LOCUS       NM_002798                824 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens proteasome 20S subunit beta 6 (PSMB6), transcript
            variant 1, mRNA.
ACCESSION   NM_002798
VERSION     NM_002798.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 824)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 824)
  AUTHORS   de Almeida,M., Hinterndorfer,M., Brunner,H., Grishkovskaya,I.,
            Singh,K., Schleiffer,A., Jude,J., Deswal,S., Kalis,R., Vunjak,M.,
            Lendl,T., Imre,R., Roitinger,E., Neumann,T., Kandolf,S.,
            Schutzbier,M., Mechtler,K., Versteeg,G.A., Haselbach,D. and
            Zuber,J.
  TITLE     AKIRIN2 controls the nuclear import of proteasomes in vertebrates
  JOURNAL   Nature 599 (7885), 491-496 (2021)
   PUBMED   34711951
REFERENCE   3  (bases 1 to 824)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 824)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 824)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   6  (bases 1 to 824)
  AUTHORS   Kristensen,P., Johnsen,A.H., Uerkvitz,W., Tanaka,K. and Hendil,K.B.
  TITLE     Human proteasome subunits from 2-dimensional gels identified by
            partial sequencing
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1785-1789 (1994)
   PUBMED   7811265
  REMARK    Erratum:[Biochem Biophys Res Commun. 1995 Feb 27;207(3):1059. doi:
            10.1006/bbrc.1995.1294.. PMID: 7864893]
REFERENCE   7  (bases 1 to 824)
  AUTHORS   Belich,M.P., Glynne,R.J., Senger,G., Sheer,D. and Trowsdale,J.
  TITLE     Proteasome components with reciprocal expression to that of the
            MHC-encoded LMP proteins
  JOURNAL   Curr Biol 4 (9), 769-776 (1994)
   PUBMED   7820546
REFERENCE   8  (bases 1 to 824)
  AUTHORS   Akiyama,K., Yokota,K., Kagawa,S., Shimbara,N., Tamura,T.,
            Akioka,H., Nothwang,H.G., Noda,C., Tanaka,K. and Ichihara,A.
  TITLE     cDNA cloning and interferon gamma down-regulation of proteasomal
            subunits X and Y
  JOURNAL   Science 265 (5176), 1231-1234 (1994)
   PUBMED   8066462
REFERENCE   9  (bases 1 to 824)
  AUTHORS   DeMartino,G.N., Orth,K., McCullough,M.L., Lee,L.W., Munn,T.Z.,
            Moomaw,C.R., Dawson,P.A. and Slaughter,C.A.
  TITLE     The primary structures of four subunits of the human,
            high-molecular-weight proteinase, macropain (proteasome), are
            distinct but homologous
  JOURNAL   Biochim Biophys Acta 1079 (1), 29-38 (1991)
   PUBMED   1888762
REFERENCE   10 (bases 1 to 824)
  AUTHORS   Lee,L.W., Moomaw,C.R., Orth,K., McGuire,M.J., DeMartino,G.N. and
            Slaughter,C.A.
  TITLE     Relationships among the subunits of the high molecular weight
            proteinase, macropain (proteasome)
  JOURNAL   Biochim Biophys Acta 1037 (2), 178-185 (1990)
   PUBMED   2306472
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF671774.1 and BC000835.2.
            
            On Nov 23, 2018 this sequence version replaced NM_002798.2.
