LOCUS       NM_002790               3815 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens proteasome 20S subunit alpha 5 (PSMA5), transcript
            variant 1, mRNA.
ACCESSION   NM_002790
VERSION     NM_002790.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3815)
  AUTHORS   Xie,S., Li,X., Yan,J., Yu,H., Chen,S. and Chen,K.
  TITLE     Knockdown of liver cancer cell-secreted exosomal PSMA5 controls
            macrophage polarization to restrain cancer progression by blocking
            JAK2/STAT3 signaling
  JOURNAL   Immun Inflamm Dis 12 (2), e1146 (2024)
   PUBMED   38415977
  REMARK    GeneRIF: Knockdown of liver cancer cell-secreted exosomal PSMA5
            controls macrophage polarization to restrain cancer progression by
            blocking JAK2/STAT3 signaling.
REFERENCE   2  (bases 1 to 3815)
  AUTHORS   Lu,F., Zhou,J., Chen,Q., Zhu,J., Zheng,X., Fang,N. and Qiao,L.
  TITLE     PSMA5 contributes to progression of lung adenocarcinoma in
            association with the JAK/STAT pathway
  JOURNAL   Carcinogenesis 43 (7), 624-634 (2022)
   PUBMED   35605971
  REMARK    GeneRIF: PSMA5 contributes to progression of lung adenocarcinoma in
            association with the JAK/STAT pathway.
REFERENCE   3  (bases 1 to 3815)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3815)
  AUTHORS   Duan,J., Li,W., Shu,X., Yang,B., He,X. and Guo,X.
  TITLE     Conserved Mitotic Phosphorylation of a Proteasome Subunit Regulates
            Cell Proliferation
  JOURNAL   Cells 10 (11), 3075 (2021)
   PUBMED   34831298
  REMARK    GeneRIF: Conserved Mitotic Phosphorylation of a Proteasome Subunit
            Regulates Cell Proliferation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3815)
  AUTHORS   de Almeida,M., Hinterndorfer,M., Brunner,H., Grishkovskaya,I.,
            Singh,K., Schleiffer,A., Jude,J., Deswal,S., Kalis,R., Vunjak,M.,
            Lendl,T., Imre,R., Roitinger,E., Neumann,T., Kandolf,S.,
            Schutzbier,M., Mechtler,K., Versteeg,G.A., Haselbach,D. and
            Zuber,J.
  TITLE     AKIRIN2 controls the nuclear import of proteasomes in vertebrates
  JOURNAL   Nature 599 (7885), 491-496 (2021)
   PUBMED   34711951
REFERENCE   6  (bases 1 to 3815)
  AUTHORS   Seeger,M., Ferrell,K., Frank,R. and Dubiel,W.
  TITLE     HIV-1 tat inhibits the 20 S proteasome and its 11 S
            regulator-mediated activation
  JOURNAL   J Biol Chem 272 (13), 8145-8148 (1997)
   PUBMED   9079628
REFERENCE   7  (bases 1 to 3815)
  AUTHORS   Coux,O., Tanaka,K. and Goldberg,A.L.
  TITLE     Structure and functions of the 20S and 26S proteasomes
  JOURNAL   Annu Rev Biochem 65, 801-847 (1996)
   PUBMED   8811196
  REMARK    Review article
REFERENCE   8  (bases 1 to 3815)
  AUTHORS   Kristensen,P., Johnsen,A.H., Uerkvitz,W., Tanaka,K. and Hendil,K.B.
  TITLE     Human proteasome subunits from 2-dimensional gels identified by
            partial sequencing
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1785-1789 (1994)
   PUBMED   7811265
  REMARK    Erratum:[Biochem Biophys Res Commun. 1995 Feb 27;207(3):1059. doi:
            10.1006/bbrc.1995.1294.. PMID: 7864893]
REFERENCE   9  (bases 1 to 3815)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   10 (bases 1 to 3815)
  AUTHORS   DeMartino,G.N., Orth,K., McCullough,M.L., Lee,L.W., Munn,T.Z.,
            Moomaw,C.R., Dawson,P.A. and Slaughter,C.A.
  TITLE     The primary structures of four subunits of the human,
            high-molecular-weight proteinase, macropain (proteasome), are
            distinct but homologous
  JOURNAL   Biochim Biophys Acta 1079 (1), 29-38 (1991)
   PUBMED   1888762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313351.1, AK225990.1,
            AL390252.9 and H08369.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002790.3.
            
            Summary: The proteasome is a multicatalytic proteinase complex with
            a highly ordered ring-shaped 20S core structure. The core structure
            is composed of 4 rings of 28 non-identical subunits; 2 rings are
            composed of 7 alpha subunits and 2 rings are composed of 7 beta
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            member of the peptidase T1A family, that is a 20S core alpha
            subunit. Multiple alternatively spliced transcript variants
            encoding two distinct isoforms have been found for this gene.
