REMARK    GeneRIF: Immunoproteasome-specific subunit PSMB9 induction is
            required to regulate cellular proteostasis upon mitochondrial
            dysfunction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1017)
  AUTHORS   Shani,S., Goldstein,O., Gana-Weisz,M., Bar-Shira,A., Thaler,A.,
            Gurevich,T., Mirelman,A., Giladi,N., Alcalay,R.N. and
            Orr-Urtreger,A.
  TITLE     Variants in PSMB9 and FGR differentially affect Parkinson's disease
            risk in GBA and LRRK2 mutation carriers
  JOURNAL   Parkinsonism Relat Disord 111, 105398 (2023)
   PUBMED   37116292
  REMARK    GeneRIF: Variants in PSMB9 and FGR differentially affect
            Parkinson's disease risk in GBA and LRRK2 mutation carriers.
REFERENCE   5  (bases 1 to 1017)
  AUTHORS   Geoffroy,K., Araripe Saraiva,B., Viens,M., Beland,D. and
            Bourgeois-Daigneault,M.C.
  TITLE     Increased expression of the immunoproteasome subunits PSMB8 and
            PSMB9 by cancer cells correlate with better outcomes for
            triple-negative breast cancers
  JOURNAL   Sci Rep 13 (1), 2129 (2023)
   PUBMED   36746983
  REMARK    GeneRIF: Increased expression of the immunoproteasome subunits
            PSMB8 and PSMB9 by cancer cells correlate with better outcomes for
            triple-negative breast cancers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1017)
  AUTHORS   Kristensen,P., Johnsen,A.H., Uerkvitz,W., Tanaka,K. and Hendil,K.B.
  TITLE     Human proteasome subunits from 2-dimensional gels identified by
            partial sequencing
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1785-1789 (1994)
   PUBMED   7811265
  REMARK    Erratum:[Biochem Biophys Res Commun. 1995 Feb 27;207(3):1059. doi:
            10.1006/bbrc.1995.1294.. PMID: 7864893]
REFERENCE   7  (bases 1 to 1017)
  AUTHORS   Beck,S., Kelly,A., Radley,E., Khurshid,F., Alderton,R.P. and
            Trowsdale,J.
  TITLE     DNA sequence analysis of 66 kb of the human MHC class II region
            encoding a cluster of genes for antigen processing
  JOURNAL   J Mol Biol 228 (2), 433-441 (1992)
   PUBMED   1453454
REFERENCE   8  (bases 1 to 1017)
  AUTHORS   Fruh,K., Yang,Y., Arnold,D., Chambers,J., Wu,L., Waters,J.B.,
            Spies,T. and Peterson,P.A.
  TITLE     Alternative exon usage and processing of the major
            histocompatibility complex-encoded proteasome subunits
  JOURNAL   J Biol Chem 267 (31), 22131-22140 (1992)
   PUBMED   1429565
REFERENCE   9  (bases 1 to 1017)
  AUTHORS   Kelly,A., Powis,S.H., Glynne,R., Radley,E., Beck,S. and
            Trowsdale,J.
  TITLE     Second proteasome-related gene in the human MHC class II region
  JOURNAL   Nature 353 (6345), 667-668 (1991)
   PUBMED   1922385
REFERENCE   10 (bases 1 to 1017)
  AUTHORS   Martinez,C.K. and Monaco,J.J.
  TITLE     Homology of proteasome subunits to a major histocompatibility
            complex-linked LMP gene
  JOURNAL   Nature 353 (6345), 664-667 (1991)
   PUBMED   1681432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF513693.1, BC065513.1 and
            AI310206.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002800.4.
            
            Summary: The proteasome is a multicatalytic proteinase complex with
            a highly ordered ring-shaped 20S core structure. The core structure
            is composed of 4 rings of 28 non-identical subunits; 2 rings are
            composed of 7 alpha subunits and 2 rings are composed of 7 beta
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            member of the proteasome B-type family, also known as the T1B
            family, that is a 20S core beta subunit. This gene is located in
            the class II region of the MHC (major histocompatibility complex).
