LOCUS       NM_002792                962 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens proteasome 20S subunit alpha 7 (PSMA7), mRNA.
ACCESSION   NM_002792
VERSION     NM_002792.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 962)
  AUTHORS   Sheng,G., Li,F., Jin,W. and Wang,K.
  TITLE     Pan-caner analysis identifies PSMA7 as a targets for amplification
            at 20q13.33 in tumorigenesis
  JOURNAL   Sci Rep 14 (1), 3034 (2024)
   PUBMED   38321088
  REMARK    GeneRIF: Pan-caner analysis identifies PSMA7 as a targets for
            amplification at 20q13.33 in tumorigenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 962)
  AUTHORS   Xu,X., Pei,M., Kim,K.Y., Xi,H., Lee,S.G., Chung,K.Y., Roh,M.R. and
            Jin,Z.
  TITLE     Proteasome Subunit Alpha Type-7 Expression Suppresses Cutaneous
            Squamous Cell Carcinoma Progression by Inhibiting Cancer-associated
            Cytokines
  JOURNAL   In Vivo 37 (4), 1584-1592 (2023)
   PUBMED   37369480
  REMARK    GeneRIF: Proteasome Subunit Alpha Type-7 Expression Suppresses
            Cutaneous Squamous Cell Carcinoma Progression by Inhibiting
            Cancer-associated Cytokines.
REFERENCE   3  (bases 1 to 962)
  AUTHORS   Zhao,J., Makhija,S., Zhou,C., Zhang,H., Wang,Y., Muralidharan,M.,
            Huang,B. and Cheng,Y.
  TITLE     Structural insights into the human PA28-20S proteasome enabled by
            efficient tagging and purification of endogenous proteins
  JOURNAL   Proc Natl Acad Sci U S A 119 (33), e2207200119 (2022)
   PUBMED   35858375
REFERENCE   4  (bases 1 to 962)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 962)
  AUTHORS   Du,H., Huang,X., Wang,S., Wu,Y., Xu,W. and Li,M.
  TITLE     PSMA7, a potential biomarker of diseases
  JOURNAL   Protein Pept Lett 16 (5), 486-489 (2009)
   PUBMED   19442227
  REMARK    Review article
REFERENCE   6  (bases 1 to 962)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   7  (bases 1 to 962)
  AUTHORS   Huang,J., Kwong,J., Sun,E.C. and Liang,T.J.
  TITLE     Proteasome complex as a potential cellular target of hepatitis B
            virus X protein
  JOURNAL   J Virol 70 (8), 5582-5591 (1996)
   PUBMED   8764072
REFERENCE   8  (bases 1 to 962)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   9  (bases 1 to 962)
  AUTHORS   Akioka,H., Forsberg,N.E., Ishida,N., Okumura,K., Nogami,M.,
            Taguchi,H., Noda,C. and Tanaka,K.
  TITLE     Isolation and characterization of the HC8 subunit gene of the human
            proteasome
  JOURNAL   Biochem Biophys Res Commun 207 (1), 318-323 (1995)
   PUBMED   7857283
REFERENCE   10 (bases 1 to 962)
  AUTHORS   Kristensen,P., Johnsen,A.H., Uerkvitz,W., Tanaka,K. and Hendil,K.B.
