LOCUS       NM_001031850            1703 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens pregnancy specific beta-1-glycoprotein 6 (PSG6),
            transcript variant 2, mRNA.
ACCESSION   NM_001031850
VERSION     NM_001031850.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1703)
  AUTHORS   Teglund,S., Zhou,G.Q. and Hammarstrom,S.
  TITLE     Characterization of cDNA encoding novel pregnancy-specific
            glycoprotein variants
  JOURNAL   Biochem Biophys Res Commun 211 (2), 656-664 (1995)
   PUBMED   7794280
REFERENCE   2  (bases 1 to 1703)
  AUTHORS   Teglund,S., Olsen,A., Khan,W.N., Frangsmyr,L. and Hammarstrom,S.
  TITLE     The pregnancy-specific glycoprotein (PSG) gene cluster on human
            chromosome 19: fine structure of the 11 PSG genes and
            identification of 6 new genes forming a third subgroup within the
            carcinoembryonic antigen (CEA) family
  JOURNAL   Genomics 23 (3), 669-684 (1994)
   PUBMED   7851896
REFERENCE   3  (bases 1 to 1703)
  AUTHORS   Olsen,A., Teglund,S., Nelson,D., Gordon,L., Copeland,A.,
            Georgescu,A., Carrano,A. and Hammarstrom,S.
  TITLE     Gene organization of the pregnancy-specific glycoprotein region on
            human chromosome 19: assembly and analysis of a 700-kb cosmid
            contig spanning the region
  JOURNAL   Genomics 23 (3), 659-668 (1994)
   PUBMED   7851895
REFERENCE   4  (bases 1 to 1703)
  AUTHORS   Chamberlin,M.E., Lei,K.J. and Chou,J.Y.
  TITLE     Subtle differences in human pregnancy-specific glycoprotein gene
            promoters allow for differential expression
  JOURNAL   J Biol Chem 269 (25), 17152-17159 (1994)
   PUBMED   8006022
REFERENCE   5  (bases 1 to 1703)
  AUTHORS   Barnett,T.R., Pickle,W. 2nd and Elting,J.J.
  TITLE     Characterization of two new members of the pregnancy-specific beta
            1-glycoprotein family from the myeloid cell line KG-1 and
            suggestion of two distinct classes of transcription unit
  JOURNAL   Biochemistry 29 (44), 10213-10218 (1990)
   PUBMED   2271648
REFERENCE   6  (bases 1 to 1703)
  AUTHORS   Leslie,K.K., Watanabe,S., Lei,K.J., Chou,D.Y., Plouzek,C.A.,
            Deng,H.C., Torres,J. and Chou,J.Y.
  TITLE     Linkage of two human pregnancy-specific beta 1-glycoprotein genes:
            one is associated with hydatidiform mole
  JOURNAL   Proc Natl Acad Sci U S A 87 (15), 5822-5826 (1990)
   PUBMED   2377620
REFERENCE   7  (bases 1 to 1703)
  AUTHORS   Zheng,Q.X., Tease,L.A., Shupert,W.L. and Chan,W.Y.
  TITLE     Characterization of cDNAs of the human pregnancy-specific beta
            1-glycoprotein family, a new subfamily of the immunoglobulin gene
            superfamily
  JOURNAL   Biochemistry 29 (11), 2845-2852 (1990)
   PUBMED   2346748
REFERENCE   8  (bases 1 to 1703)
  AUTHORS   Thompson,J., Koumari,R., Wagner,K., Barnert,S., Schleussner,C.,
            Schrewe,H., Zimmermann,W., Muller,G., Schempp,W., Zaninetta,D. et
            al.
  TITLE     The human pregnancy-specific glycoprotein genes are tightly linked
            on the long arm of chromosome 19 and are coordinately expressed
  JOURNAL   Biochem Biophys Res Commun 167 (2), 848-859 (1990)
   PUBMED   1690992
  REMARK    Erratum:[Biochem Biophys Res Commun 1990 May 16;168(3):1325]
REFERENCE   9  (bases 1 to 1703)
  AUTHORS   Zimmermann,W., Weiss,M. and Thompson,J.A.
