LOCUS       NM_001099780            1849 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens proteasome subunit beta 11 (PSMB11), mRNA.
ACCESSION   NM_001099780 XM_063287 XM_940039
VERSION     NM_001099780.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1849)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1849)
  AUTHORS   Tomaru,U., Tsuji,T., Kiuchi,S., Ishizu,A., Suzuki,A., Otsuka,N.,
            Ito,T., Ikeda,H., Fukasawa,Y. and Kasahara,M.
  TITLE     Decreased expression of thymus-specific proteasome subunit beta5t
            in Down syndrome patients
  JOURNAL   Histopathology 67 (2), 235-244 (2015)
   PUBMED   25556590
  REMARK    GeneRIF: We analysed thymic tissues from patients with trisomy 13
            (n = 4), trisomy 18 (n = 14) and trisomy 21 (n = 13) for
            histological alterations, and for the expression of functionally
            important molecules such as beta5t, a thymoproteasome subunit, and
            cathepsins.
REFERENCE   3  (bases 1 to 1849)
  AUTHORS   Yamada,Y., Tomaru,U., Ishizu,A., Kiuchi,T., Kasahara,M. and
            Matsuno,Y.
  TITLE     Expression of thymoproteasome subunit beta5t in type AB thymoma
  JOURNAL   J Clin Pathol 67 (3), 276-278 (2014)
   PUBMED   24293611
  REMARK    GeneRIF: Histological diversity of type AB thymoma correlates with
            expression of a functional marker beta5t and abundance of
            TdT-positive lymphocytes.
REFERENCE   4  (bases 1 to 1849)
  AUTHORS   Franke,N.E., Niewerth,D., Assaraf,Y.G., van Meerloo,J.,
            Vojtekova,K., van Zantwijk,C.H., Zweegman,S., Chan,E.T., Kirk,C.J.,
            Geerke,D.P., Schimmer,A.D., Kaspers,G.J., Jansen,G. and Cloos,J.
  TITLE     Impaired bortezomib binding to mutant beta5 subunit of the
            proteasome is the underlying basis for bortezomib resistance in
            leukemia cells
  JOURNAL   Leukemia 26 (4), 757-768 (2012)
   PUBMED   21941364
  REMARK    GeneRIF: provide the first evidence that the mechanism underlying
            BTZ resistance in these tumor cells is impaired binding of BTZ to
            the mutant beta5 subunit of the proteasome
REFERENCE   5  (bases 1 to 1849)
  AUTHORS   Yamada,Y., Tomaru,U., Ishizu,A., Kiuchi,T., Marukawa,K., Matsuno,Y.
            and Kasahara,M.
  TITLE     Expression of proteasome subunit beta5t in thymic epithelial tumors
  JOURNAL   Am J Surg Pathol 35 (9), 1296-1304 (2011)
   PUBMED   21836487
  REMARK    GeneRIF: Proteasome beta5t is expressed in most type B and in some
            type AB thymomas and is a marker useful in differentiating type B3
            thymomas from thymic carcinomas when used in combination with other
            diagnostic markers.
REFERENCE   6  (bases 1 to 1849)
  AUTHORS   Tomaru,U., Ishizu,A., Murata,S., Miyatake,Y., Suzuki,S.,
            Takahashi,S., Kazamaki,T., Ohara,J., Baba,T., Iwasaki,S., Fugo,K.,
            Otsuka,N., Tanaka,K. and Kasahara,M.
  TITLE     Exclusive expression of proteasome subunit {beta}5t in the human
            thymic cortex
  JOURNAL   Blood 113 (21), 5186-5191 (2009)
   PUBMED   19289856
  REMARK    GeneRIF: Human beta5t was expressed in approximately 80% of
            cortical thymic epithelial cells and some cortical dendritic cells
REFERENCE   7  (bases 1 to 1849)
  AUTHORS   Murata,S., Sasaki,K., Kishimoto,T., Niwa,S., Hayashi,H.,
            Takahama,Y. and Tanaka,K.
  TITLE     Regulation of CD8+ T cell development by thymus-specific
            proteasomes
  JOURNAL   Science 316 (5829), 1349-1353 (2007)
   PUBMED   17540904
  REMARK    GeneRIF: results suggest a key role for beta5t in generating the
            MHC class I-restricted CD8(+) T cell repertoire during thymic
            selection
REFERENCE   8  (bases 1 to 1849)
  AUTHORS   Margottin-Goguet,F., Hsu,J.Y., Loktev,A., Hsieh,H.M., Reimann,J.D.
            and Jackson,P.K.
  TITLE     Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin
            ligase activates the anaphase promoting complex to allow
            progression beyond prometaphase
  JOURNAL   Dev Cell 4 (6), 813-826 (2003)
   PUBMED   12791267
REFERENCE   9  (bases 1 to 1849)
  AUTHORS   Geley,S., Kramer,E., Gieffers,C., Gannon,J., Peters,J.M. and
            Hunt,T.
  TITLE     Anaphase-promoting complex/cyclosome-dependent proteolysis of human
            cyclin A starts at the beginning of mitosis and is not subject to
            the spindle assembly checkpoint
  JOURNAL   J Cell Biol 153 (1), 137-148 (2001)
   PUBMED   11285280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK122797.1, AB299437.1 and AL132780.5.
            
            On May 17, 2019 this sequence version replaced NM_001099780.1.
