LOCUS       NM_002801                977 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens proteasome 20S subunit beta 10 (PSMB10), mRNA.
ACCESSION   NM_002801
VERSION     NM_002801.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 977)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 977)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 977)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 977)
  AUTHORS   Wang,S., Li,J., Bai,J., Li,J.M., Che,Y.L., Lin,Q.Y., Zhang,Y.L. and
            Li,H.H.
  TITLE     The immunoproteasome subunit LMP10 mediates angiotensin II-induced
            retinopathy in mice
  JOURNAL   Redox Biol 16, 129-138 (2018)
   PUBMED   29499566
  REMARK    GeneRIF: this study provided novel evidence demonstrating that
            LMP10 is a positive regulator of NF-kB signaling, which contributes
            to Ang II-induced retinopathy.
            Erratum:[Redox Biol. 2024 Jun;72:103163. doi:
            10.1016/j.redox.2024.103163.. PMID: 38653649]
REFERENCE   5  (bases 1 to 977)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 977)
  AUTHORS   Foss,G.S., Larsen,F., Solheim,J. and Prydz,H.
  TITLE     Constitutive and interferon-gamma-induced expression of the human
            proteasome subunit multicatalytic endopeptidase complex-like 1
  JOURNAL   Biochim Biophys Acta 1402 (1), 17-28 (1998)
   PUBMED   9551082
REFERENCE   7  (bases 1 to 977)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   8  (bases 1 to 977)
  AUTHORS   Hisamatsu,H., Shimbara,N., Saito,Y., Kristensen,P., Hendil,K.B.,
            Fujiwara,T., Takahashi,E., Tanahashi,N., Tamura,T., Ichihara,A. and
            Tanaka,K.
  TITLE     Newly identified pair of proteasomal subunits regulated
            reciprocally by interferon gamma
  JOURNAL   J Exp Med 183 (4), 1807-1816 (1996)
   PUBMED   8666937
REFERENCE   9  (bases 1 to 977)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   10 (bases 1 to 977)
  AUTHORS   Larsen,F., Solheim,J., Kristensen,T., Kolsto,A.B. and Prydz,H.
  TITLE     A tight cluster of five unrelated human genes on chromosome 16q22.1
  JOURNAL   Hum Mol Genet 2 (10), 1589-1595 (1993)
   PUBMED   8268911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP289065.1 and BM981173.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002801.3.
            
            Summary: The proteasome is a multicatalytic proteinase complex with
            a highly ordered ring-shaped 20S core structure. The core structure
            is composed of 4 rings of 28 non-identical subunits; 2 rings are
            composed of 7 alpha subunits and 2 rings are composed of 7 beta
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            member of the proteasome B-type family, also known as the T1B
            family, that is a 20S core beta subunit. Proteolytic processing is
            required to generate a mature subunit. Expression of this gene is
            induced by gamma interferon, and this gene product replaces
            catalytic subunit 2 (proteasome beta 7 subunit) in the
            immunoproteasome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.276274.1,
                                           SRR1163655.467374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358514.9/ ENSP00000351314.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-555               BP289065.1         28-582
            556-977             BM981173.1         16-437              c
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..977
                     /gene="PSMB10"
                     /gene_synonym="beta2i; IMD121; LMP10; MECL1; PRAAS5"
                     /note="proteasome 20S subunit beta 10"
                     /db_xref="GeneID:5699"
                     /db_xref="HGNC:HGNC:9538"
                     /db_xref="MIM:176847"
     exon            1..157
                     /gene="PSMB10"
                     /gene_synonym="beta2i; IMD121; LMP10; MECL1; PRAAS5"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..923
                     /gene="PSMB10"
                     /gene_synonym="beta2i; IMD121; LMP10; MECL1; PRAAS5"
                     /EC_number="3.4.25.1"
