LOCUS       NM_002780               2032 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens pregnancy specific beta-1-glycoprotein 4 (PSG4),
            transcript variant 1, mRNA.
ACCESSION   NM_002780
VERSION     NM_002780.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2032)
  AUTHORS   Shanley DK, Kiely PA, Golla K, Allen S, Martin K, O'Riordan RT,
            Ball M, Aplin JD, Singer BB, Caplice N, Moran N and Moore T.
  TITLE     Pregnancy-specific glycoproteins bind integrin alphaIIbbeta3 and
            inhibit the platelet-fibrinogen interaction
  JOURNAL   PLoS ONE 8 (2), e57491 (2013)
   PUBMED   23469002
REFERENCE   2  (bases 1 to 2032)
  AUTHORS   Kimoto Y.
  TITLE     A single human cell expresses all messenger ribonucleic acids: the
            arrow of time in a cell
  JOURNAL   Mol. Gen. Genet. 258 (3), 233-239 (1998)
   PUBMED   9645429
REFERENCE   3  (bases 1 to 2032)
  AUTHORS   Teglund S, Olsen A, Khan WN, Frangsmyr L and Hammarstrom S.
  TITLE     The pregnancy-specific glycoprotein (PSG) gene cluster on human
            chromosome 19: fine structure of the 11 PSG genes and
            identification of 6 new genes forming a third subgroup within the
            carcinoembryonic antigen (CEA) family
  JOURNAL   Genomics 23 (3), 669-684 (1994)
   PUBMED   7851896
REFERENCE   4  (bases 1 to 2032)
  AUTHORS   Olsen A, Teglund S, Nelson D, Gordon L, Copeland A, Georgescu A,
            Carrano A and Hammarstrom S.
  TITLE     Gene organization of the pregnancy-specific glycoprotein region on
            human chromosome 19: assembly and analysis of a 700-kb cosmid
            contig spanning the region
  JOURNAL   Genomics 23 (3), 659-668 (1994)
   PUBMED   7851895
REFERENCE   5  (bases 1 to 2032)
  AUTHORS   Pan CJ, Chamberlin ME, Wu SM, Chan WY and Chou JY.
  TITLE     Pregnancy-specific glycoprotein gene expression and the induction
            by 5-bromo-2'-deoxyuridine
  JOURNAL   Biochemistry 33 (23), 7260-7266 (1994)
   PUBMED   8003489
REFERENCE   6  (bases 1 to 2032)
  AUTHORS   Chan WY, Zheng QX, McMahon J and Tease LA.
  TITLE     Characterization of new members of the pregnancy-specific beta
            1-glycoprotein family
  JOURNAL   Mol. Cell. Biochem. 106 (2), 161-170 (1991)
   PUBMED   1922019
REFERENCE   7  (bases 1 to 2032)
  AUTHORS   Barnett TR, Pickle W 2nd and Elting JJ.
  TITLE     Characterization of two new members of the pregnancy-specific beta
            1-glycoprotein family from the myeloid cell line KG-1 and
            suggestion of two distinct classes of transcription unit
  JOURNAL   Biochemistry 29 (44), 10213-10218 (1990)
   PUBMED   2271648
REFERENCE   8  (bases 1 to 2032)
  AUTHORS   .
  TITLE     The human pregnancy-specific glycoprotein genes are tightly linked
            on the long arm of chromosome 19 and are coordinately expressed
  JOURNAL   Biochem. Biophys. Res. Commun. 168 (3), 1325 (1990)
   PUBMED   2346490
REFERENCE   9  (bases 1 to 2032)
  AUTHORS   Thompson J, Koumari R, Wagner K, Barnert S, Schleussner C, Schrewe
            H, Zimmermann W, Muller G, Schempp W, Zaninetta D et al.
  TITLE     The human pregnancy-specific glycoprotein genes are tightly linked
            on the long arm of chromosome 19 and are coordinately expressed
  JOURNAL   Biochem. Biophys. Res. Commun. 167 (2), 848-859 (1990)
   PUBMED   1690992
  REMARK    Erratum:[Biochem Biophys Res Commun 1990 May 16;168(3):1325]
REFERENCE   10 (bases 1 to 2032)
  AUTHORS   Thompson JA, Mauch EM, Chen FS, Hinoda Y, Schrewe H, Berling B,
            Barnert S, von Kleist S, Shively JE and Zimmermann W.
