LOCUS       NM_033126               2557 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens protein serine kinase H2 (PSKH2), mRNA.
ACCESSION   NM_033126
VERSION     NM_033126.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2557)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2557)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   3  (bases 1 to 2557)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2557)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   5  (bases 1 to 2557)
  AUTHORS   Taipale,M., Krykbaeva,I., Koeva,M., Kayatekin,C., Westover,K.D.,
            Karras,G.I. and Lindquist,S.
  TITLE     Quantitative analysis of HSP90-client interactions reveals
            principles of substrate recognition
  JOURNAL   Cell 150 (5), 987-1001 (2012)
   PUBMED   22939624
REFERENCE   6  (bases 1 to 2557)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    GeneRIF: First description of PSKH2, predicted as a
            catalytically-active protein kinase homolog of PSKH1.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC126180.1, AC023194.9 and AW204502.1.
            
            On May 17, 2019 this sequence version replaced NM_033126.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC126180.1, AY037806.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2148874,
                                           SAMEA2151119 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276616.3/ ENSP00000276616.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1293              BC126180.1         30-1322
            1294-2542           AC023194.9         73114-74362         c
            2543-2557           AW204502.1         14-28               c
FEATURES             Location/Qualifiers
     source          1..2557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..2557
                     /gene="PSKH2"
                     /note="protein serine kinase H2"
                     /db_xref="GeneID:85481"
                     /db_xref="HGNC:HGNC:18997"
                     /db_xref="MIM:620394"
     exon            1..231
                     /gene="PSKH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1204
                     /gene="PSKH2"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine kinase PSKH2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase H2"
                     /protein_id="NP_149117.1"
                     /db_xref="CCDS:CCDS6240.1"
                     /db_xref="GeneID:85481"
                     /db_xref="HGNC:HGNC:18997"
                     /db_xref="MIM:620394"
                     /translation="MGCGASRKVVPGPPALAWAKHEGQNQAGVGGAGPGPEAAAQAAQ
                     RIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGR
                     EACVSELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDA
                     VRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWT
                     MKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILK
                     GKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAAGSSMKNLQR
                     AISRNLMQRASPHSQSPGSAQSSKSHYSHKSRHMWSKRNLRIVESPLSALL"
     exon            232..898
                     /gene="PSKH2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..2557
                     /gene="PSKH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2188..2193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSKH2"
                     /note="hexamer: AATAAA"
     polyA_site      2225
                     /gene="PSKH2"
                     /note="major polyA site"
ORIGIN      
        1 gcttcccgag tccccaggtc ccgcgagcgg cgggcgtgtt gcgggtatgg ggtgcggcgc
       61 cagcaggaag gtggtcccgg ggccaccagc gctggcttgg gccaagcacg aaggtcaaaa
      121 ccaagccggc gtcggaggcg cggggcctgg gcccgaggcg gcggcccagg cggcgcagag
      181 gatacaggtg gctcgcttcc gagccaagtt cgacccccgg gtccttgcca gatatgacat
      241 caaagctctt attgggacag gcagtttcag cagggttgtc agggtagagc agaagaccac
      301 caagaaacct tttgcaataa aagtgatgga aaccagagag agggaaggta gagaagcgtg
      361 cgtgtctgag ctgagcgtcc tgcggcgggt tagccatcgt tacattgtcc agctcatgga
      421 gatctttgag actgaggatc aagtttacat ggtaatggag ctggctaccg gaggggagct
      481 ctttgatcga ctcattgctc agggatcctt tacagagcgg gatgccgtca ggatcctcca
      541 gatggttgct gatgggatta ggtatttgca tgcgctgcag ataactcata ggaatctaaa
      601 gcctgaaaac ctcttatact atcatccagg tgaagagtcg aaaattttaa ttacagattt
      661 tggtttggca tactccggga aaaaaagtgg tgactggaca atgaagacac tctgtgggac
      721 cccagagtac atagctcctg aggttttgct aaggaagcct tataccagtg cagtggacat
      781 gtgggctctt ggtgtgatca catatgcttt acttagcgga ttcctgcctt ttgatgatga
      841 aagccagaca aggctttaca ggaagattct gaaaggcaaa tataattata caggagagcc
      901 ttggccaagc atttcccact tggcgaagga ctttatagac aaactactga ttttggaggc
      961 tggtcatcgc atgtcagctg gccaggccct ggaccatccc tgggtgatca ccatggctgc
     1021 agggtcttcc atgaagaatc tccagagggc catatcccga aacctcatgc agagggcctc
     1081 tccccactct cagagtcctg gatctgcaca gtcttctaag tcacattatt ctcacaaatc
     1141 caggcatatg tggagcaaga gaaacttaag gatagtagaa tcgccactgt ctgcgctttt
     1201 gtaagcagat gacctctaaa actatttttg cctattttag gaccatttca tcatgattag
     1261 ggcaccctca agctccaaag acacgggact ccatggtatt gttggatact attgatcttg
     1321 acttttaaca ttttcttgtt ctataatttt tcctatacct gtattcattt tcccaaaata
     1381 tactgctgca aatgattaac agtttagtaa atactagcta tgtttagata actggaaaca
     1441 ataaatagat aagaaaatct ttaaagtatg taatggatta aataaaatac aatactatag
     1501 aaataaggga tgtatatgtg aaggcatggt gaaccagaga catagcagga atagttagat
     1561 atggggaata tatgtattta tcctgaaatt actgattttt atttaagccc cagtatacag
     1621 tgttaactag gtaacactcg aagtagttat aaatgtctgt taatttcata tttagtctgc
     1681 aaatatttat gaaaaattat taattatggg gcctataaag aactataaga tataatttca
     1741 atctatcaga aacttttagt ctaattgggg cattattcac gggaaaaata gagattttta
     1801 agaatcataa aatagtgatt tttttctaat gttagcattc atcaaccacc agggtttaca
     1861 aaaaaatata aacatcttgc ttcttatcac tactgtcaac tcttttcagt atgtactggt
     1921 ttcttttaga attatttaat caaatatctt gatgacttta aacactcacc atgaaataat
     1981 tataggtaat gcaataaagg ggtaagtttc aaaacttagt tctctaggca agtcacatat
     2041 ggcctgatct cttatatggt aaatttttgt aaaatgatat aaagattgaa atattattaa
     2101 tcatatctgt gagtcactca tatgtgtggg taaacatagt aaataaatga ttaattagtt
     2161 gatattgctt attttattca gaaaaataat aaaatgttag aatgacattt actgtaactt
     2221 taaaatcagt ctcaattttt tcattttatt tttctctttt aggctatata gatggaacag
     2281 ctatatatct gatatataga taagaatatg taattagtga cacaactatt ttctttttat
     2341 gttgtaatgc tgtatcacat gatatatgac agacctggat taattccttt aatatagaaa
     2401 gacacttaca aattcattag ataaataata gaaaaatggg caaatatttt accaggtggt
     2461 ttataaacat atagatggct aatgagtaaa tgaaaaaaat gcttcatttc atttgtaatt
     2521 tacaaaatga aaataaaaat gacaaagaaa atgaaaa
//
