LOCUS       NM_001025096            1794 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens proteasome 20S subunit alpha 8 (PSMA8), transcript
            variant 2, mRNA.
ACCESSION   NM_001025096
VERSION     NM_001025096.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1794)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
REFERENCE   2  (bases 1 to 1794)
  AUTHORS   Kirin,M., Chandra,A., Charteris,D.G., Hayward,C., Campbell,S.,
            Celap,I., Bencic,G., Vatavuk,Z., Kirac,I., Richards,A.J.,
            Tenesa,A., Snead,M.P., Fleck,B.W., Singh,J., Harsum,S.,
            Maclaren,R.E., den Hollander,A.I., Dunlop,M.G., Hoyng,C.B.,
            Wright,A.F., Campbell,H., Vitart,V. and Mitry,D.
  TITLE     Genome-wide association study identifies genetic risk underlying
            primary rhegmatogenous retinal detachment
  JOURNAL   Hum Mol Genet 22 (15), 3174-3185 (2013)
   PUBMED   23585552
REFERENCE   3  (bases 1 to 1794)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 1794)
  AUTHORS   Nusbaum,C., Zody,M.C., Borowsky,M.L., Kamal,M., Kodira,C.D.,
            Taylor,T.D., Whittaker,C.A., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Yang,X., Abouelleil,A., Allen,N.R., Anderson,S.,
            Bloom,T., Bugalter,B., Butler,J., Cook,A., DeCaprio,D., Engels,R.,
            Garber,M., Gnirke,A., Hafez,N., Hall,J.L., Norman,C.H., Itoh,T.,
            Jaffe,D.B., Kuroki,Y., Lehoczky,J., Lui,A., Macdonald,P.,
            Mauceli,E., Mikkelsen,T.S., Naylor,J.W., Nicol,R., Nguyen,C.,
            Noguchi,H., O'Leary,S.B., O'Neill,K., Piqani,B., Smith,C.L.,
            Talamas,J.A., Topham,K., Totoki,Y., Toyoda,A., Wain,H.M.,
            Young,S.K., Zeng,Q., Zimmer,A.R., Fujiyama,A., Hattori,M.,
            Birren,B.W., Sakaki,Y. and Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 18
  JOURNAL   Nature 437 (7058), 551-555 (2005)
   PUBMED   16177791
  REMARK    Erratum:[Nature. 2005 Dec 1;438(7068):696. O'Neill, Keith [added]]
REFERENCE   5  (bases 1 to 1794)
  AUTHORS   Margottin-Goguet,F., Hsu,J.Y., Loktev,A., Hsieh,H.M., Reimann,J.D.
            and Jackson,P.K.
  TITLE     Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin
            ligase activates the anaphase promoting complex to allow
            progression beyond prometaphase
  JOURNAL   Dev Cell 4 (6), 813-826 (2003)
   PUBMED   12791267
REFERENCE   6  (bases 1 to 1794)
  AUTHORS   Claverol,S., Burlet-Schiltz,O., Girbal-Neuhauser,E., Gairin,J.E.
            and Monsarrat,B.
  TITLE     Mapping and structural dissection of human 20 S proteasome using
            proteomic approaches
  JOURNAL   Mol Cell Proteomics 1 (8), 567-578 (2002)
   PUBMED   12376572
  REMARK    GeneRIF: This article provides an overview of some of the
            components in the human 20 S proteasome.
REFERENCE   7  (bases 1 to 1794)
  AUTHORS   Geley,S., Kramer,E., Gieffers,C., Gannon,J., Peters,J.M. and
            Hunt,T.