  TITLE     Human proteasome subunits from 2-dimensional gels identified by
            partial sequencing
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1785-1789 (1994)
   PUBMED   7811265
  REMARK    Erratum:[Biochem Biophys Res Commun. 1995 Feb 27;207(3):1059. doi:
            10.1006/bbrc.1995.1294.. PMID: 7864893]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG575009.1, AF054185.1 and
            BU632089.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002792.3.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. Proteasomes are
            distributed throughout eukaryotic cells at a high concentration and
            cleave peptides in an ATP/ubiquitin-dependent process in a
            non-lysosomal pathway. This gene encodes a member of the peptidase
            T1A family that functions as a 20S core alpha subunit. The encoded
            protein interacts with the hepatitis B virus X protein and plays a
            role in regulating hepatitis C virus internal ribosome entry site
            (IRES) activity, an activity essential for viral replication. The
            encoded protein also plays a role in the cellular stress response
            by regulating hypoxia-inducible factor-1alpha. A pseudogene of this
            gene is located on the long arm of chromosome 9. [provided by
            RefSeq, Jul 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.498155.1,
                                           SRR1163657.409375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370873.9/ ENSP00000359910.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BG575009.1         52-82
            32-568              AF054185.1         26-562
            569-962             BU632089.1         23-416              c
FEATURES             Location/Qualifiers
     source          1..962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..962
                     /gene="PSMA7"
                     /gene_synonym="C6; HEL-S-276; HSPC; RC6-1; XAPC7"
                     /note="proteasome 20S subunit alpha 7"
                     /db_xref="GeneID:5688"
                     /db_xref="HGNC:HGNC:9536"
                     /db_xref="MIM:606607"
     exon            1..187
                     /gene="PSMA7"
                     /gene_synonym="C6; HEL-S-276; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..838
                     /gene="PSMA7"
                     /gene_synonym="C6; HEL-S-276; HSPC; RC6-1; XAPC7"
                     /EC_number="3.4.25.1"
                     /note="proteasome subunit alpha 4; proteasome subunit
                     RC6-1; proteasome subunit XAPC7; proteasome subunit alpha
                     7; proteasome (prosome, macropain) subunit, alpha type, 7;
                     alpha-4; epididymis secretory protein Li 276; testicular
                     tissue protein Li 151"
                     /codon_start=1
                     /product="proteasome subunit alpha type-7"
                     /protein_id="NP_002783.1"
                     /db_xref="CCDS:CCDS13489.1"
                     /db_xref="GeneID:5688"
                     /db_xref="HGNC:HGNC:9536"
                     /db_xref="MIM:606607"
                     /translation="MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLG
                     VEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPV
                     TVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANA
                     IGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLK
                     ILNPEEIEKYVAEIEKEKEENEKKKQKKAS"
     exon            188..314
                     /gene="PSMA7"
                     /gene_synonym="C6; HEL-S-276; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            315..439
                     /gene="PSMA7"
                     /gene_synonym="C6; HEL-S-276; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            440..562
                     /gene="PSMA7"
                     /gene_synonym="C6; HEL-S-276; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            563..682
                     /gene="PSMA7"
                     /gene_synonym="C6; HEL-S-276; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            683..745
                     /gene="PSMA7"
                     /gene_synonym="C6; HEL-S-276; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            746..962
                     /gene="PSMA7"
                     /gene_synonym="C6; HEL-S-276; HSPC; RC6-1; XAPC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      942..947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMA7"
                     /gene_synonym="C6; HEL-S-276; HSPC; RC6-1; XAPC7"
                     /note="hexamer: AATAAA"
     polyA_site      962
                     /gene="PSMA7"
                     /gene_synonym="C6; HEL-S-276; HSPC; RC6-1; XAPC7"
                     /note="major polyA site"
ORIGIN      
        1 gtagtggcgc cgggagtcgc gggtgcgcgc gggccgtgag tgtgcgcttt tgagagtcgc
       61 ggcggaagga gcccggccgc cgcccgccgg catgagctac gaccgcgcca tcaccgtctt
      121 ctcgcccgac ggccacctct tccaagtgga gtacgcgcag gaggccgtca agaagggctc
      181 gaccgcggtt ggtgttcgag gaagagacat tgttgttctt ggtgtggaga agaagtcagt
      241 ggccaaactg caggatgaaa gaacagtgcg gaagatctgt gctttggatg acaacgtctg
      301 catggccttt gcaggcctca ccgccgatgc aaggatagtc atcaacaggg cccgggtgga
      361 gtgccagagc caccggctga ctgtggagga cccggtcact gtggagtaca tcacccgcta
      421 catcgccagt ctgaagcagc gttatacgca gagcaatggg cgcaggccgt ttggcatctc
      481 tgccctcatc gtgggtttcg actttgatgg cactcctagg ctctatcaga ctgacccctc
      541 gggcacatac catgcctgga aggccaatgc cataggtcgg ggtgccaagt cagtgcgcga
      601 gttcctggag aagaactata ctgacgaagc cattgaaaca gatgatctga ccattaagct
      661 ggtgatcaag gcactcctgg aagtggttca gtcaggtggc aaaaacattg aacttgctgt
      721 catgaggcga gatcaatccc tcaagatttt aaatcctgaa gaaattgaga agtatgttgc
      781 tgaaattgaa aaagaaaaag aagaaaacga aaagaagaaa caaaagaaag catcatgatg
      841 aataaaatgt ctttgcttgt aatttttaaa ttcatatcaa tcatggatga gtctcgatgt
      901 gtaggccttt ccattccatt tattcacact gagtgtccta caataaactt ccgtattttt
      961 aa
//
