LOCUS       NM_182707               1440 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens pregnancy specific beta-1-glycoprotein 8 (PSG8),
            transcript variant 1, mRNA.
ACCESSION   NM_182707 XM_496314
VERSION     NM_182707.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1440)
  AUTHORS   Olsen,A., Teglund,S., Nelson,D., Gordon,L., Copeland,A.,
            Georgescu,A., Carrano,A. and Hammarstrom,S.
  TITLE     Gene organization of the pregnancy-specific glycoprotein region on
            human chromosome 19: assembly and analysis of a 700-kb cosmid
            contig spanning the region
  JOURNAL   Genomics 23 (3), 659-668 (1994)
   PUBMED   7851895
REFERENCE   2  (bases 1 to 1440)
  AUTHORS   Khan,W.N., Teglund,S., Bremer,K. and Hammarstrom,S.
  TITLE     The pregnancy-specific glycoprotein family of the immunoglobulin
            superfamily: identification of new members and estimation of family
            size
  JOURNAL   Genomics 12 (4), 780-787 (1992)
   PUBMED   1572651
REFERENCE   3  (bases 1 to 1440)
  AUTHORS   Coto,E., Martinez-Naves,E., Dominguez,O., DiScipio,R.G., Urra,J.M.
            and Lopez-Larrea,C.
  TITLE     DNA polymorphisms and linkage relationship of the human complement
            component C6, C7, and C9 genes
  JOURNAL   Immunogenetics 33 (3), 184-187 (1991)
   PUBMED   1672663
REFERENCE   4  (bases 1 to 1440)
  AUTHORS   Borjigin,J., Tease,L.A., Barnes,W. and Chan,W.Y.
  TITLE     Expression of the pregnancy-specific beta 1-glycoprotein genes in
            human testis
  JOURNAL   Biochem Biophys Res Commun 166 (2), 622-629 (1990)
   PUBMED   2302228
REFERENCE   5  (bases 1 to 1440)
  AUTHORS   Oikawa,S., Inuzuka,C., Kosaki,G. and Nakazato,H.
  TITLE     Exon-intron organization of a gene for pregnancy-specific beta
            1-glycoprotein, a subfamily member of CEA family: implications for
            its characteristic repetitive domains and C-terminal sequences
  JOURNAL   Biochem Biophys Res Commun 156 (1), 68-77 (1988)
   PUBMED   3263130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC137500.1.
            
            On May 17, 2019 this sequence version replaced NM_182707.2.
            
            Summary: The human pregnancy-specific glycoproteins (PSGs) are a
            group of molecules that are mainly produced by the placental
            syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of
            the carcinoembryonic antigen (CEA) family, which belongs to the
            immunoglobulin superfamily. For additional general information
            about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM,
            Oct 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137500.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2142853,
                                           SAMEA2149398 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306511.5/ ENSP00000305005.4
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1440              BC137500.1         2-1441
FEATURES             Location/Qualifiers
     source          1..1440
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1440
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="pregnancy specific beta-1-glycoprotein 8"
                     /db_xref="GeneID:440533"
                     /db_xref="HGNC:HGNC:9525"
                     /db_xref="MIM:176397"
     exon            1..161
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1378
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; C3 alternate; pregnancy-specific beta-1
                     glycoprotein; C1 alternate; C2 alternate; PSBG-8;
                     PS-beta-G-8; pregnancy-specific glycoprotein 8"
                     /codon_start=1
                     /product="pregnancy-specific beta-1-glycoprotein 8 isoform
                     a precursor"
                     /protein_id="NP_874366.1"
                     /db_xref="CCDS:CCDS33037.1"
                     /db_xref="GeneID:440533"
                     /db_xref="HGNC:HGNC:9525"
                     /db_xref="MIM:176397"
                     /translation="MGLLSAPPCTQRITWKGLLLTASLLNFWNPPTTAQVTIEAQPTK
                     VSEGKDVLLLVHNLPQNLTGYIWYKGQIRDLYHYITSYVVDGQIIIYGPAYSGRETIY
                     SNASLLIQNVTQEDAGSYTLHIIMGGDENRGVTGHFTFTLYLETPKPSISSSKLNPRE
                     AMEAVSLTCDPETPDASYLWWMNGQSLPMSHRLQLSETNRTLFLLGVTKYTAGPYECE
                     IRNPVSASRSDPFTLNLLPKLPKPYITINNLKPRENKDVLNFTCEPKSENYTYIWWLN
                     GQSLPVSPRVKRPIENRILILPSVTRNETGPYQCEIRDQYGGIRSYPVTLNVLYGPDL
                     PRIYPSFTYYRSGEVLYLSCSADSNPPAQYSWTINGKFQLSGQKLFIPQITTKHSGLY
                     ACSVRNSATGKESSKSMTVKVSGKRIPVSLAIGI"
     exon            162..527
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..806
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1085
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1440
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaggaggc aggacagcac tgctgagagc tgtgctcagg aagcttctgg atcctaggct
       61 catctccaca gaggagaaca cacagacagc agagaccatg gggctcctct cagcccctcc
      121 ctgcacacag cgcatcacct ggaaggggct cctgctcaca gcatcacttt taaacttctg
      181 gaacccaccc acgactgccc aagtcacgat tgaagcccag ccaaccaaag tttctgaggg
      241 gaaggatgtt cttctacttg tccacaattt gccccagaat cttactggct acatctggta
      301 caaagggcaa atcagggacc tctaccatta cattacatca tatgtagtag acggtcaaat
      361 aattatatat gggcctgcat acagtggacg agaaacaata tattccaatg catccctgct
      421 gatccagaat gtcacccagg aagacgcagg atcctacacc ttacacatca taatgggagg
      481 tgatgagaat agaggagtaa ctggacattt caccttcacc ttatatctgg agactcccaa
      541 gccctccatc tccagcagca aattaaaccc cagggaggcc atggaggctg tgagcttaac
      601 ctgtgatcct gagactccgg acgcaagcta cctgtggtgg atgaatggtc agagcctccc
      661 tatgtctcac aggttgcagt tgtctgaaac caacaggacc ctctttctat tgggtgtcac
      721 aaagtacact gcaggaccct atgaatgtga aatacggaac ccagtgagtg ccagccgcag
      781 tgacccattc accctgaatc tcctcccgaa gctgcccaag ccctacatca ccatcaacaa
      841 cttaaaaccc agggagaata aggatgtctt aaacttcacc tgtgaaccta agagtgagaa
      901 ctacacctac atttggtggc taaatggtca gagcctcccg gtcagtccca gggtaaagcg
      961 acccattgaa aacaggatcc tcattctacc cagtgtcacg agaaatgaaa caggacccta
     1021 tcaatgtgaa ataagggacc aatatggtgg catccgcagt tacccagtca ccctgaatgt
     1081 cctctatggt ccagacctcc ccagaattta cccttcattc acctattacc gttcaggaga
     1141 agtcctctac ttgtcctgtt ctgcggactc taacccaccg gcacagtatt cttggacaat
     1201 taatgggaag tttcagctat caggacaaaa gctctttatc ccccaaatta ctacaaagca
     1261 tagcgggctc tatgcttgct ctgttcgtaa ctcagccact ggcaaggaaa gctccaaatc
     1321 catgacagta aaagtctctg gtaagcggat cccagtatcc ttggcaatag ggatttaggt
     1381 ggagtctatc tggccttcag ggaagagtca ggaaaacatt tttattccca gcctgcgtcc
//
