LOCUS       NM_002793                891 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens proteasome 20S subunit beta 1 (PSMB1), mRNA.
ACCESSION   NM_002793
VERSION     NM_002793.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 891)
  AUTHORS   Munipalli,S.B. and Yenugu,S.
  TITLE     Uroplakin 1a Interacts with Regucalcin and Proteasome Subunit Beta
            1
  JOURNAL   Reprod Sci 30 (12), 3520-3528 (2023)
   PUBMED   37468792
  REMARK    GeneRIF: Uroplakin 1a Interacts with Regucalcin and Proteasome
            Subunit Beta 1.
REFERENCE   2  (bases 1 to 891)
  AUTHORS   Zhao,J., Makhija,S., Zhou,C., Zhang,H., Wang,Y., Muralidharan,M.,
            Huang,B. and Cheng,Y.
  TITLE     Structural insights into the human PA28-20S proteasome enabled by
            efficient tagging and purification of endogenous proteins
  JOURNAL   Proc Natl Acad Sci U S A 119 (33), e2207200119 (2022)
   PUBMED   35858375
REFERENCE   3  (bases 1 to 891)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 891)
  AUTHORS   de Almeida,M., Hinterndorfer,M., Brunner,H., Grishkovskaya,I.,
            Singh,K., Schleiffer,A., Jude,J., Deswal,S., Kalis,R., Vunjak,M.,
            Lendl,T., Imre,R., Roitinger,E., Neumann,T., Kandolf,S.,
            Schutzbier,M., Mechtler,K., Versteeg,G.A., Haselbach,D. and
            Zuber,J.
  TITLE     AKIRIN2 controls the nuclear import of proteasomes in vertebrates
  JOURNAL   Nature 599 (7885), 491-496 (2021)
   PUBMED   34711951
REFERENCE   5  (bases 1 to 891)
  AUTHORS   Sahu,I., Mali,S.M., Sulkshane,P., Xu,C., Rozenberg,A., Morag,R.,
            Sahoo,M.P., Singh,S.K., Ding,Z., Wang,Y., Day,S., Cong,Y.,
            Kleifeld,O., Brik,A. and Glickman,M.H.
  TITLE     The 20S as a stand-alone proteasome in cells can degrade the
            ubiquitin tag
  JOURNAL   Nat Commun 12 (1), 6173 (2021)
   PUBMED   34702852
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 891)
  AUTHORS   Okumura,K., Nogami,M., Taguchi,H., Hisamatsu,H. and Tanaka,K.
  TITLE     The genes for the alpha-type HC3 (PMSA2) and beta-type HC5 (PMSB1)
            subunits of human proteasomes map to chromosomes 6q27 and 7p12-p13
            by fluorescence in situ hybridization
  JOURNAL   Genomics 27 (2), 377-379 (1995)
   PUBMED   7558012
REFERENCE   7  (bases 1 to 891)
  AUTHORS   Kristensen,P., Johnsen,A.H., Uerkvitz,W., Tanaka,K. and Hendil,K.B.
  TITLE     Human proteasome subunits from 2-dimensional gels identified by
            partial sequencing
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1785-1789 (1994)
   PUBMED   7811265
  REMARK    Erratum:[Biochem Biophys Res Commun. 1995 Feb 27;207(3):1059. doi:
            10.1006/bbrc.1995.1294.. PMID: 7864893]
REFERENCE   8  (bases 1 to 891)
  AUTHORS   Tamura,T., Osaka,F., Kawamura,Y., Higuti,T., Ishida,N.,
            Nothwang,H.G., Tsurumi,C., Tanaka,K. and Ichihara,A.
  TITLE     Isolation and characterization of alpha-type HC3 and beta-type HC5
            subunit genes of human proteasomes
  JOURNAL   J Mol Biol 244 (1), 117-124 (1994)
   PUBMED   7966316
REFERENCE   9  (bases 1 to 891)
  AUTHORS   Tamura,T., Lee,D.H., Osaka,F., Fujiwara,T., Shin,S., Chung,C.H.,
            Tanaka,K. and Ichihara,A.
  TITLE     Molecular cloning and sequence analysis of cDNAs for five major
            subunits of human proteasomes (multi-catalytic proteinase
            complexes)
  JOURNAL   Biochim Biophys Acta 1089 (1), 95-102 (1991)
   PUBMED   2025653
REFERENCE   10 (bases 1 to 891)
  AUTHORS   Lee,L.W., Moomaw,C.R., Orth,K., McGuire,M.J., DeMartino,G.N. and
            Slaughter,C.A.
  TITLE     Relationships among the subunits of the high molecular weight
            proteinase, macropain (proteasome)
  JOURNAL   Biochim Biophys Acta 1037 (2), 178-185 (1990)
   PUBMED   2306472
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP369175.1, BC020807.1 and
            BQ685374.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002793.3.
