LOCUS       NM_002784               1707 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens pregnancy specific beta-1-glycoprotein 9 (PSG9),
            transcript variant 1, mRNA.
ACCESSION   NM_002784
VERSION     NM_002784.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1707)
  AUTHORS   Kandel,M., MacDonald,T.M., Walker,S.P., Cluver,C., Bergman,L.,
            Myers,J., Hastie,R., Keenan,E., Hannan,N.J., Cannon,P.,
            Nguyen,T.V., Pritchard,N., Tong,S. and Kaitu'u-Lino,T.J.
  TITLE     PSG7 and 9 (Pregnancy-Specific beta-1 Glycoproteins 7 and 9): Novel
            Biomarkers for Preeclampsia
  JOURNAL   J Am Heart Assoc 11 (7), e024536 (2022)
   PUBMED   35322669
  REMARK    GeneRIF: PSG7 and 9 (Pregnancy-Specific beta-1 Glycoproteins 7 and
            9): Novel Biomarkers for Preeclampsia.
REFERENCE   2  (bases 1 to 1707)
  AUTHORS   Rong,W., Zhang,Y., Yang,L., Feng,L., Wei,B., Wu,F., Wang,L.,
            Gao,Y., Cheng,S., Wu,J. and Xiao,T.
  TITLE     Post-surgical resection prognostic value of combined OPN, MMP7, and
            PSG9 plasma biomarkers in hepatocellular carcinoma
  JOURNAL   Front Med 13 (2), 250-258 (2019)
   PUBMED   29770948
  REMARK    GeneRIF: Plasma OPN + MMP7 + PSG9 elevation in combination was a
            prognostic factor for overall survival in hepatocellular carcinoma
REFERENCE   3  (bases 1 to 1707)
  AUTHORS   Rong,W., Yang,L., Yin,L., Gao,Y., Xiao,T. and Cheng,S.
  TITLE     PSG9 promotes angiogenesis by stimulating VEGFA production and is
            associated with poor prognosis in hepatocellular carcinoma
  JOURNAL   Sci China Life Sci 60 (5), 528-535 (2017)
   PUBMED   28078509
  REMARK    GeneRIF: Results indicate that pregnancy-specific glycoprotein 9
            (PSG9) may facilitate the development of hepatocellular carcinoma
            (HCC) by fostering angiogenesis via promoting VEGFA production in
            cancer HCC.
REFERENCE   4  (bases 1 to 1707)
  AUTHORS   Yang,L., Hu,S., Tan,J., Zhang,X., Yuan,W., Wang,Q., Xu,L., Liu,J.,
            Liu,Z., Jia,Y. and Huang,X.
  TITLE     Pregnancy-specific glycoprotein 9 (PSG9), a driver for colorectal
            cancer, enhances angiogenesis via activation of SMAD4
  JOURNAL   Oncotarget 7 (38), 61562-61574 (2016)
   PUBMED   27528036
  REMARK    GeneRIF: Findings illustrate the innovative mechanism by which PSG9
            drives the progression of colorectal cancer and tumor angiogenesis.
            This occurs via nuclear translocation of PSG9/SMAD4, which
            activates angiogenic cytokines.
REFERENCE   5  (bases 1 to 1707)
  AUTHORS   Jones,K., Ballesteros,A., Mentink-Kane,M., Warren,J., Rattila,S.,
            Malech,H., Kang,E. and Dveksler,G.
  TITLE     PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the
            TGF-beta1 Pathway
  JOURNAL   PLoS One 11 (7), e0158050 (2016)
   PUBMED   27389696
  REMARK    GeneRIF: PSG9, through its activation of TGFbeta-1, could be a
            potent inducer of immune tolerance
            Erratum:[PLoS One. 2017 Apr 6;12(4):e0175636. doi:
            10.1371/journal.pone.0175636.. PMID: 28384346]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1707)
  AUTHORS   Brophy,B.K., MacDonald,R.E., McLenachan,P.A. and Mansfield,B.C.
  TITLE     cDNA sequence of the pregnancy-specific beta 1-glycoprotein-11s
            (PSG-11s)
  JOURNAL   Biochim Biophys Acta 1131 (1), 119-121 (1992)
   PUBMED   1581354
REFERENCE   7  (bases 1 to 1707)
  AUTHORS   Chan,W.Y., Zheng,Q.X., McMahon,J. and Tease,L.A.
  TITLE     Characterization of new members of the pregnancy-specific beta
            1-glycoprotein family
  JOURNAL   Mol Cell Biochem 106 (2), 161-170 (1991)
   PUBMED   1922019
REFERENCE   8  (bases 1 to 1707)
  AUTHORS   Khan,W.N. and Hammarstrom,S.
