LOCUS       NM_002786               1195 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens proteasome 20S subunit alpha 1 (PSMA1), transcript
            variant 2, mRNA.
ACCESSION   NM_002786
VERSION     NM_002786.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1195)
  AUTHORS   Liu,Z., Wang,W., Zhou,Y., Li,L. and Zhou,W.
  TITLE     PSMA1, a Poor Prognostic Factor, Promotes Tumor Growth in Lung
            Squamous Cell Carcinoma
  JOURNAL   Dis Markers 2023, 5386635 (2023)
   PUBMED   36776923
  REMARK    GeneRIF: PSMA1, a Poor Prognostic Factor, Promotes Tumor Growth in
            Lung Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1195)
  AUTHORS   Yang,Q., Lu,Y., Shangguan,J. and Shu,X.
  TITLE     PSMA1 mediates tumor progression and poor prognosis of gastric
            carcinoma by deubiquitinating and stabilizing TAZ
  JOURNAL   Cell Death Dis 13 (11), 989 (2022)
   PUBMED   36424389
  REMARK    GeneRIF: PSMA1 mediates tumor progression and poor prognosis of
            gastric carcinoma by deubiquitinating and stabilizing TAZ.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1195)
  AUTHORS   Zhao,J., Makhija,S., Zhou,C., Zhang,H., Wang,Y., Muralidharan,M.,
            Huang,B. and Cheng,Y.
  TITLE     Structural insights into the human PA28-20S proteasome enabled by
            efficient tagging and purification of endogenous proteins
  JOURNAL   Proc Natl Acad Sci U S A 119 (33), e2207200119 (2022)
   PUBMED   35858375
REFERENCE   4  (bases 1 to 1195)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1195)
  AUTHORS   de Almeida,M., Hinterndorfer,M., Brunner,H., Grishkovskaya,I.,
            Singh,K., Schleiffer,A., Jude,J., Deswal,S., Kalis,R., Vunjak,M.,
            Lendl,T., Imre,R., Roitinger,E., Neumann,T., Kandolf,S.,
            Schutzbier,M., Mechtler,K., Versteeg,G.A., Haselbach,D. and
            Zuber,J.
  TITLE     AKIRIN2 controls the nuclear import of proteasomes in vertebrates
  JOURNAL   Nature 599 (7885), 491-496 (2021)
   PUBMED   34711951
REFERENCE   6  (bases 1 to 1195)
  AUTHORS   Silva Pereira,I., Bey,F., Coux,O. and Scherrer,K.
  TITLE     Two mRNAs exist for the Hs PROS-30 gene encoding a component of
            human prosomes
  JOURNAL   Gene 120 (2), 235-242 (1992)
   PUBMED   1398136
REFERENCE   7  (bases 1 to 1195)
  AUTHORS   Shimbara,N., Orino,E., Sone,S., Ogura,T., Takashina,M., Shono,M.,
            Tamura,T., Yasuda,H., Tanaka,K. and Ichihara,A.
  TITLE     Regulation of gene expression of proteasomes (multi-protease
            complexes) during growth and differentiation of human hematopoietic
            cells
  JOURNAL   J Biol Chem 267 (25), 18100-18109 (1992)
   PUBMED   1517242
REFERENCE   8  (bases 1 to 1195)
  AUTHORS   Kanayama,H., Tanaka,K., Aki,M., Kagawa,S., Miyaji,H., Satoh,M.,
            Okada,F., Sato,S., Shimbara,N. and Ichihara,A.
  TITLE     Changes in expressions of proteasome and ubiquitin genes in human
            renal cancer cells
  JOURNAL   Cancer Res 51 (24), 6677-6685 (1991)
   PUBMED   1660345
REFERENCE   9  (bases 1 to 1195)
  AUTHORS   DeMartino,G.N., Orth,K., McCullough,M.L., Lee,L.W., Munn,T.Z.,
            Moomaw,C.R., Dawson,P.A. and Slaughter,C.A.
  TITLE     The primary structures of four subunits of the human,
            high-molecular-weight proteinase, macropain (proteasome), are
            distinct but homologous
  JOURNAL   Biochim Biophys Acta 1079 (1), 29-38 (1991)
   PUBMED   1888762
REFERENCE   10 (bases 1 to 1195)
  AUTHORS   Tamura,T., Lee,D.H., Osaka,F., Fujiwara,T., Shin,S., Chung,C.H.,
            Tanaka,K. and Ichihara,A.
  TITLE     Molecular cloning and sequence analysis of cDNAs for five major
            subunits of human proteasomes (multi-catalytic proteinase
            complexes)
  JOURNAL   Biochim Biophys Acta 1089 (1), 95-102 (1991)
   PUBMED   2025653
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA549688.1 and BC002577.2.
            
            On Feb 27, 2020 this sequence version replaced NM_002786.3.