            [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) is the predominant transcript
            and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2400113.1,
                                           SRR11853562.1578.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271308.9/ ENSP00000271308.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-844               AK313351.1         1-844
            845-1007            AK225990.1         833-995
            1008-3665           AL390252.9         152442-155099       c
            3666-3815           H08369.1           24-173              c
FEATURES             Location/Qualifiers
     source          1..3815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..3815
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /note="proteasome 20S subunit alpha 5"
                     /db_xref="GeneID:5686"
                     /db_xref="HGNC:HGNC:9534"
                     /db_xref="MIM:176844"
     exon            1..147
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..844
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /EC_number="3.4.25.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     macropain subunit zeta; proteasome subunit zeta;
                     proteasome zeta chain; macropain zeta chain;
                     multicatalytic endopeptidase complex zeta chain;
                     proteasome component 5; proteasome subunit alpha type-5;
                     proteasome alpha 5 subunit; alpha-5; proteasome (prosome,
                     macropain) subunit, alpha type, 5; epididymis tissue sperm
                     binding protein Li 11n; proteasome subunit alpha 5"
                     /codon_start=1
                     /product="proteasome subunit alpha type-5 isoform 1"
                     /protein_id="NP_002781.2"
                     /db_xref="CCDS:CCDS799.1"
                     /db_xref="GeneID:5686"
                     /db_xref="HGNC:HGNC:9534"
                     /db_xref="MIM:176844"
                     /translation="MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSE
                     GVCLAVEKRITSPLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFT
                     YNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSG
                     TFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELA
                     TVQPGQNFHMFTKEELEEVIKDI"
     exon            148..214
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /inference="alignment:Splign:2.1.0"
     exon            215..341
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /inference="alignment:Splign:2.1.0"
     exon            342..409
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /inference="alignment:Splign:2.1.0"
     exon            410..517
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /inference="alignment:Splign:2.1.0"
     exon            518..576
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /inference="alignment:Splign:2.1.0"
     exon            577..679
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /inference="alignment:Splign:2.1.0"
     exon            680..766
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /inference="alignment:Splign:2.1.0"
     exon            767..3815
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      970..975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /note="hexamer: CATAAA"
     regulatory      987..992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /note="hexamer: AATAAA"
     regulatory      991..996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /note="hexamer: AAGAAA"
     polyA_site      997
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /note="major polyA site"
     polyA_site      1007
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /note="major polyA site"
     polyA_site      1017
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
     regulatory      3794..3799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
                     /note="hexamer: ATTAAA"
     polyA_site      3815
                     /gene="PSMA5"
                     /gene_synonym="PSC5; ZETA"
ORIGIN      
        1 agttggtcct tagtactgcg gccgtgtggg tgagttggct gccggtgagt tgggtgccgg
       61 tggagtcgtg ttggtcctca gaatccccgc gtagccgctg cctcctccta ccctcgccat
      121 gtttcttacc cggtctgagt acgacagggg cgtgaatact ttttctcccg aaggaagatt
      181 atttcaagtg gaatatgcca ttgaggctat caagcttggt tctacagcca ttgggatcca
