LOCUS       NM_002783               2067 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens pregnancy specific beta-1-glycoprotein 7 (PSG7),
            transcript variant 1, coding, mRNA.
ACCESSION   NM_002783
VERSION     NM_002783.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2067)
  AUTHORS   Kandel,M., MacDonald,T.M., Walker,S.P., Cluver,C., Bergman,L.,
            Myers,J., Hastie,R., Keenan,E., Hannan,N.J., Cannon,P.,
            Nguyen,T.V., Pritchard,N., Tong,S. and Kaitu'u-Lino,T.J.
  TITLE     PSG7 and 9 (Pregnancy-Specific beta-1 Glycoproteins 7 and 9): Novel
            Biomarkers for Preeclampsia
  JOURNAL   J Am Heart Assoc 11 (7), e024536 (2022)
   PUBMED   35322669
  REMARK    GeneRIF: PSG7 and 9 (Pregnancy-Specific beta-1 Glycoproteins 7 and
            9): Novel Biomarkers for Preeclampsia.
REFERENCE   2  (bases 1 to 2067)
  AUTHORS   Camolotto,S., Racca,A., Rena,V., Nores,R., Patrito,L.C.,
            Genti-Raimondi,S. and Panzetta-Dutari,G.M.
  TITLE     Expression and transcriptional regulation of individual
            pregnancy-specific glycoprotein genes in differentiating
            trophoblast cells
  JOURNAL   Placenta 31 (4), 312-319 (2010)
   PUBMED   20116096
REFERENCE   3  (bases 1 to 2067)
  AUTHORS   van der Heul-Nieuwenhuijsen,L., Dits,N., Van Ijcken,W., de Lange,D.
            and Jenster,G.
  TITLE     The FOXF2 pathway in the human prostate stroma
  JOURNAL   Prostate 69 (14), 1538-1547 (2009)
   PUBMED   19562724
REFERENCE   4  (bases 1 to 2067)
  AUTHORS   Endoh,M., Kobayashi,Y., Yamakami,Y., Yonekura,R., Fujii,M. and
            Ayusawa,D.
  TITLE     Coordinate expression of the human pregnancy-specific glycoprotein
            gene family during induced and replicative senescence
  JOURNAL   Biogerontology 10 (2), 213-221 (2009)
   PUBMED   18792801
REFERENCE   5  (bases 1 to 2067)
  AUTHORS   Beauchemin,N., Draber,P., Dveksler,G., Gold,P., Gray-Owen,S.,
            Grunert,F., Hammarstrom,S., Holmes,K.V., Karlsson,A., Kuroki,M.,
            Lin,S.H., Lucka,L., Najjar,S.M., Neumaier,M., Obrink,B.,
            Shively,J.E., Skubitz,K.M., Stanners,C.P., Thomas,P.,
            Thompson,J.A., Virji,M., von Kleist,S., Wagener,C., Watt,S. and
            Zimmermann,W.
  TITLE     Redefined nomenclature for members of the carcinoembryonic antigen
            family
  JOURNAL   Exp Cell Res 252 (2), 243-249 (1999)
   PUBMED   11501563
REFERENCE   6  (bases 1 to 2067)
  AUTHORS   Teglund,S., Zhou,G.Q. and Hammarstrom,S.
  TITLE     Characterization of cDNA encoding novel pregnancy-specific
            glycoprotein variants
  JOURNAL   Biochem Biophys Res Commun 211 (2), 656-664 (1995)
   PUBMED   7794280
REFERENCE   7  (bases 1 to 2067)
  AUTHORS   Khan,W.N., Teglund,S., Bremer,K. and Hammarstrom,S.
  TITLE     The pregnancy-specific glycoprotein family of the immunoglobulin
            superfamily: identification of new members and estimation of family
            size
  JOURNAL   Genomics 12 (4), 780-787 (1992)
   PUBMED   1572651
REFERENCE   8  (bases 1 to 2067)
  AUTHORS   Leslie,K.K., Watanabe,S., Lei,K.J., Chou,D.Y., Plouzek,C.A.,
            Deng,H.C., Torres,J. and Chou,J.Y.
  TITLE     Linkage of two human pregnancy-specific beta 1-glycoprotein genes:
            one is associated with hydatidiform mole
  JOURNAL   Proc Natl Acad Sci U S A 87 (15), 5822-5826 (1990)
   PUBMED   2377620
REFERENCE   9  (bases 1 to 2067)
  AUTHORS   Khan,W.N. and Hammarstrom,S.