            
            Summary: The proteasome is a multicatalytic proteinase complex with
            a highly ordered ring-shaped 20S core structure. The core structure
            is composed of 4 rings of 28 non-identical subunits; 2 rings are
            composed of 7 alpha subunits and 2 rings are composed of 7 beta
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            member of the peptidase T1A family, that is a 20S core alpha
            subunit. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms.[provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, compared to variant 1. The encoded isoform (2), also
            known as the short isoform, has a shorter N-terminus compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002577.2, X61969.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396394.7/ ENSP00000379676.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DA549688.1         60-81
            23-1195             BC002577.2         1-1173
FEATURES             Location/Qualifiers
     source          1..1195
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     gene            1..1195
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /note="proteasome 20S subunit alpha 1"
                     /db_xref="GeneID:5682"
                     /db_xref="HGNC:HGNC:9530"
                     /db_xref="MIM:602854"
     exon            1..90
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..879
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /EC_number="3.4.25.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     proteasome subunit nu; macropain subunit nu; alpha-6;
                     protein P30-33K; proteasome component C2; multicatalytic
                     endopeptidase complex subunit C2; proteasome nu chain; 30
                     kDa prosomal protein; proteasome subunit, alpha-type, 1;
                     proteasome subunit alpha 1; proteasome subunit alpha 6;
                     PROS-30; macropain subunit C2; epididymis secretory
                     protein Li 275; proteasome (prosome, macropain) subunit,
                     alpha type, 1; testicular tissue protein Li 150"
                     /codon_start=1
                     /product="proteasome subunit alpha type-1 isoform 2"
                     /protein_id="NP_002777.1"
                     /db_xref="CCDS:CCDS7816.1"
                     /db_xref="GeneID:5682"
                     /db_xref="HGNC:HGNC:9530"
                     /db_xref="MIM:602854"
                     /translation="MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHA
                     VLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRP
                     LPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMS
                     IGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKD
                     LEFTIYDDDDVSPFLEGLEERPQRKAQPAQPADEPAEKADEPMEH"
     exon            91..135
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /inference="alignment:Splign:2.1.0"
     exon            136..237
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /inference="alignment:Splign:2.1.0"
     exon            238..341
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /inference="alignment:Splign:2.1.0"
     exon            342..430
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /inference="alignment:Splign:2.1.0"
     exon            431..501
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /inference="alignment:Splign:2.1.0"
     exon            502..631
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /inference="alignment:Splign:2.1.0"
     exon            632..711
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /inference="alignment:Splign:2.1.0"
     exon            712..822
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1195
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1171..1176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /note="hexamer: AATAAA"
     polyA_site      1195
                     /gene="PSMA1"
                     /gene_synonym="HC2; HEL-S-275; NU; PROS30"
                     /note="major polyA site"
ORIGIN      
        1 ctctgtagat cgctgagcga tactttcggc agcacctcct tgattctcag ttttgctgga
       61 ggccgcaacc aggcccgcgc cgccaccatg tttcgaaatc agtatgacaa tgatgtcact
      121 gtttggagcc cccagggcag gattcatcaa attgaatatg caatggaagc tgttaaacaa
      181 ggttcagcca cagttggtct gaaatcaaaa actcatgcag ttttggttgc attgaaaagg
      241 gcgcaatcag agcttgcagc tcatcagaaa aaaattctcc atgttgacaa ccatattggt
      301 atctcaattg cggggcttac tgctgatgct agactgttat gtaattttat gcgtcaggag
      361 tgtttggatt ccagatttgt attcgataga ccactgcctg tgtctcgtct tgtatctcta
      421 attggaagca agacccagat accaacacaa cgatatggcc ggagaccata tggtgttggt
      481 ctccttattg ctggttatga tgatatgggc cctcacattt tccaaacctg tccatctgct
      541 aactattttg actgcagagc catgtccatt ggagcccgtt cccaatcagc tcgtacttac
      601 ttggagagac atatgtctga atttatggag tgtaatttaa atgaactagt taaacatggt
      661 ctgcgtgcct taagagagac gcttcctgca gaacaggacc tgactacaaa gaatgtttcc
      721 attggaattg ttggtaaaga cttggagttt acaatctatg atgatgatga tgtgtctcca
      781 ttcctggaag gtcttgaaga aagaccacag agaaaggcac agcctgctca acctgctgat
      841 gaacctgcag aaaaggctga tgaaccaatg gaacattaag tgataagcca gtctatatat
      901 gtattatcaa atatgtaaga atacaggcac cacatactga tgacaataat ctatactttg
      961 aaccaaaagt tgcagagtgg tggaatgcta tgttttagga atcagtccag atgtgagttt
     1021 tttccaagca acctcactga aacctatata atggaataca tttttctttg aaagggtctg
     1081 tataatcatt ttctagaaag tatgggtatc tatactaatg tttttatatg aagaacatag
     1141 gtgtctttgt ggttttaaag acaactgtga aataaaattg tttcaccgcc tggta
//
