LOCUS       NM_031246               1573 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens pregnancy specific beta-1-glycoprotein 2 (PSG2), mRNA.
ACCESSION   NM_031246
VERSION     NM_031246.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1573)
  AUTHORS   Ma,C., Li,W., Kong,Q., Yang,H., Bian,Z., Song,X., Yu,J. and Yan,M.
  TITLE     3D origami electrochemical immunodevice for sensitive point-of-care
            testing based on dual-signal amplification strategy
  JOURNAL   Biosens Bioelectron 63, 7-13 (2015)
   PUBMED   25048447
  REMARK    GeneRIF: Integrating the dual-signal amplification strategy, a
            novel 3D origami electrochemical immunodevice for simultaneous
            detecting carcinoembryonic antigen (CEA) and cancer antigen 125
            (CA125)
REFERENCE   2  (bases 1 to 1573)
  AUTHORS   Tsavaris,N., Kosmas,C., Papadoniou,N., Kopterides,P., Tsigritis,K.,
            Dokou,A., Sarantonis,J., Skopelitis,H., Tzivras,M., Gennatas,K.,
            Polyzos,A., Papastratis,G., Karatzas,G. and Papalambros,A.
  TITLE     CEA and CA-19.9 serum tumor markers as prognostic factors in
            patients with locally advanced (unresectable) or metastatic
            pancreatic adenocarcinoma: a retrospective analysis
  JOURNAL   J Chemother 21 (6), 673-680 (2009)
   PUBMED   20071292
  REMARK    GeneRIF: the authors evaluated the prognostic significance of the
            CEA and CA-19.9 serum tumor markers in advanced (unresectable)
            pancreatic cancer
            Erratum:[J Chemother. 2010 Feb;22(1):72. Kopteridis, P [corrected
            to Kopterides, P]]
REFERENCE   3  (bases 1 to 1573)
  AUTHORS   Mennuni,C., Calvaruso,F., Facciabene,A., Aurisicchio,L., Storto,M.,
            Scarselli,E., Ciliberto,G. and La Monica,N.
  TITLE     Efficient induction of T-cell responses to carcinoembryonic antigen
            by a heterologous prime-boost regimen using DNA and adenovirus
            vectors carrying a codon usage optimized cDNA
  JOURNAL   Int J Cancer 117 (3), 444-455 (2005)
   PUBMED   15906358
  REMARK    GeneRIF: This genetic cancer vaccineis highly immunogenic and can
            break tolerance to CEA tumor antigen in CEA transgenic mice.
REFERENCE   4  (bases 1 to 1573)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   5  (bases 1 to 1573)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   6  (bases 1 to 1573)
  AUTHORS   Teglund,S., Olsen,A., Khan,W.N., Frangsmyr,L. and Hammarstrom,S.
  TITLE     The pregnancy-specific glycoprotein (PSG) gene cluster on human
            chromosome 19: fine structure of the 11 PSG genes and
            identification of 6 new genes forming a third subgroup within the
            carcinoembryonic antigen (CEA) family
  JOURNAL   Genomics 23 (3), 669-684 (1994)
   PUBMED   7851896
REFERENCE   7  (bases 1 to 1573)
  AUTHORS   Leslie,K.K., Watanabe,S., Lei,K.J., Chou,D.Y., Plouzek,C.A.,
            Deng,H.C., Torres,J. and Chou,J.Y.
  TITLE     Linkage of two human pregnancy-specific beta 1-glycoprotein genes:
            one is associated with hydatidiform mole
  JOURNAL   Proc Natl Acad Sci U S A 87 (15), 5822-5826 (1990)
   PUBMED   2377620
REFERENCE   8  (bases 1 to 1573)
  AUTHORS   Zoubir,F., Khan,W.N. and Hammarstrom,S.
  TITLE     Carcinoembryonic antigen gene family members in submandibular
            salivary gland: demonstration of pregnancy-specific glycoproteins
            by cDNA cloning
  JOURNAL   Biochem Biophys Res Commun 169 (1), 203-216 (1990)
   PUBMED   2350345
REFERENCE   9  (bases 1 to 1573)
  AUTHORS   Thompson,J., Koumari,R., Wagner,K., Barnert,S., Schleussner,C.,
            Schrewe,H., Zimmermann,W., Muller,G., Schempp,W., Zaninetta,D. et
            al.