  TITLE     Identification of a new carcinoembryonic antigen (CEA) family
            member in human fetal liver--cloning and sequence determination of
            pregnancy-specific glycoprotein 7
  JOURNAL   Biochem Biophys Res Commun 168 (1), 214-225 (1990)
   PUBMED   2328001
REFERENCE   10 (bases 1 to 2067)
  AUTHORS   Thompson,J., Koumari,R., Wagner,K., Barnert,S., Schleussner,C.,
            Schrewe,H., Zimmermann,W., Muller,G., Schempp,W., Zaninetta,D. et
            al.
  TITLE     The human pregnancy-specific glycoprotein genes are tightly linked
            on the long arm of chromosome 19 and are coordinately expressed
  JOURNAL   Biochem Biophys Res Commun 167 (2), 848-859 (1990)
   PUBMED   1690992
  REMARK    Erratum:[Biochem Biophys Res Commun 1990 May 16;168(3):1325]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093055.3, DC380850.1,
            BX952498.1, U18467.1, BG434892.1, AL546656.3, BC030979.1 and
            T29414.1.
            
            On May 17, 2019 this sequence version replaced NM_002783.2.
            
            Summary: This gene is a member of the pregnancy-specific
            glycoprotein (PSG) gene family. The PSG genes are a subgroup of the
            carcinoembryonic antigen (CEA) family of immunoglobulin-like genes,
            and are found in a gene cluster at 19q13.1-q13.2 telomeric to
            another cluster of CEA-related genes. The PSG genes are expressed
            by placental trophoblasts and released into the maternal
            circulation during pregnancy, and are thought to be essential for
            maintenance of normal pregnancy. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longest isoform (1). This version of
            transcript variant 1 represents the protein-coding minor allele. A
            second version of transcript variant 1 represents the major allele
            of this polymorphic locus with a mismatch compared to the reference
            genome sequence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U18467.1, BC030979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406070.7/ ENSP00000421986.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC093055.3         3192-3220           c
            30-46               DC380850.1         2-18
            47-86               BX952498.1         16-55
            87-268              U18467.1           8-189
            269-269             BG434892.1         236-236
            270-377             U18467.1           191-298
            378-378             BG434892.1         346-346
            379-628             U18467.1           300-549
            629-1151            AL546656.3         177-699
            1152-1625           U18467.1           1073-1546
            1626-2059           BC030979.1         1592-2025
            2060-2067           T29414.1           9-16                c
FEATURES             Location/Qualifiers
     source          1..2067
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..2067
                     /gene="PSG7"
                     /gene_synonym="PS-beta-G-7; PSBG-7; PSG1; PSGGA"
                     /note="pregnancy specific beta-1-glycoprotein 7"
                     /db_xref="GeneID:5676"
                     /db_xref="HGNC:HGNC:9524"
                     /db_xref="MIM:176396"
     exon            1..195
                     /gene="PSG7"
                     /gene_synonym="PS-beta-G-7; PSBG-7; PSG1; PSGGA"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1391
                     /gene="PSG7"
                     /gene_synonym="PS-beta-G-7; PSBG-7; PSG1; PSGGA"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1, coding; putative pregnancy-specific
                     beta-1-glycoprotein 7; pregnancy-specific glycoprotein 7"
                     /codon_start=1
                     /product="pregnancy-specific beta-1-glycoprotein 7 isoform
                     1 precursor"
                     /protein_id="NP_002774.2"
                     /db_xref="GeneID:5676"
                     /db_xref="HGNC:HGNC:9524"
                     /db_xref="MIM:176396"
                     /translation="MGPLSAPPCTQHITWKGLLLTASLLNFWNPPTTAQVTIEAQPPK
                     VSEGKDVLLLVHNLPQNLTGYIWYKGQIRDLYHYVTSYIVDGQIIKYGPAYSGRETVY