  TITLE     Anaphase-promoting complex/cyclosome-dependent proteolysis of human
            cyclin A starts at the beginning of mitosis and is not subject to
            the spindle assembly checkpoint
  JOURNAL   J Cell Biol 153 (1), 137-148 (2001)
   PUBMED   11285280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC042820.1 and BC025393.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001025096.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1, resulting
            in a shorter isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.156840.1,
                                           SRR1803613.290871.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000415576.7/ ENSP00000409284.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1262              BC042820.1         18-1279
            1263-1794           BC025393.1         1154-1685
FEATURES             Location/Qualifiers
     source          1..1794
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     gene            1..1794
                     /gene="PSMA8"
                     /gene_synonym="PSMA7L"
                     /note="proteasome 20S subunit alpha 8"
                     /db_xref="GeneID:143471"
                     /db_xref="HGNC:HGNC:22985"
                     /db_xref="MIM:617841"
     exon            1..199
                     /gene="PSMA8"
                     /gene_synonym="PSMA7L"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..850
                     /gene="PSMA8"
                     /gene_synonym="PSMA7L"
                     /EC_number="3.4.25.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     proteasome (prosome, macropain) subunit, alpha type, 8;
                     proteasome subunit alpha-type 8; proteasome subunit alpha
                     8; alpha4s; proteasome alpha 4 subunit"
                     /codon_start=1
                     /product="proteasome subunit alpha-type 8 isoform 2"
                     /protein_id="NP_001020267.1"
                     /db_xref="CCDS:CCDS45842.1"
                     /db_xref="GeneID:143471"
                     /db_xref="HGNC:HGNC:22985"
                     /db_xref="MIM:617841"
                     /translation="MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVV
                     LGVEKKSVAKLQDERTVRKICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVED
                     PVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKA
                     NAIGRSAKTVREFLEKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQP
                     LKMFSAKEVELYVTEIEKEKEEAEKKKSKKSV"
     exon            200..326
                     /gene="PSMA8"
                     /gene_synonym="PSMA7L"
                     /inference="alignment:Splign:2.1.0"
     exon            327..451
                     /gene="PSMA8"
                     /gene_synonym="PSMA7L"
                     /inference="alignment:Splign:2.1.0"
     exon            452..574
                     /gene="PSMA8"
                     /gene_synonym="PSMA7L"
                     /inference="alignment:Splign:2.1.0"
     exon            575..694
                     /gene="PSMA8"
                     /gene_synonym="PSMA7L"
                     /inference="alignment:Splign:2.1.0"
     exon            695..757
                     /gene="PSMA8"
                     /gene_synonym="PSMA7L"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1794
                     /gene="PSMA8"
                     /gene_synonym="PSMA7L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1774..1779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMA8"
                     /gene_synonym="PSMA7L"
                     /note="hexamer: AATAAA"
     polyA_site      1794
                     /gene="PSMA8"
                     /gene_synonym="PSMA7L"
                     /note="major polyA site"
ORIGIN      
        1 gcttccgggc ggtagcacgc tgtgttggcg gcggctcccc gcttgcctca gctgcagcag
       61 cgggaagctc ggtggcaagc ccttgtagtc ctgtgcgatg gcgtctcgat atgacagggc
      121 gatcactgtc ttctccccag acggacacct ttttcaagtt gaatatgccc aggaagcggt
      181 gaagaaagga tccaccgcgg tcggaattcg aggtaccaat atagttgttc ttggggtaga
      241 aaaaaaatct gttgccaagc ttcaagatga aagaactgtg aggaaaattt gtgcccttga
      301 tgaccatgtc tgcatggctt ttgcaggact tactgctgat gctagagtag taataaacag
      361 agcccgtgtg gagtgccaga gccataagct tacggttgag gacccagtca ctgtagaata
      421 cataactcgc ttcatagcaa ctttaaagca gaaatatacc caaagcaatg gacgaagacc
      481 ttttggtatt tctgccttaa ttgtaggttt tgatgatgat ggtatctcaa gattgtatca
      541 gacagatcct tctggtactt atcatgcttg gaaggcaaat gcaataggcc gaagtgctaa
      601 aactgttcga gaatttctag aaaagaatta cacagaagat gccatagcaa gtgacagtga
      661 agctatcaag ttagcaataa aagctttgct agaagttgtc cagtctggtg gaaaaaacat
      721 tgaacttgct ataataagaa gaaatcaacc tttgaagatg tttagtgcaa aagaagttga
      781 attatatgta actgaaatag aaaaggaaaa ggaagaagca gagaagaaaa aatcaaagaa
      841 atctgtctaa ttcttaggat gaccactggg aggtcttaat gttttgtttt attgtactgc
      901 ctgaggttgt ttagtgaaat tttagaggaa aacagttatt ttgcagcatt acatgcagta
      961 cttgtgtgat gttttgagaa tgccagatct gtggctgtct tcattctatt acatagtcaa
     1021 acataggttt atgtgaagat tttctttgaa aggggatttc agtaattgtt gagagcagtc
     1081 ataattccac ataagcctga gactctataa tttgtccagt gtcttactta ccttcatata
     1141 tgcaaatata attttaaaaa attttttaat taaaaaaatt taataatttg gtgatgtttg
     1201 aatattgact gtcagttaag gacatagcta ttccaaataa actaaatata atattgagct
     1261 gcatttctca aagaatgaca aaagcatcct tatactgatg agttcttaaa attttgtcag
     1321 agccttcttc attttacaat attttgttat ttttatttta cctttttcat tttacaatat
     1381 ttcgttattt ttattttacc tttttcattt tacaagttgc aatatattgt ttcgttcatg
     1441 gaacaaatat aggctgaatt caaacatgca attaaagcat gggaagagct tctaagggca
     1501 tcttaacagg atgctacatg aaaataagga aagaaattaa tacatatcac ttttagttta
     1561 gatttttatt ttatctcaag tatgtccagt gtgttcggtt tgttacatat tccatgaaat
     1621 atctgagtgt gtattttatg attggtatta tggaaggctt attgggggaa caagaaaaat
     1681 ataaaaagtg atctctgccc acggaaagga tttaatccaa atggtccaca agaggaatgt
     1741 gcttaattcc tacagtgagt ttatattttt gaaaataaaa gctagtaaat attc
//
