LOCUS       NM_002799                984 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens proteasome 20S subunit beta 7 (PSMB7), mRNA.
ACCESSION   NM_002799
VERSION     NM_002799.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 984)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 984)
  AUTHORS   de Almeida,M., Hinterndorfer,M., Brunner,H., Grishkovskaya,I.,
            Singh,K., Schleiffer,A., Jude,J., Deswal,S., Kalis,R., Vunjak,M.,
            Lendl,T., Imre,R., Roitinger,E., Neumann,T., Kandolf,S.,
            Schutzbier,M., Mechtler,K., Versteeg,G.A., Haselbach,D. and
            Zuber,J.
  TITLE     AKIRIN2 controls the nuclear import of proteasomes in vertebrates
  JOURNAL   Nature 599 (7885), 491-496 (2021)
   PUBMED   34711951
REFERENCE   3  (bases 1 to 984)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 984)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   5  (bases 1 to 984)
  AUTHORS   Zhu,Y., Wang,W.L., Yu,D., Ouyang,Q., Lu,Y. and Mao,Y.
  TITLE     Structural mechanism for nucleotide-driven remodeling of the
            AAA-ATPase unfoldase in the activated human 26S proteasome
  JOURNAL   Nat Commun 9 (1), 1360 (2018)
   PUBMED   29636472
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 984)
  AUTHORS   Madani,N. and Kabat,D.
  TITLE     An endogenous inhibitor of human immunodeficiency virus in human
            lymphocytes is overcome by the viral Vif protein
  JOURNAL   J Virol 72 (12), 10251-10255 (1998)
   PUBMED   9811770
REFERENCE   7  (bases 1 to 984)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   8  (bases 1 to 984)
  AUTHORS   Hisamatsu,H., Shimbara,N., Saito,Y., Kristensen,P., Hendil,K.B.,
            Fujiwara,T., Takahashi,E., Tanahashi,N., Tamura,T., Ichihara,A. and
            Tanaka,K.
  TITLE     Newly identified pair of proteasomal subunits regulated
            reciprocally by interferon gamma
  JOURNAL   J Exp Med 183 (4), 1807-1816 (1996)
   PUBMED   8666937
REFERENCE   9  (bases 1 to 984)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   10 (bases 1 to 984)
  AUTHORS   Kristensen,P., Johnsen,A.H., Uerkvitz,W., Tanaka,K. and Hendil,K.B.
  TITLE     Human proteasome subunits from 2-dimensional gels identified by
            partial sequencing
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1785-1789 (1994)
   PUBMED   7811265
  REMARK    Erratum:[Biochem Biophys Res Commun. 1995 Feb 27;207(3):1059. doi:
            10.1006/bbrc.1995.1294.. PMID: 7864893]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from GU727627.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002799.3.
            
            Summary: The proteasome is a multicatalytic proteinase complex with
            a highly ordered ring-shaped 20S core structure. The core structure
            is composed of 4 rings of 28 non-identical subunits; 2 rings are
            composed of 7 alpha subunits and 2 rings are composed of 7 beta
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. The
            encoded protein is a member of the proteasome B-type family, also
            known as the T1B family, and is a 20S core beta subunit in the
            proteasome. Expression of this catalytic subunit is downregulated
            by gamma interferon, and proteolytic processing is required to
            generate a mature subunit. A pseudogene of this gene is located on
            the long arm of chromosome 14. [provided by RefSeq, Jul 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GU727627.1, SRR5189652.206633.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259457.8/ ENSP00000259457.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-984               GU727627.1         1-984
FEATURES             Location/Qualifiers
     source          1..984
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..984
                     /gene="PSMB7"
                     /note="proteasome 20S subunit beta 7"
                     /db_xref="GeneID:5695"
                     /db_xref="HGNC:HGNC:9544"
                     /db_xref="MIM:604030"
     exon            1..79
                     /gene="PSMB7"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..851
                     /gene="PSMB7"
                     /EC_number="3.4.25.1"
                     /note="proteasome catalytic subunit 2; macropain chain Z;
                     proteasome subunit beta 7; proteasome subunit beta2;
                     proteasome subunit alpha; multicatalytic endopeptidase
                     complex chain Z; protein serine kinase c17; proteasome
                     subunit Z; proteasome subunit beta type-7; proteasome
                     (prosome, macropain) subunit, beta type, 7; epididymis
                     secretory sperm binding protein; beta-2; proteasome
                     subunit beta-2"
                     /codon_start=1
                     /product="proteasome subunit beta type-7 precursor"
                     /protein_id="NP_002790.1"
                     /db_xref="CCDS:CCDS6855.1"
                     /db_xref="GeneID:5695"
                     /db_xref="HGNC:HGNC:9544"
                     /db_xref="MIM:604030"
                     /translation="MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGT
                     TIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLI
                     SSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHG
                     STDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDL
                     CVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDT
                     S"
     exon            80..173
                     /gene="PSMB7"
                     /inference="alignment:Splign:2.1.0"
     exon            174..271
                     /gene="PSMB7"
                     /inference="alignment:Splign:2.1.0"
     exon            272..412
                     /gene="PSMB7"
                     /inference="alignment:Splign:2.1.0"
     exon            413..528
                     /gene="PSMB7"
                     /inference="alignment:Splign:2.1.0"
     exon            529..587
                     /gene="PSMB7"
                     /inference="alignment:Splign:2.1.0"
     exon            588..739
                     /gene="PSMB7"
                     /inference="alignment:Splign:2.1.0"
     exon            740..984
                     /gene="PSMB7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      938..943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMB7"
                     /note="hexamer: AATGAA"
     regulatory      953..958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMB7"
                     /note="hexamer: AATAAA"
     polyA_site      967
                     /gene="PSMB7"
     polyA_site      984
                     /gene="PSMB7"
                     /note="major polyA site"
ORIGIN      
        1 actgctttct tgggaagatg gcggctgtgt cggtgtatgc tccaccagtt ggaggcttct
       61 cttttgataa ctgccgcagg aatgccgtct tggaagccga ttttgcaaag aggggataca
      121 agcttccaaa ggtccggaaa actggcacga ccatcgctgg ggtggtctat aaggatggca
      181 tagttcttgg agcagataca agagcaactg aagggatggt tgttgctgac aagaactgtt
      241 caaaaataca cttcatatct cctaatattt attgttgtgg tgctgggaca gctgcagaca
      301 cagacatgac aacccagctc atttcttcca acctggagct ccactccctc tccactggcc
      361 gtcttcccag agttgtgaca gccaatcgga tgctgaagca gatgcttttc aggtatcaag
      421 gttacattgg tgcagcccta gttttagggg gagtagatgt tactggacct cacctctaca
      481 gcatctatcc tcatggatca actgataagt tgccttatgt caccatgggt tctggctcct
      541 tggcagcaat ggctgtattt gaagataagt ttaggccaga catggaggag gaggaagcca
      601 agaatctggt gagcgaagcc atcgcagctg gcatcttcaa cgacctgggc tccggaagca
      661 acattgacct ctgcgtcatc agcaagaaca agctggattt tctccgccca tacacagtgc
      721 ccaacaagaa ggggaccagg cttggccggt acaggtgtga gaaagggact actgcagtcc
      781 tcactgagaa aatcactcct ctggagattg aggtgctgga agaaacagtc caaacaatgg
      841 acacttcctg aatggcatca gtgggtggct ggccgcggtt ctggaaggtg gtgagcattg
      901 aggcccagta agacactcat gtggctagtg tttgccgaat gaaactcaac tcaataaaaa
      961 acaaaaacca aattgggcag ctga
//