            
            Summary: The proteasome is a multicatalytic proteinase complex with
            a highly ordered ring-shaped 20S core structure. The core structure
            is composed of 4 rings of 28 non-identical subunits; 2 rings are
            composed of 7 alpha subunits and 2 rings are composed of 7 beta
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. The
            encoded protein is a member of the proteasome B-type family, also
            known as the T1B family, and is a 20S core beta subunit in the
            proteasome. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.44608.1,
                                           SRR5189661.178261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270586.8/ ENSP00000270586.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BF671774.1         22-34
            14-824              BC000835.2         1-811
FEATURES             Location/Qualifiers
     source          1..824
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..824
                     /gene="PSMB6"
                     /gene_synonym="DELTA; LMPY"
                     /note="proteasome 20S subunit beta 6"
                     /db_xref="GeneID:5694"
                     /db_xref="HGNC:HGNC:9543"
                     /db_xref="MIM:600307"
     exon            1..133
                     /gene="PSMB6"
                     /gene_synonym="DELTA; LMPY"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..751
                     /gene="PSMB6"
                     /gene_synonym="DELTA; LMPY"
                     /EC_number="3.4.25.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proteasome subunit delta; PSY large multifunctional
                     protease Y; proteasome delta chain; macropain delta chain;
                     multicatalytic endopeptidase complex delta chain;
                     proteasome catalytic subunit 1; proteasome subunit Y;
                     proteasome (prosome, macropain) subunit, beta type, 6;
                     proteasome subunit beta 6; proteasome subunit beta1;
                     beta-1; proteasome subunit beta-1"
                     /codon_start=1
                     /product="proteasome subunit beta type-6 isoform 1"
                     /protein_id="NP_002789.1"
                     /db_xref="CCDS:CCDS11056.1"
                     /db_xref="GeneID:5694"
                     /db_xref="HGNC:HGNC:9543"
                     /db_xref="MIM:600307"
                     /translation="MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDG
                     GVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSI
                     ELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFA
                     IGGSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGV
                     ERQVLLGDQIPKFAVATLPPA"
     exon            134..201
                     /gene="PSMB6"
                     /gene_synonym="DELTA; LMPY"
                     /inference="alignment:Splign:2.1.0"
     exon            202..333
                     /gene="PSMB6"
                     /gene_synonym="DELTA; LMPY"
                     /inference="alignment:Splign:2.1.0"
     exon            334..463
                     /gene="PSMB6"
                     /gene_synonym="DELTA; LMPY"
                     /inference="alignment:Splign:2.1.0"
     exon            464..608
                     /gene="PSMB6"
                     /gene_synonym="DELTA; LMPY"
                     /inference="alignment:Splign:2.1.0"
     exon            609..824
                     /gene="PSMB6"
                     /gene_synonym="DELTA; LMPY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      804..809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMB6"
                     /gene_synonym="DELTA; LMPY"
                     /note="hexamer: AATAAA"
     polyA_site      824
                     /gene="PSMB6"
                     /gene_synonym="DELTA; LMPY"
                     /note="major polyA site"
ORIGIN      
        1 agttgctttg aggcagtacc ggaggagaaa gatggcggct accttactag ctgctcgggg
       61 agccgggcca gcaccggctt gggggccgga ggcgttcact ccagactggg aaagccgaga
      121 agtttccact gggaccacta tcatggccgt gcagtttgac gggggcgtgg ttctgggggc
      181 ggactccaga acaaccactg ggtcctacat cgccaatcga gtgactgaca agctgacacc
      241 tattcacgac cgcattttct gctgtcgctc aggctcagct gctgataccc aggcagtagc
      301 tgatgctgtc acctaccagc tcggtttcca cagcattgaa ctgaatgagc ctccactggt
      361 ccacacagca gccagcctct ttaaggagat gtgttaccga taccgggaag acctgatggc
      421 gggaatcatc atcgcaggct gggaccctca agaaggaggg caggtgtact cagtgcctat
      481 ggggggtatg atggtaaggc agtcctttgc cattggaggc tccgggagct cctacatcta
      541 tggctatgtt gatgctacct accgggaagg catgaccaag gaagagtgtc tgcaattcac
      601 tgccaatgct ctcgctttgg ccatggagcg ggatggctcc agtggaggag tgatccgcct
      661 ggcagccatt gcagagtcag gggtagagcg gcaagtactt ttgggagacc agatacccaa
      721 attcgccgtt gccactttac cacccgcctg aatcctggga ttctagtatg caataagaga
      781 tgccctgtac tgatgcaaaa tttaataaag tttgtcacag agaa
//
