LOCUS       NM_021016               1873 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens pregnancy specific beta-1-glycoprotein 3 (PSG3), mRNA.
ACCESSION   NM_021016
VERSION     NM_021016.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1873)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   2  (bases 1 to 1873)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   3  (bases 1 to 1873)
  AUTHORS   Teglund,S., Olsen,A., Khan,W.N., Frangsmyr,L. and Hammarstrom,S.
  TITLE     The pregnancy-specific glycoprotein (PSG) gene cluster on human
            chromosome 19: fine structure of the 11 PSG genes and
            identification of 6 new genes forming a third subgroup within the
            carcinoembryonic antigen (CEA) family
  JOURNAL   Genomics 23 (3), 669-684 (1994)
   PUBMED   7851896
REFERENCE   4  (bases 1 to 1873)
  AUTHORS   Olsen,A., Teglund,S., Nelson,D., Gordon,L., Copeland,A.,
            Georgescu,A., Carrano,A. and Hammarstrom,S.
  TITLE     Gene organization of the pregnancy-specific glycoprotein region on
            human chromosome 19: assembly and analysis of a 700-kb cosmid
            contig spanning the region
  JOURNAL   Genomics 23 (3), 659-668 (1994)
   PUBMED   7851895
REFERENCE   5  (bases 1 to 1873)
  AUTHORS   Shupert,W.L. and Chan,W.Y.
  TITLE     Pregnancy specific beta 1-glycoprotein in human intestine
  JOURNAL   Mol Cell Biochem 120 (2), 159-170 (1993)
   PUBMED   8487756
REFERENCE   6  (bases 1 to 1873)
  AUTHORS   Streydio,C., Swillens,S., Georges,M., Szpirer,C. and Vassart,G.
  TITLE     Structure, evolution and chromosomal localization of the human
            pregnancy-specific beta 1-glycoprotein gene family
  JOURNAL   Genomics 7 (4), 661-662 (1990)
   PUBMED   2387594
REFERENCE   7  (bases 1 to 1873)
  AUTHORS   Zoubir,F., Khan,W.N. and Hammarstrom,S.
  TITLE     Carcinoembryonic antigen gene family members in submandibular
            salivary gland: demonstration of pregnancy-specific glycoproteins
            by cDNA cloning
  JOURNAL   Biochem Biophys Res Commun 169 (1), 203-216 (1990)
   PUBMED   2350345
REFERENCE   8  (bases 1 to 1873)
  AUTHORS   Streydio,C., Swillens,S., Georges,M., Szpirer,C. and Vassart,G.
  TITLE     Structure, evolution and chromosomal localization of the human
            pregnancy-specific beta 1 glycoprotein gene family
  JOURNAL   Genomics 6 (4), 579-592 (1990)
   PUBMED   2341148
  REMARK    Erratum:[Genomics 1990 Aug;7(4):661-2]
REFERENCE   9  (bases 1 to 1873)
  AUTHORS   Borjigin,J., Tease,L.A., Barnes,W. and Chan,W.Y.
  TITLE     Expression of the pregnancy-specific beta 1-glycoprotein genes in
            human testis
  JOURNAL   Biochem Biophys Res Commun 166 (2), 622-629 (1990)
   PUBMED   2302228
REFERENCE   10 (bases 1 to 1873)
  AUTHORS   McLenachan,T. and Mansfield,B.
  TITLE     Expression of CEA-related genes in the first trimester human
            placenta
  JOURNAL   Biochem Biophys Res Commun 162 (3), 1486-1493 (1989)
   PUBMED   2788412
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA833589.1, M93061.1 and BG620196.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021016.3.
            
            Summary: The human pregnancy-specific glycoproteins (PSGs) are a
            family of proteins that are synthesized in large amounts by
            placental trophoblasts and released into the maternal circulation
            during pregnancy. Molecular cloning and analysis of several PSG
            genes has indicated that the PSGs form a subgroup of the
            carcinoembryonic antigen (CEA) gene family, which belongs to the
            immunoglobulin superfamily of genes. Members of the CEA family
            consist of a single N domain, with structural similarity to the
            immunoglobulin variable domains, followed by a variable number of
            immunoglobulin constant-like A and/or B domains. Most PSGs have an
            arg-gly-asp (RGD) motif, which has been shown to function as an
            adhesion recognition signal for several integrins, in the
            N-terminal domain (summary by Teglund et al., 1994 [PubMed
            7851896]). For additional general information about the PSG gene
            family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005924.1, M23575.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2149398,
                                           SAMEA2162568 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000327495.10/
                                                ENSP00000332215.5
            RefSeq Select criteria           :: based on expression, longest
                                                protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                DA833589.1         36-87
            53-1824             M93061.1           14-1785