  TITLE     Identification of a new carcinoembryonic antigen (CEA) family
            member in human fetal liver--cloning and sequence determination of
            pregnancy-specific glycoprotein 7
  JOURNAL   Biochem Biophys Res Commun 168 (1), 214-225 (1990)
   PUBMED   2328001
REFERENCE   9  (bases 1 to 1707)
  AUTHORS   Arakawa,F., Kuroki,M., Misumi,Y., Matsuo,Y. and Matsuoka,Y.
  TITLE     The nucleotide and deduced amino acid sequences of a cDNA encoding
            a new species of pregnancy-specific beta 1-glycoprotein (PS beta G)
  JOURNAL   Biochim Biophys Acta 1048 (2-3), 303-305 (1990)
   PUBMED   2322584
REFERENCE   10 (bases 1 to 1707)
  AUTHORS   Thompson,J., Koumari,R., Wagner,K., Barnert,S., Schleussner,C.,
            Schrewe,H., Zimmermann,W., Muller,G., Schempp,W., Zaninetta,D. et
            al.
  TITLE     The human pregnancy-specific glycoprotein genes are tightly linked
            on the long arm of chromosome 19 and are coordinately expressed
  JOURNAL   Biochem Biophys Res Commun 167 (2), 848-859 (1990)
   PUBMED   1690992
  REMARK    Erratum:[Biochem Biophys Res Commun 1990 May 16;168(3):1325]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC380417.1, M34481.1 and BC005925.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002784.4.
            
            Summary: The protein encoded by this gene is a member of the
            pregnancy-specific glycoprotein (PSG) family. This protein family
            and the closely related carcinoembryonic antigen cell adhesion
            molecule (CEACAM) gene family are both members of the
            immunoglobulin superfamily, and are organized as a large gene
            cluster. This protein is thought to inhibit platelet-fibrinogen
            interactions. Several studies suggest that reduced serum
            concentrations of PSGs are associated with fetal growth
            restrictions, while up-regulation of this gene has been observed in
            colorectal cancers. Several pseudogenes of this gene are found on
            chromosome 19. Alternative splicing results in multiple transcript
            variants that encode multiple protein isoforms. [provided by
            RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279829.5656.1, BC020759.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568, SAMN03465410
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270077.8/ ENSP00000270077.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DC380417.1         34-66
            34-1686             M34481.1           4-1656
            1687-1707           BC005925.1         1405-1425
FEATURES             Location/Qualifiers
     source          1..1707
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..1707
                     /gene="PSG9"
                     /gene_synonym="PS34; PSBG-11; PSBG-9; PSG11; PSGII"
                     /note="pregnancy specific beta-1-glycoprotein 9"
                     /db_xref="GeneID:5678"
                     /db_xref="HGNC:HGNC:9526"
                     /db_xref="MIM:176398"
     exon            1..163
                     /gene="PSG9"
                     /gene_synonym="PS34; PSBG-11; PSBG-9; PSG11; PSGII"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1380
                     /gene="PSG9"
                     /gene_synonym="PS34; PSBG-11; PSBG-9; PSG11; PSGII"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; pregnancy specific beta-1-glycoprotein 11;
                     PS-beta-B; PS-beta-G-9; PS-beta-G-11; pregnancy-specific
                     beta-1 glycoprotein B; pregnancy-specific
                     beta-1-glycoprotein 11 C-R domain"
                     /codon_start=1
                     /product="pregnancy-specific beta-1-glycoprotein 9 isoform
                     1 precursor"
                     /protein_id="NP_002775.3"
                     /db_xref="CCDS:CCDS12618.1"
                     /db_xref="GeneID:5678"
                     /db_xref="HGNC:HGNC:9526"