                     /note="proteasome MECl-1; macropain subunit MECl-1;
                     multicatalytic endopeptidase complex subunit MECl-1;
                     proteasome catalytic subunit 2i; proteasome subunit beta
                     7i; proteasome subunit MECL1; proteasome subunit beta-2i;
                     low molecular mass protein 10; proteasome (prosome,
                     macropain) subunit, beta type, 10; proteasome subunit beta
                     10; proteasome subunit beta2i"
                     /codon_start=1
                     /product="proteasome subunit beta type-10"
                     /protein_id="NP_002792.1"
                     /db_xref="CCDS:CCDS10853.1"
                     /db_xref="GeneID:5699"
                     /db_xref="HGNC:HGNC:9538"
                     /db_xref="MIM:176847"
                     /translation="MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAG
                     LVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKM
                     ELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSR
                     LPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVIT
                     KTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE"
     exon            158..245
                     /gene="PSMB10"
                     /gene_synonym="beta2i; IMD121; LMP10; MECL1; PRAAS5"
                     /inference="alignment:Splign:2.1.0"
     exon            246..343
                     /gene="PSMB10"
                     /gene_synonym="beta2i; IMD121; LMP10; MECL1; PRAAS5"
                     /inference="alignment:Splign:2.1.0"
     exon            344..484
                     /gene="PSMB10"
                     /gene_synonym="beta2i; IMD121; LMP10; MECL1; PRAAS5"
                     /inference="alignment:Splign:2.1.0"
     exon            485..600
                     /gene="PSMB10"
                     /gene_synonym="beta2i; IMD121; LMP10; MECL1; PRAAS5"
                     /inference="alignment:Splign:2.1.0"
     exon            601..659
                     /gene="PSMB10"
                     /gene_synonym="beta2i; IMD121; LMP10; MECL1; PRAAS5"
                     /inference="alignment:Splign:2.1.0"
     exon            660..811
                     /gene="PSMB10"
                     /gene_synonym="beta2i; IMD121; LMP10; MECL1; PRAAS5"
                     /inference="alignment:Splign:2.1.0"
     exon            812..977
                     /gene="PSMB10"
                     /gene_synonym="beta2i; IMD121; LMP10; MECL1; PRAAS5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      953..958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMB10"
                     /gene_synonym="beta2i; IMD121; LMP10; MECL1; PRAAS5"
                     /note="hexamer: AATAAA"
     polyA_site      977
                     /gene="PSMB10"
                     /gene_synonym="beta2i; IMD121; LMP10; MECL1; PRAAS5"
                     /note="major polyA site"
ORIGIN      
        1 agacgtgaag cctagcagag gactttttag ctgctcactg gccccgcttg tctggccgac
       61 tcatccgccc gcgaccccta atcccctctg cctgccccaa gatgctgaag ccagccctgg
      121 agccccgagg gggcttctcc ttcgagaact gccaaagaaa tgcatcattg gaacgcgtcc
      181 tcccggggct caaggtccct cacgcacgca agaccgggac caccatcgcg ggcctggtgt
      241 tccaagacgg ggtcattctg ggcgccgata cgcgagccac taacgattcg gtcgtggcgg
      301 acaagagctg cgagaagatc cacttcatcg cccccaaaat ctactgctgt ggggctggag
      361 tagccgcgga cgccgagatg accacacgga tggtggcgtc caagatggag ctacacgcgt
      421 tatctacggg ccgcgagccc cgcgtggcca cggtcactcg catcctgcgc cagacgctct
      481 tcaggtacca gggccacgtg ggtgcatcgc tgatcgtggg cggcgtagac ctgactggac
      541 cgcagctcta cggtgtgcat ccccatggct cctacagccg tctgcccttc acagccctgg
      601 gctctggtca ggacgcggcc ctggcggtgc tagaagaccg gttccagccg aacatgacgc
      661 tggaggctgc tcaggggctg ctggtggaag ccgtcaccgc cgggatcttg ggtgacctgg
      721 gctccggggg caatgtggac gcatgtgtga tcacaaagac tggcgccaag ctgctgcgga
      781 cactgagctc acccacagag cccgtgaaga ggtctggccg ctaccacttt gtgcctggaa
      841 ccacagctgt cctgacccag acagtgaagc cactaaccct ggagctagtg gaggaaactg
      901 tgcaggctat ggaggtggag taagctgagg cttagagctt ggaacaaggg ggaataaacc
      961 cagaaaatac agttaaa
//