            
            Summary: Proteasomes generate peptides that are presented by major
            histocompatibility complex (MHC) I molecules to other cells of the
            immune system. Proteolysis is conducted by 20S proteasomes,
            complexes of 28 subunits arranged as a cylinder in 4
            heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7,
            and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM
            600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM
            600306). Three additional subunits, beta-1i (PSMB9; MIM 177045),
            beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are
            induced by gamma-interferon (IFNG; MIM 147570) and are
            preferentially incorporated into proteasomes to make
            immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit
            expressed exclusively in cortical thymic epithelial cells (Murata
            et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK122797.1, AB299437.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408907.5/ ENSP00000386212.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK122797.1         46-59
            15-917              AB299437.1         1-903
            918-1849            AL132780.5         146926-147857
FEATURES             Location/Qualifiers
     source          1..1849
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1849
                     /gene="PSMB11"
                     /gene_synonym="BETA5T"
                     /note="proteasome subunit beta 11"
                     /db_xref="GeneID:122706"
                     /db_xref="HGNC:HGNC:31963"
                     /db_xref="MIM:611137"
     exon            1..1849
                     /gene="PSMB11"
                     /gene_synonym="BETA5T"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..917
                     /gene="PSMB11"
                     /gene_synonym="BETA5T"
                     /EC_number="3.4.25.1"
                     /note="proteasome subunit beta 5T; proteasome subunit
                     beta-5t; proteasome (prosome, macropain) subunit, beta
                     type, 11"
                     /codon_start=1
                     /product="proteasome subunit beta type-11"
                     /protein_id="NP_001093250.1"
                     /db_xref="CCDS:CCDS41923.1"
                     /db_xref="GeneID:122706"
                     /db_xref="HGNC:HGNC:31963"
                     /db_xref="MIM:611137"
                     /translation="MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGP
                     RLAHGTTTLAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCA
                     TWYRVLQRELRLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPEL
                     FYVYSDGTRLQGDIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAY
                     SGGSVDLFHVRESGWEHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAED
                     RELSVGPGEVTPGDSRMPAGTETV"
     regulatory      1099..1104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMB11"
                     /gene_synonym="BETA5T"
                     /note="hexamer: AACAAG"
     polyA_site      1120
                     /gene="PSMB11"
                     /gene_synonym="BETA5T"
                     /note="major polyA site"
ORIGIN      
        1 attcagcccc agggatggct ctgcaggatg tgtgcaagtg gcagtcccct gacacccagg
       61 gaccatcacc tcacctgcct cgggctggcg gctgggctgt gccccggggt tgtgaccctc
      121 aaaccttcct gcagatccat ggccccagac tggcccacgg caccaccact ctggccttcc
      181 gcttccgtca tggagtcatt gctgcagctg acacgcgttc ctcctgtggc agctatgtgg
      241 cgtgtccagc ctcatgcaag gtcatccctg tgcaccagca cctcctgggt accacctctg
      301 gcacctctgc cgactgtgct acctggtatc gggtattaca gcgggagctg cggcttcggg
      361 aactgaggga gggtcagctg cccagtgtgg ccagtgctgc caagctcttg tcagccatga
      421 tgtctcaata ccggggactg gatctctgtg tggccactgc cctctgcggc tgggaccgct
      481 ctggccctga gctcttctac gtctatagcg acggcacccg cctgcagggg gacatcttct
      541 ctgtgggctc tggatctccc tatgcctacg gcgtgctaga ccgtggctat cgctacgaca
      601 tgagcaccca ggaagcctac gccctggctc gctgcgccgt ggcccacgcc acccaccgtg
      661 atgcctattc agggggctct gtagaccttt tccacgtgcg ggagagtgga tgggagcatg
      721 tgtcacgcag tgatgcctgt gtgctgtacg tggagttaca gaagctcctg gagccggagc
      781 cagaggagga tgccagccat gcccatcctg agcctgccac tgcccacaga gctgcagaag
      841 atagagagct ctctgtgggg ccaggggagg tgacaccagg agactccagg atgccagcag
      901 ggactgagac ggtgtgagaa gcaggacttg gttggggatg gtgtaggcct ggggagtggg
      961 tgggaggatg ggcagcaggg ggagggtccc gctggcagca gcctcacagc gtctggctct
     1021 agcctgtatg ggttgctggc ttcatttatt gcaagtctcc atcctttcat gactcccaga
     1081 gctattatgg ctctgcccaa caagttccta ttgactccca gtggattggt ccagcctcct
     1141 tcttggcacc aagtccgtct ttcattcaac acttgcagtg tgcctactgc atgccagacg
     1201 catgctaggt gctagaccct cttttcttgc catcttctct gcttttttcc atcatctcat
     1261 ccccagtttc tcttagtttc ggtcctttat gtgtctcagc ttcagcgtct ttgtcttttt
     1321 ctcctgatca ctttgtcagc atggtaagat ggggcacccg ggaagggagc agcccctctc
     1381 agaacgaggc gtagtgatag acaccctttg gatggtgatg ggcttgtctt atctgctctc
     1441 cttctctgac ttgaccatca tgactagaat gattatccct ttactgaatg cagttctcat
     1501 cgcaaccctt tgaggtaaaa atgagtctct ctttacagaa gaggaatcag gttcaaaggg
     1561 ttatgtggct tgccagggtc acacagtaag tggcagggat gacacttaga tccaggcctt
     1621 ctcctccagg gtccatgctc tttcagcaca gctccccctc ccaggccctc tgccctgcct
     1681 ttcctctctt ccctgcaggc ttccggagag ggatgtggag ggagaaagta gctaggccag
     1741 tcccctgcct ggtggctcat gtggctttat cttccaggcc tggagccatc ccccacagcc
     1801 cacccttgct ctccagcttt ctgggcctgg cggtgccgct gccagactt
//