            
            Summary: The proteasome is a multicatalytic proteinase complex with
            a highly ordered ring-shaped 20S core structure. The core structure
            is composed of 4 rings of 28 non-identical subunits; 2 rings are
            composed of 7 alpha subunits and 2 rings are composed of 7 beta
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway.  An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            member of the proteasome B-type family, also known as the T1B
            family, that is a 20S core beta subunit. This gene is tightly
            linked to the TBP (TATA-binding protein) gene in human and in
            mouse, and is transcribed in the opposite orientation in both
            species. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.404183.1, HM005585.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153733, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262193.7/ ENSP00000262193.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BP369175.1         35-61
            28-888              BC020807.1         1-861
            889-891             BQ685374.1         641-643
FEATURES             Location/Qualifiers
     source          1..891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..891
                     /gene="PSMB1"
                     /gene_synonym="HC5; NEDMHAL; PMSB1; PSC5"
                     /note="proteasome 20S subunit beta 1"
                     /db_xref="GeneID:5689"
                     /db_xref="HGNC:HGNC:9537"
                     /db_xref="MIM:602017"
     exon            1..178
                     /gene="PSMB1"
                     /gene_synonym="HC5; NEDMHAL; PMSB1; PSC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..791
                     /gene="PSMB1"
                     /gene_synonym="HC5; NEDMHAL; PMSB1; PSC5"
                     /EC_number="3.4.25.1"
                     /note="proteasome subunit HC5; beta-6; proteasome
                     component C5; macropain subunit C5; proteasome gamma
                     chain; multicatalytic endopeptidase complex subunit C5;
                     proteasome beta 1 subunit; proteasome (prosome, macropain)
                     subunit, beta type, 1; proteasome subunit beta 1;
                     proteasome subunit beta6; testicular secretory protein Li
                     45; proteasome subunit beta-6"
                     /codon_start=1
                     /product="proteasome subunit beta type-1"
                     /protein_id="NP_002784.1"
                     /db_xref="CCDS:CCDS34577.1"
                     /db_xref="GeneID:5689"
                     /db_xref="HGNC:HGNC:9537"
                     /db_xref="MIM:602017"
                     /translation="MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIA
                     GEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKM
                     YKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQR
                     DSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTG
                     DALRICIVTKEGIREETVSLRKD"
     exon            179..286
                     /gene="PSMB1"
                     /gene_synonym="HC5; NEDMHAL; PMSB1; PSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            287..368
                     /gene="PSMB1"
                     /gene_synonym="HC5; NEDMHAL; PMSB1; PSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            369..498
                     /gene="PSMB1"
                     /gene_synonym="HC5; NEDMHAL; PMSB1; PSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            499..605
                     /gene="PSMB1"
                     /gene_synonym="HC5; NEDMHAL; PMSB1; PSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            606..891
                     /gene="PSMB1"
                     /gene_synonym="HC5; NEDMHAL; PMSB1; PSC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      870..875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMB1"
                     /gene_synonym="HC5; NEDMHAL; PMSB1; PSC5"
                     /note="hexamer: ATTAAA"
     polyA_site      891
                     /gene="PSMB1"
                     /gene_synonym="HC5; NEDMHAL; PMSB1; PSC5"
                     /note="major polyA site"
ORIGIN      
        1 gtccggtcaa ggcagccatc tcgccgtgag acagcaagtg tcggatccgc aggcgcagcc
       61 gtgcgatgtt gtcctctaca gccatgtatt cggctcctgg cagagacttg gggatggaac
      121 cgcacagagc cgcgggccct ttgcagctgc gattttcgcc ctacgttttc aacggaggta
      181 ctatactggc aattgctgga gaagattttg caattgttgc ttctgatact cgattgagtg
      241 aagggttttc aattcatacg cgggatagcc ccaaatgtta caaattaaca gacaaaacag
      301 tcattggatg cagcggtttt catggagact gtcttacgct gacaaagatt attgaagcaa
      361 gactaaagat gtataagcat tccaataata aggccatgac tacgggggca attgctgcaa
      421 tgctgtctac aatcctgtat tcaaggcgct tctttccata ctatgtttac aacatcatcg
      481 gtggacttga tgaagaagga aagggggctg tatacagctt tgatccagta gggtcttacc
      541 agagagactc cttcaaggct ggaggctcag caagtgccat gctacagccc ctgcttgaca
      601 accaggttgg ttttaagaac atgcagaatg tggagcatgt tccgctgtcc ttggacagag
      661 ccatgcggct ggtgaaagat gtcttcattt ctgcggctga gagagatgtg tacactgggg
      721 acgcactccg gatctgcata gtgaccaaag agggcatcag ggaggaaact gtttccttaa
      781 ggaaggactg atctgtgtgc tcttatcacc aatcagttca gacctggttg attttgtact
      841 ttggaactgt accttggatg gttttgttta ttaaaagaga aacctgaagt a
//