            1825-1873           BG620196.1         211-259
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1873
                     /gene="PSG3"
                     /note="pregnancy specific beta-1-glycoprotein 3"
                     /db_xref="GeneID:5671"
                     /db_xref="HGNC:HGNC:9520"
                     /db_xref="MIM:176392"
     exon            1..161
                     /gene="PSG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1384
                     /gene="PSG3"
                     /note="PSBG-3; PS-beta-G-3; carcinoembryonic antigen SG5;
                     pregnancy-specific glycoprotein 3"
                     /codon_start=1
                     /product="pregnancy-specific beta-1-glycoprotein 3
                     precursor"
                     /protein_id="NP_066296.2"
                     /db_xref="CCDS:CCDS12611.1"
                     /db_xref="GeneID:5671"
                     /db_xref="HGNC:HGNC:9520"
                     /db_xref="MIM:176392"
                     /translation="MGPLSAPPCTQRITWKGLLLTALLLNFWNLPTTAQVTIEAEPTK
                     VSKGKDVLLLVHNLPQNLAGYIWYKGQMKDLYHYITSYVVDGQIIIYGPAYSGRETVY
                     SNASLLIQNVTREDAGSYTLHIVKRGDGTRGETGHFTFTLYLETPKPSISSSNLYPRE
                     DMEAVSLTCDPETPDASYLWWMNGQSLPMTHSLQLSKNKRTLFLFGVTKYTAGPYECE
                     IRNPVSASRSDPVTLNLLPKLPKPYITINNLNPRENKDVLAFTCEPKSENYTYIWWLN
                     GQSLPVSPRVKRPIENRILILPSVTRNETGPYQCEIQDRYGGIRSYPVTLNVLYGPDL
                     PRIYPSFTYYHSGENLYLSCFADSNPPAEYSWTINGKFQLSGQKLFIPQITTKHSGLY
                     ACSVRNSATGMESSKSMTVKVSAPSGTGHLPGLNPL"
     exon            162..527
                     /gene="PSG3"
                     /inference="alignment:Splign:2.1.0"
     exon            528..806
                     /gene="PSG3"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1085
                     /gene="PSG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1340
                     /gene="PSG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1424
                     /gene="PSG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1873
                     /gene="PSG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1850..1855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSG3"
                     /note="hexamer: AATAAA"
     polyA_site      1873
                     /gene="PSG3"
                     /note="major polyA site"
ORIGIN      
        1 agaaggagga aggacagcac agctgagagc catgctcagg aagtttctgg atcctaggct
       61 cagctccaca gaggagaaca cgcaggcagc agagaccatg gggcccctct cagcccctcc
      121 ctgcacacag cgcatcacct ggaaggggct cctgctcaca gcattacttt taaacttctg
      181 gaacttgcct accactgccc aagtcacgat tgaagccgag ccaaccaaag tttccaaggg
      241 gaaggacgtt cttctacttg tccacaattt gccccagaat cttgctggct acatctggta
      301 caaagggcaa atgaaggacc tctaccatta cattacatca tacgtagtag atggtcaaat
      361 aattatatat gggcctgcat acagtggacg agaaacagta tattccaatg catccctgct
      421 gatccagaat gtcacccggg aggacgcagg atcctacacc ttacacatcg taaagcgagg
      481 tgatgggact agaggagaaa ctggacattt caccttcacc ttatacctgg agactcccaa
      541 gccctccatc tccagcagca acttataccc cagggaggac atggaggctg tgagcttaac
      601 ctgtgatcct gagactccgg acgcaagcta cctgtggtgg atgaatggtc agagcctccc
      661 tatgactcac agcttgcagt tgtccaaaaa caaaaggacc ctctttctat ttggtgtcac
      721 aaagtacact gcaggaccct atgaatgtga aatacggaac ccagtgagtg ccagccgcag
      781 tgacccagtc accctgaatc tcctcccgaa gctgcccaag ccctacatca ccatcaacaa
      841 cttaaacccc agggagaata aggatgtctt agccttcacc tgtgaaccta agagtgagaa
      901 ctacacctac atttggtggc taaatggtca gagcctcccg gtcagtccca gggtaaagcg
      961 acccattgaa aacaggatcc tcattctacc cagtgtcacg agaaatgaaa caggacccta
     1021 tcaatgtgaa atacaggacc gatatggtgg catccgcagt tacccagtca ccctgaatgt
     1081 cctctatggt ccagacctcc ccagaattta cccttcattc acctattacc attcaggaga
     1141 aaacctctac ttgtcctgct tcgcggactc taacccacca gcagaatatt cttggacaat
     1201 taatgggaag tttcagctat caggacaaaa gctctttatc ccccagatta ctacaaagca
     1261 tagcgggctc tatgcttgct ctgttcgtaa ctcagccact ggcatggaaa gctccaaatc
     1321 catgacagtc aaagtctctg ctccttcagg aacaggacat cttcctggcc ttaatccatt
     1381 atagcagccg tgatgtcatt tctgtatttc aggaagactg gcagacagtt gctttcattc
     1441 ttcctcaaag tatttaccat cagctacagt ccaaaattgc tttttgttca aggagattta
     1501 tgaaaagact ctgacaagga ctcttgaata caagttcctg ataacttcaa gatcatacca
     1561 ctggactaag aactttcaaa attttaatga acaggctgat acttcatgaa attcaagaca
     1621 aagaaaaaaa cccaatttta ttggactaaa tagtcaaaac aatgttttca taattttcta
     1681 tttgaaaatg tgctgattct ttgaatgttt tattctccag atttatgcac tttttttctt
     1741 cagcaattgg taaagtatac ttttgtaaac aaaaattgaa acatttgctt ttgctcccta
     1801 agtgccccag aattgggaaa ctattcagga gtattcatat gtttatggta ataaagttat
     1861 ctgcacaagt tca
//