  TITLE     cDNA cloning demonstrates the expression of pregnancy-specific
            glycoprotein genes, a subgroup of the carcinoembryonic antigen gene
            family, in fetal liver
  JOURNAL   Biochem Biophys Res Commun 163 (3), 1197-1209 (1989)
   PUBMED   2783133
REFERENCE   10 (bases 1 to 1703)
  AUTHORS   Thompson,J.A., Mauch,E.M., Chen,F.S., Hinoda,Y., Schrewe,H.,
            Berling,B., Barnert,S., von Kleist,S., Shively,J.E. and
            Zimmermann,W.
  TITLE     Analysis of the size of the carcinoembryonic antigen (CEA) gene
            family: isolation and sequencing of N-terminal domain exons
  JOURNAL   Biochem Biophys Res Commun 158 (3), 996-1004 (1989)
   PUBMED   2537643
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA833634.1, BC020652.1 and
            AI148792.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001031850.3.
            
            Summary: This gene is a member of the pregnancy-specific
            glycoprotein (PSG) gene family. The PSG genes are a subgroup of the
            carcinoembryonic antigen (CEA) family of immunoglobulin-like genes,
            and are found in a gene cluster at 19q13.1-q13.2 telomeric to
            another cluster of CEA-related genes. The PSG genes are expressed
            by placental trophoblasts and released into the maternal
            circulation during pregnancy, and are thought to be essential for
            maintenance of normal pregnancy. The protein encoded by this gene
            contains the Arg-Gly-Asp tripeptide associated with cellular
            adhesion and recognition. Alternative splicing results in multiple
            transcript variants and protein isoforms. [provided by RefSeq, Jul
            2012].
            
            Transcript Variant: This variant (2) contains an alternate 3'
            terminal exon, compared to variant 1. The resulting protein
            (isoform 2) is shorter and has a distinct C-terminus, compared to
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279824.6288.1, ERR279861.2072.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000187910.7/ ENSP00000187910.3
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DA833634.1         31-33
            4-1701              BC020652.1         1-1698
            1702-1703           AI148792.1         11-12               c
FEATURES             Location/Qualifiers
     source          1..1703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..1703
                     /gene="PSG6"
                     /gene_synonym="PSBG-10; PSBG-12; PSBG-6; PSG10; PSGGB"
                     /note="pregnancy specific beta-1-glycoprotein 6"
                     /db_xref="GeneID:5675"
                     /db_xref="HGNC:HGNC:9523"
                     /db_xref="MIM:176395"
     exon            1..166
                     /gene="PSG6"
                     /gene_synonym="PSBG-10; PSBG-12; PSBG-6; PSG10; PSGGB"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1377
                     /gene="PSG6"
                     /gene_synonym="PSBG-10; PSBG-12; PSBG-6; PSG10; PSGGB"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; pregnancy-specific beta-1-glycoprotein 10;
                     PS-beta-G-6; PS-beta-G-10; PS-beta-G-12;
                     pregnancy-specific beta-1-glycoprotein 12"
                     /codon_start=1
                     /product="pregnancy-specific beta-1-glycoprotein 6 isoform
                     b precursor"
                     /protein_id="NP_001027020.1"
                     /db_xref="CCDS:CCDS33038.1"
                     /db_xref="GeneID:5675"
                     /db_xref="HGNC:HGNC:9523"
                     /db_xref="MIM:176395"
                     /translation="MGPLSAPPCTQHITWKGLLLTASLLNFWNLPTTAQVIIEAKPPK
                     VSEGKDVLLLVHNLPQNLTGYIWYKGQMTDLYHYITSYVVHGQIIYGPAYSGRETVYS