      241 gacatcagag ggtgtgtgcc tagctgtgga gaagagaatt acttccccac tgatggagcc
      301 cagcagcatt gagaaaattg tagagattga tgctcacata ggttgtgcca tgagtgggct
      361 aattgctgat gctaagactt taattgataa agccagagtg gagacacaga accactggtt
      421 cacctacaat gagacaatga cagtggagag tgtgacccaa gctgtgtcca atctggcttt
      481 gcagtttgga gaagaagatg cagatccagg tgccatgtct cgtccctttg gagtagcatt
      541 attatttgga ggagttgatg agaaaggacc ccagctgttt catatggacc catctgggac
      601 ctttgtacag tgtgatgctc gagcaattgg ctctgcttca gagggtgccc agagctcctt
      661 gcaagaagtt taccacaagt ctatgacttt gaaagaagcc atcaagtctt cactcatcat
      721 cctcaaacaa gtaatggagg agaagctgaa tgcaacaaac attgagctag ccacagtgca
      781 gcctggccag aatttccaca tgttcacaaa ggaagaactt gaagaggtta tcaaggacat
      841 ttaaggaatc ctgatcctca gaacttctct gggacaattt cagttctaat aatgtcctta
      901 aattttattt ccagctcctg ttccttggaa aatctccatt gtatgtgcat tttttaaatg
      961 atgtctgtac ataaaggcag ttctgaaata aagaaaattt taaaatattt gttaatagac
     1021 tgttctcttc taatagtctt tttttttttt ttttttttaa gagatgaggt ctcactatat
     1081 tgcccaggct ggtttcaaac tcctgggttc aagtgatctt cccgcctctg cctcctgaag
     1141 tgctaggatt ataggcgaga gccactgtgc ccagccattg taatacagtc ttttgtttga
     1201 aatgcaaatg ttagtgggcc aaaaggacag tgttattaat atccctattc tatgaagatg
     1261 tctgttctaa aactgtttta gtgatgctct ataacagaat caactatatc cattaatccc
     1321 atggtgttga taaatgaact agtccagctc ttcccagtgg ttaatagatg ttaacagcac
     1381 tgtaaatcca tttcggccct ataatttctg gagcaaacgt gtatttttgc tgcttttctt
     1441 ataaggagat gctactaatt gactatcaga agaacatgtt ttgaggtcct cctcaaaaca
     1501 ttgatgggtt ggaatcagcc atcaacagtg ttgtaccagt tcttgggtct tgatagacaa
     1561 tttggaaaga gatttccttg tttacgaagt gaaggactaa gaattaaatt aatgaccttg
     1621 gcctcactgg caatcaatta caaatctcta tatcagtaag agaattgtaa aattcagaag
     1681 cagtttacat tagactttgg aatgaatgat gaactttccc cattagagct gccatcatat
     1741 gattggtgga gattgtttaa agaatcattc tatctcagcc tcaaaaatta ccacgggaag
     1801 atggtatcag tatcactact taacagatga agaatctaat gctgtgtgcc catggacaca
     1861 caaaattaag ctgttgggac ttgaacagct caaattttct tgtttcagat caccagctct
     1921 tgagtaatag ggaaatctgg agatttgaaa agtacttgca ctgtccacaa catggctaat
     1981 ccatatgtgg atgatgcaga attgatttaa ttcactaaca gggaccccat aattatttgc
     2041 tgggctctgg gtatattgat gtgtaggaag ttgtactata tgttaataaa ttatgactat
     2101 ttggataggc tgaattcata ctaaatccat actgtagttc aacaaaaaac aacatgttta
     2161 tatacatttg gaaactgcaa tgataggaaa catttggaag aaagggattt tgccctagaa
     2221 taacacataa ggaaagcaga gaattagagt atattgttac tgaatgttcc agagacttct
     2281 agtgatttta acacttatta agtatagcat gttgatgggg agatttgttt ctctaaagat
     2341 cactttgttt tattaaatcc taatagaaaa tacccttgaa aatcctatct catttattcc
     2401 tgtaacaaat ttattgagca cctacctact atatgccaag aaatgtatta gccatcaggc
     2461 agagagctgt tcaaatggta gatatgatct gtgctcctgt gaaacttcta gtggggagag
     2521 ccaaacaata aacaatattc ctttttaact ctaggttaat gcagaaatgg ataaagccca
     2581 tgttgctttt gggagaggtg agttgtgtct ctgaatcaca tgcatttcat agggggaaaa
     2641 atgcccaaat actaaggagt agctcttagc ctatgtccgt tcgcctcagc ttaagttgtt
     2701 ttccctccca ctggctgggc agcatatttg tgttttacct ggtaaaacag taaatttcgt
     2761 accttctata attggcattc ttcaaagagg tagaactttg atttttttgt agaatattaa
     2821 aacaagcttt cttaggttaa agaagtgatc ttactacgaa cagcaatggt ttcatgatgt
     2881 gtaattgctt tatgttatct ttctgctata gaatgtttcc tggagaaagg tacggttttt
     2941 agtaataaga taaatttact ttagtcctgc aaataaggtg aaatcttatg tccagtatct
     3001 cacaaaggag aactgacagt gccactttta tatttaatgt caatctcatt agacaaaaat
     3061 gaaatatagt tcctagggtt tccaatttaa aaagtgaaat aataaatata ttcactcaaa
     3121 cattttctca gtgccatatg caagttacca tgtcccagaa gctgatacag tttgaagaag
     3181 gaaatatata agtactgtaa gcctgtgata actaaaagca acatactaaa aagtgaaggt
     3241 acagataatt ggaacaaatt taatagcgtt taaaagtgta tttggtaatt tctccaggag
     3301 gtggcactgt tgagttgttt tttcttttca gacagtaaga caatagacca ttcatctttg
     3361 tgtcacccaa acaaagaaat attcctttat aacccccttt cctcccccca cctaatcaca
     3421 tgctactgga actgactgtc ttgtgatcta ctcccatagt tggcatagat ttaaaaataa
     3481 tcttttttaa attaatctga tagtagttat ggaaaggaac aaattgttca ccaattttca
     3541 tcagctttat cttttcagtc cagtaactga gaacttaaaa agactattct agtgatttta
     3601 ctatcctgct cagatggcat tcaaaaacat ttttcacttc tcacgtcttg gaaaaatttg
     3661 taaattcgtt aagtcttttt gtttgaaagt taatgtgact ggaaatattt taatgtaaat
     3721 atcgggttgg gtgcattgta tcattttgct ctacaatgac tatatcctca tttgggttta
     3781 tggccagttt ataattaaaa gtaatcttta cttgc
//