                     SNASLLIQNVTQEDTGSYTLHIIKRGDGTGGVTGRFTFTLYLETPKPSISSSNFNPRE
                     ATEAVILTCDPETPDASYLWWMNGQSLPMTHSLQLSETNRTLYLFGVTNYTAGPYECE
                     IRNPVSASRSDPVTLNLLPKLPKPYITINNLNPRENKDVSTFTCEPKSENYTYIWWLN
                     GQSLPVSPRVKRRIENRILILPSVTRNETGPYQCEIRDRYGGIRSDPVTLNVLYGPDL
                     PRIYPSFTYYHSGQNLYLSCFADSNPPAQYSWTINGKFQLSGQKLSIPQITTKHSGLY
                     ACSVRNSATGKESSKSVTVRVSDWTLP"
     exon            196..561
                     /gene="PSG7"
                     /gene_synonym="PS-beta-G-7; PSBG-7; PSG1; PSGGA"
                     /inference="alignment:Splign:2.1.0"
     exon            562..840
                     /gene="PSG7"
                     /gene_synonym="PS-beta-G-7; PSBG-7; PSG1; PSGGA"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1119
                     /gene="PSG7"
                     /gene_synonym="PS-beta-G-7; PSBG-7; PSG1; PSGGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1374
                     /gene="PSG7"
                     /gene_synonym="PS-beta-G-7; PSBG-7; PSG1; PSGGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..2067
                     /gene="PSG7"
                     /gene_synonym="PS-beta-G-7; PSBG-7; PSG1; PSGGA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2042..2047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSG7"
                     /gene_synonym="PS-beta-G-7; PSBG-7; PSG1; PSGGA"
                     /note="hexamer: AATAAA"
     polyA_site      2067
                     /gene="PSG7"
                     /gene_synonym="PS-beta-G-7; PSBG-7; PSG1; PSGGA"
                     /note="major polyA site"
ORIGIN      
        1 agaagtgctc ctgccccggg aagaggctca gtgcagaagg aggaaggaca gcacagctga
       61 cagccgtgct caggaagatt ctggatccta ggctcatctc cacagaggag aacacgcagg
      121 gagcagagac catggggccc ctctcagccc ctccctgcac acagcatata acctggaaag
      181 ggctcctgct cacagcatca cttttaaact tctggaaccc gcccaccaca gcccaagtca
      241 cgattgaagc ccagccacca aaagtttccg aggggaagga tgttcttcta cttgtccaca
      301 atttgcccca gaatcttact ggctacatct ggtacaaagg acaaatcagg gacctctacc
      361 attatgttac atcatatata gtagacggtc aaataattaa atatgggcct gcatacagtg
      421 gacgagaaac agtatattcc aatgcatccc tgctgatcca gaatgtcacc caggaagaca
      481 caggatccta cactttacac atcataaagc gaggtgatgg gactggagga gtaactggac
      541 gtttcacctt caccttatac ctggagactc ccaaaccctc catctccagc agcaatttca
      601 accccaggga ggccacggag gctgtgattt taacctgtga tcctgagact ccagatgcaa
      661 gctacctgtg gtggatgaat ggtcagagcc tccctatgac tcacagcttg cagctgtctg
      721 aaaccaacag gaccctctac ctatttggtg tcacaaacta tactgcagga ccctatgaat
      781 gtgaaatacg gaacccagtg agtgccagcc gcagtgaccc agtcaccctg aatctcctcc
      841 cgaagctgcc caagccctac atcaccatca ataacttaaa ccccagggag aataaggatg
      901 tctcaacctt cacctgtgaa cctaagagtg agaactacac ctacatttgg tggctaaatg
      961 gtcagagcct cccggtcagt cccagggtaa agcgacgcat tgaaaacagg atcctcattc
     1021 tacccagtgt cacgagaaat gaaacaggac cctatcaatg tgaaatacgg gaccgatatg
     1081 gtggcatccg cagtgaccca gtcaccctga atgtcctcta tggtccagac ctccccagaa
     1141 tttacccttc attcacctat taccattcag gacaaaacct ctacttgtcc tgctttgcgg
     1201 actctaaccc accggcacag tattcttgga caattaatgg gaagtttcag ctatcaggac
     1261 aaaagctttc tatcccccag attactacaa agcatagcgg gctctatgct tgctctgttc
     1321 gtaactcagc cactggcaag gaaagctcca aatccgtgac agtcagagtc tctgactgga
     1381 cattaccctg aattctacta gttcctccaa ttccatcttc tcccatggaa cctcaaagag
     1441 caagacccac tctgttccag aagccctata agtcagagtt ggacaactca atgtaaattt
     1501 catgggaaaa tccttgtacc tgatgtctga gccactcaga actcaccaaa atgttcaaca
     1561 ccataacaac agctgctcaa actgtaaaca aggaaaacaa gttgatgact tcacactgtg
     1621 gacagctttt cccaagatgt cagaataaga ctccccatca tgatgaggct ctcacccctc
     1681 ttagctgtcc ttgcttgtgc ctgcctcttt cacttggcag gataatgcag tcattagaat
     1741 ttcacatgta gtataggagc ttctgagggt aacaacagag tgtcagatat gtcatctcaa
     1801 cctcagactt ttacataaca tctcaggagg aaatgtggct ctctccatct tgcatacagg
     1861 gctcccaata gaaatgaaca cagagatatt gcctgtgtgt ttgcagagaa gatggtttct
     1921 ataaagagta ggaaagctga aattatagta gactcccctt taaatgcaca ttgtgtggat
     1981 ggctctcacc atttcctaag agatacattg taaaacgtga cagtaagact gattctagca
     2041 gaataaaaca tgtactacat ttgctaa
//