                     NASLLIQNVTQEDAGSYTLHIIKRGDGTGGVTGYFTVTLYSETPKPSISSSNLNPREV
                     MEAVRLICDPETPDASYLWLLNGQNLPMTHRLQLSKTNRTLYLFGVTKYIAGPYECEI
                     RNPVSASRSDPVTLNLLPKLPMPYITINNLNPREKKDVLAFTCEPKSRNYTYIWWLNG
                     QSLPVSPRVKRPIENRILILPSVTRNETGPYQCEIRDRYGGIRSNPVTLNVLYGPDLP
                     RIYPSFTYYRSGENLDLSCFADSNPPAEYSWTINGKFQLSGQKLFIPQITTNHSGLYA
                     CSVRNSATGKEISKSMIVKVSGPCHGNQTESH"
     exon            167..529
                     /gene="PSG6"
                     /gene_synonym="PSBG-10; PSBG-12; PSBG-6; PSG10; PSGGB"
                     /inference="alignment:Splign:2.1.0"
     exon            530..808
                     /gene="PSG6"
                     /gene_synonym="PSBG-10; PSBG-12; PSBG-6; PSG10; PSGGB"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1087
                     /gene="PSG6"
                     /gene_synonym="PSBG-10; PSBG-12; PSBG-6; PSG10; PSGGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1342
                     /gene="PSG6"
                     /gene_synonym="PSBG-10; PSBG-12; PSBG-6; PSG10; PSGGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1703
                     /gene="PSG6"
                     /gene_synonym="PSBG-10; PSBG-12; PSBG-6; PSG10; PSGGB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSG6"
                     /gene_synonym="PSBG-10; PSBG-12; PSBG-6; PSG10; PSGGB"
                     /note="hexamer: AATAAA"
     polyA_site      1703
                     /gene="PSG6"
                     /gene_synonym="PSBG-10; PSBG-12; PSBG-6; PSG10; PSGGB"
                     /note="major polyA site"
ORIGIN      
        1 agcacagaag gaggaaggac agcacacctg acagccctgc tcaggaagtc tctggatcct
       61 aggctcatct ccacagggga gaacacacag acagcagaga ccatgggacc cctctcagcc
      121 cctccctgca ctcagcacat cacctggaag gggctcctgc tcacagcatc acttttaaac
      181 ttctggaacc tgcccaccac tgcccaagta ataattgaag ccaagccacc caaagtttcc
      241 gaggggaagg atgttcttct acttgtccac aatttgcccc agaatcttac tggctacatc
      301 tggtacaaag ggcaaatgac ggacctctac cattacatta catcatatgt agtacacggt
      361 caaattatat atgggcctgc ctacagtgga cgagaaacag tatattccaa tgcatccctg
      421 ctgatccaga atgtcacaca ggaggatgca ggatcctaca ccttacacat cataaagcga
      481 ggcgatggga ctggaggagt aactggatat ttcactgtca ccttatactc ggagactccc
      541 aagccctcca tctccagcag caacttaaac cccagggagg tcatggaggc tgtgcgctta
      601 atctgtgatc ctgagactcc ggatgcaagc tacctgtggt tgctgaatgg tcagaacctc
      661 cctatgactc acaggttgca gctgtccaaa accaacagga ccctctatct atttggtgtc
      721 acaaagtata ttgcaggacc ctatgaatgt gaaatacgga acccagtgag tgccagccgc
      781 agtgacccag tcaccctgaa tctcctcccg aagctgccca tgccttacat caccatcaac
      841 aacttaaacc ccagggagaa gaaggatgtg ttagccttca cctgtgaacc taagagtcgg
      901 aactacacct acatttggtg gctaaatggt cagagcctcc cggtcagtcc gagggtaaag
      961 cgacccattg aaaacaggat actcattcta cccagtgtca cgagaaatga aacaggaccc
     1021 tatcaatgtg aaatacggga ccgatatggt ggcatccgca gtaacccagt caccctgaat
     1081 gtcctctatg gtccagacct ccccagaatt tacccttcat tcacctatta ccgttcagga
     1141 gaaaacctcg acttgtcctg ctttgcggac tctaacccac cggcagagta ttcttggaca
     1201 attaatggga agtttcagct atcaggacaa aagctcttta tcccccaaat tactacaaat
     1261 catagcgggc tctatgcttg ctctgttcgt aactcagcca ctggcaagga aatctccaaa
     1321 tccatgatag tcaaagtctc tggtccctgc catggaaacc agacagagtc tcattaatgg
     1381 ctgccacaat agagacactg agaaaaagaa caggttgata ccttcatgaa attcaagaca
     1441 aagaagaaaa aaactcaatg ttattggact aaataatcaa aaggataatg ttttcataat
     1501 tttttattgg aaaatgtgct gattcttgga atgttttatt ctccagattt atgaactttt
     1561 tttcttcagc aattggtaaa gtatactttt gtaaacaaaa attgaaacat ttgcttttgc
     1621 tctctatctg agtgccccag aattgggaaa ctattcatga gtattcatag gtttatggta
     1681 ataaagttat ttgcacaagt tca
//