                     /db_xref="MIM:176398"
                     /translation="MGPLPAPSCTQRITWKGLLLTASLLNFWNPPTTAEVTIEAQPPK
                     VSEGKDVLLLVHNLPQNLPGYFWYKGEMTDLYHYIISYIVDGKIIIYGPAYSGRETVY
                     SNASLLIQNVTRKDAGTYTLHIIKRGDETREEIRHFTFTLYLETPKPYISSSNLNPRE
                     AMEAVRLICDPETLDASYLWWMNGQSLPVTHRLQLSKTNRTLYLFGVTKYIAGPYECE
                     IRNPVSASRSDPVTLNLLPKLPIPYITINNLNPRENKDVLAFTCEPKSENYTYIWWLN
                     GQSLPVSPGVKRPIENRILILPSVTRNETGPYQCEIRDRYGGLRSNPVILNVLYGPDL
                     PRIYPSFTYYRSGENLDLSCFTESNPPAEYFWTINGKFQQSGQKLFIPQITRNHSGLY
                     ACSVHNSATGKEISKSMTVKVSGPCHGDLTESQS"
     exon            164..529
                     /gene="PSG9"
                     /gene_synonym="PS34; PSBG-11; PSBG-9; PSG11; PSGII"
                     /inference="alignment:Splign:2.1.0"
     exon            530..808
                     /gene="PSG9"
                     /gene_synonym="PS34; PSBG-11; PSBG-9; PSG11; PSGII"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1087
                     /gene="PSG9"
                     /gene_synonym="PS34; PSBG-11; PSBG-9; PSG11; PSGII"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1342
                     /gene="PSG9"
                     /gene_synonym="PS34; PSBG-11; PSBG-9; PSG11; PSGII"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1707
                     /gene="PSG9"
                     /gene_synonym="PS34; PSBG-11; PSBG-9; PSG11; PSGII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSG9"
                     /gene_synonym="PS34; PSBG-11; PSBG-9; PSG11; PSGII"
                     /note="hexamer: AATAAA"
     polyA_site      1707
                     /gene="PSG9"
                     /gene_synonym="PS34; PSBG-11; PSBG-9; PSG11; PSGII"
                     /note="major polyA site"
ORIGIN      
        1 acagaaggag gaaggacagc acagctgaca gccgtgctca gacagcttct ggatcccagg
       61 ctcatctcca cagaggagaa cacacaggca gcagagacca tggggcccct cccagcccct
      121 tcctgcacac agcgcatcac ctggaagggg ctcctgctca cagcatcact tttaaacttc
      181 tggaacccgc ccaccactgc cgaagtcacg attgaagccc agccacccaa agtttctgag
      241 gggaaggatg ttcttctact tgtccacaat ttgccccaga atcttcctgg ctacttctgg
      301 tacaaagggg aaatgacgga cctctaccat tacattatat cgtatatagt tgatggtaaa
      361 ataattatat atgggcctgc atacagtgga agagaaacag tatattccaa cgcatccctg
      421 ctgatccaga atgtcacccg gaaggatgca ggaacctaca ccttacacat cataaagcga
      481 ggtgatgaga ctagagaaga aattcgacat ttcaccttca ccttatactt ggagactccc
      541 aagccctaca tctccagcag caacttaaac cccagggagg ccatggaggc tgtgcgctta
      601 atctgtgatc ctgagactct ggacgcaagc tacctatggt ggatgaatgg tcagagcctc
      661 cctgtgactc acaggttgca gctgtccaaa accaacagga ccctctatct atttggtgtc
      721 acaaagtata ttgcaggacc ctatgaatgt gaaatacgga acccagtgag tgccagtcgc
      781 agtgacccag tcaccctgaa tctcctcccg aagctgccca tcccctacat caccatcaac
      841 aacttaaacc ccagggagaa taaggatgtc ttagccttca cctgtgaacc taagagtgag
      901 aactacacct acatttggtg gctaaacggt cagagcctcc ccgtcagtcc cggggtaaag
      961 cgacccattg aaaacaggat actcattcta cccagtgtca cgagaaatga aacaggaccc
     1021 tatcaatgtg aaatacggga ccgatatggt ggcctccgca gtaacccagt catcctaaat
     1081 gtcctctatg gtccagacct ccccagaatt tacccttcat tcacctatta ccgttcagga
     1141 gaaaacctcg acttgtcctg cttcacggaa tctaacccac cggcagagta tttttggaca
     1201 attaatggga agtttcagca atcaggacaa aagctcttta tcccccaaat tactagaaat
     1261 catagcgggc tctatgcttg ctctgttcat aactcagcca ctggcaagga aatctccaaa
     1321 tccatgacag tcaaagtctc tggtccctgc catggagacc tgacagagtc tcagtcatga
     1381 ctgcaacaac tgagacactg agaaaaagaa caggctgata ccttcatgaa attcaagaca
     1441 aagaagaaaa aaactcaatg ttattggact aaataatcaa aaggataatg ttttcataat
     1501 tttttattgg aaaatgtgct gattctttga atgttttatt ctccagattt atgaactttt
     1561 tttcttcagc aattggtaaa gtatactttt gtaaacaaaa attgaaatat ttgcttttgc
     1621 tgtctatctg aatgccccag aattgtgaaa ctattcatga gtattcatag gtttatggta
     1681 ataaagttat ttgcacatgt tccgtaa
//