            Expression of this gene is induced by gamma interferon and this
            gene product replaces catalytic subunit 1 (proteasome beta 6
            subunit) in the immunoproteasome. Proteolytic processing is
            required to generate a mature subunit. [provided by RefSeq, Mar
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.229991.1,
                                           SRR5189658.127609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374859.3/ ENSP00000363993.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BF513693.1         353-366
            15-751              BC065513.1         1-737
            752-1017            AI310206.1         4-269               c
FEATURES             Location/Qualifiers
     source          1..1017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..1017
                     /gene="PSMB9"
                     /gene_synonym="beta1i; LMP2; PRAAS3; PRAAS6; PSMB6i;
                     RING12"
                     /note="proteasome 20S subunit beta 9"
                     /db_xref="GeneID:5698"
                     /db_xref="HGNC:HGNC:9546"
                     /db_xref="MIM:177045"
     exon            1..98
                     /gene="PSMB9"
                     /gene_synonym="beta1i; LMP2; PRAAS3; PRAAS6; PSMB6i;
                     RING12"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..698
                     /gene="PSMB9"
                     /gene_synonym="beta1i; LMP2; PRAAS3; PRAAS6; PSMB6i;
                     RING12"
                     /EC_number="3.4.25.1"
                     /note="proteasome-related gene 2; proteasome chain 7;
                     macropain chain 7; low molecular mass protein 2;
                     multicatalytic endopeptidase complex chain 7; proteasome
                     catalytic subunit 1i; proteasome subunit beta 6i;
                     proteasome subunit beta type-9; proteasome subunit
                     beta-1i; really interesting new gene 12 protein;
                     proteasome (prosome, macropain) subunit, beta type, 9
                     (large multifunctional peptidase 2); proteasome subunit
                     beta 9; proteasome subunit beta1i"
                     /codon_start=1
                     /product="proteasome subunit beta type-9 precursor"
                     /protein_id="NP_002791.1"
                     /db_xref="CCDS:CCDS4759.1"
                     /db_xref="GeneID:5698"
                     /db_xref="HGNC:HGNC:9546"
                     /db_xref="MIM:177045"
                     /translation="MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGE
                     AVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANV
                     VRNISYKYREDLSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDA
                     AYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYD
                     E"
     exon            99..166
                     /gene="PSMB9"
                     /gene_synonym="beta1i; LMP2; PRAAS3; PRAAS6; PSMB6i;
                     RING12"
                     /inference="alignment:Splign:2.1.0"
     exon            167..298
                     /gene="PSMB9"
                     /gene_synonym="beta1i; LMP2; PRAAS3; PRAAS6; PSMB6i;
                     RING12"
                     /inference="alignment:Splign:2.1.0"
     exon            299..428
                     /gene="PSMB9"
                     /gene_synonym="beta1i; LMP2; PRAAS3; PRAAS6; PSMB6i;
                     RING12"
                     /inference="alignment:Splign:2.1.0"
     exon            429..570
                     /gene="PSMB9"
                     /gene_synonym="beta1i; LMP2; PRAAS3; PRAAS6; PSMB6i;
                     RING12"
                     /inference="alignment:Splign:2.1.0"
     exon            571..1017
                     /gene="PSMB9"
                     /gene_synonym="beta1i; LMP2; PRAAS3; PRAAS6; PSMB6i;
                     RING12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      730..735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMB9"
                     /gene_synonym="beta1i; LMP2; PRAAS3; PRAAS6; PSMB6i;
                     RING12"
                     /note="hexamer: AATAAA"
     polyA_site      751
                     /gene="PSMB9"
                     /gene_synonym="beta1i; LMP2; PRAAS3; PRAAS6; PSMB6i;
                     RING12"
                     /note="major polyA site"
     polyA_site      1017
                     /gene="PSMB9"
                     /gene_synonym="beta1i; LMP2; PRAAS3; PRAAS6; PSMB6i;
                     RING12"
ORIGIN      
        1 agtgccccag gcggcgagga gagcggtgcc ttgcagggat gctgcgggcg ggagcaccaa
       61 ccggggactt accccgggcg ggagaagtcc acaccgggac caccatcatg gcagtggagt
      121 ttgacggggg cgttgtgatg ggttctgatt cccgagtgtc tgcaggcgag gcggtggtga
      181 accgagtgtt tgacaagctg tccccgctgc acgagcgcat ctactgtgca ctctctggtt
      241 cagctgctga tgcccaagcc gtggccgaca tggccgccta ccagctggag ctccatggga
      301 tagaactgga ggaacctcca cttgttttgg ctgctgcaaa tgtggtgaga aatatcagct
      361 ataaatatcg agaggacttg tctgcacatc tcatggtagc tggctgggac caacgtgaag
      421 gaggtcaggt atatggaacc ctgggaggaa tgctgactcg acagcctttt gccattggtg
      481 gctccggcag cacctttatc tatggttatg tggatgcagc atataagcca ggcatgtctc
      541 ccgaggagtg caggcgcttc accacagacg ctattgctct ggccatgagc cgggatggct
      601 caagcggggg tgtcatctac ctggtcacta ttacagctgc cggtgtggac catcgagtca
      661 tcttgggcaa tgaactgcca aaattctatg atgagtgaac cttccccaga cttctctttc
      721 ttattttgta ataaactctc tagggccaaa acctggtatg gtcattggga aatgagtgct
      781 cagggagatg gagcttaggg gaggtgggtg cttccctcct agatgtcagc atacactctt
      841 tcttcttttg tcccaggtct aaaacatctt tcctagagaa aacaaaaggg actaaactag
      901 aaatataaag agccctatac atgacaggtg atcacgtact gaatgatttt gaagtagtac
      961 aaacaataaa aattctcatt ccgcatcatc atgcggtcca tgatgatgag gccgcaa
//