  TITLE     The human pregnancy-specific glycoprotein genes are tightly linked
            on the long arm of chromosome 19 and are coordinately expressed
  JOURNAL   Biochem Biophys Res Commun 167 (2), 848-859 (1990)
   PUBMED   1690992
  REMARK    Erratum:[Biochem Biophys Res Commun 1990 May 16;168(3):1325]
REFERENCE   10 (bases 1 to 1573)
  AUTHORS   Streydio,C., Lacka,K., Swillens,S. and Vassart,G.
  TITLE     The human pregnancy-specific beta 1-glycoprotein (PS beta G) and
            the carcinoembryonic antigen (CEA)-related proteins are members of
            the same multigene family
  JOURNAL   Biochem Biophys Res Commun 154 (1), 130-137 (1988)
   PUBMED   3260773
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024077.2.
            
            On Nov 22, 2018 this sequence version replaced NM_031246.3.
            
            Summary: The human pregnancy-specific glycoproteins (PSGs) are a
            family of proteins that are synthesized in large amounts by
            placental trophoblasts and released into the maternal circulation
            during pregnancy. Molecular cloning and analysis of several PSG
            genes has indicated that the PSGs form a subgroup of the
            carcinoembryonic antigen (CEA) gene family, which belongs to the
            immunoglobulin superfamily of genes. Members of the CEA family
            consist of a single N domain, with structural similarity to the
            immunoglobulin variable domains, followed by a variable number of
            immunoglobulin constant-like A and/or B domains. Most PSGs have an
            arg-gly-asp (RGD) motif, which has been shown to function as an
            adhesion recognition signal for several integrins, in the
            N-terminal domain (summary by Teglund et al., 1994 [PubMed
            7851896]). For additional general information about the PSG gene
            family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022316.1, M20882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406487.6/ ENSP00000385706.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC024077.2         14500-14695
            197-562             AC024077.2         15955-16320
            563-841             AC024077.2         21569-21847
            842-1096            AC024077.2         25247-25501
            1097-1180           AC024077.2         30601-30684
            1181-1573           AC024077.2         32600-32992
FEATURES             Location/Qualifiers
     source          1..1573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..1573
                     /gene="PSG2"
                     /gene_synonym="CEA; PSBG2; PSG1"
                     /note="pregnancy specific beta-1-glycoprotein 2"
                     /db_xref="GeneID:5670"
                     /db_xref="HGNC:HGNC:9519"
                     /db_xref="MIM:176391"
     exon            1..196
                     /gene="PSG2"
                     /gene_synonym="CEA; PSBG2; PSG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1140
                     /gene="PSG2"
                     /gene_synonym="CEA; PSBG2; PSG1"
                     /note="pregnancy-specific beta-1-glycoprotein 7;
                     carcinoembryonic antigen SG8; PSBG-2; PS-beta-E;
                     PS-beta-G-2; pregnancy-specific glycoprotein 2;
                     pregnancy-specific beta-1 glycoprotein E"
                     /codon_start=1
                     /product="pregnancy-specific beta-1-glycoprotein 2
                     precursor"
                     /protein_id="NP_112536.2"
                     /db_xref="CCDS:CCDS12616.1"
                     /db_xref="GeneID:5670"