  TITLE     Analysis of the size of the carcinoembryonic antigen (CEA) gene
            family: isolation and sequencing of N-terminal domain exons
  JOURNAL   Biochem. Biophys. Res. Commun. 158 (3), 996-1004 (1989)
   PUBMED   2537643
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005392.2, BC013431.1 and
            BC008405.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002780.4.
            
            Summary: The protein encoded by this gene is a pregnancy-specific
            glycoprotein (PSG), one of several encoded by a cluster of similar
            genes on chromosome 19. This gene is a member of the
            carcinoembryonic antigen (CEA) gene family and may play a role in
            regulation of the innate immune system. Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063127.1, BC013431.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2142853,
                                           SAMEA2149398 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405312.8/ ENSP00000384770.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC005392.2         53798-53934         c
            138-274             BC013431.1         135-271
            275-276             AC005392.2         52438-52439         c
            277-814             BC013431.1         273-810
            815-815             AC005392.2         43566-43566         c
            816-2029            BC013431.1         812-2025
            2030-2032           BC008405.1         2025-2027
FEATURES             Location/Qualifiers
     source          1..2032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..2032
                     /gene="PSG4"
                     /gene_synonym="PSBG-4; PSBG-9; PSG9"
                     /note="pregnancy specific beta-1-glycoprotein 4"
                     /db_xref="GeneID:5672"
                     /db_xref="HGNC:HGNC:9521"
                     /db_xref="MIM:176393"
     exon            1..166
                     /gene="PSG4"
                     /gene_synonym="PSBG-4; PSBG-9; PSG9"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1362
                     /gene="PSG4"
                     /gene_synonym="PSBG-4; PSBG-9; PSG9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Pregnancy-specific beta-1-glycoprotein-4;
                     PS-beta-G-4; PS-beta-G-9; pregnancy-specific glycoprotein
                     4; pregnancy-specific glycoprotein 9; pregnancy-specific
                     beta-1-glycoprotein 9"
                     /codon_start=1
                     /product="pregnancy-specific beta-1-glycoprotein 4 isoform
                     1 precursor"
                     /protein_id="NP_002771.2"
                     /db_xref="CCDS:CCDS46093.1"
                     /db_xref="GeneID:5672"
                     /db_xref="HGNC:HGNC:9521"
                     /db_xref="MIM:176393"
                     /translation="MGPLSAPPCTQRITWKGVLLTASLLNFWNPPTTAQVTIEAQPPK
                     VSEGKDVLLLVHNLPQNLAGYIWYKGQMTYLYHYITSYVVDGQRIIYGPAYSGRERVY
                     SNASLLIQNVTQEDAGSYTLHIIKRRDGTGGVTGHFTFTLHLETPKPSISSSNLNPRE
                     AMEAVILTCDPATPAASYQWWMNGQSLPMTHRLQLSKTNRTLFIFGVTKYIAGPYECE
                     IRNPVSASRSDPVTLNLLPKLSKPYITINNLNPRENKDVLTFTCEPKSKNYTYIWWLN
                     GQSLPVSPRVKRPIENRILILPNVTRNETGPYQCEIRDRYGGIRSDPVTLNVLYGPDL
                     PSIYPSFTYYRSGENLYLSCFAESNPRAQYSWTINGKFQLSGQKLSIPQITTKHSGLY
                     ACSVRNSATGKESSKSITVKVSDWILP"
     exon            167..532
                     /gene="PSG4"
                     /gene_synonym="PSBG-4; PSBG-9; PSG9"