                     /db_xref="HGNC:HGNC:9519"
                     /db_xref="MIM:176391"
                     /translation="MGPLSAPPCTEHIKWKGLLVTASLLNFWNLPTTAQVTIEAQPPK
                     VSEGKDVLLLVHNLPQNLTGYIWYKGQIRDLYHYITSYVVDGQIIIYGPAYSGRETAY
                     SNASLLIQNVTREDAGSYTLHIIKRGDGTRGVTGYFTFTLYLETPKPSISSSNLNPRE
                     AMETVILTCDPETPDTSYQWWMNGQSLPMTHRFQLSETNRTLFLFGVTKYTAGPYECE
                     IRNSGSASRSDPVTLNLLHGPDLPRIHPSYTNYRSGDNLYLSCFANSNPPAQYSWTIN
                     GKFQQSGQNLFIPQITTKHSGLYVCSVRNSATGEESSTSLTVKVSASTRIGLLPLLNP
                     T"
     exon            197..562
                     /gene="PSG2"
                     /gene_synonym="CEA; PSBG2; PSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..841
                     /gene="PSG2"
                     /gene_synonym="CEA; PSBG2; PSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1096
                     /gene="PSG2"
                     /gene_synonym="CEA; PSBG2; PSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1180
                     /gene="PSG2"
                     /gene_synonym="CEA; PSBG2; PSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1573
                     /gene="PSG2"
                     /gene_synonym="CEA; PSBG2; PSG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1550..1555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSG2"
                     /gene_synonym="CEA; PSBG2; PSG1"
                     /note="hexamer: AATAAA"
     polyA_site      1573
                     /gene="PSG2"
                     /gene_synonym="CEA; PSBG2; PSG1"
                     /note="major polyA site"
ORIGIN      
        1 gggaattgct gctgccccag gaagaggctc agtgcagaag gaggaaggac agcacagctg
       61 acagccgtgc tcaggaagtt tctggatcct aggctcatct ccacagagga gaacacacag
      121 gcagcagaga ccatggggcc cctctcagcc cctccctgca cagagcacat caaatggaag
      181 gggctcctgg tcacagcatc acttttaaac ttctggaacc tgcccaccac tgcccaagtc
      241 acgattgaag cccagccacc aaaagtttcc gaggggaagg atgttcttct acttgtccac
      301 aatttgcccc agaatcttac tggctacatc tggtacaaag ggcaaatcag ggacctctac
      361 cattacatta catcatatgt agtagacggt caaataatta tatatgggcc tgcatatagt
      421 ggacgagaaa cagcatattc caatgcatcc ctgctgatcc agaatgtcac ccgggaggac
      481 gcaggatcct acaccttaca catcataaag cgaggtgatg ggactagagg agtaactgga
      541 tatttcacct tcaccttata cctggagact cccaagccct ccatctccag cagcaactta
      601 aaccccaggg aggccatgga aactgtgatc ttaacctgtg atcctgagac tccggacaca
      661 agctaccagt ggtggatgaa tggtcagagc ctccctatga ctcataggtt tcagctgtcc
      721 gaaaccaaca ggaccctctt tctatttggt gtcacaaagt atactgcagg accctatgaa
      781 tgtgaaatac ggaactcagg gagtgccagc cgcagtgacc cagtcaccct gaatctcctc
      841 catggtccag acctccccag aattcaccct tcatacacca attaccgttc aggagataac
      901 ctctacttgt cttgcttcgc gaactctaac ccaccggcac agtattcttg gacaattaat
      961 gggaagtttc agcaatcagg acaaaatctg tttatccccc aaattactac aaagcatagc
     1021 gggctctatg tttgctctgt tcgtaactca gccactggcg aggaaagctc cacatcgttg
     1081 acagtcaaag tctctgcttc tacaagaata ggacttcttc ctctccttaa tccaacatag
     1141 cagctgtgat gtcatttctg tatttcagga agactggcag gagatttatg gaaaggtctc
     1201 ttacaaggac tcttgaatac aagctcctga taacttcaag atcataccac tggactaaga
     1261 actttcaaaa ttttaatgaa caggctgata ccttcatgaa attcaagaca aagaagaaaa
     1321 atactcaatg ttattggact aaataatcaa aaggataatg atttcataat tttctatttg
     1381 aaaatgtgct gattcttgga atgtttcatt ctccagattt atgaacattt tttcttgagc
     1441 aattggtaaa gtatactttt gtaaacaaaa attgaaacat ttccttttgc tctctatctg
     1501 agtgccccag aattgggaat ctattcatga gtattcatat gtttatggta ataaagctat
     1561 ttgcacaagt tca
//