                     /inference="alignment:Splign:2.1.0"
     exon            533..811
                     /gene="PSG4"
                     /gene_synonym="PSBG-4; PSBG-9; PSG9"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1090
                     /gene="PSG4"
                     /gene_synonym="PSBG-4; PSBG-9; PSG9"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1345
                     /gene="PSG4"
                     /gene_synonym="PSBG-4; PSBG-9; PSG9"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..2032
                     /gene="PSG4"
                     /gene_synonym="PSBG-4; PSBG-9; PSG9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2007..2012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSG4"
                     /gene_synonym="PSBG-4; PSBG-9; PSG9"
                     /note="hexamer: AATAAA"
     polyA_site      2032
                     /gene="PSG4"
                     /gene_synonym="PSBG-4; PSBG-9; PSG9"
                     /note="major polyA site"
ORIGIN      
        1 agcacagaag gaggaaggac agcacagctg acagccgtac tcaggaagct tctggatcct
       61 aggcttatct ccacagagga gaacacacaa gcagcagaga ccatggggcc cctctcagcc
      121 cctccctgca cacagcgcat cacctggaag ggggtcctgc tcacagcatc acttttaaac
      181 ttctggaatc cgcccacaac tgcccaagtc acgattgaag cccagccacc caaagtttct
      241 gaggggaagg atgttcttct acttgtccac aatttgcccc agaatcttgc tggctacatt
      301 tggtacaaag ggcaaatgac atacctctac cattacatta catcatatgt agtagacggt
      361 caaagaatta tatatgggcc tgcatacagt ggaagagaaa gagtatattc caatgcatcc
      421 ctgctgatcc agaatgtcac gcaggaggat gcaggatcct acaccttaca catcataaag
      481 cgacgcgatg ggactggagg agtaactgga catttcacct tcaccttaca cctggagact
      541 cccaagccct ccatctccag cagcaactta aatcccaggg aggccatgga ggctgtgatc
      601 ttaacctgtg atcctgcgac tccagccgca agctaccagt ggtggatgaa tggtcagagc
      661 ctccctatga ctcacaggtt gcagctgtcc aaaaccaaca ggaccctctt tatatttggt
      721 gtcacaaagt atattgcagg accctatgaa tgtgaaatac ggaacccagt gagtgccagc
      781 cgcagtgacc cagtcaccct gaatctcctc ccaaagctgt ccaagcccta catcacaatc
      841 aacaacttaa accccagaga gaataaggat gtcttaacct tcacctgtga acctaagagt
      901 aagaactaca cctacatttg gtggctaaat ggtcagagcc tccctgtcag tcccagggta
      961 aagcgaccca ttgaaaacag gatcctcatt ctacccaatg tcacgagaaa tgaaacagga
     1021 ccttatcaat gtgaaatacg ggaccgatat ggtggcatcc gcagtgaccc agtcaccctg
     1081 aatgtcctct atggtccaga cctccccagc atttaccctt cattcaccta ttaccgttca
     1141 ggagaaaacc tctacttgtc ctgcttcgcc gagtctaacc cacgggcaca atattcttgg
     1201 acaattaatg ggaagtttca gctatcagga caaaagctct ctatccccca aataactaca
     1261 aagcatagtg ggctctatgc ttgctctgtt cgtaactcag ccactggcaa ggaaagctcc
     1321 aaatccatca cagtcaaagt ctctgactgg atattaccct gaattctact agttcctcca
     1381 attccatttt ctcccatgga atcacgaaga gcaagaccca ctctgttcca gaagccctat
     1441 aagctggagg tggacaactc gatgtaaatt tcatgggaaa acccttgtac ctgacatgtg
     1501 agccactcag aactcaccaa aatgttcgac accataacaa cagctactca aactgtaaac
     1561 caggataaca agttgatgac ttcacactgt ggacagtttt tccaaagatg tcagaacaag
     1621 actccccatc atgataaggc tcccacccct cttaaccgtc cttgctcatg cctgcctctt
     1681 tcacttggca ggataatgca gtcattagaa tttcacatgt agtagcttct gagggtaaca
     1741 acagagtgtc agatatgtca tctcaacctc aaacttttac gtaacatctc aggggaaatg
     1801 tggctctctc catcttgcat acagggctcc caatagaaat gaacacagag atattgcctg
     1861 tgtgtttgca gagaagatgg tttctataaa gagtaggaaa gctgaaatta tagtagagtc
     1921 tcctttaaat gcacattgtg tggatggctc tcaccatttc ctaagagata cagtgtaaaa
     1981 cgtgacagta atactgattc tagcagaata aaacatgtac cacatttgct aa
//
